Stat3

Summary

Gene Symbol: Stat3
Description: signal transducer and activator of transcription 3
Alias: signal transducer and activator of transcription 3, signal transducer and activator of transcription 3 (acute-phase response factor)
Species: rat
Products:     Stat3

Top Publications

  1. Dronadula N, Liu Z, Wang C, Cao H, Rao G. STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motility. J Biol Chem. 2005;280:3112-20 pubmed
    ..Together, these results show that thrombin-induced VSMC motility requires STAT-3-dependent induction of expression of cPLA(2). ..
  2. Choi J, Kim S, Cha J, Choi Y, Sung K, Oh S, et al. Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Glia. 2003;41:237-46 pubmed
    ..of gp130 and its downstream transcription factor, signal transducer and activator of transcription factor 3 (STAT3), in the rat hippocampus of a four-vessel occlusive ischemia model...
  3. Quinton L, Jones M, Robson B, Simms B, Whitsett J, Mizgerd J. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2008;38:699-706 pubmed publisher
    ..Human patients with dominant-negative mutations in the Stat3 gene develop recurrent pneumonias, suggesting a role for STAT3 in pulmonary host defense...
  4. Harris T, Grosso J, Yen H, Xin H, Kortylewski M, Albesiano E, et al. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179:4313-7 pubmed
    b>STAT3 activation has been observed in several autoimmune diseases, suggesting that STAT3-mediated pathways promote pathologic immune responses...
  5. Dziennis S, Jia T, Rønnekleiv O, Hurn P, Alkayed N. Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection. J Neurosci. 2007;27:7268-74 pubmed
    ..Signal transducer and activator of transcription-3 (STAT3) is a transcription factor that is activated by estrogen, translocates to the nucleus, and induces the ..
  6. Siddiquee K, Zhang S, Guida W, Blaskovich M, Greedy B, Lawrence H, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007;104:7391-6 pubmed
    S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain ..
  7. Yu X, Zhu S, Xu Z, Hu X, Zhu T, Chen J, et al. Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats. J Cancer Res Clin Oncol. 2007;133:145-52 pubmed
    The purpose of this study is to investigate if the EGFR-Stat3 signal pathway contributes to the carcinogenesis of hepatoma in rats. Hepatoma was induced in rats by 3'Me-DAB as a model...
  8. Gautron L, De Smedt Peyrusse V, Layé S. Characterization of STAT3-expressing cells in the postnatal rat brain. Brain Res. 2006;1098:26-32 pubmed
    b>Signal transducer and activator of transcription 3 (STAT3) is a transcription factor abundantly expressed in the postnatal brain that is involved in the differentiation of cultured astrocytes...
  9. Jing N, Li Y, Xiong W, Sha W, Jing L, Tweardy D. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res. 2004;64:6603-9 pubmed
    b>Stat3 is a signaling molecular and oncogene activated frequently in many human malignancies including the majority of prostate, breast, and head and neck cancers; yet, no current chemotherapeutic approach has been implemented clinically ..

More Information

Publications62

  1. Weng Y, Aroor A, Shukla S. Ethanol inhibition of angiotensin II-stimulated Tyr705 and Ser727 STAT3 phosphorylation in cultured rat hepatocytes: relevance to activation of p42/44 mitogen-activated protein kinase. Alcohol. 2008;42:397-406 pubmed publisher
    ..Angiotensin II (100 nM) stimulated Tyr705 and Ser727 phosphorylation of STAT3 and formation of sis-inducing factor complexes...
  2. Qiu J, Cafferty W, McMahon S, Thompson S. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. J Neurosci. 2005;25:1645-53 pubmed
    ..results in time-dependent phosphorylation and activation of the transcription factor, signal transducer and activator of transcription 3 (STAT3), in dorsal root ganglion (DRG) neurons...
  3. Al Shabrawey M, Bartoli M, El Remessy A, Ma G, Matragoon S, Lemtalsi T, et al. Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008;49:3231-8 pubmed publisher
    ..Prior studies have implicated oxidative stress and NADPH oxidase-mediated activation of signal transducer and activator of transcription 3 (STAT3) in diabetes-induced increases in expression of vascular endothelial growth factor (..
