Gene Symbol: Stat6
Description: signal transducer and activator of transcription 6
Alias: signal transducer and activator of transcription 6, signal transducer and activator of transcription 6, interleukin-4 induced, signal transducer and transcription activator 6
Species: rat
Products:     Stat6

Top Publications

  1. Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 2007;27:89-99 pubmed
    ..Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch. ..
  2. Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel R, et al. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008;9:1347-55 pubmed publisher
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation. ..
  3. Kaminski A, Welters H, Kaminski E, Morgan N. Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep. 2009;30:169-75 pubmed publisher
    ..Increased tyrosine phosphorylation of STAT6 (signal transducer and activator of transcription 6) also occurred in response to IL-4 and a selective JAK3 (Janus kinase 3) inhibitor reduced ..
  4. Murray P. The JAK-STAT signaling pathway: input and output integration. J Immunol. 2007;178:2623-9 pubmed
    ..New data suggests that SOCS proteins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated STATs that alters downstream gene activation. ..
  5. Matsukawa A, Kaplan M, Hogaboam C, Lukacs N, Kunkel S. Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J Exp Med. 2001;193:679-88 pubmed
    Signal transducer and activator of transcription (Stat)4 and Stat6 are transcription factors that provide type 1 and type 2 response, respectively...
  6. Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, et al. STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med. 2010;207:2493-506 pubmed publisher
    ..In this study, we show that activation of STAT6 induces displacement of the PcG complex by the TrxG complex at the upstream region of the gene encoding GATA3, a ..
  7. Li C, Ye L, Chen X, Li S, Cai X, Dong L, et al. [Expression of signal transducer and activator of transcription 6 in rat asthma model and the modulatory effect of dexamethasone]. Zhonghua Er Ke Za Zhi. 2005;43:521-5 pubmed
    To study the expression of signal transducer and activator of transcription 6 and its mRNA in rat asthma model and the modulatory effect of dexamethasone (DXM)...
  8. Zhang S, Wei J, Li C, Barnstable C, Fu X. Expression and activation of STAT proteins during mouse retina development. Exp Eye Res. 2003;76:421-31 pubmed
    ..Strong expression of Stat3, Stat5a, and Stat6 was observed in the RPE. Activated Stat3 and Stat5a were found in the neural retina and the RPE...
  9. Kotanides H, Reich N. Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J Biol Chem. 1996;271:25555-61 pubmed
    This study addresses the function of STAT6 in interleukin-4-stimulated gene expression...

More Information


  1. Liu Z, Wang Y, Zou M, Wang J, Xu D. [Effects of interleukin 1 receptor antagonist on allergy asthma in rat model and its mechanism]. Zhonghua Yi Xue Za Zhi. 2008;88:2432-6 pubmed
    ..was used to examine the mRNA expression of NF-kappaB and signal transducer and activator of the transcription 6 (STAT6)...
  2. Börner C, Wöltje M, Hollt V, Kraus J. STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors. J Neurochem. 2004;91:1493-500 pubmed interleukin-4-responsive element at nt -671 on the murine gene promoter, to which the transcription factor STAT6 binds, as shown by reporter gene analysis and STAT6/DNA interaction studies in living cells with transcription ..
  3. Jiang D, Kolosov V, Perelman J, Zhou X. [Molecular mechanism of interleukin-13-induced mucus hypersecretion in rat airway]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:73-6 pubmed
    ..RT-PCR was performed to examine the mRNA level of STAT4 and STAT6, and electrophoretic mobility shift assays (EMSA) was used to detect the DNA-binding activities of Forkhead box a2 ..
  4. Robinson K, Vona Davis L, Riggs D, Jackson B, McFadden D. Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. J Am Coll Surg. 2006;202:788-96 pubmed
    ..Interestingly, PYY attenuated their protein/DNA binding, which may have an impact on development of the disease. Additional investigation of STAT proteins and PYY could provide new therapeutic strategies for pancreatitis. ..
