Gene Symbol: Tada3
Description: transcriptional adaptor 3
Alias: Tada3l, transcriptional adapter 3, ADA3 homolog, ADA3-like protein
Species: rat
Products:     Tada3

Top Publications

  1. Benecke A, Gaudon C, Garnier J, vom Baur E, Chambon P, Losson R. ADA3-containing complexes associate with estrogen receptor alpha. Nucleic Acids Res. 2002;30:2508-14 pubmed
    ..However, the ADA3-containing TBP-free-TAF-containing complex (TFTC) can interact with ERalpha in a ligand-independent manner, indicating that other subunits of the complex are sufficient to mediate interaction with NRs. ..
  2. Brand M, Yamamoto K, Staub A, Tora L. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem. 1999;274:18285-9 pubmed
    ..Thus, the polypeptide composition of TFTC suggests that TFTC is recruited to chromatin templates by activators to acetylate histones and thus may potentiate initiation and activation of transcription. ..
  3. Kurabe N, Katagiri K, Komiya Y, Ito R, Sugiyama A, Kawasaki Y, et al. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. Oncogene. 2007;26:5626-34 pubmed
    ..These results show that rSGF29 is a novel component of TFTC/STAGA complexes and could be involved in the c-Myc-mediated malignant transformation. ..
  4. Li C, Ai N, Dinh G, Welsh W, Chen J. Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket. Nucleic Acids Res. 2010;38:5291-303 pubmed publisher
    ..These results suggest that hADA3 is a bona fide transcriptional coactivator for RAR?, acting through a conserved mechanism involving direct contacts between NR boxes and the receptor's co-activator pocket. ..
  5. Orpinell M, Fournier M, Riss A, Nagy Z, Krebs A, Frontini M, et al. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J. 2010;29:2381-94 pubmed publisher
    ..Thus, we have uncovered an essential function for ATAC in regulating Cyclin A activity and consequent mitotic progression. ..