  4. Rajan P, Panchision D, Newell L, McKay R. BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells. J Cell Biol. 2003;161:911-21 pubmed
    ..predominates at high local densities in response to BMP4 and is specifically blocked by a dominant-negative mutant Stat3. Upon BMP4 treatment, the serine-threonine kinase FKBP12/rapamycin-associated protein (FRAP), mammalian target of ..
  5. Dominguez E, Mauborgne A, Mallet J, Desclaux M, Pohl M. SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J Neurosci. 2010;30:5754-66 pubmed publisher
    ..We showed recently that spinal nerve lesion leads to rapid activation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signal transduction pathway in dorsal spinal cord microglia in relation with ..
  6. Brock M, Trenkmann M, Gay R, Michel B, Gay S, Fischler M, et al. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ Res. 2009;104:1184-91 pubmed publisher
    ..Because IL-6 signaling is mainly mediated by STAT3 (signal transducer and activator of transcription 3), the expression of STAT3 was knocked down by small interfering RNA, which abolished the IL-..
  7. Fuglesteg B, Suleman N, Tiron C, Kanhema T, Lacerda L, Andreasen T, et al. Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion. Basic Res Cardiol. 2008;103:444-53 pubmed publisher
    ..3 mU/ml) +/- AG490 (5 microM, JAK-STAT inhibitor), the phosphorylation state of STAT3 and Akt was determined after 15 min of reperfusion. Infarct size was measured after 120 min of reperfusion...
  8. Zhang S, Wei J, Li C, Barnstable C, Fu X. Expression and activation of STAT proteins during mouse retina development. Exp Eye Res. 2003;76:421-31 pubmed
    ..For example, Stat3 expression and activation gradually increased in the inner neuroblast layer and ciliary margin during development...
  9. Tang M, Zhang Z, Fu J, Ning J, Wang Y. [Stat 3 signal transduction pathway correlates with proliferation of vascular smooth muscle cells of rats]. Zhonghua Xin Xue Guan Bing Za Zhi. 2005;33:832-5 pubmed
    To investigate the role of Stat3 (one of the signal transductant and activator) signal transduction pathway in proliferation of vascular smooth muscle cells (VSMCs). VSMC was transfected with Stat3 antisense oligonucleotide...
  10. Shyu W, Lin S, Chiang M, Chen D, Su C, Wang H, et al. Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke. J Clin Invest. 2008;118:133-48 pubmed
    ..SN also induced expression of the antiapoptotic proteins Bcl-2 and Bcl-xL through the Jak2/Stat3 pathway and inhibited apoptosis by blocking caspase-3 activation...
  11. Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner A, Sepuri N. The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem. 2013;288:4723-32 pubmed publisher
    The signal transducer and activator of transcription 3 (STAT3), a nuclear transcription factor, is also present in mitochondria and regulates cellular respiration in a transcriptional-independent manner...
  12. Liu X, Lee Y, Yu C, Egwuagu C. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J Immunol. 2008;180:6070-6 pubmed
    Th17 cells are implicated in CNS autoimmune diseases. We show that mice with targeted-deletion of Stat3 in CD4(+) T cells (CD4(Stat3)(-/-)) do not develop experimental autoimmune uveoretinitis (EAU) or experimental autoimmune ..
  13. Lin W, Chen C, Chang Y, Chen S, Chiu I, Chen L. SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway. Cell Signal. 2009;21:1060-72 pubmed publisher
    ..We also provided the first evidence that FGF1 induces the phosphorylation of signal transducer and activator of transcription 3 (STAT3) at serine 727 [pSTAT3(S727)] in PC12 cells...
  14. Ben Yaakov K, Dagan S, Segal Ruder Y, Shalem O, Vuppalanchi D, Willis D, et al. Axonal transcription factors signal retrogradely in lesioned peripheral nerve. EMBO J. 2012;31:1350-63 pubmed publisher
    ..Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin ?5 to ..
  15. Duan W, Yang Y, Yan J, Yu S, Liu J, Zhou J, et al. The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway. Basic Res Cardiol. 2012;107:263 pubmed publisher
    ..We also examined whether the Janus kinase 2 and signal transducer and activator 3 of transcription (JAK2/STAT3) signaling pathway plays a role in the cardioprotective effects of Cur post-treatment...