  5. Ikeuchi Y, Kobayashi Y, Arakawa H, Suzuki M, Tamra K, Morikawa A. Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome. Pediatr Nephrol. 2009;24:489-95 pubmed publisher
    ..the association of genetic variations of IL-4 receptor alpha chain (IL-4Ralpha), IL-13 and signal transducer and activator of transcription 6 (STAT6) genes with MCNS...
  6. He H, Isnard A, Kouriba B, Cabantous S, Dessein A, Doumbo O, et al. A STAT6 gene polymorphism is associated with high infection levels in urinary schistosomiasis. Genes Immun. 2008;9:195-206 pubmed publisher
    ..By logistic regression analysis, we found an association between a single-nucleotide polymorphism (SNP) in the STAT6 gene (rs324013) and infection levels (P=0.04)...
  7. Dent A, Doherty T, Paul W, Sher A, Staudt L. BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major. J Immunol. 1999;163:2098-103 pubmed
    ..By contrast, BCL-6-/-STAT6-/- double-mutant mice were resistant to L. major infection despite also producing elevated levels of IL-13...
  8. Acharya B, Shirakawa T, Pungky A, Damanik P, Massi M, Miyata M, et al. Polymorphism of the interleukin-4, interleukin-13, and signal transducer and activator of transcription 6 genes in Indonesian children with minimal change nephrotic syndrome. Am J Nephrol. 2005;25:30-5 pubmed
    ..We investigated the associations of gene polymorphisms of IL-4, IL-13, and signal transducer and activator 6 (STAT6) in Indonesian children with MCNS (n = 84) and controls with neither allergic nor renal disease (n = 61)...
  9. Yukawa K, Kishino M, Goda M, Liang X, Kimura A, Tanaka T, et al. STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. Int J Mol Med. 2005;15:225-30 pubmed
    ..of signal transducer and activator of transcription (STAT) 6 to the pathophysiology of chronic renal injury, STAT6-/- mice were subjected to unilateral ureteral ligation together with wild-type control mice...
  10. Oliver C, Khaled W, Frend H, Nichols J, Watson C. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012;26:1086-97 pubmed publisher
    ..These data suggest that the luminal alveolar compartment of the mammary gland is comprised of a number of distinct cell populations that, although interdependant, exhibit considerable cell fate plasticity. ..
  11. Chun K, Koenen M, Katus H, Zehelein J. Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development. Exp Mol Med. 2004;36:367-71 pubmed
    ..It seems likely that KCNH2 and KCNE2 are linked to form cardiac IKr channels, associated to cardiogenesis and cardiomyocyte excitability. ..
  12. Harris M, Mostecki J, Rothman P. Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function. J Biol Chem. 2005;280:13114-21 pubmed
    ..Previous studies have demonstrated that BCL-6 and Stat6 can both bind and regulate the Iepsilon promoter that controls immunoglobulin heavy chain class switching to IgE...
  13. Kisseleva T, Bhattacharya S, Braunstein J, Schindler C. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002;285:1-24 pubmed
    ..Similarly, the solution of the crystal structure of two STATs has and will continue to facilitate our understanding of how STATs function. This review will highlight these exciting developments in JAK/STAT signaling. ..
  14. Ni Z, Lou W, Lee S, Dhir R, DeMiguel F, Grandis J, et al. Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma. J Urol. 2002;167:1859-62 pubmed
    ..Significant levels of activated Stat4 and Stat6 were detected in primary prostate tissues...
  15. Zhao J, Xie Y, Qian C, Li L, Jiang R, Kan H, et al. Imbalance of Th1 and Th2 cells in cardiac injury induced by ambient fine particles. Toxicol Lett. 2012;208:225-31 pubmed publisher
    ..signal transducer and activator of transcriptionl 1 (STAT1), signal transducer and activator of transcriptional 6 (STAT6), GATA-3 and T-bet were assessed in left ventricle of rats using real-time PCR...
  16. Lu X, Chen J, Sasmono R, Hsi E, Sarosiek K, Tiganis T, et al. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol. 2007;27:2166-79 pubmed
    ..We reported distinct interleukin 4 (IL-4) responsiveness and STAT6 signaling in these DLBCL subtypes...
