Tap1

Summary

Gene Symbol: Tap1
Description: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Alias: Abcb2, Cim, APT1, ATP-binding cassette sub-family B member 2, antigen peptide transporter 1, peptide transporter TAP1, transporter 1 ABC (ATP binding cassette)
Species: rat

Top Publications

  1. ncbi MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters
    E V Deverson
    Department of Immunology, Cambridge Research Station, UK
    Nature 348:738-41. 1990
  2. ncbi Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population
    Kazuhiko Takeuchi
    Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan
    Ann Otol Rhinol Laryngol 111:460-3. 2002
  3. doi Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer
    Alina Deshpande
    Decision Applications Division, Los Alamos National Laboratory, Los Alamos, California, USA
    J Infect Dis 197:371-81. 2008
  4. ncbi Susceptibility to Reiter's syndrome is associated with alleles of TAP genes
    K S Barron
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Rheum 38:684-9. 1995
  5. pmc TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis
    Kyung Rae Kim
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea
    J Korean Med Sci 22:825-31. 2007
  6. ncbi TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk
    Bobbie S Gostout
    Section of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Gynecol Oncol 88:326-32. 2003
  7. doi Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?
    Barbara Fellerhoff
    Institute for Immunology, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
    Med Hypotheses 72:535-8. 2009
  8. doi Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus-tuberculosis co-infection
    Sharada Ramaseri Sunder
    LEPRA India Blue Peter Public Health and Research Centre, Cherlapally, Hyderabad, India
    Hum Immunol 72:908-11. 2011
  9. ncbi Transporter associated with antigen processing gene 1 codon 333 and codon 637 polymorphisms are associated with primary open-angle glaucoma
    Hui Ju Lin
    Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
    Mol Diagn 8:245-52. 2004
  10. pmc Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLE
    F Takeuchi
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
    Ann Rheum Dis 55:924-6. 1996

Research Grants

Scientific Experts

  • A Vambutas
  • B S Gostout
  • Barbara Fellerhoff
  • Qiao Liu
  • M R Knittler
  • Deniz Dogru
  • Mingliang Feng
  • Ralf M Leonhardt
  • Sarah Ehses
  • Sharada Ramaseri Sunder
  • Alina Deshpande
  • Marieke C Verweij
  • Arnoldo Aquino-Galvez
  • Elke Rufer
  • Kyung Rae Kim
  • Kirstin Keusekotten
  • Erik Procko
  • Yeong Wook Song
  • Hui Ju Lin
  • G Yan
  • Fuu Jen Tsai
  • Wen Chi Chen
  • Huey Yi Chen
  • Liang Wen Hang
  • Hicham Bouabe
  • Markus G Rudolph
  • Antony N Antoniou
  • Kazuhiko Takeuchi
  • G Velarde
  • O Daumke
  • L Ma
  • Subbanna Jonnalagada
  • Vijaya Lakshmi Valluri
  • Surekha Rani Hanumanth
  • Sumanlatha Gaddam
  • Cosette M Wheeler
  • Emmanuel J H J Wiertz
  • Joaquin Zuniga
  • Armida Juarez
  • Edwin Quinten
  • Joachim Koch
  • William C Hunt
  • Paul J Lehner
  • Robert Tampe
  • Henri de la Salle
  • Moises Selman
  • Danijela Koppers-Lalic
  • Georgina Gonzalez-Avila
  • Marco Checa
  • Martha Montaño
  • Ana C Zamora
  • Gilberto Vargas-Alarcon
  • Sandra Loch
  • Maaike E Ressing
  • Arend Mulder
  • Florian Klauschies
  • Annie Pardo
  • P Scott White
  • John P Nolan
  • Cheri L Peyton
  • Gabriel Sandoval-López
  • Julio Granados
  • Yolanda E Valdez
  • Angel Camarena
  • Seok Hyun Cho
  • Jin Hyeok Jeong
  • Suk Joo Choi
  • Chul Won Park
  • Seung Hwan Lee
  • Kyung Tae
  • Rachelle Gaudet
  • Sze Ling Ng
  • Ian Ferrin-O'Connell
  • Fujio Takeuchi
  • Dong Hee Whang
  • Eun Bong Lee
  • Guido Hansen
  • Su Jin Kang
  • Myoung Hee Park
  • Seng Sheen Fan
  • D Schoenfeld
  • D L Faustman
  • X Wang
  • A Penfornis
  • Chang Hai Tsai
  • Y Fu
  • Te Chun Hsia
  • James Stevens
  • Atsushi Yuta
  • Sawako Masuda

