Gene Symbol: Stc2
Description: stanniocalcin 2
Alias: stanniocalcin-2, STC-2
Species: rat
Products:     Stc2

Top Publications

  1. Xiao L, Yuan J, Song X, Li Y, Hu Z, Liu Y. Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization. Reproduction. 2006;131:1137-49 pubmed
    ..These data suggest, for the first time, that STC-1 together with STC-2 may play important roles in the processes of implantation and decidualization in the rat. ..
  2. Chang A, Hook J, Lemckert F, McDonald M, Nguyen M, Hardeman E, et al. The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology. 2008;149:2403-10 pubmed publisher
    ..There are two closely related proteins in mammals, STC1 and STC2, with functions that are currently unclear...
  3. Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, et al. Stanniocalcin 2 is associated with ectopic calcification in ?-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone. 2012;50:998-1005 pubmed publisher
    ..Quantitative RT-PCR revealed that renal mRNA expression of STC2 was increased in both kl/kl mice and fibroblast growth factor 23 (Fgf23)-null mice compared with wild type mice...
  4. Ito D, Walker J, Thompson C, Moroz I, Lin W, Veselits M, et al. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Mol Cell Biol. 2004;24:9456-69 pubmed
    ..Here we describe the characterization of stanniocalcin 2 (STC2), a mammalian homologue of a calcium- and phosphate-regulating hormone first identified in fish, as a ..
  5. Jiang J, Westberg J, Andersson L. Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein. Biochem Biophys Res Commun. 2012;421:274-9 pubmed publisher
    b>Stanniocalcin 2 (STC2) is a homolog of stanniocalcin 1, a 56kD glycoprotein hormone that originally was found to confer calcitonin-like activity in fish...
  6. Honda S, Kashiwagi M, Ookata K, Tojo A, Hirose S. Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of stanniocalcin messages in the rat kidney and ovary. FEBS Lett. 1999;459:119-22 pubmed
  7. Luo C, Pisarska M, Hsueh A. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology. 2005;146:469-76 pubmed publisher
    ..Two related mammalian stanniocalcin genes, STC1 and STC2, were found to be expressed in various tissues as paracrine regulators...
  8. Zeiger W, Ito D, Swetlik C, Oh Hora M, Villereal M, Thinakaran G. Stanniocalcin 2 is a negative modulator of store-operated calcium entry. Mol Cell Biol. 2011;31:3710-22 pubmed publisher
    ..While there are two mammalian Stanniocalcin homologs (STC1 and STC2), their precise molecular functions remain unknown...
  9. Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, et al. Molecular cloning of a second human stanniocalcin homologue (STC2). Biochem Biophys Res Commun. 1998;250:252-8 pubmed
    ..Here we report the cloning of a second mammalian stanniocalcin (STC2) from the human osteosarcoma cDNA library. STC2 has 302 amino acid residues with 34% identity with STC1 and eel STC...

More Information


  1. Lee H, Lee Y, Kang C, Bae S, Jeoung D, Jang J, et al. Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation. Radiat Res. 2008;170:579-90 pubmed publisher
    ..cDNA microarray and real-time RT-PCR analysis of radiation- or DMBA-induced tumor tissues, revealed that stanniocalcin 2 (Stc2), interferon regulatory factor 1 (Irf1), interleukin 18 binding protein (Il18bp), and chloride channel ..