Sycp1

Summary

Gene Symbol: Sycp1
Description: synaptonemal complex protein 1
Alias: SCP1, synaptonemal complex protein 1, A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes, SCP-1
Species: rat
Products:     Sycp1

Top Publications

  1. Schmekel K, Meuwissen R, Dietrich A, Vink A, Van Marle J, van Veen H, et al. Organization of SCP1 protein molecules within synaptonemal complexes of the rat. Exp Cell Res. 1996;226:20-30 pubmed
    b>SCP1, a major protein component of synaptonemal complexes (SCs), is probably a constituent of the transverse filaments (TFs)...
  2. Yang F, Eckardt S, Leu N, McLaughlin K, Wang P. Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J Cell Biol. 2008;180:673-9 pubmed publisher
    ..Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination. ..
  3. de Vries F, de Boer E, van den Bosch M, Baarends W, Ooms M, Yuan L, et al. Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. Genes Dev. 2005;19:1376-89 pubmed
    ..We disrupted the mouse gene encoding TF protein Sycp1 to analyze the role of TFs in meiotic chromosome behavior and recombination...
  4. Kouznetsova A, Novak I, Jessberger R, Hoog C. SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. J Cell Sci. 2005;118:2271-8 pubmed
    ..This finding supports a model in which the removal of bulk cohesin from paired sister chromatids at late prophase in both meiotic and mitotic cells ensures proper chromosome compaction and segregation. ..
  5. Kumar R, Bourbon H, de Massy B. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 2010;24:1266-80 pubmed publisher
  6. Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Tränkner D, Toth A. Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 2016;12:e1006393 pubmed publisher
  7. Hamer G, Gell K, Kouznetsova A, Novak I, Benavente R, Hoog C. Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. J Cell Sci. 2006;119:4025-32 pubmed
    ..models, we show that these proteins and TEX12 specifically depend on the synaptonemal transverse filament protein SYCP1 for localization to the meiotic chromosomes...
  8. Luangpraseuth Prosper A, Lesueur E, Jouneau L, Pailhoux E, Cotinot C, Mandon Pépin B. TOPAZ1, a germ cell specific factor, is essential for male meiotic progression. Dev Biol. 2015;406:158-71 pubmed publisher
    ..Our results also showed that 10% of these transcripts are long non-coding RNA. This suggests that a highly regulated balance of lncRNAs seems to be essential during spermatogenesis for induction of appropriate male gamete production. ..
  9. Beyret E, Lin H. Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev Biol. 2011;355:215-26 pubmed publisher
    ..These results pinpoint a function of the PIWI protein subfamily to meiosis during spermatogenesis. ..