Detail Information

Publications36

  1. ncbi MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters
    E V Deverson
    Department of Immunology, Cambridge Research Station, UK
    Nature 348:738-41. 1990
    ..Here we show that one of these, the rat cim gene, maps to a highly polymorphic part of the MHC class II region encoding two novel members of the family of ..
  2. ncbi Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population
    Kazuhiko Takeuchi
    Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan
    Ann Otol Rhinol Laryngol 111:460-3. 2002
    Gene products of TAP1 and TAP2 (transporters associated with antigen processing) are involved in antigen presentation. It has been reported that polymorphisms in the TAP1 gene are associated with atopy in Tunisians...
  3. doi Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer
    Alina Deshpande
    Decision Applications Division, Los Alamos National Laboratory, Los Alamos, California, USA
    J Infect Dis 197:371-81. 2008
    ..Genetic variation in these genes may affect protein structure and function and, consequently, the ability of an individual to clear HPV infection...
  4. ncbi Susceptibility to Reiter's syndrome is associated with alleles of TAP genes
    K S Barron
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Rheum 38:684-9. 1995
    ..The recently described TAP genes (transporters associated with antigen processing) are potential candidates because they are polymorphic and their function is to transport antigenic peptides to be loaded in HLA class I molecules...
  5. pmc TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis
    Kyung Rae Kim
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea
    J Korean Med Sci 22:825-31. 2007
    ..The aim of this study was to investigate the association of TAP genes polymorphism with allergic rhinitis. TAP1 and TAP2 genotyping were performed on 110 allergic rhinitis patients and 107 healthy controls...
  6. ncbi TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk
    Bobbie S Gostout
    Section of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Gynecol Oncol 88:326-32. 2003
    ..We evaluated immune response genes in the HLA region of chromosome 6 to see if individual or interactive associations with cervical cancer risk could be identified...
  7. doi Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia?
    Barbara Fellerhoff
    Institute for Immunology, University of Munich, Goethestrasse 31, D 80336 Munich, Germany
    Med Hypotheses 72:535-8. 2009
    ..in a small group of schizophrenic patients and control individuals allele frequencies of the transporter proteins TAP1/TAP2, which select the immunoproteasome-tailored peptides for transportation...
  8. doi Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus-tuberculosis co-infection
    Sharada Ramaseri Sunder
    LEPRA India Blue Peter Public Health and Research Centre, Cherlapally, Hyderabad, India
    Hum Immunol 72:908-11. 2011
    ..by transporter associated with antigen processing (TAP), an integral ER membrane protein composed of two subunits, TAP1 and TAP2...
  9. ncbi Transporter associated with antigen processing gene 1 codon 333 and codon 637 polymorphisms are associated with primary open-angle glaucoma
    Hui Ju Lin
    Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
    Mol Diagn 8:245-52. 2004
    ..The TAP gene polymorphisms we evaluated were TAP1-1 codon 333 A/G (Ile-Val), TAP1-2 codon 637 (Asp-Gly), TAP2-1 codon 379 (Val-Ile), TAP2-2 codon 665 (Thr-Ala) and ..
  10. pmc Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLE
    F Takeuchi
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan
    Ann Rheum Dis 55:924-6. 1996
    To determine how polymorphism of transporter associated with antigen processing 1 and 2 (TAP1 and 2) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Japanese patients.
  11. ncbi Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients
    Yeong Wook Song
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, Korea
    Hum Immunol 66:810-7. 2005
    ..b>TAP1 and TAP2 gene polymorphisms were analyzed in 61 Korean patients with SSc and 100 ethnically matched healthy Koreans ..
  12. doi Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression
    Qiao Liu
    Department of Cellular and Molecular Biology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Scand J Gastroenterol 44:960-9. 2009
    ....
