Gene Symbol: Steap3
Description: STEAP3 metalloreductase
Alias: metalloreductase STEAP3, STEAP family member 3, metalloreductase, pHyde, six-transmembrane epithelial antigen of prostate 3, tumor suppressor pHyde
Amzallag N, Passer B, Allanic D, Segura E, Thery C, Goud B, et al
. TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J Biol Chem. 2004;279:46104-12 pubmed
..Altogether, these data identify a novel role for TSAP6 in the export of TCTP and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion. ..
Ohgami R, Campagna D, Greer E, Antiochos B, McDonald A, Chen J, et al
. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005;37:1264-9 pubmed
..Using a positional cloning strategy, we identified a gene, six-transmembrane epithelial antigen of the prostate 3 (Steap3), responsible for the iron deficiency anemia in the mouse mutant nm1054...
Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine J, et al
. Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 2008;15:1723-33 pubmed publisher
TSAP6 (tumor suppressor-activated pathway 6), also known as Steap3, is a direct p53 transcriptional target gene...
Ohgami R, Campagna D, McDonald A, Fleming M. The Steap proteins are metalloreductases. Blood. 2006;108:1388-94 pubmed
..Previously, we identified a mammalian ferrireductase, Steap3, critical for erythroid iron homeostasis...
Sendamarai A, Ohgami R, Fleming M, Lawrence C. Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. Proc Natl Acad Sci U S A. 2008;105:7410-5 pubmed publisher
..Upon endosomal acidification, iron is released from Tf, reduced to Fe(2+) by Steap3, and transported across the endosomal membrane by divalent metal iron transporter 1...
Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al
. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
Wan C, Fu J, Wang Y, Miao S, Song W, Wang L. Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. PLoS ONE. 2012;7:e37452 pubmed publisher
..Taken together, our findings suggest that RHBDD1 is involved in the regulation of a nonclassical exosomal secretion pathway through the restriction of TSAP6. ..
Steiner M, Zhang X, Wang Y, Lu Y. Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde. Cancer Res. 2000;60:4419-25 pubmed
..New therapeutic strategies against locally advanced prostate cancer are desperately needed. A novel gene (pHyde) was identified by an improved cDNA competition hybridization technique for Dunning rat prostate cancer cell lines...
Lambe T, Simpson R, Dawson S, Bouriez Jones T, Crockford T, Lepherd M, et al
. Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. Blood. 2009;113:1805-8 pubmed publisher
..strain, fragile-red, with hypochromic microcytic anemia resulting from a Y228H substitution in the ferrireductase Steap3 (Steap3(Y288H))...