Gene Symbol: Stxbp3
Description: syntaxin binding protein 3
Alias: Munc18-c, syntaxin-binding protein 3
Species: rat
Products:     Stxbp3

Top Publications

  1. Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, et al. Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J Clin Invest. 2005;115:291-301 pubmed
  2. Ke B, Oh E, Thurmond D. Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis. J Biol Chem. 2007;282:21786-97 pubmed
    ..Taken together, these data support a model wherein Munc18c transiently switches from association with Syntaxin 4 to association with Doc2beta at the plasma membrane to facilitate exocytosis. ..
  3. Schraw T, Lemons P, Dean W, Whiteheart S. A role for Sec1/Munc18 proteins in platelet exocytosis. Biochem J. 2003;374:207-17 pubmed publisher
    ..These studies demonstrate a clear role for SM proteins in platelet exocytosis and aggregation and suggest a dominant role for Munc18c in all three granule-release events...
  4. Imai A, Nashida T, Shimomura H. Roles of Munc18-3 in amylase release from rat parotid acinar cells. Arch Biochem Biophys. 2004;422:175-82 pubmed
    ..The results indicate that Munc18-3 regulates exocytosis in the acinar cells for IPR-induced amylase release and that phosphorylation of Munc18-3 by PKA is not involved in the mechanism. ..
  5. Ciufo L, Barclay J, Burgoyne R, Morgan A. Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Mol Biol Cell. 2005;16:470-82 pubmed
    ..These results clarify the data on the function of SM proteins in mutant organisms and indicate that Munc18-1 controls multiple stages of exocytosis via both syntaxin-dependent and -independent protein interactions. ..
  6. Fu J, Naren A, Gao X, Ahmmed G, Malik A. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. J Biol Chem. 2005;280:3178-84 pubmed
  7. Hodgkinson C, Mander A, Sale G. Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. Biochem J. 2005;388:785-93 pubmed
    ..The results suggest a model whereby insulin triggers the formation of a PKCzeta-80K-H-munc18c complex that enhances GLUT4 translocation to the plasma membrane. ..
  8. Cosen Binker L, Binker M, Wang C, Hong W, Gaisano H. VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. J Clin Invest. 2008;118:2535-51 pubmed publisher
    ..These findings indicate that VAMP8 is the ZG-SNARE that mediates basolateral exocytosis in alcoholic pancreatitis and that VAMP8 is critical for ZG-ZG homotypic fusion. ..
  9. Zaid H, Antonescu C, Randhawa V, Klip A. Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J. 2008;413:201-15 pubmed publisher

More Information


  1. Macaulay S, Grusovin J, Stoichevska V, Ryan J, Castelli L, Ward C. Cellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cells. FEBS Lett. 2002;528:154-60 pubmed
    ..They further show that altering the level of available munc18c in 3T3L1 cells can modulate glucose transport rates, indicating its potential as a target for therapeutics in diabetes. ..
  2. Houng A, Polgar J, Reed G. Munc18-syntaxin complexes and exocytosis in human platelets. J Biol Chem. 2003;278:19627-33 pubmed
    ..Acute inhibition of the SM-syntaxin complex promotes Ca2+-induced exocytosis, suggesting that complex formation per se has a regulatory effect on triggered secretion. ..
  3. Widberg C, Bryant N, Girotti M, Rea S, James D. Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J Biol Chem. 2003;278:35093-101 pubmed
    ..These data suggest that Tomosyn and Munc18c operate at a similar stage of the Syntaxin4 SNARE assembly cycle, which likely primes Syntaxin4 for entry into the ternary SNARE complex. ..
  4. Larance M, Ramm G, James D. The GLUT4 code. Mol Endocrinol. 2008;22:226-33 pubmed
    ..Many are now taking on this challenge. ..
  5. Procino G, Barbieri C, Tamma G, De Benedictis L, Pessin J, Svelto M, et al. AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. J Cell Sci. 2008;121:2097-106 pubmed publisher
  6. Brochetta C, Vita F, Tiwari N, Scandiuzzi L, Soranzo M, Guérin Marchand C, et al. Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. Biochim Biophys Acta. 2008;1783:1781-91 pubmed publisher
    ..Our results suggest that Munc18-2 acts as a regulator of primary granule exocytosis, while Munc18-3 may preferentially regulate the fusion of secondary granules. ..
  7. Oh E, Thurmond D. Munc18c depletion selectively impairs the sustained phase of insulin release. Diabetes. 2009;58:1165-74 pubmed publisher