Scientific Experts

More Information

Publications27

  1. Tang M, Jacobs S, Mattiske D, Soh Y, Graham A, Tran A, et al. Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice. PLoS Genet. 2015;11:e1004964 pubmed publisher
    ..3 deficiency. They also reveal partial redundancy in function of H3f3a and H3f3b, with the latter gene being generally the most important. ..
  2. Paredes A, Garcia Rudaz C, Kerr B, Tapia V, Dissen G, Costa M, et al. Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary. Endocrinology. 2005;146:5267-77 pubmed
    ..One of them encodes synaptonemal complex protein-1 (SCP1), a core component of the protein complex that maintains recombining chromosomes together during prophase I of the ..
  3. Parra M, Viera A, Gómez R, Page J, Carmena M, Earnshaw W, et al. Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. J Cell Sci. 2003;116:961-74 pubmed
    ..We discuss the complex dynamic relocalization of the chromosomal passenger complex during prophase I. Additionally, we suggest that this complex may regulate sister-chromatid centromere cohesion during both meiotic divisions...
  4. Llano E, Herrán Y, García Tuñón I, Gutiérrez Caballero C, de Alava E, Barbero J, et al. Meiotic cohesin complexes are essential for the formation of the axial element in mice. J Cell Biol. 2012;197:877-85 pubmed publisher
  5. Modzelewski A, Holmes R, Hilz S, Grimson A, Cohen P. AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Dev Cell. 2012;23:251-64 pubmed publisher
    ..This is associated with a dramatic loss of microRNAs, >20% of which arises from the X chromosome. Thus, AGO4 regulates meiotic entry and MSCI in mammalian germ cells, implicating small RNA pathways in these processes...
  6. Berkowitz K, Sowash A, Koenig L, Urcuyo D, Khan F, Yang F, et al. Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet. 2012;8:e1002996 pubmed publisher
    ..These findings demonstrate essential roles for CHTF18 in mammalian spermatogenesis and meiosis, and suggest that CHTF18 may function during the double-strand break repair pathway to promote the formation of crossovers. ..
  7. Ishiguro K, Kim J, Shibuya H, Hern ndez Hern ndez A, Suzuki A, Fukagawa T, et al. Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev. 2014;28:594-607 pubmed publisher
    ..These findings suggest the intriguing possibility that homolog recognition is achieved primarily by searching for homology in the chromosome architecture as defined by meiosis-specific cohesin rather than in the DNA sequence itself...
  8. Ryu K, Sinnar S, Reinholdt L, Vaccari S, Hall S, Garcia M, et al. The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol. 2008;28:1136-46 pubmed
  9. La Salle S, Palmer K, O Brien M, Schimenti J, Eppig J, Handel M. Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Biol Reprod. 2012;86:45 pubmed publisher
    ..The repro42 mutation thus identifies a novel mammalian germ cell-specific gene required for meiotic progression. ..
  10. Holloway J, Sun X, Yokoo R, Villeneuve A, Cohen P. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J Cell Biol. 2014;205:633-41 pubmed publisher
  11. Sowa N, Horie T, Kuwabara Y, Baba O, Watanabe S, Nishi H, et al. MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene. J Cell Biochem. 2012;113:3455-65 pubmed publisher
    ..On the other hand, overexpression of SCP1 induced the mRNA expression of ANF and ?MHC and increased the cell surface area in cardiomyocytes...
  12. Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Herault Y, et al. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016;354:909-912 pubmed
    ..DNMT3C reveals the plasticity of the mammalian DNA methylation system and expands the scope of the mechanisms involved in the epigenetic control of retrotransposons. ..
  13. Di Carlo A, Travia G, De Felici M. The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. Int J Dev Biol. 2000;44:241-4 pubmed
    The synaptonemal complex proteins SCP3 and SCP1 are components of the synaptonemal complex, a meiosis-specific protein structure essential for synapsis of homologous chromosomes...
  14. Costa Y, Speed R, Ollinger R, Alsheimer M, Semple C, Gautier P, et al. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. J Cell Sci. 2005;118:2755-62 pubmed
    ..These new proteins, SYCE1 and CESC1, interact with the transverse filament protein SYCP1, and their localisation to the central element appears to depend on recruitment by SYCP1...
  15. Tay J, Hodgman R, Sarkissian M, Richter J. Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev. 2003;17:1457-62 pubmed
    ..The temporal control of CPEB phosphorylation suggests a mechanism in which CPE-containing mRNA translation is stimulated at pachytene and metaphase I. ..
  16. Ollinger R, Alsheimer M, Benavente R. Mammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes. Mol Biol Cell. 2005;16:212-7 pubmed
    ..Major components of mammalian SCs are the meiosis-specific proteins SCP1, 2, and 3. To investigate the role of SCP1 in SC assembly, we expressed SCP1 in a heterologous system, i.e...
  17. Meuwissen R, Offenberg H, Dietrich A, Riesewijk A, van Iersel M, Heyting C. A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes. EMBO J. 1992;11:5091-100 pubmed
    ..The protein predicted from the nucleotide sequence of a full-length cDNA, named SCP1, consists of 946 amino acid residues and has a molecular weight of 111 kDa...
  18. Sun X, Brieño Enríquez M, Cornelius A, Modzelewski A, Maley T, Campbell Peterson K, et al. FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma. 2016;125:237-52 pubmed publisher