Stat5a

Summary

Gene Symbol: Stat5a
Description: signal transducer and activator of transcription 5A
Alias: Stat5, signal transducer and activator of transcription 5A, mammary gland factor, signal transducer and activator of transcription 5
Species: rat
Products:     Stat5a

Top Publications

  1. Ren S, Cai H, Li M, Furth P. Loss of Stat5a delays mammary cancer progression in a mouse model. Oncogene. 2002;21:4335-9 pubmed
    A genetic study was conducted to determine if activated Stat5a contributes to mammary carcinogenesis and to evaluate the mechanism...
  2. Murray M, Butler A, Fiala Beer E, Su G. Phospho-STAT5 accumulation in nuclear fractions from vitamin A-deficient rat liver. FEBS Lett. 2005;579:3669-73 pubmed
    ..Nuclear tyrosine- and serine-phosphorylated STAT5 accumulated in VAD liver, whereas nuclear JAK2 tyrosine kinase and SHP-1 phosphatase were decreased...
  3. Teglund S, McKay C, Schuetz E, van Deursen J, Stravopodis D, Wang D, et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998;93:841-50 pubmed
    ..Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines...
  4. Wakao H, Gouilleux F, Groner B. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 1994;13:2182-91 pubmed
    ..The mammary gland factor, MGF, has been shown to be a central mediator in the lactogenic hormone response...
  5. Murray P. The JAK-STAT signaling pathway: input and output integration. J Immunol. 2007;178:2623-9 pubmed
    ..New data suggests that SOCS proteins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated STATs that alters downstream gene activation. ..
  6. Moriggl R, Sexl V, Piekorz R, Topham D, Ihle J. Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity. 1999;11:225-30 pubmed
    ..Mice deficient in Stat5a and Stat5b have demonstrated the essential role that these highly related proteins play in cell cycle progression ..
  7. Sexl V, Piekorz R, Moriggl R, Rohrer J, Brown M, Bunting K, et al. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood. 2000;96:2277-83 pubmed
    ..Using mice deficient for the 2 highly related transcription factors, Stat5a and Stat5b (Stat5a/b(-/-)), we investigated the role of Stat5 for B-cell differentiation, expansion, and function...
  8. Hwang Y, Shaw S, Kaneko M, Redd H, Marrero M, Ramasamy R. Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury. FASEB J. 2005;19:795-7 pubmed
    ..Induction of global ischemia in rats resulted in JAK2 activation followed by STAT5 activation...
  9. Piekorz R, Gingras S, Hoffmeyer A, Ihle J, Weinstein Y. Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol. 2005;19:431-40 pubmed
    The two highly related signal transducers and activators of transcription (Stats), Stat5a and Stat5b, are major mediators of prolactin signaling in both the mammary gland and in the ovary...

More Information

Publications62

  1. Sjoeholm A, Bridges R, Grattan D, Anderson G. Region-, neuron-, and signaling pathway-specific increases in prolactin responsiveness in reproductively experienced female rats. Endocrinology. 2011;152:1979-88 pubmed publisher
    ..The brains underwent immunohistochemistry for the phosphorylated forms of signal transducer and activator of transcription 5 (pSTAT5) or ERK1/2 (pERK1/2)...
  2. Bratthauer G, Strauss B, Tavassoli F. STAT 5a expression in various lesions of the breast. Virchows Arch. 2006;448:165-71 pubmed
    ..The absence of STAT 5a in the abnormal breast epithelial cells may indicate a defect contributory to the abnormal state. ..
  3. Dentelli P, Rosso A, Orso F, Olgasi C, Taverna D, Brizzi M. microRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5A expression. Arterioscler Thromb Vasc Biol. 2010;30:1562-8 pubmed publisher
    ..In addition, we identified signal transducer and activator of transcription 5A (STAT5A) as a bona fide target of miR-222 and observed that miR-222 negatively correlated ..