  17. Lau M, Tsantikos E, Maxwell M, Tarlinton D, Anderson G, Hibbs M. Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background. J Autoimmun. 2012;39:388-97 pubmed publisher
    ..To examine this apparent contradiction, we derived Lyn(-/-) mice with a null mutation in STAT6, a regulator of Th2 immunity that integrates signaling from the IL-4/IL-13 receptor complex...
  18. Harris M, Chang C, Berton M, Danial N, Zhang J, Kuehner D, et al. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol. 1999;19:7264-75 pubmed
    ..for BCL-6 shares striking homology to the sites that are the target sequence for the interleukin-4 (IL-4)-induced Stat6 (signal transducers and activators of transcription) signaling molecule...
  19. Li C, Ye L, Su M, Hu X, Zhang W, Luo Y. [Effect of achyranthes bidentata polysaccharides on signal transducer and activator of transcription 6 and its mRNA expression in a rat model of asthma]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006;22:210-4 pubmed
    To study the effect of achyranthes bidentata polysaccharides(ABPS) on the expression of signal transducer and activator of transcription 6 and its mRNA in bronchus of a rat model of asthma...
  20. Nishimura Y, Inoue T, Morooka T, Node K. Mechanical stretch and angiotensin II increase interleukin-13 production and interleukin-13 receptor alpha2 expression in rat neonatal cardiomyocytes. Circ J. 2008;72:647-53 pubmed
    ..mechanical stretch, angiotensin II treatment and IL-13 treatment was inhibited by anti-IL-13Ralpha1 antibody and STAT6 depletion through RNA interference...
  21. Olsan E, Mukherjee S, Wulkersdorfer B, Shillingford J, Giovannone A, Todorov G, et al. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proc Natl Acad Sci U S A. 2011;108:18067-72 pubmed publisher
    ..shown that PC1 regulates the transcriptional activity of signal transducer and activator of transcription-6 (STAT6). Here we show that STAT6 is aberrantly activated in cyst-lining cells in PKD mouse models...
  22. Wang L, Carr T, Xiong Y, Wildt K, Zhu J, Feigenbaum L, et al. The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol. 2010;40:2385-90 pubmed publisher
    ..These findings identify the sequential activity of Gata3 and Thpok as a hallmark of CD4(+) T-cell differentiation, regardless of MHC restriction. ..
  23. Jang S, Choi J, Im D, Park S, Park J, Park S, et al. The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex. Neuroreport. 2014;25:18-22 pubmed publisher
    ..hyperexcitation in the neuron and inflammation occurring following I/R, the temporal and spatial activation of STAT6 protein in the ischemic cortex still remain elusive...
  24. Park S, Lee J, Kim H, Choi Y, Park J, Suh Y, et al. Astrocytes, but not microglia, rapidly sense H?O?via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. J Immunol. 2012;188:5132-41 pubmed publisher
    ..current study, we demonstrated that astrocytes sense H(2)O(2) by rapidly phosphorylating the transcription factor STAT6, a response not observed in microglia...
  25. Wang C, Li Z. [Relationship of reduced lung function with Th1/Th2 polarization, STAT4/6 expression in rats of chronic obstructive pulmonary disease]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:1233-6 pubmed
    ..The mRNA expressions of IFN-? and IL-4 were examined by PCR, and STAT4, STAT6 proteins in lung tissues were detected by Western blotting...
  26. Sun S, Li T, Yang P, Qiu Y, Rui Y. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Clin Exp Pharmacol Physiol. 2007;34:1097-101 pubmed
  27. Horiuchi M, Itoh A, Pleasure D, Itoh T. MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells. J Biol Chem. 2006;281:20095-106 pubmed
    ..Our study has implications with respect to the mechanisms of periventricular leukomalacia in infants and of persistent demyelination in multiple sclerosis lesions in adults. ..
  28. Low S, Vasanth S, Larson C, Mukherjee S, Sharma N, Kinter M, et al. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev Cell. 2006;10:57-69 pubmed
    ..The PC1 tail interacts with the transcription factor STAT6 and the coactivator P100, and it stimulates STAT6-dependent gene expression...