  13. doi TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population
    Mingliang Feng
    Shanghai Blood Center, Shanghai, People s Republic of China
    Hum Immunol 70:257-61. 2009
    ..In this study, we investigated the association of TAP1 and TAP2 polymorphisms in genetically homogenous Chinese AS patients...
  14. ncbi [Rehabilitative evaluation of 18 cases of anterior cruciate ligament lesions surgically treated by the Kenneth-Jones technique]
    G Masserano
    Servizio di Recupero e Rieducazione Funzionale, USSL n 47, Ospedale degli Infermi, Biella, Vercelli
    Minerva Med 83:89-91. 1992
  15. ncbi Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2
    Kirstin Keusekotten
    Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50674 Cologne, Germany
    J Biol Chem 281:17545-51. 2006
    ..TAP is a heterodimeric transmembrane protein that comprises the homologous subunits TAP1 and TAP2...
  16. ncbi Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter
    Erik Procko
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Cell 24:51-62. 2006
    ..Since asymmetry of the ATPase site motifs is a feature of many mammalian homologs, our proposed model has broad implications for ABC transporters...
  17. ncbi The role of TAP1 and TAP2 gene polymorphism in idiopathic bronchiectasis in children
    Deniz Dogru
    Pediatric Pulmonary Medicine Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pediatr Pulmonol 42:237-41. 2007
    ..DNA was extracted and gene polymorphisms for TAP1 and TAP2 were studied...
  18. ncbi Molecular architecture of the TAP-associated MHC class I peptide-loading complex
    Elke Rufer
    Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Institute of Immunology, Tuebingen, Germany
    J Immunol 179:5717-27. 2007
    ..peptide-receptive MHC class I (MHC-I) and accessory chaperones to the N-terminal regions of the TAP subunits TAP1 and TAP2...
  19. ncbi TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells
    L van Kaer
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Cell 71:1205-14. 1992
    The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules...
  20. doi Transporter associated with antigen processing (TAP) 1 gene polymorphisms in patients with hypersensitivity pneumonitis
    Arnoldo Aquino-Galvez
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col Seccion XVI, 14080, Mexico City, Mexico
    Exp Mol Pathol 84:173-7. 2008
    ..The distribution of single nucleotide polymorphisms (SNPs) in TAP1 genes was analyzed in 73 hypersensitivity pneumonitis (HP) patients and 58 normal subjects...
  21. ncbi The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex
    Marieke C Verweij
    Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 181:4894-907. 2008
    ..changes of TAP required for the translocation of peptides into the endoplasmic reticulum, and 2) by targeting TAP1 and TAP2 for proteasomal degradation. At present, it is unknown whether UL49.5 interacts with TAP1, TAP2, or both...
  22. ncbi Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells
    M Salcedo
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 152:1702-8. 1994
    ..174, and its derivative T2, have a large homozygous deletion in the MHC class II region encompassing the TAP1 and TAP2 as well as the LMP2 and LMP7 genes...
  23. ncbi Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter
    G Yan
    Immunobiology Laboratory, Massachusetts General Hospital East, Charlestown 02129, USA
    J Immunol 159:3068-80. 1997
    The MHC is an essential contributor to autoimmunity. Lmp2 and Tap1 are genes located in the MHC class II region, and they encode proteins participating in the generation and transport of endogenous peptides for T cell education...
  24. ncbi Functional role of C-terminal sequence elements in the transporter associated with antigen processing
    Sarah Ehses
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    J Immunol 174:328-39. 2005
    ..TAP consists of two subunits (TAP1 and TAP2), each with a transmembrane (TMD) and a nucleotide-binding (NBD) domain...
  25. ncbi Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls
    G Yan
    Immunobiology Laboratory, Massachusetts General Hospital, Charlestown 02129, USA
    Tissue Antigens 50:576-85. 1997
    New protective or disease-associated polymorphisms in the TAP1 gene were sought in insulin-dependent diabetes mellitus (IDDM) patients with the use of denaturing gradient gel electrophoresis (DGGE) screening of genomic DNA...
