Star

Summary

Gene Symbol: Star
Description: steroidogenic acute regulatory protein
Alias: steroidogenic acute regulatory protein, mitochondrial, START domain-containing protein 1, stARD1
Species: rat
Products:     Star

Top Publications

  1. Fester L, Zhou L, Bütow A, Huber C, von Lossow R, Prange Kiel J, et al. Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus. Hippocampus. 2009;19:692-705 pubmed publisher
    ..Our data indicate that in the hippocampus cholesterol-promoted synapse formation requires the conversion of cholesterol to estradiol. ..
  2. Rune G, Lohse C, Prange Kiel J, Fester L, Frotscher M. Synaptic plasticity in the hippocampus: effects of estrogen from the gonads or hippocampus?. Neurochem Res. 2006;31:145-55 pubmed
    ..Alternatively, we used siRNA against Steroidogenic acute regulatory protein (StAR)...
  3. Fester L, Ribeiro Gouveia V, Prange Kiel J, von Schassen C, Bottner M, Jarry H, et al. Proliferation and apoptosis of hippocampal granule cells require local oestrogen synthesis. J Neurochem. 2006;97:1136-44 pubmed
    ..Alternatively, we used siRNA against steroidogenic acute regulatory protein (StAR)...
  4. Feng Y, Zhang Q, Dai D, Ying H, Dai Y. Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system. Clin Exp Pharmacol Physiol. 2007;34:1131-7 pubmed
    ..related enzyme function and gene regulation and the mRNA levels of steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (P450scc), 3beta-hydroxysteroid dehydrogenase (3beta-HSD), prepro-..
  5. Karri S, Dertien J, Stocco D, Syapin P. Steroidogenic acute regulatory protein expression and pregnenolone synthesis in rat astrocyte cultures. J Neuroendocrinol. 2007;19:860-9 pubmed
    ..We studied the potential role of the steroidogenic acute regulatory (StAR) protein in neurosterodogenesis by using rat brain astrocytes...
  6. Luo D, Yang G, Liu J, Yang Y, Dong Q. Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells. Asian J Androl. 2011;13:287-91 pubmed publisher
    ..Leydig cells were studied for apoptosis and expression of steroidogenetic acute regulatory (StAR) protein mRNA levels...
  7. Sandhoff T, Hales D, Hales K, McLean M. Transcriptional regulation of the rat steroidogenic acute regulatory protein gene by steroidogenic factor 1. Endocrinology. 1998;139:4820-31 pubmed
    Steroidogenic acute regulatory (StAR) protein is synthesized in response to tropic hormones to facilitate cholesterol transport to the inner mitochondrial membrane-bound P450 side-chain cleavage enzyme (P450scc), the first enzymatic step ..
  8. Clark B, Wells J, King S, Stocco D. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994;269:28314-22 pubmed
    ..We conclude that this protein is required in the acute regulation of steroidogenesis and propose to call this protein the Steroidogenic Acute Regulatory protein (StAR).
  9. Furukawa A, Miyatake A, Ohnishi T, Ichikawa Y. Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: colocalization of StAR, cytochrome P-450SCC (CYP XIA1), and 3beta-hydroxysteroid dehydrogenase in the rat brain. J Neurochem. 1998;71:2231-8 pubmed
    Steroidogenic acute regulatory protein (StAR) is a 30-kDa protein involved in the transport of cholesterol to the inner mitochondrial membrane and thus plays a key role in steroid biosynthesis...
  10. Campbell J, Kiraly M, Atkinson D, D souza A, Vranic M, Riddell M. Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol. 2010;299:R168-76 pubmed publisher

Detail Information

Publications62

  1. Fester L, Zhou L, Bütow A, Huber C, von Lossow R, Prange Kiel J, et al. Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus. Hippocampus. 2009;19:692-705 pubmed publisher
    ..Our data indicate that in the hippocampus cholesterol-promoted synapse formation requires the conversion of cholesterol to estradiol. ..
