Tcap

Summary

Gene Symbol: Tcap
Description: titin-cap
Alias: telethonin, LOW QUALITY PROTEIN: telethonin, titin cap protein
Species: rat
Products:     Tcap

Top Publications

  1. Gregorio C, Trombitas K, Centner T, Kolmerer B, Stier G, Kunke K, et al. The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol. 1998;143:1013-27 pubmed
  2. Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang M, Labeit D, et al. Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J Mol Biol. 2001;313:775-84 pubmed
    ..We report here that minK specifically interacts with the sarcomeric Z-line component, T-cap (also called telethonin)...
  3. Knoll R, Hoshijima M, Hoffman H, Person V, Lorenzen Schmidt I, Bang M, et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002;111:943-55 pubmed
    ..MLP interacts with and colocalizes with telethonin (T-cap), a titin interacting protein...
  4. Hayashi T, Arimura T, Itoh Satoh M, Ueda K, Hohda S, Inagaki N, et al. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 2004;44:2192-201 pubmed
    We sought to explore the relationship between a Tcap gene (TCAP) abnormality and cardiomyopathy. Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) cause severe heart failure and sudden death...
  5. Itoh Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Koyanagi T, et al. Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun. 2002;291:385-93 pubmed
    ..were found in the Z-line region of titin and decreased binding affinities of titin to Z-line proteins T-cap/telethonin and alpha-actinin, respectively, in yeast two-hybrid assays...
  6. Heng A, Ventadour S, Jarzaguet M, Pouch PĂ©lissier M, Guezennec C, Bigard X, et al. Coordinate expression of the 19S regulatory complex and evidence for ubiquitin-dependent telethonin degradation in the unloaded soleus muscle. Int J Biochem Cell Biol. 2008;40:2544-52 pubmed publisher
    ..Purification of ubiquitin conjugates using the S5a 19S subunit followed by deubiquitination identified telethonin as a 26S proteasome substrate...
  7. Candasamy A, Haworth R, Cuello F, Ibrahim M, Aravamudhan S, Kruger M, et al. Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes. J Biol Chem. 2014;289:1282-93 pubmed publisher
    b>Telethonin (also known as titin-cap or t-cap) is a muscle-specific protein whose mutation is associated with cardiac and skeletal myopathies through unknown mechanisms...
  8. Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, et al. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H3396-403 pubmed
    ..surface and at stretch-sensing Z disc of cardiomyocytes, where BMP10 interacted with a protein called titin-cap (Tcap)...