  16. Neeli I, Liu Z, Dronadula N, Ma Z, Rao G. An essential role of the Jak-2/STAT-3/cytosolic phospholipase A(2) axis in platelet-derived growth factor BB-induced vascular smooth muscle cell motility. J Biol Chem. 2004;279:46122-8 pubmed
    ..Together, these results for the first time show that PDGF-BB-induced VSMC motility requires activation of the Jak-2/STAT-3/cPLA(2) signaling axis. ..
  17. Booz G, Day J, Baker K. Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation. Basic Res Cardiol. 2003;98:33-8 pubmed
    Experiments were performed to define the basis for negative regulation of STAT3 activation (i.e., Tyr705 phosphorylation) by angiotensin II in cardiomyocytes...
  18. Kataoka K, Kim D, Carbajal S, Clifford J, DiGiovanni J. Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis. Carcinogenesis. 2008;29:1108-14 pubmed publisher
    Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a variety of human malignancies and has been suggested to play an important role in carcinogenesis...
  19. Howard J, Flier J. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab. 2006;17:365-71 pubmed
  20. Cheng X, Jin G, Zhang X, Tian M, Zou L. Stage-dependent STAT3 activation is involved in the differentiation of rat hippocampus neural stem cells. Neurosci Lett. 2011;493:18-23 pubmed publisher
    ..molecular mechanisms we studied the potential involvement of signal transducer and activator of transcription3 (STAT3) activation in the NSCs response to hippocampal extracts...
  21. Mir S, Chatterjee A, Mitra A, Pathak K, Mahata S, Sarkar S. Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart. J Biol Chem. 2012;287:2666-77 pubmed publisher
    ..During induction of hypertrophy, increased phosphorylation of STAT1, STAT3, MAPK, and ERK proteins was observed both in vitro and in vivo...
  22. Kandalam U, Clark M. Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes. Regul Pept. 2010;159:110-6 pubmed publisher
    ..The JAK2 inhibitor, AG490 (50 microM), prevented Ang II JAK2 phosphorylation. Ang II also stimulated STAT3 in a concentration- and time-dependent manner. Maximal phosphorylation of 0.8+/-0...
  23. Boengler K, Hilfiker Kleiner D, Heusch G, Schulz R. Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol. 2010;105:771-85 pubmed publisher
    The signal transducer and activator of transcription 3 (STAT3) contributes to cardioprotection by ischemic pre- and postconditioning...
  24. Izumi Nagai K, Nagai N, Ozawa Y, Mihara M, Ohsugi Y, Kurihara T, et al. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol. 2007;170:2149-58 pubmed
    ..The present study reveals the critical contribution of IL-6 signaling and its downstream STAT3 pathway to the murine model of laser-induced CNV...
  25. Suleman N, Somers S, Smith R, Opie L, Lecour S. Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning. Cardiovasc Res. 2008;79:127-33 pubmed publisher
    ..In contrast, during an IPC stimulus, both prosurvival signalling molecule cascades acted in concert so that inhibiting activation of STAT-3 also inhibited that of Akt and vice versa. ..
  26. Jones S, Scheller J, Rose John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest. 2011;121:3375-83 pubmed publisher
    ..Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer. ..
  27. Ryu H, Lee J, Kim K, Jeong S, Kim P, Chung H. Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J Immunol. 2000;165:2116-23 pubmed
    ..Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils...
  28. Lin P, Ke C, Khor C, Cai Y, Lee Y. Involvement of SDF1a and STAT3 in granulocyte colony-stimulating factor rescues optic ischemia-induced retinal function loss by mobilizing hematopoietic stem cells. Invest Ophthalmol Vis Sci. 2013;54:1920-30 pubmed publisher
    ..indicated superior retinal function in animals treated with G-CSF than in untreated animals postischemia, and that STAT3 might play an important role...
  29. Ghosh A, Pechota A, Coleman D, Upchurch G, Eliason J. Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. Hum Pathol. 2015;46:284-94 pubmed publisher
    ..extracts from CSE-treated RASMC showed up-regulation of pStat3, pJak2, and T-Jak2 and unchanged levels of T-Stat3. Transfection of RASMC with small interfering RNAs for Jak2, Stat3, or both Jak2 and Stat3 significantly reduced ..