  4. Carvalho C, Carvalheira J, Lima M, Zimmerman S, Caperuto L, Amanso A, et al. Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology. 2003;144:638-47 pubmed
    ..These results indicate a new signal transduction pathway for LH and show that there is positive cross-talk between the insulin and LH signaling pathways at the level of phosphoinositol 3-kinase/AKT pathway in this tissue. ..
  5. Wiezel D, Assadi M, Landau D, Troib A, Kachko L, Rabkin R, et al. Impaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease. Nephrol Dial Transplant. 2014;29:791-9 pubmed publisher
    ..Kidney GHR mRNA and protein levels were reduced and basal phosphorylation of JAK2 and STAT5 was significantly impaired...
  6. Bergad P, Towle H, Berry S. Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene. J Biol Chem. 2000;275:8114-20 pubmed
    ..1, was found to contain Stat5a and -5b, as well as additional components...
  7. Rui L, Gunter D, Herrington J, Carter Su C. Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta. Mol Cell Biol. 2000;20:3168-77 pubmed
    ..This would result in a more rapid and robust cellular response to hormones and cytokines that activate JAK2. This interaction between inactive JAK2 and SH2-B may also help prevent abnormal activation of JAK2. ..
  8. Gupta S, Mishra K, Surolia A, Banerjee K. Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition. PLoS ONE. 2011;6:e26674 pubmed publisher
    ..Transcription factors Stat5a and Stat5b were involved in SOCS6 gene upregulation leading to neuronal differentiation...
  9. Ikeda K, Nakajima H, Suzuki K, Watanabe N, Kagami S, Iwamoto I. Stat5a is essential for the proliferation and survival of murine mast cells. Int Arch Allergy Immunol. 2005;137 Suppl 1:45-50 pubmed
    ..and activator of transcription (Stat) 5a in the proliferation and survival of mast cells was determined using Stat5a-deficient (Stat5a(-/-)) mice...
  10. Kieslinger M, Woldman I, Moriggl R, Hofmann J, Marine J, Ihle J, et al. Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 2000;14:232-44 pubmed
    ..Our findings with dnStat5-expressing chicken myeloblasts were confirmed with primary hematopoietic cells from Stat5a/Stat5b-deficient mice...
  11. Kang J, DiBenedetto B, Narayan K, Zhao H, Der S, Chambers C. STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol. 2004;173:2307-14 pubmed
    Diverse cytokines necessary for normal lymphopoiesis and lymphocyte homeostasis activate STAT5 in responder cells...
  12. Kazansky A, Raught B, Lindsey S, Wang Y, Rosen J. Regulation of mammary gland factor/Stat5a during mammary gland development. Mol Endocrinol. 1995;9:1598-609 pubmed
    The rat homolog of sheep mammary gland factor (MGF)/Stat5 has been isolated and used to study the regulation of Stat5 during mammary gland development and PRL regulation in COS cells transfected with Stat5a and the PRL receptor...
  13. Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, et al. Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. J Immunol. 2013;190:5702-11 pubmed publisher
    ..Taken together, AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs. ..
  14. Shillingford J, Miyoshi K, Flagella M, Shull G, Hennighausen L. Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol Endocrinol. 2002;16:1309-21 pubmed
  15. Kisseleva T, Bhattacharya S, Braunstein J, Schindler C. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002;285:1-24 pubmed
    ..Similarly, the solution of the crystal structure of two STATs has and will continue to facilitate our understanding of how STATs function. This review will highlight these exciting developments in JAK/STAT signaling. ..
  16. Lerant A, Kanyicska B, Freeman M. Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration. Brain Res. 2001;904:259-69 pubmed
    ..We used nuclear translocation of STAT5 as a marker of prolactin receptor induced signaling and expression of Fos related antigens (FRAs) as an indicator ..
  17. Ilan N, Cheung L, Miller S, Mohsenin A, Tucker A, Madri J. Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse. Dev Biol. 2001;232:219-32 pubmed
    ..We noted an attenuation of mammary gland development at early stages of virgin ductal branching morphogenesis. STAT5a, a modulator of milk protein gene expression during lactation, was localized to the nuclei of ductal epithelial ..
