syndecan 2


Gene Symbol: syndecan 2
Description: syndecan 2
Alias: HSPG, syndecan-2, Ryudocan/syndecan 2, SYND2, fibroglycan, heparan sulfate proteoglycan core protein
Species: rat
Products:     syndecan 2

Top Publications

  1. Hsueh Y, Yang F, Kharazia V, Naisbitt S, Cohen A, Weinberg R, et al. Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J Cell Biol. 1998;142:139-51 pubmed
    ..the PDZ domain of CASK and the COOH terminal tail of syndecan-2, a cell surface heparan sulfate proteoglycan (HSPG). The interaction was confirmed by coimmunoprecipitation from heterologous cells...
  2. Landgraf P, Wahle P, Pape H, Gundelfinger E, Kreutz M. The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity. J Biol Chem. 2008;283:25036-45 pubmed publisher
    ..This identifies a new mechanism of communication between the nervous and the immune system that might directly affect the wiring of the brain during development. ..
  3. Hsueh Y, Roberts A, Volta M, Sheng M, Roberts R. Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. J Neurosci. 2001;21:3764-70 pubmed
    ..Syndecan-2, a transmembrane heparan sulfate proteoglycan (HSPG), was isolated as a binding partner for two distinct regions of the neurofibromin protein...
  4. Hsueh Y, Sheng M. Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J Neurosci. 1999;19:7415-25 pubmed
    ..Moreover, CASK is appropriately expressed and localized to interact with both syndecan-2 and -3 in different compartments of the neuron throughout postnatal development. ..
  5. Choi Y, Kwon M, Lim Y, Yun J, Lee W, Oh E. Trans-regulation of Syndecan Functions by Hetero-oligomerization. J Biol Chem. 2015;290:16943-53 pubmed publisher
    ..Taken together, these data provide evidence that hetero-oligomerization produces distinct syndecan functions and offer insights into the underlying signaling mechanisms of syndecans. ..
  6. Lee J, Park H, Chung H, Choi S, Kim Y, Yoo H, et al. Syndecan-2 regulates the migratory potential of melanoma cells. J Biol Chem. 2009;284:27167-75 pubmed publisher
    ..Together, these data strongly suggest that syndecan-2 plays a crucial role in the migratory potential of melanoma cells. ..
  7. Ethell I, Irie F, Kalo M, Couchman J, Pasquale E, Yamaguchi Y. EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron. 2001;31:1001-13 pubmed
    ..Our observations suggest that spine morphogenesis is triggered by the activation of Eph receptors, which causes tyrosine phosphorylation of target molecules, such as syndecan-2, in presumptive spines. ..
  8. Choi S, Kim Y, Park H, Han I, Chung E, Lee S, et al. Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2. Biochem Biophys Res Commun. 2009;384:231-5 pubmed publisher
    ..This interactive dynamic might be a possible mechanism underlying the tumorigenic activities of colon cancer cells. ..
  9. Kaur C, Sivakumar V, Yip G, Ling E. Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflammation in the hypoxic developing brain. Glia. 2009;57:336-49 pubmed publisher
    ..In this connection, edaravone suppressed the hypoxia- and Sdc-2-induced increased cytokine and ROS production suggesting its therapeutic potential in ameliorating neuroinflammation. ..

