Gene Symbol: Tagln
Description: transgelin
Alias: Sm22, transgelin, SM22-alpha, smooth muscle 22 protein, smooth muscle protein 22-alpha
Species: rat
Products:     Tagln

Top Publications

  1. Nishida W, Kitami Y, Abe M, Hiwada K. Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. Biochem Int. 1991;23:663-8 pubmed
    A full length of cDNA encoding SM22 alpha from chicken gizzard smooth muscle was cloned and sequenced...
  2. Prinjha R, Shapland C, Hsuan J, Totty N, Mason I, Lawson D. Cloning and sequencing of cDNAs encoding the actin cross-linking protein transgelin defines a new family of actin-associated proteins. Cell Motil Cytoskeleton. 1994;28:243-55 pubmed
    ..Our data have shown that transgelin and several other proteins of unknown function, SM22 alpha [Pearlstone et al., 1987: J. Biol. Chem. 262:5985-5991], mouse p27 [Almendral et al., 1989: Exp. Cell Res...
  3. Nishida W, Kitami Y, Hiwada K. cDNA cloning and mRNA expression of calponin and SM22 in rat aorta smooth muscle cells. Gene. 1993;130:297-302 pubmed
    We cloned and sequenced cDNAs encoding calponin (Calp) and SM22 (smooth muscle-specific 22-kDa protein) from rat aorta (RaA) smooth muscle (Smu) cells...
  4. Shanahan C, Weissberg P, Metcalfe J. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Circ Res. 1993;73:193-204 pubmed
    ..and phospholamban, which are all proteins associated with the contractile function of differentiated VSMCs; SM22 alpha, a smooth muscle-specific protein of unknown function, and CHIP28, a putative membrane channel protein that is ..
  5. Koike G, Miano J, VanVooren P, Shiozawa M, Szpirer C, Jacob H. Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy. Mamm Genome. 1998;9:76-7 pubmed
  6. Fujii Y, Funakoshi T, Unuma K, Noritake K, Aki T, Uemura K. Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation. J Toxicol Sci. 2016;41:645-54 pubmed publisher
    ..NaHS caused shrinkage and death of the cells without caspase activation. An actin-binding protein, transgelin, was identified as one of the NaHS-inducible proteins in the cells...
  7. Wamhoff B, Hoofnagle M, Burns A, Sinha S, McDonald O, Owens G. A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circ Res. 2004;95:981-8 pubmed
  8. Zeidan A, Swärd K, Nordström I, Ekblad E, Zhang J, Parmacek M, et al. Ablation of SM22alpha decreases contractility and actin contents of mouse vascular smooth muscle. FEBS Lett. 2004;562:141-6 pubmed
    ..Ablation of SM22alpha did not affect stretch sensitivity of any of these proteins. Thus, SM22alpha plays a role in contractility, possibly by affecting actin filament organisation. ..
  9. Ferland D, Darios E, Watts S. The persistence of active smooth muscle in the female rat cervix through pregnancy. Am J Obstet Gynecol. 2015;212:244.e1-8 pubmed publisher
    ..2% KCl contraction, n = 4). These findings strongly support that smooth muscle is present in the cervix through pregnancy and continuous with the uterus. ..

More Information


  1. Lin Z, Liu L, Xi Z, Huang J, Lin B. Single-walled carbon nanotubes promote rat vascular adventitial fibroblasts to transform into myofibroblasts by SM22-? expression. Int J Nanomedicine. 2012;7:4199-206 pubmed publisher
    ..SWCNTs also promoted the transformation by the TGF-?(l)/Smads signal pathway at the advanced stage in a persistent manner. These results indicate that SWCNTs can possibly be used as artery tissue-engineering materials. ..
  2. Ogawa A, Sakatsume M, Wang X, Sakamaki Y, Tsubata Y, Alchi B, et al. SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis. Nephron Exp Nephrol. 2007;106:e77-87 pubmed
    ..The injured glomerular epithelial cells in anti-GBM nephritis might undergo structural and functional alterations, including the expression of a smooth muscle marker, SM22alpha. ..
  3. Hauser P, Perco P, Mühlberger I, Pippin J, Blonski M, Mayer B, et al. Microarray and bioinformatics analysis of gene expression in experimental membranous nephropathy. Nephron Exp Nephrol. 2009;112:e43-58 pubmed publisher
    ..The single most increased gene was transgelin (Tagln) showing a 70-fold upregulation in animals with PHN...
  4. Dong L, Wen J, Liu G, McNutt M, Miao S, Gao R, et al. Blockade of the Ras-extracellular signal-regulated kinase 1/2 pathway is involved in smooth muscle 22 alpha-mediated suppression of vascular smooth muscle cell proliferation and neointima hyperplasia. Arterioscler Thromb Vasc Biol. 2010;30:683-91 pubmed publisher
    ..We studied the inhibitory effect of smooth muscle 22 alpha (SM22 alpha) on VSMC proliferation in vitro and in vivo and explored the potential molecular mechanisms of this effect...
  5. Shen J, Yang M, Ju D, Jiang H, Zheng J, Xu Z, et al. Disruption of SM22 promotes inflammation after artery injury via nuclear factor kappaB activation. Circ Res. 2010;106:1351-62 pubmed publisher
    SM22 (or transgelin), an actin-binding protein abundant in vascular smooth muscle cells (VSMCs), is downregulated in atherosclerosis, aneurysm and various cancers...
  6. Inomata S, Sakatsume M, Sakamaki Y, Wang X, Goto S, Yamamoto T, et al. Expression of SM22? (transgelin) in glomerular and interstitial renal injury. Nephron Exp Nephrol. 2011;117:e104-13 pubmed publisher
    SM22?, transgelin, is abundantly expressed in smooth muscle tissues and our previous work demonstrated that it is a novel marker of injured glomerular epithelial cells in rat antiglomerular basement membrane nephritis...
  7. Dong L, Li L, Song Y, Duan Z, Sun S, Lin Y, et al. TRAF6-Mediated SM22α K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo. Circ Res. 2015;117:684-94 pubmed publisher
    ..To identify the relationship between dihydronicotinamide adenine dinucleotide phosphate production and SM22α activity in the development and progression of vascular diseases...
  8. Shu Y, Zhang F, Bi W, Dong L, Zhang D, Chen R, et al. SM22α inhibits vascular inflammation via stabilization of IκBα in vascular smooth muscle cells. J Mol Cell Cardiol. 2015;84:191-9 pubmed publisher
    Smooth muscle (SM) 22α, an actin-binding protein, is down-regulated in atherosclerotic arteries. Disruption of SM22α promotes arterial inflammation through activation of reactive oxygen species (ROS)-mediated nuclear factor (NF)-κ..
  9. Kaplan Albuquerque N, Garat C, Van Putten V, Nemenoff R. Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2003;285:H1444-52 pubmed
    ..However, it is unknown whether these agents regulate other SM genes in a similar fashion. SM22 alpha appears secondary to SMA during development and is also a marker for SMC...
  10. Shields J, Rogers Graham K, Der C. Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. J Biol Chem. 2002;277:9790-9 pubmed
    ..We further characterized transgelin as a gene whose expression was abolished by Ras...
  11. Wen J, Shi J, Zheng B, Meng F, Han M. [The molecular mechanisms of SM22alpha in cytoskeleton remodeling of vascular smooth muscle cells]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008;24:393-7 pubmed
    ..It can not only induce polymerization of G-actin to F-actin, but also promote cross-linking of F-actin to bundled stress fibres, indicating its vital role in cytoskeleton remodeling. ..
  12. Daniel C, Lüdke A, Wagner A, Todorov V, Hohenstein B, Hugo C. Transgelin is a marker of repopulating mesangial cells after injury and promotes their proliferation and migration. Lab Invest. 2012;92:812-26 pubmed publisher
    ..Using self-organizing maps, transgelin was identified as a new marker for repopulating glomerular cells...
  13. Feil S, Hofmann F, Feil R. SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis. Circ Res. 2004;94:863-5 pubmed
    ..These results identify a role for SM22alpha in the regulation of SMC phenotype during atherogenesis. ..
  14. Rattan S, Ali M. Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2015;308:G605-12 pubmed publisher
    ..phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs...
  15. Leguillette R, Laviolette M, Bergeron C, Zitouni N, Kogut P, Solway J, et al. Myosin, transgelin, and myosin light chain kinase: expression and function in asthma. Am J Respir Crit Care Med. 2009;179:194-204 pubmed publisher
    ..We observed an increased expression of the fast myosin heavy chain isoform, transgelin, and myosin light chain kinase in patients with asthma...
  16. Shi J, Zheng B, Meng F, Wen J, Han M. [Recombinant C-terminal fragment of SM22 induces cytoskeleton reorganization]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007;23:370-4 pubmed
    ..The recombinant SM22alpha C-terminal domains have the ability to bind F-actin, by which SM22alpha interacts with actin and participates in cytoskeleton reorganization. ..
  17. Lv P, Miao S, Shu Y, Dong L, Liu G, Xie X, et al. Phosphorylation of smooth muscle 22? facilitates angiotensin II-induced ROS production via activation of the PKC?-P47phox axis through release of PKC? and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cel. Circ Res. 2012;111:697-707 pubmed publisher
    ..The recent study indicates that SM22? disruption can independently promote arterial inflammation through activation of reactive oxygen species (ROS)-..
  18. Karagianni F, Prakoura N, Kaltsa G, Politis P, Arvaniti E, Kaltezioti V, et al. Transgelin Up-Regulation in Obstructive Nephropathy. PLoS ONE. 2013;8:e66887 pubmed publisher
    ..renal parenchyma in the well-established rat model of unilateral ureteral obstruction (UUO model) suggested that transgelin was up-regulated during the development of fibrosis...
  19. Zhang J, Kim S, Helmke B, Yu W, Du K, Lu M, et al. Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol Cell Biol. 2001;21:1336-44 pubmed
    ..To examine the function of SM22alpha, gene targeting was used to generate SM22alpha-deficient (SM22(-/-LacZ)) mice...