Gene Symbol: Stau1
Description: staufen double-stranded RNA binding protein 1
Alias: Stau, double-stranded RNA-binding protein Staufen homolog 1, staufen RNA binding protein homolog 1
Lebeau G, Maher Laporte M, Topolnik L, Laurent C, Sossin W, DesGroseillers L, et al
. Staufen1 regulation of protein synthesis-dependent long-term potentiation and synaptic function in hippocampal pyramidal cells. Mol Cell Biol. 2008;28:2896-907 pubmed publisher
Staufen1 (Stau1) is an RNA-binding protein involved in transport, localization, decay, and translational control of mRNA. In neurons, it is present in cell bodies and also in RNA granules which are transported along dendrites...
Lebeau G, Miller L, Tartas M, McAdam R, Laplante I, Badeaux F, et al
. Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons. Learn Mem. 2011;18:314-26 pubmed publisher
The two members of the Staufen family of RNA-binding proteins, Stau1 and Stau2, are present in distinct ribonucleoprotein complexes and associate with different mRNAs...
Kiebler M, Hemraj I, Verkade P, Kohrmann M, Fortes P, Marion R, et al
. The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport. J Neurosci. 1999;19:288-97 pubmed
..One attractive candidate to achieve transport of mRNAs into dendrites is Staufen (Stau), a double-stranded RNA-binding protein, which plays a pivotal role in mRNA transport, localization, and ..
Thomas M, Martinez Tosar L, Desbats M, Leishman C, Boccaccio G. Mammalian Staufen 1 is recruited to stress granules and impairs their assembly. J Cell Sci. 2009;122:563-73 pubmed publisher
..Mammalian Staufen 1 (Stau1) is a ubiquitous double-stranded RNA-binding protein associated with polysomes...
Ghoujal B, Milev M, Ajamian L, Abel K, Mouland A. ESCRT-II's involvement in HIV-1 genomic RNA trafficking and assembly. Biol Cell. 2012;104:706-21 pubmed publisher
..Our data provide the first evidence that the Staufen1-ESCRT-II interaction is evolutionarily conserved from lower to higher eukaryotes and reveal a novel role for EAP30 in the control of HIV-1 RNA trafficking and gene expression...
Blackham S, McGarvey M. A host cell RNA-binding protein, Staufen1, has a role in hepatitis C virus replication before virus assembly. J Gen Virol. 2013;94:2429-36 pubmed publisher
..g. in translation, replication or trafficking of the HCV genome, rather than in virion morphogenesis. ..
Monshausen M, Putz U, Rehbein M, Schweizer M, DesGroseillers L, Kuhl D, et al
. Two rat brain staufen isoforms differentially bind RNA. J Neurochem. 2001;76:155-65 pubmed
..Thus in neurones, rat Staufen may serve to link RNAs to the dendritic microtubular cytoskeleton and may thereby regulate their subcellular localization. ..
Monshausen M, Rehbein M, Richter D, Kindler S. The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1. J Neurochem. 2002;81:557-64 pubmed
..Cellular functions of Staufen may be regulated via phosphorylation or Staufen may recruite the phosphatase into specific ribonucleoprotein complexes. ..
Macchi P, Kroening S, Palacios I, Baldassa S, Grunewald B, Ambrosino C, et al
. Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. J Neurosci. 2003;23:5778-88 pubmed
..Together, our data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic RNPs in hippocampal neurons. ..