  2. Rune G, Lohse C, Prange Kiel J, Fester L, Frotscher M. Synaptic plasticity in the hippocampus: effects of estrogen from the gonads or hippocampus?. Neurochem Res. 2006;31:145-55 pubmed
    ..Alternatively, we used siRNA against Steroidogenic acute regulatory protein (StAR)...
  3. Fester L, Ribeiro Gouveia V, Prange Kiel J, von Schassen C, Bottner M, Jarry H, et al. Proliferation and apoptosis of hippocampal granule cells require local oestrogen synthesis. J Neurochem. 2006;97:1136-44 pubmed
    ..Alternatively, we used siRNA against steroidogenic acute regulatory protein (StAR)...
  4. Feng Y, Zhang Q, Dai D, Ying H, Dai Y. Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system. Clin Exp Pharmacol Physiol. 2007;34:1131-7 pubmed
    ..related enzyme function and gene regulation and the mRNA levels of steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (P450scc), 3beta-hydroxysteroid dehydrogenase (3beta-HSD), prepro-..
  5. Karri S, Dertien J, Stocco D, Syapin P. Steroidogenic acute regulatory protein expression and pregnenolone synthesis in rat astrocyte cultures. J Neuroendocrinol. 2007;19:860-9 pubmed
    ..We studied the potential role of the steroidogenic acute regulatory (StAR) protein in neurosterodogenesis by using rat brain astrocytes...
  6. Luo D, Yang G, Liu J, Yang Y, Dong Q. Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells. Asian J Androl. 2011;13:287-91 pubmed publisher
    ..Leydig cells were studied for apoptosis and expression of steroidogenetic acute regulatory (StAR) protein mRNA levels...
  7. Sandhoff T, Hales D, Hales K, McLean M. Transcriptional regulation of the rat steroidogenic acute regulatory protein gene by steroidogenic factor 1. Endocrinology. 1998;139:4820-31 pubmed
    Steroidogenic acute regulatory (StAR) protein is synthesized in response to tropic hormones to facilitate cholesterol transport to the inner mitochondrial membrane-bound P450 side-chain cleavage enzyme (P450scc), the first enzymatic step ..
  8. Clark B, Wells J, King S, Stocco D. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994;269:28314-22 pubmed
    ..We conclude that this protein is required in the acute regulation of steroidogenesis and propose to call this protein the Steroidogenic Acute Regulatory protein (StAR).
  9. Furukawa A, Miyatake A, Ohnishi T, Ichikawa Y. Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: colocalization of StAR, cytochrome P-450SCC (CYP XIA1), and 3beta-hydroxysteroid dehydrogenase in the rat brain. J Neurochem. 1998;71:2231-8 pubmed
    Steroidogenic acute regulatory protein (StAR) is a 30-kDa protein involved in the transport of cholesterol to the inner mitochondrial membrane and thus plays a key role in steroid biosynthesis...
  10. Campbell J, Kiraly M, Atkinson D, D souza A, Vranic M, Riddell M. Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol. 2010;299:R168-76 pubmed publisher
  11. Miller W. Androgen synthesis in adrenarche. Rev Endocr Metab Disord. 2009;10:3-17 pubmed publisher
    ..Acute regulation is mediated by the steroidogenic acute regulatory protein (StAR), which facilitates the rapid influx of cholesterol into mitochondria, where P450scc resides...
  12. Chen M, Wang S, Kan S, Tsai S, Wu Y, Wang P. Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells. Toxicol Sci. 2010;118:667-74 pubmed publisher
    ..Interestingly, the levels of steroidogenic acute regulatory protein (StAR) in both total cell lysate and the mitochondrial fraction were significantly increased by PTU treatment...
  13. Colón E, Zaman F, Axelson M, Larsson O, Carlsson Skwirut C, Svechnikov K, et al. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Endocrinology. 2007;148:128-39 pubmed
    ..Inhibition of IGF-IR by picropodophyllin decreases the survival of Leydig cells, both in the presence and absence of IGF-I, demonstrating that signaling via the IGF-IR plays an important role in Leydig cell survival. ..