  29. Suzuki K, Nakajima H, Kagami S, Suto A, Ikeda K, Hirose K, et al. Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J Exp Med. 2002;196:27-38 pubmed
    Accumulating evidence has shown the importance of Stat6-mediated signaling in allergic diseases. In this study, we show a novel regulatory mechanism of Stat6-mediated signaling in mast cells...
  30. Ostrand Rosenberg S, Grusby M, Clements V. Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. J Immunol. 2000;165:6015-9 pubmed
    STAT4 and STAT6 are essential for the development of CD4(+) Th1 and Th2 development, respectively...
  31. Ong C, Ip S, Teh S, Wong C, Jirik F, Grusby M, et al. A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Cell Immunol. 1999;196:60-8 pubmed
    ..the development of Th2 cells in non-Tsk mice is abrogated in mice with null mutation for either the IL-4 or the Stat6 gene...
  32. Dent A, Shaffer A, Yu X, Allman D, Staudt L. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science. 1997;276:589-92 pubmed
    ..IL-4)-induced transcription when bound to a site recognized by the IL-4-responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and ..
  33. Das S, Roth C, Wasson L, Vishwanatha J. Signal transducer and activator of transcription-6 (STAT6) is a constitutively expressed survival factor in human prostate cancer. Prostate. 2007;67:1550-64 pubmed
    ..In this investigation, we examined STAT6 expression in clinical prostate cancer tissue specimen and determined its role in prostate cell proliferation and ..
  34. Pauleau A, Rutschman R, Lang R, Pernis A, Watowich S, Murray P. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol. 2004;172:7565-73 pubmed
    ..PU.1, IL-4-induced STAT6, and C/EBPbeta assemble at the enhancer and await the effect of another STAT6-regulated protein(s) that must be ..
  35. Land K, Moll J, Kaplan M, Seetharamaiah G. Signal transducer and activator of transcription (Stat)-6-dependent, but not Stat4-dependent, immunity is required for the development of autoimmunity in Graves' hyperthyroidism. Endocrinology. 2004;145:3724-30 pubmed
    ..we tested mice with targeted deletion of signal transducer and activator of transcription-4 (Stat4) or Stat6 genes that, respectively, have impaired Th1 and Th2 immunity...
  36. Summers S, Phoon R, Odobasic D, Dewage L, Kitching A, Holdsworth S. Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Th1) and Th17 nephritogenic immunity in experimental crescentic glomerulonephritis. Clin Exp Immunol. 2011;166:227-34 pubmed publisher
    ..We sought to determine the role of signal transducer and activation of transcription 6 (STAT6), a key regulator of Th2 responses, in experimental crescentic glomerulonephritis...
  37. Kobayashi Y, Arakawa H, Suzuki M, Takizawa T, Tokuyama K, Morikawa A. Polymorphisms of interleukin-4--related genes in Japanese children with minimal change nephrotic syndrome. Am J Kidney Dis. 2003;42:271-6 pubmed
    ..the associations of gene polymorphisms of IL-4, its receptor (IL-4R), and the signal transducer and activator 6 (STAT6) gene with MCNS...
  38. Jacob C, Zang S, Li L, Ciobanu V, Quismorio F, Mizutani A, et al. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol. 2003;171:1564-71 pubmed
    ..lupus-prone (NZB x NZW)F(1)-derived congenic New Zealand mixed (NZM) 2328 lines, which are either Stat4- or Stat6-deficient...
  39. Yokota N, Burne Taney M, Racusen L, Rabb H. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2003;285:F319-25 pubmed
    ..The enzymes signal transducers and activators of transcription (STAT) 4 and STAT6 regulate Th1 or Th2 differentiation and cytokine production, respectively...
  40. Li Z, Zhang Y, Liu Z, Wu X, Zheng Y, Tao Z, et al. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol. 2011;12:178-85 pubmed publisher
    ..Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression. ..
  41. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, et al. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell. 2011;147:436-46 pubmed publisher
    b>STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection...