Tbp

Summary

Gene Symbol: Tbp
Description: TATA box binding protein
Alias: TFIID, TATA-box-binding protein
Species: rat
Products:     Tbp

Top Publications

  1. Louder R, He Y, López Blanco J, Fang J, Chacón P, Nogales E. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature. 2016;531:604-9 pubmed publisher
    The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter...
  2. Martianov I, Brancorsini S, Gansmuller A, Parvinen M, Davidson I, Sassone Corsi P. Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Development. 2002;129:945-55 pubmed
    TLF (TBP-like factor) is a protein commonly thought to belong to the general transcription initiation complex. TLF is evolutionarily conserved and has been shown to be essential for early development in C. elegans, zebrafish and Xenopus...
  3. Gazdag E, Rajkovic A, Torres Padilla M, Tora L. Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development. Reproduction. 2007;134:51-62 pubmed
    ..Here, we have examined the expression and localisation of the TATA-binding protein (TBP) and the related protein TBP2 (also called TRF3, TBP-related factor 3) during oogenesis and in early mouse embryos...
  4. Qadri I, Iwahashi M, Simon F. Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3. Biochim Biophys Acta. 2002;1592:193-204 pubmed
    ..vivo co-immunoprecipitation and pull-down assays demonstrated that NS5A forms a heteromeric complex with TATA box binding protein (TBP) and tumor suppressor protein p53. Mutants of TBP and p53 showed reduced binding to NS5A...
  5. Grünberg S, Hahn S. Structural insights into transcription initiation by RNA polymerase II. Trends Biochem Sci. 2013;38:603-11 pubmed publisher
    ..Here, we review recent developments in dissecting the architecture of the Pol II core machinery with a focus on early and regulated steps in transcription initiation. ..
  6. Pointud J, Mengus G, Brancorsini S, Monaco L, Parvinen M, Sassone Corsi P, et al. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. J Cell Sci. 2003;116:1847-58 pubmed
    ..Here we describe TAF7L, a germ-cell-specific paralogue of the TFIID subunit TAF7...
  7. Kodeboyina S, Balamurugan P, Liu L, Pace B. cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol Dis. 2010;44:7-15 pubmed publisher
    ..We conclude that these data indicate that cJun activates the Ggamma-globin promoter via the G-CRE in a manner comparable with CREB1 and propose a model for gamma-globin activation based on DNA-protein interactions in the G-CRE. ..
  8. Reid S, van Roon Mom W, Wood P, Rees M, Owen M, Faull R, et al. TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease. Brain Res Mol Brain Res. 2004;125:120-8 pubmed
    ..this family of disorders, SCA17, is caused by an expansion of a polymorphic polyQ repeat in TATA binding protein (TBP), an essential transcription factor...
  9. Mittal V, Hernandez N. Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science. 1997;275:1136-40 pubmed
    ..from the human RNA polymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)-activating protein complex (SNAPc)...