  14. Peters B, Teubner P, Clausmeyer S, Puschner T, Maser Gluth C, Wrede H, et al. StAR expression and the long-term aldosterone response to high-potassium diet in Wistar-Kyoto and spontaneously hypertensive rats. Am J Physiol Endocrinol Metab. 2007;292:E16-23 pubmed
    ANG II and potassium are known to increase steroidogenic acute regulatory protein (StAR) levels. However, a corresponding increase in StAR mRNA levels has so far been observed only in response to ANG II...
  15. Supriya C, Girish B, Reddy P. Aflatoxin B1-Induced Reproductive Toxicity in Male Rats: Possible Mechanism of Action. Int J Toxicol. 2014;33:155-161 pubmed
    ..In silico docking studies illustrated AFB1 binds with steroidogenic acute regulatory (StAR) protein thereby affecting the transport of cholesterol into mitochondria resulting in decreased steroidogenesis.
  16. Kanzaki M, Morris P. Growth hormone regulates steroidogenic acute regulatory protein expression and steroidogenesis in Leydig cell progenitors. Endocrinology. 1999;140:1681-6 pubmed
    ..GH induces significant increases in the levels of steroidogenic acute regulatory protein (StAR), 3beta-hydroxysteroid dehydrogenase (3beta-HSD) expression, and androgen production in PLCs...
  17. Jana K, Samanta P, De D. Nicotine diminishes testicular gametogenesis, steroidogenesis, and steroidogenic acute regulatory protein expression in adult albino rats: possible influence on pituitary gonadotropins and alteration of testicular antioxidant status. Toxicol Sci. 2010;116:647-59 pubmed publisher
    ..that the nicotine induced a marked decrease in the expression of testicular steroidogenic acute regulatory (StAR) protein, which helps in the transfer of cholesterol in mitochondria for the testosterone biosynthesis...
  18. Xiao Y, Huang Y, Hardy D, Li X, Ge R. Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells. J Androl. 2010;31:365-71 pubmed publisher
    ..RU38486 also reversed DEX-induced reductions in steady-state mRNA levels of steroidogenic acute regulatory protein (Star) and 3?-hydroxysteroid dehydrogenase 1 (Hsd3b1)...
  19. Chen M, Wang T, Liao Z, Pan X, Feng Y, Wang H. Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat. Exp Toxicol Pathol. 2007;59:245-51 pubmed
    ..The mRNA expressions of adrenal steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side chain cleavage (P450scc) and placental 11 beta-hydroxysteroid dehydrogenase type ..
  20. Chen Y, Lee M, Yao H, Hsiao P, Ke F, Hwang J. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Endocrinology. 2008;149:4658-68 pubmed publisher
  21. Wu X, Wang W, Wang R, Xie L, Fang Z, Chen G. [Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats]. Zhonghua Nan Ke Xue. 2008;14:371-6 pubmed
    ..by enzyme linked immunosorbent assay (ELISA), and the mRNA levels in the steroidogenic acute regulatory protein (StAR), cytochrome P450 side chain cleavage (P450scc), cytochrome P450 17a-hydroxylase (P450c17), 17beta-hydroxysteroid ..
  22. Parthasarathy C, Balasubramanian K. Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis. J Cell Biochem. 2008;104:1671-83 pubmed publisher
    ..b>StAR mRNA and protein levels were significantly increased in Leydig cells of corticosterone-deficient animals...
  23. Abarikwu S, Farombi E, Pant A. Kolaviron biflavanoids of Garcinia kola seeds protect atrazine-induced cytotoxicity in primary cultures of rat Leydig cells. Int J Toxicol. 2012;31:407-15 pubmed publisher
    ..alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), and 3?-hydroxysteroid dehydrogenase (3?-HSD) were shifted ..
  24. Herman M, Kang S, Lee S, James P, Rivier C. Systemic administration of alcohol to adult rats inhibits leydig cell activity: Time course of effect and role of nitric oxide. Alcohol Clin Exp Res. 2006;30:1479-91 pubmed
    ..was studied by measuring changes in the levels of the steroidogenic proteins steroidogenic acute regulatory (StAR), the peripheral-type benzodiazepine receptor (PBR), and the cytochrome P450 side-chain cleavage enzyme (P450scc)...