  26. ncbi Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules
    M R Knittler
    Institute for Genetics University of Cologne D 50674, Cologne, Germany
    Curr Biol 9:999-1008. 1999
    ..To investigate the role of TAP in this process, mutations that block nucleotide binding were introduced into the ATP-binding site of TAP...
  27. pmc Altered expression of TAP-1 and major histocompatibility complex class I in laryngeal papillomatosis: correlation of TAP-1 with disease
    A Vambutas
    Department of Otolaryngology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Clin Diagn Lab Immunol 7:79-85. 2000
    ..This up-regulation of class I MHC antigen at the cell surface potentially allows the infected cell to become a target for the immune system again. This finding provides some promise for nonsurgical treatment of laryngeal papillomas...
  28. ncbi Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains
    O Daumke
    Institute for Genetics, University of Cologne, Germany
    Eur J Biochem 268:4776-86. 2001
    ..TAP consists of two polypeptides (TAP1 and TAP2) each with an N-terminal transmembrane (TMD) and a C-terminal nucleotide binding domain (NBD)...
  29. ncbi Three-dimensional structure of transporter associated with antigen processing (TAP) obtained by single Particle image analysis
    G Velarde
    Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, United Kingdom
    J Biol Chem 276:46054-63. 2001
    ..Immunoaffinity-purified TAP particles comprising TAP1 and TAP2 polypeptides, and TAP2 particles alone were characterized after detergent solubilization and studied by ..
  30. ncbi Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group
    L Ma
    Immunobiology Laboratory, Massachusetts General Hospital, Charlestown, USA
    Hum Immunol 53:159-66. 1997
    ..Five coding region variants of TAP1 were typed in a cohort of well characterized Finnish patients with diabetes (n = 119) and compared to racially ..
  31. pmc Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits
    Antony N Antoniou
    Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, UK
    Immunology 106:182-9. 2002
    ..TAP comprises two polypeptides, TAP1 and TAP2, each a 'half-transporter' encoding a transmembrane domain and a nucleotide-binding domain...
  32. ncbi Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B
    Markus G Rudolph
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 324:975-90. 2002
    ..This loop change contributes to profound changes in the shape of the A-pocket in the peptide-binding groove and may explain the function of RT1-A1(c) as an inhibitory natural killer cell ligand...
  33. ncbi TAP1 gene AccI polymorphism is associated with atopic bronchial asthma
    Liang Wen Hang
    Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan
    J Clin Lab Anal 17:57-60. 2003
    ..A transporter associated with the antigen processing 1 gene (TAP1) is involved in antigen processing, and is therefore considered to play a role in the pathogenesis of bronchial ..
  34. ncbi The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2
    Hicham Bouabe
    Institute for Genetics, University of Cologne, Germany
    Eur J Biochem 270:4531-46. 2003
    ..TAP comprises two polypeptides, TAP1 and TAP2, each with an N-terminal transmembrane domain and a C-terminal cytosolic nucleotide binding domain (NBD)...
  35. ncbi Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11
    Andrea Vambutas
    North Shore Long Island Jewish Research Institute, and Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    J Infect Dis 189:871-9. 2004
    ..One way in which HPV subverts the immune system in RRP is by interfering with TAP1 (transporter associated with antigen presentation 1)...
  36. ncbi TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitus
    S Caillat-Zucman
    I N S E R M U25, Hopital Necker, Paris
    C R Acad Sci III 315:535-9. 1992
    ..The participation of TAP1 and TAP2 genes, located in the MHC region and coding for antigenic peptide transporters, was investigated in 116 ..

Research Grants1

  1. TAP-1/E7 INTERACTION: ROLE IN RESPIRATORY PAPILLOMAS
    Andrea Vambutas; Fiscal Year: 2004
    ..To determine whether the interaction between TAP-1 and E7 in naturally occurring infections sufficient to result in a loss of peptide transport and whether this loss correlates with viral protein load and the patients clinical course. ..