More Information

Publications57

  1. Igarashi A, Makino Y, Tamura T, Nohara H. Isolation of rat TATA factor as an active 75kDa protein complex. Biochem Biophys Res Commun. 1994;204:1125-30 pubmed
    A general transcription factor TFIID was purified from rat liver by a sequential column chromatography including organomercurial Sepharose and Sephacryl S-200 chromatographies, which were developed with an acidic buffer (pH5.5)...
  2. Todd R, Lippard S. Inhibition of transcription by platinum antitumor compounds. Metallomics. 2009;1:280-91 pubmed publisher
    ..A thorough understanding of the molecular mechanism of action of platinum antitumor agents will aid in the development of new compounds in the family. ..
  3. Munz C, Psichari E, Mandilis D, Lavigne A, Spiliotaki M, Oehler T, et al. TAF7 (TAFII55) plays a role in the transcription activation by c-Jun. J Biol Chem. 2003;278:21510-6 pubmed
    ..TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals. ..
  4. Wang K, Sun F, Sheng H. Regulated expression of TAF1 in 1-cell mouse embryos. Zygote. 2006;14:209-15 pubmed
    TATA binding protein (TBP) associated factor 1 (TAF1) is a member of the general transcription machinery. Interference in the function of TAF1 causes a broad transcriptional defect in early development...
  5. SCHNEIDER D. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Gene. 2012;493:176-84 pubmed publisher
    ..This review describes the factors required for rRNA synthesis and focuses on recent works that have begun to identify and characterize factors that influence transcription elongation by RNA polymerase I and its regulation. ..
  6. Xu Z, Cawthon D, McCastlain K, Duhart H, Newport G, Fang H, et al. Selective alterations of transcription factors in MPP+-induced neurotoxicity in PC12 cells. Neurotoxicology. 2005;26:729-37 pubmed
    ..In addition, three TFs decreased within the range of 33-50% (TFIID, E2F1, CREB) and two TFs increased within the range of 50-100% (PAX-5, Stat4)...
  7. Hellqvist M, Mahlapuu M, Blixt A, Enerback S, Carlsson P. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. J Biol Chem. 1998;273:23335-43 pubmed
    ..FREAC-2 was shown to interact in vitro with TBP and TFIIB. The target site for FREAC-2 on TBP was localized to the N-terminal repeat in the core domain of TBP...
  8. Ozer J, Bolden A, Lieberman P. Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. J Biol Chem. 1996;271:11182-90 pubmed
    ..The gamma W72A mutant failed to stimulate TFIID-DNA binding (D-A complex) but was able to form a complex with TFIID and DNA in the presence of Zta (Z-D-A complex)...
  9. Prigge J, Schmidt E. Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP. J Biol Chem. 2006;281:12260-9 pubmed
    ..system to screen mouse pregnancy-associated libraries for proteins that interact with TATA-binding protein (TBP)...
  10. Owerbach D, Piña L, Gabbay K. Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes. Biochem Biophys Res Commun. 2004;323:865-9 pubmed
    ..However, a novel CAG/CAA polymorphism was detected in exon 3 of the TATA box-binding protein gene, which shows preliminary evidence of association with diabetes susceptibility (p<0.05). ..
  11. Malkowska M, Kokoszynska K, Rychlewski L, Wyrwicz L. Structural bioinformatics of the general transcription factor TFIID. Biochimie. 2013;95:680-91 pubmed publisher
    ..Despite numerous previous studies of the TFIID complex, the knowledge concerning the structure of its components, and thus the exact mechanism of its function, ..
  12. Catena R, Argentini M, Martianov I, Parello C, Brancorsini S, Parvinen M, et al. Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells. FEBS Lett. 2005;579:3401-10 pubmed
    ..Our observations highlight how cleavage of ALF and coexpression with TFIIA and TRF2 increases the combinatorial possibilities for gene regulation at different developmental stages of spermatogenesis. ..
  13. Sawaguchi T, Patricia F, Kadhim H, Groswasser J, Sottiaux M, Nishida H, et al. The presence of TATA-binding protein in the brainstem, correlated with sleep apnea in SIDS victims. Early Hum Dev. 2003;75 Suppl:S109-18 pubmed
    ..as a causative factor in the Sudden Infant Death Syndrome (SIDS), the correlation between TATA-binding protein (TBP) in the brainstem of SIDS victims as a marker of transcription and the incidence of sleep apnea was investigated...
  14. DeJong J, Bernstein R, Roeder R. Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. Proc Natl Acad Sci U S A. 1995;92:3313-7 pubmed
    ..transcription by RNA polymerase II, possibly by regulating the activity of the TATA-binding subunit (TBP) of TFIID. TFIIA purified from HeLa extracts consists of 35-, 19-, and 12-kDa subunits...
  15. Payne F, Smyth D, Pask R, Cooper J, Masters J, Wang W, et al. No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. Biochem Biophys Res Commun. 2005;331:435-41 pubmed
    ..chromosome 6q27 and, moreover, recently associated with one of the genes in the region, TATA box-binding protein (TBP)...
  16. Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, et al. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. EMBO J. 1995;14:1520-31 pubmed
    ..cDNAs encoding three novel TAFIIs [TATA-binding protein (TBP)-associated factors] from the human (h) HeLa cell TFIID complexes hTAFII28, hTAFII20 and hTAFII18...