  18. Gerland K, Bataille Simoneau N, Basle M, Fourcin M, Gascan H, Mercier L. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Mol Cell Endocrinol. 2000;168:1-9 pubmed
    ..The results show a GH-induced and sustained phosphorylation of Jak2 and Stat5 on tyrosine residues. The tyrosine phosphorylation status of Jak2 was increased in a dose-dependent manner...
  19. Xu J, Chen S, Chen H, Xiao Q, Hsu C, Michael D, et al. STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J Neurosci. 2009;29:2022-6 pubmed publisher
    ..Based on published findings of the functional interactions between GR and STAT5, a transcription factor from the family of signal transducers and activators of transcription (STAT), we examined ..
  20. Isshiki K, He Z, Maeno Y, Ma R, Yasuda Y, Kuroki T, et al. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008;74:1434-43 pubmed publisher
    ..growth factor 1 receptor (IGF-1R) were increased while those of suppressor of cytokine signaling 2 (SOCS2) and STAT5 were decreased. All of these changes were normalized by islet cell transplantation...
  21. Strange R, Westerlind K, Ziemiecki A, Andres A. Proliferation and apoptosis in mammary epithelium during the rat oestrous cycle. Acta Physiol (Oxf). 2007;190:137-49 pubmed
    ..Growth factor-, hormone- and anchorage-mediated cell survival signalling, indicated by activation of Stat5A, FAK and Akt 1 and expression of anti-apoptotic Bcl-2 family members, was greater in proestrus and reduced in ..
  22. Mütze J, Roth J, Gerstberger R, Hübschle T. Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Neurosci Lett. 2007;417:286-91 pubmed
    ..time that systemic treatment with leptin (5 mg/kg; intraperitoneal injection) also increased the number of nuclear STAT5 signals in the hypothalamus...
  23. Imada K, Bloom E, Nakajima H, Horvath Arcidiacono J, Udy G, Davey H, et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med. 1998;188:2067-74 pubmed
    We have analyzed the immune system in Stat5-deficient mice. Although Stat5a-/- splenocytes have a partial defect in anti-CD3-induced proliferation that can be overcome by high dose interleukin (IL)-2, we now demonstrate that defective ..
  24. Li Z, Zhang Y, Liu Z, Wu X, Zheng Y, Tao Z, et al. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol. 2011;12:178-85 pubmed publisher
    ..Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression. ..
  25. Meyer R, Laz E, Su T, Waxman D. Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Mol Endocrinol. 2009;23:1914-26 pubmed publisher
    ..Indeed, STAT5 was bound to Bcl6 STAT5-binding region-B, previously associated with Bcl6 repression, in both male and female ..
  26. Cave B, Norman M, Flynn A, Townsend J, Wakerley J, Tortonese D. Prolactin-induced activation of STAT5 within the hypothalamic arcuate nucleus. Neuroreport. 2005;16:1423-6 pubmed
    ..Following exogenous prolactin treatment, phosphorylation of STAT5 (signal transducer and activator of transcription) within the arcuate nucleus was measured using a highly ..
  27. Qian Y, Xiao Q, Chen H, Xu J. Dexamethasone inhibits camptothecin-induced apoptosis in C6-glioma via activation of Stat5/Bcl-xL pathway. Biochim Biophys Acta. 2009;1793:764-71 pubmed publisher
    ..gene, Bcl-xL expression, and its transcription factor, signaling transducer and activator of transcription 5 (Stat5), DNA binding activity and phospho-Stat5 expression...
  28. Shankar K, Hidestrand M, Liu X, Xiao R, Skinner C, Simmen F, et al. Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity. Exp Biol Med (Maywood). 2006;231:1379-97 pubmed
    ..0005). Examination of maternal GH signaling via STAT5a and -5b revealed significant reduction in both gene and protein expression produced by both EtOH and ..
  29. Papaconstantinou A, Snyderwine E. Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a. FEBS Lett. 2007;581:29-33 pubmed
    ..mammary gland carcinomas were different between carcinomas with high and low expression of phosphotyrosine (pY)-STAT5a. We determined that carcinomas with high pY-STAT5a were more proliferative (MIB5 immunostaining) and had a higher ..