Scientific Experts

More Information


  1. Chiquet B, Hashmi S, Henry R, Burt A, Mulliken J, Stal S, et al. Genomic screening identifies novel linkages and provides further evidence for a role of MYH9 in nonsyndromic cleft lip and palate. Eur J Hum Genet. 2009;17:195-204 pubmed publisher
    ..3-24.12 and 22q12.2-12.3 with LOD scores of 2.98 and 2.66, respectively. On the basis of biological function, syndecan 2 (SDC2) and growth differentiation factor 6 (GDF6) in 8q21.3-24...
  2. Pierce A, Lyon M, Hampson I, Cowling G, Gallagher J. Molecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver. J Biol Chem. 1992;267:3894-900 pubmed
    ..23 kDa) has a high degree of homology with the published partial sequence of the human lung fibroblast HSPG, fibroglycan. The deduced protein sequence contains a 24-amino acid transmembrane domain and a 33-amino acid cytoplasmic ..
  3. Luyten A, Mortier E, Van Campenhout C, Taelman V, Degeest G, Wuytens G, et al. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. Mol Biol Cell. 2008;19:1594-604 pubmed publisher
    ..We propose that syntenin is a novel component of the Wnt signal transduction cascade and that it might function as a direct intracellular link between Frizzled and syndecans. ..
  4. Chen L, Klass C, Woods A. Syndecan-2 regulates transforming growth factor-beta signaling. J Biol Chem. 2004;279:15715-8 pubmed
    ..Syndecan-2 specifically co-immunoprecipitated with betaglycan but not with TbetaRI or TbetaRII. This is a novel mechanism of control of TGF-beta action that may be important in fibrosis. ..
  5. Dews I, MacKenzie K. Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc Natl Acad Sci U S A. 2007;104:20782-7 pubmed
  6. Kuribayashi M, Asamoto M, Suzuki S, Hokaiwado N, Ogawa K, Shirai T. Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences. Cancer Lett. 2006;232:289-99 pubmed
    ..The results suggest that suppression of syndecan-2 (Sdc2) and induction of cell cycle arrest through a p21-dependent pathway might have counter-acted any promotion effects of up-regulation of CYP1A2. ..
  7. Chen C, Lin C, Chang C, Jiang S, Hsueh Y. Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol. 2011;193:769-84 pubmed publisher
    ..These functions likely involve Sarm1-mediated regulation of microtubule stability, as Sarm1 influenced tubulin acetylation. This study thus reveals the molecular mechanism underlying the action of Sarm1 in neuronal morphogenesis. ..
  8. Horiguchi K, Syaidah R, Fujiwara K, Tsukada T, Ramadhani D, Jindatip D, et al. Expression of the cell-surface heparan sulfate proteoglycan syndecan-2 in developing rat anterior pituitary gland. Cell Tissue Res. 2013;353:473-81 pubmed publisher
    ..Therefore, syndecan-2 expression occurs in developmentally regulated patterns and syndecan-2 probably has different roles in adult and developing anterior pituitary glands. ..
  9. Landgraf P, Mikhaylova M, Macharadze T, Borutzki C, Zenclussen A, Wahle P, et al. Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK. PLoS ONE. 2014;9:e85924 pubmed publisher
    ..During early development a protein knockdown of SDC-3 also attenuated the effect of Y-P30 on axon outgrowth. Taken together these data suggest that Y-P30 can control the nuclear localization of CASK in a SDC-dependent manner...
  10. Kwon M, Choi Y, Yun J, Lee W, Han I, Oh E. A unique phenylalanine in the transmembrane domain strengthens homodimerization of the syndecan-2 transmembrane domain and functionally regulates syndecan-2. J Biol Chem. 2015;290:5772-82 pubmed publisher
    ..Taken together, these data suggest that Phe(167) in the TMD of syndecan-2 endows the protein with specific functions. Our work offers new insights into the signaling mediated by the TMD of syndecan family members. ..
  11. Worapamorn W, Xiao Y, Li H, Young W, Bartold P. Differential expression and distribution of syndecan-1 and -2 in periodontal wound healing of the rat. J Periodontal Res. 2002;37:293-9 pubmed
    ..The appearance of syndecan-1 may involve both cell-cell and cell-matrix interactions, while syndecan-2 showed a predilection to associate with cell-matrix interactions during hard tissue formation. ..
  12. Jang B, Jung H, Choi S, Lee Y, Lee S, Oh E. Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase C?-mediated FAK/ERK signaling pathway in colon cancer. J Biol Chem. 2017;292:16321-16332 pubmed publisher
    ..Taken together, these findings suggest that syndecan-2's cytoplasmic domain up-regulates MMP-7 expression in colon cancer cells via PKC?-mediated activation of FAK/ERK signaling. ..