  17. Sabbah M, Kang K, Tora L, Redeuilh G. Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB. Biochem J. 1998;336 ( Pt 3):639-46 pubmed
    ..We show that ER does not stabilize the binding of the TATA-box binding protein (TBP) of the TFIID complex, or of TFIIB to the promoter, although a stable ER-TBP-TFIIB-promoter complex was detected, suggesting ..
  18. Nakamura K, Jeong S, Uchihara T, Anno M, Nagashima K, Nagashima T, et al. SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Hum Mol Genet. 2001;10:1441-8 pubmed
    ..SCA) form in four Japanese pedigrees which is caused by an abnormal CAG expansion in the TATA-binding protein (TBP) gene, a general transcription initiation factor...
  19. Yuan C, Gurley W. Potential targets for HSF1 within the preinitiation complex. Cell Stress Chaperones. 2000;5:229-42 pubmed
    ..The negative regulatory region (NR) of HSF1 did not interact with any general factors tested in vitro but did bind TFIID in nuclear extracts through contacts that probably involve TATA associated proteins (TAFs)...
  20. Plessy C, Pascarella G, Bertin N, Akalin A, Carrieri C, Vassalli A, et al. Promoter architecture of mouse olfactory receptor genes. Genome Res. 2012;22:486-97 pubmed publisher
    ..factors for OR gene expression and among them confirmed by chromatin immunoprecipitation the binding of TBP, EBF1 (OLF1), and MEF2A to OR promoters...
  21. Chen C, Lane H, Wu Y, Ro L, Chen F, Hung W, et al. Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia. Schizophr Res. 2005;78:131-6 pubmed
    ..TBP/SCA17 is the TATA box binding protein gene mapped to chromosome 6q27...
  22. Yoshida T, Makino Y, Tamura T. Association of the rat heterogeneous nuclear RNA-ribonucleoprotein F with TATA-binding protein. FEBS Lett. 1999;457:251-4 pubmed
    ..Here, we present evidence for an association between a splicing factor, hnRNP-F, and TATA-binding protein (TBP), which is an essential factor needed for transcription initiation...
  23. Vannini A. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Biochim Biophys Acta. 2013;1829:258-64 pubmed publisher
    ..This article is part of a Special Issue entitled: Transcription by Odd Pols. ..
  24. Cheng Y, Buffone M, Kouadio M, Goodheart M, Page D, Gerton G, et al. Abnormal sperm in mice lacking the Taf7l gene. Mol Cell Biol. 2007;27:2582-9 pubmed
    b>TFIID is a general transcription factor required for transcription of most protein-coding genes by RNA polymerase II. TAF7L is an X-linked germ cell-specific paralogue of TAF7, which is a generally expressed component of TFIID...
  25. Kelp A, Koeppen A, Petrasch Parwez E, Calaminus C, Bauer C, Portal E, et al. A novel transgenic rat model for spinocerebellar ataxia type 17 recapitulates neuropathological changes and supplies in vivo imaging biomarkers. J Neurosci. 2013;33:9068-81 pubmed publisher
    ..neurodegenerative disorder caused by an expanded polyglutamine (polyQ) repeat in the TATA-box-binding protein (TBP)...
  26. Aoki T, Okada N, Ishida M, Yogosawa S, Makino Y, Tamura T. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. Biochem Biophys Res Commun. 1999;261:911-6 pubmed
    TATA-binding protein (TBP) forms complexes with various nuclear proteins and plays roles in all eukaryotic transcription. We previously identified TBP-interacting protein 120 (TIP120) from rat liver...
  27. Zhao Q, Zhou W, Rank G, Sutton R, Wang X, Cumming H, et al. Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood. 2006;107:2138-45 pubmed
    ..p45 NF-E2 recruitment to the gamma-promoter is also lost, resulting in a reduction in RNA polymerase II and TBP binding and a fall in promoter transcriptional activity...
  28. Remmers E, Griffiths M, Longman R, Gulko P, Kawahito Y, Chen S, et al. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Transplant Proc. 1999;31:1549-54 pubmed
  29. Schmidt E, Bondareva A, Radke J, Capecchi M. Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein. J Biol Chem. 2003;278:6168-74 pubmed
    ..We have generated a line of mice in which the tbp allele is replaced with a version, tbp(Delta N), which lacks 111 of 135 N-terminal amino acid residues...
  30. Ou S, García Martínez L, Paulssen E, Gaynor R. Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J Virol. 1994;68:7188-99 pubmed
    ..Gel retardation analysis demonstrated that binding of both the recombinant TATA-binding protein (TBP) and the TFIID fraction which contains both TBP and TBP-associated factors was dependent primarily on the TATA element...
  31. Martianov I, Viville S, Davidson I. RNA polymerase II transcription in murine cells lacking the TATA binding protein. Science. 2002;298:1036-9 pubmed
    Inactivation of the murine TATA binding protein (TBP) gene by homologous recombination leads to growth arrest and apoptosis at the embryonic blastocyst stage...
  32. Friedman M, Wang C, Li X, Li S. Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity. J Biol Chem. 2008;283:8283-90 pubmed publisher
    TATA-binding protein (TBP) is essential for eukaryotic gene transcription. Human TBP contains a polymorphic polyglutamine (polyQ) domain in its N terminus and a DNA-binding domain in its highly conserved C terminus...
  33. Knutson B, Hahn S. TFIIB-related factors in RNA polymerase I transcription. Biochim Biophys Acta. 2013;1829:265-73 pubmed publisher