  25. Khisti R, Kumar S, Morrow A. Ethanol rapidly induces steroidogenic acute regulatory protein expression and translocation in rat adrenal gland. Eur J Pharmacol. 2003;473:225-7 pubmed
    ..showed that ethanol administration rapidly increases the expression of steroidogenic acute regulatory protein (StAR) in the cytosolic and mitochondrial fractions of adrenal glands...
  26. Nackley A, Shea Eaton W, Lopez D, McLean M. Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1. Endocrinology. 2002;143:1085-96 pubmed
    The transport of cholesterol to the inner mitochondrial membrane by the steroidogenic acute regulatory (StAR) protein is a critical step in steroidogenesis...
  27. Chen C, Kuo J, Wong A, Micevych P. Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes. Endocrinology. 2014;155:2976-85 pubmed publisher
    ..was to characterize the estradiol-induced signaling leading to activation of steroid acute regulatory protein (StAR) and transporter protein (TSPO), which mediate the rate-limiting step in steroidogenesis, ie, the transport of ..
  28. Tajima K, Dantes A, Yao Z, Sorokina K, Kotsuji F, Seger R, et al. Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1. J Clin Endocrinol Metab. 2003;88:2288-99 pubmed
    ..these cell cultures concomitantly with specific elevation of intracellular steroidogenic acute regulatory protein (StAR). Intracellular levels of the cytochrome P450 side-chain cleavage enzyme system do not seem to be affected...
  29. Banu S, Samuel J, Arosh J, Burghardt R, Aruldhas M. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Toxicol Appl Pharmacol. 2008;232:180-9 pubmed publisher
    ..Cr(VI) decreased the mRNA expressions of StAR, SF-1, 17beta-HSD-1, 17beta-HSD-2, FSHR, LHR, ER alpha and ER beta...
  30. Casal A, Silvestre J, Delcayre C, Capponi A. Expression and modulation of steroidogenic acute regulatory protein messenger ribonucleic acid in rat cardiocytes and after myocardial infarction. Endocrinology. 2003;144:1861-8 pubmed
    We examined whether the mRNA for steroidogenic acute regulatory (StAR) protein, a crucial factor in the rate-limiting step of aldosterone biosynthesis, is expressed and regulated in rat heart...
  31. Benmessahel Y, Guennoun R, Cadepond F, Baulieu E, Schumacher M, Groyer G. Expression of steroidogenic acute regulatory protein in cultured Schwann cells and its regulation by cAMP. Ann N Y Acad Sci. 2002;973:83-7 pubmed
    In steroidogenic cells the steroidogenic acute regulatory (StAR) protein plays a key role in the transport of cholesterol to the inner mitochondrial membrane, where the first step of steroidogenesis, the conversion of cholesterol to ..
  32. Chen H, Chu G, Zhao L, Yamauchi N, Shigeyoshi Y, Hashimoto S, et al. Rev-erb? regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112. Biochem Biophys Res Commun. 2012;420:374-9 pubmed publisher
    ..GSK4112 significantly inhibited Bmal1 mRNA expression, whereas it did clearly stimulate expression of StAR mRNA in a dose-dependent manner...
  33. King S, Ronen Fuhrmann T, Timberg R, Clark B, Orly J, Stocco D. Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein. Endocrinology. 1995;136:5165-76 pubmed
    We have previously demonstrated that steroidogenic acute regulatory protein (StAR) is essential for the rate-limiting step in the acute regulation of steroidogenesis, which is the transport of cholesterol from the outer to the inner ..
  34. Lu X, Yu T, Ma M, Jin C, Liu Q, Wu S, et al. [Effect on the testis development and StAR, CYP19a1 and CYP11a1 expression of prepubertal male rats after sub-acute exposure to DEHP]. Wei Sheng Yan Jiu. 2010;39:263-7 pubmed
    ..The effect of DEHP on gene expression of StAR, CYP19a1 and CYP11a1 was compared to each other in different DEHP group...
