Gene Symbol: Syt5
Description: synaptotagmin 5
Alias: SytIX, synaptotagmin-5, synaptotagmin IX, synaptotagmin V, sytV
Species: rat
Products:     Syt5

Top Publications

  1. Li C, Ullrich B, Zhang J, Anderson R, Brose N, Sudhof T. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature. 1995;375:594-9 pubmed
    ..The same C2 domains also bind syntaxin as a function of Ca2+ but the Ca(2+)-concentration dependence of Syt I, II and V (> 200 microM) differs from that of Syt III and VII (< 10 microM).(ABSTRACT TRUNCATED AT 250 WORDS) ..
  2. Craxton M, Goedert M. Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain. FEBS Lett. 1995;361:196-200 pubmed
    ..We report here the cloning and sequencing of a novel isoform of 386 amino acids. Synaptotagmin V is 54% identical in sequence to synaptotagmin I and possesses all the domains that characterise this ..
  3. Hudson A, Birnbaum M. Identification of a nonneuronal isoform of synaptotagmin. Proc Natl Acad Sci U S A. 1995;92:5895-9 pubmed
    ..Antiserum specific for the synaptotagmin-5 isoform recognizes a protein of about 50 kDa which is about 6-fold more abundant in brain synaptic vesicles than in whole brain membranes. ..
  4. Fukuda M, Mikoshiba K. A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms. J Biol Chem. 1999;274:31428-34 pubmed
    ..These results suggest that Syt VI and Syt VIDeltaTM may play distinct roles in vesicular trafficking. ..
  5. Haberman Y, Grimberg E, Fukuda M, Sagi Eisenberg R. Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules. J Cell Sci. 2003;116:4307-18 pubmed
    ..These results therefore indicate that Syt IX is involved in regulating transport from the ERC to the cell surface, and suggest that it may play a role in linking vesicles that exit the ERC with the microtubules network...
  6. Iezzi M, Kouri G, Fukuda M, Wollheim C. Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis. J Cell Sci. 2004;117:3119-27 pubmed
    ..Remarkably, hormone release in response to glucose was selectively and strongly reduced, indicating that Syt V and Syt IX are directly involved in the Ca2+ -dependent stimulation of exocytosis. ..
  7. Zhang Q, Fukuda M, Van Bockstaele E, Pascual O, Haydon P. Synaptotagmin IV regulates glial glutamate release. Proc Natl Acad Sci U S A. 2004;101:9441-6 pubmed
  8. Fukuda M. Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport. 2006;17:179-82 pubmed
    b>Synaptotagmin IX has been postulated to function as a major Ca2+ sensor for dense-core vesicle exocytosis in neuroendocrine cells...
  9. Fukuda M, Kojima T, Mikoshiba K. Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV. J Biol Chem. 1996;271:8430-4 pubmed
    ..However, it binds PS with a positive cooperativity and an affinity similar to those of the C2A domains of other isoforms. Our results suggest that synaptotagmin IV is also a potential Ca2+ sensor for neurotransmitter release. ..

More Information


  1. Tucker W, Edwardson J, Bai J, Kim H, Martin T, Chapman E. Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. J Cell Biol. 2003;162:199-209 pubmed
    ..These data suggest that syts trigger fusion via their Ca2+-regulated interactions with t-SNAREs and PIP2, target molecules known to play critical roles in exocytosis. ..
  2. Dandoy Dron F, Griffond B, Mishal Z, Tovey M, Dron M. Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells. Eur J Neurosci. 2003;18:2449-59 pubmed
    ..iii) Scrg1 is enriched in fractions of sucrose density gradient where synaptotagmin V, a dense-core vesicle-associated protein, is also enriched...
  3. Saegusa C, Fukuda M, Mikoshiba K. Synaptotagmin V is targeted to dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells. J Biol Chem. 2002;277:24499-505 pubmed
    ..Based on these results, we propose that Syt V is a dense-core vesicle-specific Syt isoform that controls a specific type of Ca2+-regulated secretion. ..
  4. Haberman Y, Ziv I, Gorzalczany Y, Fukuda M, Sagi Eisenberg R. Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment. J Cell Sci. 2005;118:1641-9 pubmed
    ..As such, correct targeting of Syt IX is facilitated by the phorbol ester TPA but prevented by the cPKC inhibitor Go 6976. ..
  5. Lynch K, Martin T. Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells. J Cell Sci. 2007;120:617-27 pubmed
    ..By contrast, Ca2+-dependent exocytosis persisted in cells expressing only synaptotagmin I or only synaptotagmin IX, which indicated a redundancy in function for these isoforms...
  6. Qiu X, Ge J, Gao Y, Teng M, Niu L. Structural analysis of Ca2+-binding pocket of synaptotagmin 5 C2A domain. Int J Biol Macromol. 2017;95:946-953 pubmed publisher
    ..This study presents the crystal structure of the first C2 domain (C2A domain) of synaptotagmin 5 complexed with Ca2+ at 1.90Å resolution...