    ..Models for Pol I transcription initiation are reexamined in light of these recent findings. This article is part of a Special Issue entitled: Transcription by Odd Pols. ..
  34. Anderson D, Beres B, Wilson Rawls J, Rawls A. The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex. Dev Dyn. 2009;238:572-80 pubmed publisher
    ..co-repressor complex (Sin3A, Hdac1, and Sap18) and a subset of Polymerase II general transcription factors (Tbp, TFIIA1 and TFIIB)...
  35. Dumay Odelot H, Durrieu Gaillard S, Da Silva D, Roeder R, Teichmann M. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Cell Cycle. 2010;9:3687-99 pubmed
    ..Here, we review major regulatory mechanisms of RNA polymerase III transcription during the cell cycle, cell growth and cell differentiation. ..
  36. Persengiev S, Robert S, Kilpatrick D. Transcription of the TATA binding protein gene is highly up-regulated during spermatogenesis. Mol Endocrinol. 1996;10:742-7 pubmed
    TATA-binding protein (TBP) and its associated factors are required for transcriptional initiation by all three RNA polymerases, and evidence for regulation of their activities during early development has been recently reported...
  37. Wu Y, Lin J, Piluso L, Dhahbi J, Bobadilla S, Spindler S, et al. Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol Cell. 2014;53:63-74 pubmed publisher
    ..ChIP-sequencing analysis reveals p53 dissociates from promoters genome wide as cells recover from DNA damage, suggesting the general nature of this mechanism. ..
  38. Makino Y, Yoshida T, Yogosawa S, Tanaka K, Muramatsu M, Tamura T. Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120. Genes Cells. 1999;4:529-39 pubmed
    SUG1 belongs to proteasomal ATPase. Previous studies have demonstrated that SUG1 is associated with TBP. It is assumed to be involved in transcriptional regulation in addition to proteolysis...
  39. Bottardi S, Zmiri F, Bourgoin V, Ross J, Mavoungou L, Milot E. Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation. Nucleic Acids Res. 2011;39:3505-19 pubmed publisher
    ..Ikaros contributes to transcription initiation and elongation of the hu?-genes, since it is not only required for TBP and RNA Polymerase II (Pol II) assembly at the hu?-promoters but also for conversion of Pol II into the elongation-..
  40. Ding T, Wen H, Wei H, Wu H, Zhao J, Chen F, et al. Increased Expression of TBP/TFIID after spinal cord injury in adult rats. Cell Mol Neurobiol. 2014;34:669-77 pubmed publisher
    Transcription factor IID (TFIID), as a general transcription factor, plays a pivotal role in the preinitiation complex (PIC) assembly and transcription initiation by recruiting RNA polymerase II to the promoter...
  41. Yogosawa S, Makino Y, Yoshida T, Kishimoto T, Muramatsu M, Tamura T. Molecular cloning of a novel 120-kDa TBP-interacting protein. Biochem Biophys Res Commun. 1996;229:612-7 pubmed
    TATA-binding protein (TBP) is a central component for transcriptional regulation and is a target for various transcription regulators...
  42. Kabe Y, Yamada J, Uga H, Yamaguchi Y, Wada T, Handa H. NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol. 2005;25:512-22 pubmed
    ..analysis reveals that NF-Y is required for the recruitment of RNA polymerase II (RNAPII) and TATA box binding protein on the ODF promoter...
  43. Watt K, Jess T, Kelly S, Price N, McEwan I. Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. Biochemistry. 2005;44:734-43 pubmed
    ..studies, the acidic Q-rich region bound to components of the general transcription machinery [TATA-binding protein (TBP), TAF4, and TAF6] as well as the coactivator proteins SRC-1a and TIF2...
  44. Huang S, Ling J, Yang S, Li X, Li S. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain. 2011;134:1943-58 pubmed publisher
    ..These findings demonstrate how mutant TATA box-binding protein at the endogenous level affects neuronal function, with important implications for the pathogenesis and treatment of polyglutamine diseases. ..
  45. Gouge J, Satia K, Guthertz N, Widya M, Thompson A, Cousin P, et al. Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell. 2015;163:1375-87 pubmed publisher
    ..We have solved crystal structures of a human Brf2-TBP complex bound to natural promoters, obtaining a detailed view of the molecular interactions occurring at Brf2-..
  46. Wang Y, Shan Q, Meng Y, Pan J, Yi S. Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..hypoxanthine guanine phosphoribosyl transferase), Pgk1 (phosphoglycerate kinase 1), Tbp (TATA box binding protein), Ubc (ubiquitin C), YwhaZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation),..
  47. Imai K, Okamoto T. Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J Biol Chem. 2006;281:12495-505 pubmed
    ..U1 cells, and they are dissociated from the promoter concomitantly with the association of acetylated histone H3, TBP, and RNA polymerase II upon TNF-alpha stimulation of HIV-1 replication...
  48. van Roon Mom W, Reid S, Jones A, MacDonald M, Faull R, Snell R. Insoluble TATA-binding protein accumulation in Huntington's disease cortex. Brain Res Mol Brain Res. 2002;109:1-10 pubmed
    ..A proportion of TBP alleles fall within the range of glutamine length that causes neurodegeneration when located in the huntingtin ..