Gene Symbol: Tctex3
Description: PHD finger protein 1
Alias: Tctex3, PHD finger protein 1, T-complex testis-expressed 3, polycomb-like 1
Kawakami S, Mitsunaga K, Kikuti Y, Ando A, Inoko H, Yamamura K, et al
. Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex. Mamm Genome. 1998;9:874-80 pubmed
b>Tctex3 showing restricted expression in male germ cells has been isolated during the process of chromosome walking in the mouse t-complex region...
Han Y, Song X, Feng H, Cheung C, Lam P, Wang C, et al
. Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse. Asian J Androl. 2008;10:219-26 pubmed publisher
..We established that mutations that occur in the Tctex5 long transcript of the t-haplotype mice are important for normal sperm function, whereas the short transcript of Tctex5 might have a conserved function among different tissues. ..
Ballaré C, Lange M, Lapinaite A, Martin G, Morey L, Pascual G, et al
. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012;19:1257-65 pubmed publisher
..These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells. ..
Herz H, Garruss A, Shilatifard A. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci. 2013;38:621-39 pubmed publisher
Musselman C, Avvakumov N, Watanabe R, Abraham C, Lalonde M, Hong Z, et al
. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol. 2012;19:1266-72 pubmed publisher
The PHD finger protein 1 (PHF1) is essential in epigenetic regulation and genome maintenance. Here we show that the Tudor domain of human PHF1 binds to histone H3 trimethylated at Lys36 (H3K36me3). We report a 1...
Cai L, Rothbart S, Lu R, Xu B, Chen W, Tripathy A, et al
. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell. 2013;49:571-82 pubmed publisher
..Collectively, our data suggest that PCL recognition of H3K36me3 promotes intrusion of PRC2 complexes into active chromatin regions to promote gene silencing and modulate the chromatin landscape during development. ..
Saha S, Hu Y, Martin S, Bandyopadhyay S, Russek S, Farb D. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. BMC Pharmacol Toxicol. 2013;14:37 pubmed publisher
Lu R, Wang G. Tudor: a versatile family of histone methylation 'readers'. Trends Biochem Sci. 2013;38:546-55 pubmed publisher
..SAGA-associated factor 29 (SGF29), Spindlin1, ubiquitin-like with PHD and RING finger domains 1 (UHRF1), PHD finger protein 1 (PHF1), PHD finger protein 19 (PHF19), and SAWADEE homeodomain homolog 1 (SHH1)] in 'reading' unique ..