Gene Symbol: Stra6
Description: stimulated by retinoic acid 6
Alias: RGD1307551, receptor for retinol uptake STRA6, retinol-binding protein receptor STRA6, stimulated by retinoic acid gene 6 homolog, stimulated by retinoic acid gene 6 protein homolog
Species: rat
Products:     Stra6

Top Publications

  1. Pasutto F, Sticht H, Hammersen G, Gillessen Kaesbach G, Fitzpatrick D, Nurnberg G, et al. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet. 2007;80:550-60 pubmed
    ..revealed linkage to a common locus on chromosome 15, and pathogenic homozygous mutations were identified in STRA6, a member of a large group of "stimulated by retinoic acid" genes encoding novel transmembrane proteins, ..
  2. Berry D, Jacobs H, Marwarha G, Gely Pernot A, O Byrne S, DeSantis D, et al. The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem. 2013;288:24528-39 pubmed publisher
    The plasma membrane protein STRA6 is thought to mediate uptake of retinol from its blood carrier retinol-binding protein (RBP) into cells and to function as a surface receptor that, upon binding of holo-RBP, activates a JAK/STAT cascade...
  3. Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen J, et al. First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype. Hum Mutat. 2011;32:1417-26 pubmed publisher
    ..We identified a double-nucleotide polymorphism (g.1157G>A and g.1156G>A; p.G304K) in STRA6 that was homozygous in all of the MCOPCB patients. The STRA6 p...
  4. Stankiewicz P, Sen P, Bhatt S, Storer M, Xia Z, Bejjani B, et al. Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. Am J Hum Genet. 2009;84:780-91 pubmed publisher
    ..These differences reveal the phenotypic consequences of gene alterations in cis. ..
  5. Napoli J. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152-67 pubmed publisher
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..
  6. Wu L, Ross A. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. J Lipid Res. 2010;51:378-87 pubmed publisher
    ..Retinol uptake and esterification during the period of absorption correlated with increased expression of both STRA6 (retinol-binding protein receptor) and LRAT (retinol esterification), while a reduction in RE after 12 h in Am580-..
  7. Berry D, Noy N. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochim Biophys Acta. 2012;1821:168-76 pubmed publisher
    ..binding protein (RBP) and is transported into cells by a membrane protein termed stimulated by retinoic acid 6 (STRA6)...
  8. Alapatt P, Guo F, Komanetsky S, Wang S, Cai J, Sargsyan A, et al. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). J Biol Chem. 2013;288:1250-65 pubmed publisher
    ..The only known high affinity receptor for RBP4, Stra6, is not expressed in the liver...