Gene Symbol: Stra6
Description: stimulated by retinoic acid 6
Alias: RGD1307551, receptor for retinol uptake STRA6, retinol-binding protein receptor STRA6, stimulated by retinoic acid gene 6 homolog, stimulated by retinoic acid gene 6 protein homolog
Pasutto F, Sticht H, Hammersen G, Gillessen Kaesbach G, Fitzpatrick D, Nurnberg G, et al
. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet. 2007;80:550-60 pubmed
..revealed linkage to a common locus on chromosome 15, and pathogenic homozygous mutations were identified in STRA6, a member of a large group of "stimulated by retinoic acid" genes encoding novel transmembrane proteins, ..
Berry D, Jacobs H, Marwarha G, Gely Pernot A, O Byrne S, DeSantis D, et al
. The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem. 2013;288:24528-39 pubmed publisher
The plasma membrane protein STRA6 is thought to mediate uptake of retinol from its blood carrier retinol-binding protein (RBP) into cells and to function as a surface receptor that, upon binding of holo-RBP, activates a JAK/STAT cascade...
Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen J, et al
. First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype. Hum Mutat. 2011;32:1417-26 pubmed publisher
..We identified a double-nucleotide polymorphism (g.1157G>A and g.1156G>A; p.G304K) in STRA6 that was homozygous in all of the MCOPCB patients. The STRA6 p...
Stankiewicz P, Sen P, Bhatt S, Storer M, Xia Z, Bejjani B, et al
. Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. Am J Hum Genet. 2009;84:780-91 pubmed publisher
..These differences reveal the phenotypic consequences of gene alterations in cis. ..
Napoli J. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152-67 pubmed publisher
..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..
Wu L, Ross A. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. J Lipid Res. 2010;51:378-87 pubmed publisher
..Retinol uptake and esterification during the period of absorption correlated with increased expression of both STRA6 (retinol-binding protein receptor) and LRAT (retinol esterification), while a reduction in RE after 12 h in Am580-..
Berry D, Noy N. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochim Biophys Acta. 2012;1821:168-76 pubmed publisher
..binding protein (RBP) and is transported into cells by a membrane protein termed stimulated by retinoic acid 6 (STRA6)...
Alapatt P, Guo F, Komanetsky S, Wang S, Cai J, Sargsyan A, et al
. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). J Biol Chem. 2013;288:1250-65 pubmed publisher
..The only known high affinity receptor for RBP4, Stra6, is not expressed in the liver...