  30. Zhang L, Li Y, Liu Y, Wang X, Chen M, Xing Y, et al. STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration. J Steroid Biochem Mol Biol. 2015;149:106-17 pubmed publisher
    ..15-HETE-stimulated VAF phenotypic changes and migration as measured by the wound healing assay required STAT3 phosphorylation. JNK1 and CREB inhibition blocked 15-HETE-induced STAT3 activation and VAF changes...
  31. Scarpace P, Matheny M, Zhang Y, Shek E, Prima V, Zolotukhin S, et al. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology. 2002;143:3026-35 pubmed
    ..We propose that both elevated leptin and obesity may be necessary for the development of leptin resistance. ..
  32. Riediger T, Cordani C, Potes C, Lutz T. Involvement of nitric oxide in lipopolysaccharide induced anorexia. Pharmacol Biochem Behav. 2010;97:112-20 pubmed publisher
    ..that the tolerance to the anorectic effect occurring after repeated LPS treatment is paralleled by a blunted STAT3 phosphorylation in the ARC...
  33. Matsuo R, Morihara H, Mohri T, Murasawa S, Takewaki K, Nakayama H, et al. The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes. PLoS ONE. 2014;9:e111097 pubmed publisher
    ..specific receptors and activate glycoprotein 130 (gp130), a common receptor, followed by further activation of STAT3 and extracellular signal-regulated kinase (ERK)1/2 through janus kinases (JAKs); however the importance of ..
  34. Chang Y, Chen K, Chen C, Lin M, Sun Y, Lee J, et al. SH2B1? interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. Mol Cell Biol. 2014;34:1003-19 pubmed publisher
    ..we show that SH2B1? interacts with the transcription factor, signal transducer, and activator of transcription 3 (STAT3) in neuronal PC12 cells, cortical neurons, and COS7 fibroblasts...
  35. Couto J, Daly L, Almeida A, Knauf J, Fagin J, Sobrinho Simoes M, et al. STAT3 negatively regulates thyroid tumorigenesis. Proc Natl Acad Sci U S A. 2012;109:E2361-70 pubmed publisher
    Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated...
  36. Shimizu H, Yisireyili M, Nishijima F, Niwa T. Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence. Am J Nephrol. 2012;36:184-9 pubmed publisher
    Increased phosphorylation (activation) of signal transducer and activator of transcription 3 (Stat3) on tyrosine 705 leads to renal fibrosis...
  37. Luo M, Liu Z, Chen G, Hao H, Lu T, Cui Y, et al. High glucose enhances TGF-?1 expression in rat bone marrow stem cells via ERK1/2-mediated inhibition of STAT3 signaling. Life Sci. 2012;90:509-18 pubmed publisher
    ..The expression and activation of ERK1/2 and STAT3 were examined in MAPCs cultured in HG media with Western blot...
  38. Zang Y, Yu L, Pang T, Fang L, Feng X, Wen T, et al. AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase. J Biol Chem. 2008;283:6201-8 pubmed
    ..We also found AICAR could activate the Janus kinase (JAK) STAT3 pathway in both C17.2-NSC and E14-NSC but Metformin fails...
  39. Osuka K, Watanabe Y, Yamauchi K, Nakazawa A, Usuda N, Tokuda M, et al. Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage. Brain Res. 2006;1072:1-7 pubmed
    ..Western blot analysis with JAK1, phosphospecific-JAK1, STAT3, phosphospecific STAT3 at Tyr705 and Ser727, cyclooxygenase-2 (COX-2), and actin antibodies was performed in ..
  40. Lee C, Yi E, Kim H, Huh S, Sung S, Chung M, et al. Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression. J Ethnopharmacol. 2011;135:747-53 pubmed publisher
    ..CD3+ cells), inducible nitric oxide synthase (iNOS) expression, skin thickness, and expression of phosphorylated STAT3 (signal transducers and activators of transcription 3) protein were tested in a DNCB-induced contact dermatitis ..