  35. Zhou X, He Q, Liu C. [Effect of tianoan zhuangyang powder on the stAR protein expression of Leydig cells in model rats with partial androgen deficiency of aging male]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011;31:542-6 pubmed
    To observe the effect of Tiancan Zhuangyang Powder (TCZYP) on the steroidogenic acute regulatory protein (stAR protein) expression of Leydig cells in model rats with partial androgen deficiency of aging male (PADAM)...
  36. Shi Z, Zhang H, Liu Y, Xu M, Dai J. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Toxicol Sci. 2007;98:206-15 pubmed
    ..Our results demonstrate that PFDoA affects the reproduction function of male rats via alterations in steroidogenesis genes, testosterone levels, and testes ultrastructure. ..
  37. Jaroenporn S, Nagaoka K, Ohta R, Shirota M, Watanabe G, Taya K. Differences in adrenocortical secretory and gene expression responses to stimulation in vitro by ACTH or prolactin between high- and low-avoidance Hatano rats. Stress. 2009;12:22-9 pubmed publisher
    ..The basal level of expression of steroidogenic acute regulatory protein (StAR) and the long form of the PRL receptor (PRLR-L) mRNAs was higher in adrenals of LAA rats...
  38. Adamsson A, Simanainen U, Viluksela M, Paranko J, Toppari J. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Int J Androl. 2009;32:575-85 pubmed publisher
    ..AR) and estrogen receptors (ER), steroidogenic enzymes (P450scc and 3beta-HSD) and four regulatory factors (StAR, SF-1, GATA-4 and Insl-3) involved in foetal Leydig cell and adrenal function were analysed on ED 19.5...
  39. Svechnikov K, Supornsilchai V, Strand M, Wahlgren A, Seidlova Wuttke D, Wuttke W, et al. Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis. J Endocrinol. 2005;187:117-24 pubmed
    ..to stimulation by hCG or dibutyryl cAMP, as well as elevated expression of steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage (P450 scc) and cytochrome P450 17alpha (P450c17)...
  40. Nakamura E, Otsuka F, Inagaki K, Miyoshi T, Yamanaka R, Tsukamoto N, et al. A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells. Endocrinology. 2010;151:5506-18 pubmed publisher
    ..Considering that BMPs suppressed PRLR in granulosa cells, it is likely that the BMP system in growing follicles plays a key role in antagonizing PRLR signaling actions in the ovary exposed to high concentrations of PRL. ..
  41. Huang H, Chiang M, Lin C, Pu H. Lipopolysaccharide directly stimulates aldosterone production via toll-like receptor 2 and toll-like receptor 4 related PI(3)K/Akt pathway in rat adrenal zona glomerulosa cells. J Cell Biochem. 2010;111:872-80 pubmed publisher
    ..steroidogenesis enzyme expression such as scavenger receptor-B1 (SR-B1), steroidogenic acute regulatory protein (StAR) and P450 side chain cleavage (P450scc) enzyme...
  42. Sierra A, Lavaque E, Perez Martin M, Azcoitia I, Hales D, Garcia Segura L. Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury. Eur J Neurosci. 2003;18:1458-67 pubmed
    ..This delivery is mediated by steroidogenic acute regulatory protein (StAR)...
  43. Kumar V, Balomajumder C, Roy P. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Toxicology. 2008;250:124-31 pubmed publisher
    ..dehydrogenase (3beta-HSD), 17beta-hydroxysteroid dehydrogenase (17beta-HSD) and steroidogenic acute regulatory (StAR) protein, also decreased in a dose-dependent manner in TCS-treated Leydig cells as determined by RT-PCR, enzyme ..
  44. Shen W, Patel S, Natu V, Hong R, Wang J, Azhar S, et al. Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal. J Biol Chem. 2003;278:43870-6 pubmed
    ..Steroidogenic acute regulatory protein (StAR) facilitates the movement of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane ..
