Genomes and Genes
Gene Symbol: Sycp1
Description: synaptonemal complex protein 1
Alias: SCP1, synaptonemal complex protein 1, A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes, SCP-1
- Tang M, Jacobs S, Mattiske D, Soh Y, Graham A, Tran A, et al. Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice. PLoS Genet. 2015;11:e1004964 pubmed publisher..3 deficiency. They also reveal partial redundancy in function of H3f3a and H3f3b, with the latter gene being generally the most important. ..
- Paredes A, Garcia Rudaz C, Kerr B, Tapia V, Dissen G, Costa M, et al. Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary. Endocrinology. 2005;146:5267-77 pubmed..One of them encodes synaptonemal complex protein-1 (SCP1), a core component of the protein complex that maintains recombining chromosomes together during prophase I of the ..
- Parra M, Viera A, Gómez R, Page J, Carmena M, Earnshaw W, et al. Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. J Cell Sci. 2003;116:961-74 pubmed..We discuss the complex dynamic relocalization of the chromosomal passenger complex during prophase I. Additionally, we suggest that this complex may regulate sister-chromatid centromere cohesion during both meiotic divisions...
- Modzelewski A, Holmes R, Hilz S, Grimson A, Cohen P. AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Dev Cell. 2012;23:251-64 pubmed publisher..This is associated with a dramatic loss of microRNAs, >20% of which arises from the X chromosome. Thus, AGO4 regulates meiotic entry and MSCI in mammalian germ cells, implicating small RNA pathways in these processes...
- Berkowitz K, Sowash A, Koenig L, Urcuyo D, Khan F, Yang F, et al. Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet. 2012;8:e1002996 pubmed publisher..These findings demonstrate essential roles for CHTF18 in mammalian spermatogenesis and meiosis, and suggest that CHTF18 may function during the double-strand break repair pathway to promote the formation of crossovers. ..
- Ishiguro K, Kim J, Shibuya H, Hern ndez Hern ndez A, Suzuki A, Fukagawa T, et al. Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev. 2014;28:594-607 pubmed publisher..These findings suggest the intriguing possibility that homolog recognition is achieved primarily by searching for homology in the chromosome architecture as defined by meiosis-specific cohesin rather than in the DNA sequence itself...
- Ryu K, Sinnar S, Reinholdt L, Vaccari S, Hall S, Garcia M, et al. The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol. 2008;28:1136-46 pubmed
- La Salle S, Palmer K, O Brien M, Schimenti J, Eppig J, Handel M. Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Biol Reprod. 2012;86:45 pubmed publisher..The repro42 mutation thus identifies a novel mammalian germ cell-specific gene required for meiotic progression. ..
- Sowa N, Horie T, Kuwabara Y, Baba O, Watanabe S, Nishi H, et al. MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene. J Cell Biochem. 2012;113:3455-65 pubmed publisher..On the other hand, overexpression of SCP1 induced the mRNA expression of ANF and ?MHC and increased the cell surface area in cardiomyocytes...
- Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Herault Y, et al. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016;354:909-912 pubmed..DNMT3C reveals the plasticity of the mammalian DNA methylation system and expands the scope of the mechanisms involved in the epigenetic control of retrotransposons. ..
- Di Carlo A, Travia G, De Felici M. The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. Int J Dev Biol. 2000;44:241-4 pubmedThe synaptonemal complex proteins SCP3 and SCP1 are components of the synaptonemal complex, a meiosis-specific protein structure essential for synapsis of homologous chromosomes...
- Costa Y, Speed R, Ollinger R, Alsheimer M, Semple C, Gautier P, et al. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. J Cell Sci. 2005;118:2755-62 pubmed..These new proteins, SYCE1 and CESC1, interact with the transverse filament protein SYCP1, and their localisation to the central element appears to depend on recruitment by SYCP1...
- Tay J, Hodgman R, Sarkissian M, Richter J. Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev. 2003;17:1457-62 pubmed..The temporal control of CPEB phosphorylation suggests a mechanism in which CPE-containing mRNA translation is stimulated at pachytene and metaphase I. ..
- Ollinger R, Alsheimer M, Benavente R. Mammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes. Mol Biol Cell. 2005;16:212-7 pubmed..Major components of mammalian SCs are the meiosis-specific proteins SCP1, 2, and 3. To investigate the role of SCP1 in SC assembly, we expressed SCP1 in a heterologous system, i.e...
- Meuwissen R, Offenberg H, Dietrich A, Riesewijk A, van Iersel M, Heyting C. A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes. EMBO J. 1992;11:5091-100 pubmed..The protein predicted from the nucleotide sequence of a full-length cDNA, named SCP1, consists of 946 amino acid residues and has a molecular weight of 111 kDa...
- Sun X, BrieÃ±o EnrÃquez M, Cornelius A, Modzelewski A, Maley T, Campbell Peterson K, et al. FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma. 2016;125:237-52 pubmed publisher