Gene Symbol: Tek
Description: TEK receptor tyrosine kinase
Alias: Tie-2, Tie2, angiopoietin-1 receptor, TEK tyrosine kinase, endothelial, endothelial-specific receptor tyrosine kinase, tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2
Species: rat
Products:     Tek

Top Publications

  1. Willam C, Koehne P, Jürgensen J, Grafe M, Wagner K, Bachmann S, et al. Tie2 receptor expression is stimulated by hypoxia and proinflammatory cytokines in human endothelial cells. Circ Res. 2000;87:370-7 pubmed
    The tyrosine kinase receptor Tie2 (also known as Tek) plays an important role in the development of the embryonic vasculature and persists in adult endothelial cells (ECs)...
  2. Lewinson D, Maor G, Rozen N, Rabinovich I, Stahl S, Rachmiel A. Expression of vascular antigens by bone cells during bone regeneration in a membranous bone distraction system. Histochem Cell Biol. 2001;116:381-8 pubmed
    ..As the source of the bone-forming cells in regenerating tissue during distraction is not yet fully understood, this observation might support the possibility of their vascular origin. ..
  3. Zhang Z, Zhang L, Tsang W, Soltanian Zadeh H, Morris D, Zhang R, et al. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab. 2002;22:379-92 pubmed
    ..Two to 28 days after the onset of stroke, increased expression of VEGF/VEGF receptors and Ang/Tie2 was detected at the boundary of the ischemic lesion...
  4. Miyabayashi K, Shimizu T, Kawauchi C, Sasada H, Sato E. Changes of mRNA expression of vascular endothelial growth factor, angiopoietins and their receptors during the periovulatory period in eCG/hCG-treated immature female rats. J Exp Zool A Comp Exp Biol. 2005;303:590-7 pubmed
    ..Our findings suggest that ovarian vascular formation during the periovulatory period including preovulatory follicles, ovulation and CL formation may develop via crosstalk of the VEGF-Flt-1 and Ang-Tie2 systems.
  5. Dumont D, Gradwohl G, Fong G, Puri M, Gertsenstein M, Auerbach A, et al. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994;8:1897-909 pubmed
    ..Expression of the Tek RTK during mouse development is restricted primarily to endothelial cells and their progenitors, the angioblasts, ..
  6. Sato T, Tozawa Y, Deutsch U, Wolburg Buchholz K, Fujiwara Y, Gendron Maguire M, et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 1995;376:70-4 pubmed
    ..Our in vivo analyses indicate that the structurally related receptor tyrosine kinases Tie-1 and Tie-2 have important but distinct roles in the formation of blood vessels. ..
  7. Yamamoto A, Takahashi H, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, et al. Downregulation of angiopoietin-1 and Tie2 in chronic hypoxic pulmonary hypertension. Respiration. 2008;75:328-38 pubmed
    ..The cellular distribution and expression of angiopoietins and their receptor Tie2 and VEGF were investigated by RT-PCR, immunoblot, and immunohistochemical methods in rat lung under normal and ..
  8. Sato H, Kasai S, Maesawa C. Temporal expression in rats of receptor tyrosine kinase Tie2 during early wound healing after tooth extraction. J Oral Sci. 2015;57:313-8 pubmed publisher
    We examined the role of Tie2 in regulating wound healing after tooth extraction. Wistar rats underwent maxillary incisor tooth extraction, and immunodetection techniques were used to determine Tie2 expression in the healing wound...
  9. Lekas M, Lekas P, Mei S, Deng Y, Dumont D, Stewart D. Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2. PLoS ONE. 2012;7:e43568 pubmed publisher
    The angiopoietins (ANGPT) are ligands for the endothelial cell (EC) receptor tyrosine kinase, Tie2. Angpt-1 is a Tie2 agonist that promotes vascular maturation and stabilization, whereas Angpt-2 is a partial agonist/antagonist involved in ..

More Information


  1. Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, et al. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol. 2008;10:527-37 pubmed publisher
    The receptor tyrosine kinase Tie2, and its activating ligand Angiopoietin-1 (Ang1), are required for vascular remodelling and vessel integrity, whereas Ang2 may counteract these functions...
