Gene Symbol: Tbc1d1
Description: TBC1 domain family member 1
Alias: TBC1 domain family member 1, TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
Funai K, Schweitzer G, Sharma N, Kanzaki M, Cartee G. Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2009;297:E242-51 pubmed publisher
..Akt substrate of 160 kDa (AS160) and TBC1D1 are paralog Rab GTPase-activating proteins that have been proposed to contribute to these exercise effects...
Paglialunga S, Simnett G, Robson H, Hoang M, Pillai R, Arkell A, et al
. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and Î²-cell mass. Appl Physiol Nutr Metab. 2017;42:647-655 pubmed publisher
Tre-2/USP6, BUB2, cdc16 domain family, member 1 (TBC1D1), a Rab-GTPase activating protein, is a paralogue of AS160, and has been implicated in the canonical insulin-signaling cascade in peripheral tissues...
Rütti S, Arous C, Nica A, Kanzaki M, Halban P, Bouzakri K. Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells. FEBS Lett. 2014;588:15-20 pubmed publisher
The Rab-GTPase activating protein TBC1D1 is a paralog of AS160/TBC1D4. AS160/TBC1D4, a downstream effector of Akt, has been shown to play a central role in beta-cell function and survival...
Klip A, Sun Y, Chiu T, Foley K. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Am J Physiol Cell Physiol. 2014;306:C879-86 pubmed publisher
..Finally, we illustrate how actin filaments interact with myosin 1c and ?-Actinin4 to promote vesicle tethering as preamble to fusion with the membrane...
Whitfield J, Paglialunga S, Smith B, Miotto P, Simnett G, Robson H, et al
. Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats. J Biol Chem. 2017;292:16653-16664 pubmed publisher
b>TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate of 160 kDa (AS160), has been implicated in both insulin- and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP ..
Castorena C, MacKrell J, Bogan J, Kanzaki M, Cartee G. Clustering of GLUT4, TUG, and RUVBL2 protein levels correlate with myosin heavy chain isoform pattern in skeletal muscles, but AS160 and TBC1D1 levels do not. J Appl Physiol (1985). 2011;111:1106-17 pubmed publisher
..are established or putative GLUT4 regulators [Akt substrate of 160 kDa (AS160), Tre-2/Bub2/Cdc 16-domain member 1 (TBC1D1), Tethering protein containing an UBX-domain for GLUT4 (TUG), and RuvB-like protein two (RUVBL2)] in 12 skeletal ..
Imai A, Yoshie S, Ishibashi K, Haga Tsujimura M, Nashida T, Shimomura H, et al
. EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells. J Biol Chem. 2011;286:33854-62 pubmed publisher
..Our findings indicated that EPI64 acted as a physiological Rab27-GAP that enhanced GTPase activity of Rab27 in response to IPR stimulation, and that this activity is required for IPR-induced amylase release. ..
Ishikura S, Klip A. Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation. Am J Physiol Cell Physiol. 2008;295:C1016-25 pubmed publisher
..Two Rab-GTPase-activating proteins (Rab-GAP), AS160 and TBC1D1, were identified as Akt substrates...