  30. Rhodes J, York R, Tara D, Tajinda K, Druker B. CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells. Exp Hematol. 2000;28:305-10 pubmed
    ..MO7e, or 32D) or Bcr-Abl-expressing cells (Rat-1p185, MO7p210, 32Dp210, K562) followed by immunoblotting for pTyr, Stat5, or CrkL. Interactions were confirmed in vitro using GST-CrkL fusion proteins...
  31. Si J, Collins S. IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3-dependent manner. Blood. 2002;100:4401-9 pubmed
    ..Constitutively active Stat5 constructs enhance both the transcriptional activity of RARs in EML cells and the commitment of these cells to ..
  32. Augustine R, Bouwer G, Seymour A, Grattan D, Brown C. Reproductive Regulation of Gene Expression in the Hypothalamic Supraoptic and Paraventricular Nuclei. J Neuroendocrinol. 2016;28: pubmed publisher
    ..Prolactin receptor activation changes gene expression via phosphorylation of signal transducer and activator of transcription 5 (STAT5)...
  33. Sun S, Li T, Yang P, Qiu Y, Rui Y. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Clin Exp Pharmacol Physiol. 2007;34:1097-101 pubmed
  34. Nevalainen M, Ahonen T, Yamashita H, Chandrashekar V, Bartke A, Grimley P, et al. Epithelial defect in prostates of Stat5a-null mice. Lab Invest. 2000;80:993-1006 pubmed
    The transcription factor Stat5a critically mediates prolactin (PRL)-induced mammary gland development and lactogenesis. PRL also stimulates growth and differentiation of prostate tissue...
  35. Laz E, Sugathan A, Waxman D. Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites. Mol Endocrinol. 2009;23:1242-54 pubmed publisher
    ..upstream (100 kb) and downstream regions (25 kb), was aligned across four species and searched for conserved STAT5-binding sites using TFBS matrices...
  36. Kamigaki M, Hide I, Yanase Y, Shiraki H, Harada K, Tanaka Y, et al. The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling. Neurochem Int. 2016;93:82-94 pubmed publisher
    ..As for the GM-CSFR downstream signal, LPS resulted in the phosphorylation of STAT5 and its translocation to the nucleus in the surviving microglia...
  37. Lv N, Kim E, Song M, Choi H, Moon W, Park S, et al. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp Cell Res. 2009;315:2064-71 pubmed publisher
  38. Ripperger J, Fritz S, Richter K, Hocke G, Lottspeich F, Fey G. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J Biol Chem. 1995;270:29998-30006 pubmed
    ..The amino acid sequence of rat Stat5b showed 26.7% overall identity with rat Stat3, 87.3% with sheep Stat5a, 92.5% with murine Stat5a, and 98.7% with murine Stat5b.
  39. Schirra H, Anderson C, Wilson W, Kerr L, Craik D, Waters M, et al. Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study. PLoS ONE. 2008;3:e2764 pubmed publisher
    ..of the growth hormone receptor, and thus exhibit either low (around 30% maximum) or no growth hormone-dependent STAT5 signalling respectively. These mutations result in altered liver metabolism, obesity and insulin resistance...
  40. Fujinaka Y, Takane K, Yamashita H, Vasavada R. Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation. J Biol Chem. 2007;282:30707-17 pubmed
    ..this protective effect is the janus-activated-kinase-2/signal transducer and activator of transcription-5 (JAK2/STAT5) pathway...
  41. Nanashima N, Asano J, Hayakari M, Nakamura T, Nakano H, Yamada T, et al. Nuclear localization of STAT5A modified with O-linked N-acetylglucosamine and early involution in the mammary gland of Hirosaki hairless rat. J Biol Chem. 2005;280:43010-6 pubmed
    ..Nuclear localization of STAT5A in HHR and SDR was confirmed by immunohistochemistry...