  2. Yuan J, Fang W, Ni Z, Dai H, Lin A, Cao L, et al. Peritoneal morphologic changes in a peritoneal dialysis rat model correlate with angiopoietin/Tie-2. Pediatr Nephrol. 2009;24:163-70 pubmed publisher
    ..An increased level of Ang-2 and a reduced level of Tie-2 in conditions of uremia and PD therapy correlated with peritoneal angiogenesis and functional deterioration. ..
  3. Bogdanovic E, Coombs N, Dumont D. Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1. Histochem Cell Biol. 2009;132:225-37 pubmed publisher
    The tyrosine kinase receptor Tie2 is expressed on endothelial cells, and together with its ligand angiopoietin-1 (Ang1), is important for angiogenesis and vascular stability...
  4. Ye F, Florian M, Magder S, Hussain S. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Steroids. 2002;67:305-10 pubmed
  5. Lee J, Song S, Kim J, Shin I, Kim K, Suh Y, et al. Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor. Cardiovasc Res. 2008;78:572-80 pubmed publisher
    ..However, overexpression of soluble Tie2 receptor completely abolished these beneficial effects of COMP-Ang-1 gene transfer on SHRs, indicating that ..
  6. Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, et al. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999;274:30896-905 pubmed
    The Tek/Tie2 receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development...
  7. Witzenbichler B, Maisonpierre P, Jones P, Yancopoulos G, Isner J. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. J Biol Chem. 1998;273:18514-21 pubmed
    ..Excess soluble Tie2, but not Tie1 receptor, abolish the chemotactic response of endothelial cells toward angiopoietin-1...
  8. Sullivan C, Du L, Chu D, Cho A, Kido M, Wolf P, et al. Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Proc Natl Acad Sci U S A. 2003;100:12331-6 pubmed
    ..We demonstrate that Ang-1 stimulates pulmonary arteriolar endothelial cells through a TIE2 (receptor with tyrosine kinase activity containing IgG-like loops and epidermal growth factor homology domains) ..
  9. Vikkula M, Boon L, Carraway K, Calvert J, Diamonti A, Goumnerov B, et al. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell. 1996;87:1181-90 pubmed
    ..in an arginine-to-tryptophan substitution at position 849 in the kinase domain of the receptor tyrosine kinase TIE2 segregates with dominantly inherited VM in two unrelated families...
  10. Li W, Yang P, Peng G, Tang H, Zhou J, Fu C, et al. [Expression of Ang2 and Tie2 and their relation with the angiogenesis of hepatocellular carcinoma in rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31:523-7 pubmed
    To investigate the relationship between the expression of Ang2, Tie2 and the angiogenesis of hepatocellular carcinoma in rats...
  11. Murray B, Padrique E, Pinko C, McTigue M. Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2. Biochemistry. 2001;40:10243-53 pubmed
    ..Autophosphorylation of the angiogenic receptor tyrosine kinase Tie2 was studied in terms of the autophosphorylation sites, sequence of phosphorylation at these sites, kinetic effects, ..
  12. Ma X, Lu Y, Yang L, Song J, Luo G, Shi Y, et al. Expressions of Angiopoietin-1, Angiopoietin-2, and Tie2 and their roles in rat renal allografts with chronic allograft nephropathy. Transplant Proc. 2008;40:2795-9 pubmed publisher
    Angiopoietin-1 (Ang1) and -2(Ang2) are 2 ligands for the endothelium-specific tyrosine kinase Tie2. Previous studies have shown that reciprocal regulation of Ang1, Ang2, and Tie2 plays an important role in chronic cardiac allograft ..
  13. Jones N, Chen S, Sturk C, Master Z, Tran J, Kerbel R, et al. A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function. Mol Cell Biol. 2003;23:2658-68 pubmed
    b>Tie2/Tek is an endothelial cell receptor tyrosine kinase that induces signal transduction pathways involved in cell migration upon angiopoietin-1 (Ang1) stimulation...
  14. Cho Y, Han J, Lee S, Jeon B, Choi W, Hwang Y, et al. Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension. Comp Med. 2009;59:350-6 pubmed
    ..In this study, we evaluated the temporal expression of angiopoietin (Ang) 1, Ang2, and their receptor (Tie2) as well as VEGF, endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), and heme oxygenase 1 (HO1) in the ..
  15. Abdulmalek K, Ashur F, Ezer N, Ye F, Magder S, Hussain S. Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats. Am J Physiol Lung Cell Mol Physiol. 2001;281:L582-90 pubmed
    ..Induction of angiopoietin-3 in the kidney and diaphragm of hypoxic rats could be mediated through the HIF-1 transcription factor...
  16. Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004;118:149-61 pubmed
    ..Here, we demonstrate that HSCs expressing the receptor tyrosine kinase Tie2 are quiescent and antiapoptotic, and comprise a side-population (SP) of HSCs, which adhere to osteoblasts (OBs) in ..
  17. Shyu K, Liang Y, Chang H, Wang B, Leu J, Kuan P. Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction. J Biomed Sci. 2004;11:163-71 pubmed
    Modulation of Tie2 receptor activity by angiopoietin ligands is crucial for angiogenesis, blood vessel maturation, and vascular endothelium integrity...
  18. Wang M, Klaus J, Joh H, Traystman R, Hurn P. Postischemic angiogenic factor expression in stroke-prone rats. Exp Neurol. 2002;173:283-8 pubmed
    ..Thus, the SHRSP brain elaborates a unique and specific pattern of angiopoietin system gene expression after stroke which may underlie stroke susceptibility of these rats. ..
  19. Lin P, Polverini P, Dewhirst M, Shan S, Rao P, Peters K. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. J Clin Invest. 1997;100:2072-8 pubmed
    b>Tie2 is a novel receptor tyrosine kinase that is expressed almost exclusively by vascular endothelium...
  20. Debusk L, Chen Y, Nishishita T, Chen J, Thomas J, Lin P. Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. 2003;48:2461-71 pubmed
    ..Our objective was to study the role of an endothelium-specific receptor tyrosine kinase, Tie2, in angiogenesis of inflammatory arthritis...
  21. Villanueva S, Cespedes C, Vio C. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am J Physiol Regul Integr Comp Physiol. 2006;290:R861-70 pubmed
  22. Dedkov E, Zheng W, Tomanek R. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. Am J Physiol Heart Circ Physiol. 2006;291:H1686-93 pubmed
  23. Peoch M, Farion R, Hiou A, Le Bas J, Pasquier B, Remy C. Immunohistochemical study of VEGF, angiopoietin 2 and their receptors in the neovascularization following microinjection of C6 glioma cells into rat brain. Anticancer Res. 2002;22:2147-51 pubmed
    ..This study is favorable to the new model of tumor angiogenesis, with successive vessel cooption, regression and growth mediated by angiopoietins and VEGF. ..
  24. Qiao J, Luan B, Han S, Wang X. [Expression of angiopoietin-1 and its tyrosine kinase receptor Tie-2 in the airway of asthmatic rats]. Zhongguo Dang Dai Er Ke Za Zhi. 2008;10:642-6 pubmed
    ..Ang-1 and Tie-2 may participate in the process of airway remodeling in asthma. Dexamethasone can decrease the expression of Ang-1 and Tie-2 in the airway and relieve the changes of airway morphology. ..
  25. Liu L, Jiang Y, Steinle J. Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion. PLoS ONE. 2016;11:e0159532 pubmed publisher
    ..3 (IGFBP-3), vascular endothelial cell growth factor (VEGF) and its receptor (KDR), angiopoietin 1 and its receptor Tie2 for Western blotting...
  26. Voskas D, Jones N, Van Slyke P, Sturk C, Chang W, Haninec A, et al. A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Am J Pathol. 2005;166:843-55 pubmed
    ..system in psoriasis has been suggested by studies that demonstrate an up-regulation of the tyrosine kinase receptor Tie2 (also known as Tek) as well as angiopoietin-1 and angiopoietin-2 in human psoriatic lesions...
  27. Jones N, Voskas D, Master Z, Sarao R, Jones J, Dumont D. Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function. EMBO Rep. 2001;2:438-45 pubmed
    Disruption of the signaling pathways mediated by the receptor tyrosine kinase Tek/Tie2 has shown that this receptor plays a pivotal role in vascularization of the developing embryo...
  28. Puri M, Bernstein A. Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis. Proc Natl Acad Sci U S A. 2003;100:12753-8 pubmed
    ..TIE1 (TIE) and TIE2 (TEK) are related receptor tyrosine kinases with an embryonic expression pattern in endothelial cells, their ..
  29. Gu H, Cui M, Bai Y, Chen F, Ma K, Zhou C, et al. Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells. Biochem Biophys Res Commun. 2010;392:178-82 pubmed publisher
    Angiopoietin-1 (Ang1) is a ligand for the endothelial-specific tyrosine kinase receptor Tie2 and has been shown to play an essential role in embryonic vasculature development...
  30. Zheng W, Christensen L, Tomanek R. Differential effects of cyclic and static stretch on coronary microvascular endothelial cell receptors and vasculogenic/angiogenic responses. Am J Physiol Heart Circ Physiol. 2008;295:H794-800 pubmed publisher
    ..In conclusion, EC angiogenic responses to these two types of stretch display both differences and similarities, but both CS and SS are dependent on VEGF-R2 signaling for their vasculogenic/angiogenic effects. ..
  31. Cascone I, Audero E, Giraudo E, Napione L, Maniero F, Philips M, et al. Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1. Blood. 2003;102:2482-90 pubmed
    ..Taken together, these results further expand our understanding of angiopoietin-1-mediated endothelial cell motility during vascular network assembly and angiogenesis. ..
  32. Tachibana K, Jones N, Dumont D, Puri M, Bernstein A. Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Mol Cell Biol. 2005;25:4693-702 pubmed
    ..and the development of the early hematopoietic systems are closely related, and both require signaling through the Tie2 receptor tyrosine kinase...
  33. Patan S. TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc Res. 1998;56:1-21 pubmed
    As shown previously, TIE1 and TIE2 receptor tyrosine kinases are specifically expressed in endothelial cells during embryonic angiogenesis...
  34. Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, et al. Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells. J Biol Chem. 2004;279:13224-33 pubmed
    ..sprouting, and survival of endothelial cells through activation of different signaling pathways triggered by the Tie2 tyrosine kinase receptor...
  35. Su D, Gudas L. Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol. 2008;36:624-41 pubmed publisher
    ..We assessed Tie1, Tie2, Flk1, Runx1, Peg/Mest2, and angiopoietin-1 and 2 mRNA levels and Tie1 promoter activity...
  36. Zacharek A, Chen J, Zhang C, Cui X, Roberts C, Jiang H, et al. Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Neurosci Lett. 2006;404:28-32 pubmed
    ..aminio] diazen-1-ium-1,2-diolate (DETA-NONOate), increases expression of Angiopoietin (Ang1)/Tie2, which may play a role in regulating angiogenesis and vascular integrity after stroke in rats...
  37. Bai Y, Meng Z, Cui M, Zhang X, Chen F, Xiao J, et al. An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience. 2009;160:371-81 pubmed publisher
    ..Ang1 significantly elevated tunica intima endothelial kinase 2 (Tie2) autophosphorylation level, suggesting the existence of functional Tie2 receptors on NPCs...
  38. Davis S, Aldrich T, Jones P, Acheson A, Compton D, Jain V, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell. 1996;87:1161-9 pubmed
    b>TIE2 is a receptor-like tyrosine kinase expressed almost exclusively in endothelial cells and early hemopoietic cells and required for the normal development of vascular structures during embryogenesis...
  39. Wehrle C, Van Slyke P, Dumont D. Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. Biochem J. 2009;423:375-80 pubmed publisher
    b>Tie2 [where 'Tie' is an acronym from tyrosine kinase with Ig and EGF (epidermal growth factor) homology domains] is a receptor tyrosine kinase expressed predominantly on the surface of endothelial cells...