  41. Yamaguchi T, Mukasa T, Uchida E, Kanayasu Toyoda T, Hayakawa T. The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3. J Biol Chem. 1999;274:15575-81 pubmed
    ..hand, G-CSF rapidly induced tyrosine phosphorylation of signal transducers and activators of transcription-3 (STAT3), but did not induce serine727 phosphorylation...
  42. Yu Y, Li M, Su N, Zhang Z, Zhao H, Yu H, et al. Honokiol protects against renal ischemia/reperfusion injury via the suppression of oxidative stress, iNOS, inflammation and STAT3 in rats. Mol Med Rep. 2016;13:1353-60 pubmed publisher
    ..The levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and the protein expression levels of STAT3 were determined using western blotting...
  43. Ma L, Huang C, Wang X, Xin D, Wang L, Zou Q, et al. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol Cell. 2017;65:296-309 pubmed publisher
    ..LOX-like 3 (Loxl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl-lysine sites...
  44. Alten J, Moran A, Tsimelzon A, Mastrangelo M, Hilsenbeck S, Poli V, et al. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS ONE. 2008;3:e1605 pubmed publisher
    ..Pre-treatment of rats with a selective inhibitor of Stat3, T40214, reduced the IL-6-mediated increase in cardiac Stat3 activity, blocked successful resuscitation by IL-6 ..
  45. Han C, Bowen W, Michalopoulos G, Wu T. Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. J Cell Physiol. 2008;216:486-97 pubmed publisher
    ..describes a novel alpha(1)-AR-mediated transactivation of signal transducer and activator of transcription-3 (Stat3) in primary and transformed hepatocytes...
  46. Grigorov I, Lazic T, Cvetkovic I, Milosavljevic T, Petrovic M. Opposite nuclear level and binding activity of STAT5B and STAT3 proteins with rat haptoglobin gene under normal and turpentine induced acute phase conditions. Mol Biol Rep. 2001;28:217-22 pubmed
    ..is highly induced during acute phase (AP) response which has been previously shown to be mediated by inducible STAT3 member of the Signal Transducer and Activators of Transcription (STATs) family proteins...
  47. Min K, Choi K, Kwon T. Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells. Int Immunopharmacol. 2011;11:1137-42 pubmed publisher
    ..Withaferin A significantly inhibited LPS-induced STAT1 and STAT3 phosphorylation in a dose-dependent manner...
  48. Lam S, Luk J, Man K, Ng K, Cheung C, Rose John S, et al. Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration. Liver Transpl. 2010;16:1195-206 pubmed publisher
    ..During hepatic differentiation, signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK)..
  49. Lejeune D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa J, Renauld J. Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem. 2002;277:33676-82 pubmed
    ..We found that IL-22 induces activation of JAK1 and Tyk2 but not JAK2, as well as phosphorylation of STAT1, STAT3, and STAT5 on tyrosine residues, extending the similarities between IL-22 and IL-10...
  50. Valapala M, Edwards M, Hose S, Hu J, Wawrousek E, Lutty G, et al. βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes. Sci Rep. 2015;5:8755 pubmed publisher
    ..Several studies have shown that the signal transducer and activator of transcription 3 (STAT3) is involved in the co-regulation of GFAP and VEGF...
  51. Girotti M, Donegan J, Morilak D. Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress. Psychoneuroendocrinology. 2013;38:1158-69 pubmed publisher
    ..6 (IL-6), a stress-inducible cytokine that signals through gp130 and IL-6R? receptors to activate the JAK/STAT3 signaling cascade, is elevated in some subtypes of depression, and may have a modulatory effect on HPA activation, ..
  52. Wang L, Lee H, Seo I, Shin Y, Lee K, Park H. Cell type-specific STAT3 activation by gp130-related cytokines in the peripheral nerves. Neuroreport. 2009;20:663-8 pubmed publisher
    Nerve injury-induced activation of signal transducer and activator of transcription 3 (STAT3) in sensory neurons and Schwann cells has been implicated in peripheral nerve regeneration...
  53. Heldsinger A, Grabauskas G, Song I, Owyang C. Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways: implications for leptin as a regulator of short term satiety. J Biol Chem. 2011;286:11707-15 pubmed publisher
    ..In addition, STAT3, PI3K, Src, and MAPK genes were silenced by lentiviral infection and transient Lipofectamine transfection of ..