  42. Townsend J, Cave B, Norman M, Flynn A, Uney J, Tortonese D, et al. Effects of prolactin on hypothalamic supraoptic neurones: evidence for modulation of STAT5 expression and electrical activity. Neuro Endocrinol Lett. 2005;26:125-30 pubmed
    The study investigated the role of prolactin (PRL) in modulating STAT5 and electrical activity of magnocellular neurones in the supraoptic (SO) nucleus of male rats...
  43. Shan L, Yu M, Clark B, Snyderwine E. Possible role of Stat5a in rat mammary gland carcinogenesis. Breast Cancer Res Treat. 2004;88:263-72 pubmed
    ..In the mammary gland, Stat5a is well recognized for its function in prolactin signaling, lobuloalveolar development, and milk protein ..
  44. Miyoshi K, Meyer B, Gruss P, Cui Y, Renou J, Morgan F, et al. Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. Mol Endocrinol. 2002;16:2892-901 pubmed
    ..The epithelial cells retained the ductal marker Na-K-Cl cotransporter (NKCC)1. Nuclear localization of Stat5a and down-regulation of NKCC1 was observed in some areas, indicating a limited response to pregnancy signals...
  45. Ji S, Frank S, Messina J. Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylation. J Biol Chem. 2002;277:28384-93 pubmed
    ..both of which are required for male-specific pattern of liver gene expression and GH-induced phosphorylation of STAT5. The present study suggests that regulation of GH receptor (GHR) levels in rat hepatoma cells by repeated GH ..
  46. Mziaut H, Kersting S, Knoch K, Fan W, Trajkovski M, Erdmann K, et al. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci U S A. 2008;105:674-9 pubmed publisher
    ..resulting cytosolic fragment (ICA512-CCF) moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis...
  47. Anderson S, Barclay J, Fanning K, Kusters D, Waters M, Curlewis J. Mechanisms underlying the diminished sensitivity to prolactin negative feedback during lactation: reduced STAT5 signaling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neuron. Endocrinology. 2006;147:1195-202 pubmed
    ..Dual-label confocal immunofluorescence studies were used to determine the intracellular distribution of STAT5 within TIDA neurons in the dorsomedial arcuate nucleus...
  48. Huang J, Chuang L, Guh J, Chen C, Yang Y, Chiang T, et al. Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts. J Am Soc Nephrol. 2005;16:2318-29 pubmed
    ..both AGE-induced proliferation and Janus kinase 2 (JAK2)-signal transducers and activators of transcription 5 (STAT5) activation but not p42/p44 mitogen-activated protein kinase (MAPK) activation...
  49. Cao J, Wood M, Liu Y, Hoffman T, Hyde J, Park Sarge O, et al. Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a. Endocrinology. 2004;145:1739-49 pubmed
    ..shift analysis revealed that E(2)-bound ERalpha decreased the tyrosine phosphorylation and DNA-binding activity of Stat5a, indicating that the inhibitory effect of E(2) was mediated, at least in part, by interfering with PRL-mediated ..
  50. Olsen H, Hedengran Faulds M, Saharinen P, Silvennoinen O, Haldosén L. Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochem Biophys Res Commun. 2002;296:139-44 pubmed
    Prolactin, the Janus kinase 2 (JAK2) and the signal transducer and activator of transcription 5 (STAT5) are important for mammary gland development and have also been implicated in development and growth of breast tumors...
  51. Morales O, Faulds M, Lindgren U, Haldosén L. 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. J Biol Chem. 2002;277:34879-84 pubmed
    ..GH mainly activates JAK2 and STAT5a and b...
  52. Sun S, Silver P, Caspi R, Du Y, Chan C, Wilder R, et al. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Int Immunol. 1999;11:529-34 pubmed
    ..Further analysis of these genomic regions may lead to identification of the susceptibility genes and to characterization of their function. ..
  53. Hu X, Chen P, Wu Y, Wang K, Xu Y, Chen H, et al. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016;34:1846-58 pubmed publisher
    ..By using a loss or gain of gene function approach, we demonstrated that miR-211 targeted STAT5A to modulate MSCs migration, possibly by interacting with MAPK signaling...