  40. Fang Z, He Q, Li Q, Chen X, Baral S, Jin H, et al. MicroRNA-150 regulates blood-brain barrier permeability via Tie-2 after permanent middle cerebral artery occlusion in rats. FASEB J. 2016;30:2097-107 pubmed publisher
    ..Fang, Z., He, Q.-W., Li, Q., Chen, X.-L., Baral, S., Jin, H.-J., Zhu, Y.-Y., Li, M., Xia, Y.-P., Mao, L., Hu, B. MicroRNA-150 regulates blood-brain barrier permeability via Tie-2 after permanent middle cerebral artery occlusion in rats. ..
  41. Yuan H, Khankin E, Karumanchi S, Parikh S. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol. 2009;29:2011-22 pubmed publisher
    Angiopoietin 2 (Ang2) was originally shown to be a competitive antagonist for Ang1 of the receptor tyrosine kinase Tie2 in endothelial cells (ECs). Since then, reports have conflicted on whether Ang2 is an agonist or antagonist of Tie2...
  42. Ramsden J, Cocks H, Shams M, Nijjar S, Watkinson J, Sheppard M, et al. Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3',5'-monophosphate. J Clin Endocrinol Metab. 2001;86:2709-16 pubmed
    ..Tie-2 expression is increased in goiter in both humans and rats, consistent with a role in goitrogenesis. ..
  43. Xu J, Lan D, Li T, Yang G, Liu L. Angiopoietins regulate vascular reactivity after haemorrhagic shock in rats through the Tie2-nitric oxide pathway. Cardiovasc Res. 2012;96:308-19 pubmed publisher
    ..were adopted to evaluate the regulatory effects of Ang-1 and Ang-2 on vascular reactivity and their relationship to Tie2 (receptor tyrosine kinase)-Akt-endothelial nitric oxide synthase (eNOS) and Tie2-extracellular signal-regulated ..
  44. Wang X, Zheng W, Christensen L, Tomanek R. DITPA stimulates bFGF, VEGF, angiopoietin, and Tie-2 and facilitates coronary arteriolar growth. Am J Physiol Heart Circ Physiol. 2003;284:H613-8 pubmed
    ..We conclude that DITPA, which is known to improve ventricular function after infarction, is angiogenic in normal nonischemic hearts. ..
  45. Hughes D, Marron M, Brindle N. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. Circ Res. 2003;92:630-6 pubmed
    b>Tie2 is a receptor tyrosine kinase expressed predominantly in endothelial cells and is essential for blood vessel formation and maintenance...
  46. Runting A, Stacker S, Wilks A. tie2, a putative protein tyrosine kinase from a new class of cell surface receptor. Growth Factors. 1993;9:99-105 pubmed
    The cDNA of a novel mouse cell surface receptor (tie2) has been isolated from a mouse lung library...
  47. Madsen K, Marcussen N, Pedersen M, Kjaersgaard G, Facemire C, Coffman T, et al. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. J Am Soc Nephrol. 2010;21:448-59 pubmed publisher
    ..Taken together, these data demonstrate that angiotensin II promotes postnatal expansion of postglomerular capillaries and organization of vasa recta bundles, which are necessary for development of normal renal blood flow. ..
  48. Wen C, Ito M, Chen L, Matsuu M, Shichijo K, Nakayama T, et al. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. J Gastroenterol. 2003;38:431-5 pubmed
    ..These findings suggest that Tie-2 and Ang-1 and -2 play an important role in angiogenesis in the early phase of ulcer healing. ..
  49. Takakura N, Huang X, Naruse T, Hamaguchi I, Dumont D, Yancopoulos G, et al. Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity. 1998;9:677-86 pubmed
    We have investigated the function of TIE2/TEK receptor tyrosine kinase in the development of definitive hematopoiesis. In the vitelline artery at 9.5 days postcoitum (d.p.c...
  50. Lee H, Cho C, Hwang S, Choi H, Kim K, Ahn S, et al. Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB J. 2004;18:1200-8 pubmed
    ..growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs...
  51. Zheng W, Christensen L, Tomanek R. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Am J Physiol Heart Circ Physiol. 2004;287:H2739-45 pubmed
    ..These in vitro findings support the concept that stretch of cardiac myocytes and EC plays a key role in coronary angiogenesis. ..
  52. Fukuhara S, Sako K, Minami T, Noda K, Kim H, Kodama T, et al. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol. 2008;10:513-26 pubmed publisher
    b>Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1)...
  53. Horton B, Solanki R, Rajneesh K, Kulesza P, Ardelt A. Localization of angiopoietin-1 and Tie2 immunoreactivity in rodent ependyma and adjacent blood vessels suggests functional relationships. J Histochem Cytochem. 2010;58:53-60 pubmed publisher
    ..We also evaluated patterns of IR of endothelium-specific receptor tyrosine kinase 2 (Tie2, the receptor for Angpt1)...
  54. Shyu K, Chang C, Wang B, Kuan P, Chang H. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Clin Sci (Lond). 2003;105:287-94 pubmed
    ..Angiopoietin-1 (Ang1), angiopoietin-2 (Ang2), Tie1 and Tie2 were measured immediately after relief of occlusion, and 1, 6, 24 and 72 h after reperfusion, by Northern blot, ..
  55. Dewachter L, Adnot S, Fadel E, Humbert M, Maitre B, Barlier Mur A, et al. Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. Am J Respir Crit Care Med. 2006;174:1025-33 pubmed
    ..One consequence of endothelium-specific tyrosine kinase-2 (Tie2) receptor activation by angiopoietin-1 (Ang1) is the release of endothelium-derived growth factors that recruit ..
  56. Abramovich D, Irusta G, Bas D, Cataldi N, Parborell F, Tesone M. Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome. Endocrinology. 2012;153:3446-56 pubmed publisher
    ..study, we examined the ovarian expression of angiopoietins (ANGPT) and their receptor tyrosine kinase receptor (TIE2), involved in the stabilization of blood vessels, in a rat model of dehydroepiandrosterone-induced PCOS...
  57. Reiss Y, Machein M, Plate K. The role of angiopoietins during angiogenesis in gliomas. Brain Pathol. 2005;15:311-7 pubmed
  58. Katoh S, Kamimoto T, Yamakawa D, Takakura N. Lipid rafts serve as signaling platforms for Tie2 receptor tyrosine kinase in vascular endothelial cells. Exp Cell Res. 2009;315:2818-23 pubmed publisher
    The Tie2 receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development. The major intracellular signaling systems activated by Tie2 in response to Angiopoietin-1 (Ang1) include the Akt and Erk1/2 pathways...
  59. Kosacka J, Figiel M, Engele J, Hilbig H, Majewski M, Spanel Borowski K. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Cell Tissue Res. 2005;320:11-9 pubmed
    ..We conclude that Ang-1 promotes neurite outgrowth from DRG cells positive for Tie-2 receptor. The signalling pathway appears to involve transactivation of the trkA receptor. ..
  60. Cordeiro A, Figueiredo A, Tomada I, de Almeida H, Neves D. Characterization of the expression of Ang1, Ang2, and Tie2 in the Corpus Cavernosum of the rat during aging. Microsc Microanal. 2010;16:699-709 pubmed publisher
    ..The angiopoietin/Tie2 system has been recently considered as a potential target for therapy of vascular disorders, including ED...
  61. Zheng Q, Zhu D, Bai Y, Wu Y, Jia J, Hu Y. Exercise improves recovery after ischemic brain injury by inducing the expression of angiopoietin-1 and Tie-2 in rats. Tohoku J Exp Med. 2011;224:221-8 pubmed publisher
    ..Our results suggest the importance of angiogenesis in rehabilitation for post-ischemia brain injury and help to explain the underlying mechanism. ..
  62. Johansson A, Rudolfsson S, Wikstrom P, Bergh A. Altered levels of angiopoietin 1 and tie 2 are associated with androgen-regulated vascular regression and growth in the ventral prostate in adult mice and rats. Endocrinology. 2005;146:3463-70 pubmed
    ..receptor expression, vascular morphology, and the expression of angiopoietin (ang) 1 and 2 and their receptor tie 2 were examined 1, 3, and 7 d after castration and after testosterone treatment of castrated animals using ..