Gene Symbol: Tab1
Description: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Alias: Map3k7ip1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Tak1-binding protein 1, mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Species: rat
Products:     Tab1

Top Publications

  1. Komatsu Y, Shibuya H, Takeda N, Ninomiya Tsuji J, Yasui T, Miyado K, et al. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002;119:239-49 pubmed
    ..TGF-beta activated kinase-1 binding protein-1 (TAB1) was identified as a molecule that activates TGF-beta activated kinase-1 (TAK1)...
  2. Lu G, Kang Y, Han J, Herschman H, Stefani E, Wang Y. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem. 2006;281:6087-95 pubmed
    ..These results suggest a previously unknown mechanism for stress-MAP kinase regulation in mammalian cells. ..
  3. Xia W, Mruk D, Lee W, Cheng C. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. J Biol Chem. 2006;281:16799-813 pubmed
    ..of p38 and ERK signaling pathways is dependent on the association of the TGF-beta3-TbetaR1 complex with adaptors TAB1 and CD2AP because if TbetaR1 was associated preferentially with CD2AP, only Sertoli-germ cell adhesion was ..
  4. Verstrepen L, Bekaert T, Chau T, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci. 2008;65:2964-78 pubmed publisher
    ..In this review, we will discuss our current knowledge of NF-kappaB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways. ..
  5. Weber A, Wasiliew P, Kracht M. Interleukin-1 (IL-1) pathway. Sci Signal. 2010;3:cm1 pubmed publisher
    ..Of note, most intracellular components that participate in the cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like-receptors (TLRs), and many forms of cytotoxic stresses. ..
  6. Moriguchi M, Yamada M, Miake Y, Yanagisawa T. Immunolocalization of TAK1, TAB1, and p38 in the developing rat molar. Anat Sci Int. 2011;86:69-77 pubmed publisher
    ..TGF-?-activated kinase 1 (TAK1) is activated by TGF-? or BMP and binds to TAK1-binding protein (TAB1), activating p38 or c-Jun N-terminal kinase (JNK), forming the non-Smad signaling pathway...
  7. Brown J, Wang H, Hajishengallis G, Martin M. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res. 2011;90:417-27 pubmed publisher
    ..TIR-domain-containing adapter-inducing interferon-?; IRAK, IL-1R-associated kinase; TAK1, TGF-?-activated kinase; TAB1, TAK1-binding protein; NF-?B, nuclear factor kappa-light-chain-enhancer of activated B-cells; MAPK, mitogen-..
  8. Liu S, Chen Z. Expanding role of ubiquitination in NF-?B signaling. Cell Res. 2011;21:6-21 pubmed publisher
  9. Du C, Yang R, Song S, Wang Y, Kang J, Zhang R, et al. Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. Front Pharmacol. 2010;1:111 pubmed publisher
    ..Interestingly, MLB specifically inhibited the TGF?-activated protein kinase 1-binding protein 1 (TAB1) mediated p38 phosphorylation through disrupting the interaction between TAB1 and p38, but it did not affect the ..