  45. Hwang E, Min K, Jung S, Ryu S, Ahn K, Lee K, et al. Testicular steroidogenesis is decreased by hyperthermia in old rats. Urol Int. 2010;84:347-52 pubmed publisher
    ..The protein levels of 2 steroidogenic enzymes, StAR and P450c17, were measured by Western blot. The testes were examined histologically by light microscopy...
  46. Ohtani T, Mano T, Hikoso S, Sakata Y, Nishio M, Takeda Y, et al. Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure. J Hypertens. 2009;27:1074-83 pubmed publisher
    ..Cardiac steroidogenesis system and local glucocorticoid may play important roles in the development of hypertrophy and the progression to heart failure. ..
  47. Wu J, Wang K, Wang S, Hwang G, Mao I, Chen M, et al. Differential effects of nonylphenol on testosterone secretion in rat Leydig cells. Toxicology. 2010;268:1-7 pubmed publisher
    ..5 microM) alone stimulated testosterone release through increase of both protein levels and activities of the StAR and P450(SCC). In contrast, NP inhibited hCG-induced testosterone release in rat Leydig cells...
  48. Morales V, Santana P, Diaz R, Tabraue C, Gallardo G, López Blanco F, et al. Intratesticular delivery of tumor necrosis factor-alpha and ceramide directly abrogates steroidogenic acute regulatory protein expression and Leydig cell steroidogenesis in adult rats. Endocrinology. 2003;144:4763-72 pubmed
    ..delivery of TNF alpha induced a rapid (4 h) and sustained (up to 24 h) reduction in steroidogenic acute regulatory (StAR) protein expression and testosterone biosynthesis in nonstimulated or human chorionic gonadotropin-treated intact ..
  49. Rucinski M, Tortorella C, Ziolkowska A, Nowak M, Nussdorfer G, Malendowicz L. Steroidogenic acute regulatory protein gene expression, steroid-hormone secretion and proliferative activity of adrenocortical cells in the presence of proteasome inhibitors: in vivo studies on the regenerating rat adrenal cortex. Int J Mol Med. 2008;21:593-7 pubmed
    ..studies have shown that proteasome inhibitors promote the accumulation of steroidogenic acute regulatory protein (StAR) in cultured rat adrenocortical cells...
  50. Srivastava V, Dearth R, Hiney J, Ramirez L, Bratton G, Dees W. The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. Toxicol Sci. 2004;77:35-40 pubmed
    ..exposed maternally to lead (Pb); thus, we assessed effects of Pb on ovarian steroidogenic acute regulatory protein (StAR) as a potential mechanism for this action...
  51. Pu H, Wang S, Tseng C, Huang H, Lin C, Hsu J, et al. Mechanisms of digoxin and digitoxin on the production of corticosterone in zona fasciculata-reticularis cells of ovariectomized rats. J Cell Biochem. 2006;97:303-13 pubmed
    ..side chain cleavage enzyme (P450scc), the protein expression of P450scc and steroidogenic acute regulatory protein (StAR), and mRNA expression of StAR are unclear...
  52. Zurvarra F, Salvetti N, Mason J, Velazquez M, Alfaro N, Ortega H. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Reprod Fertil Dev. 2009;21:827-39 pubmed publisher
    ..aromatase (P450arom), 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and steroidogenic acute regulatory protein (StAR)) in letrozole-induced polycystic ovaries of rats...
  53. Granot Z, Geiss Friedlander R, Melamed Book N, Eimerl S, Timberg R, Weiss A, et al. Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins. Mol Endocrinol. 2003;17:2461-76 pubmed
    Steroidogenic acute regulatory protein (StAR) is a nuclear encoded mitochondrial protein that enhances steroid synthesis by facilitating the transfer of cholesterol to the inner membranes of mitochondria in hormonally regulated ..
  54. Dhanabalan S, Jubendradass R, Latha P, Mathur P. Effect of restraint stress on 2,3,7,8 tetrachloro dibenzo-p-dioxin induced testicular and epididymal toxicity in rats. Hum Exp Toxicol. 2011;30:567-78 pubmed publisher
    ..raised the serum level of corticosterone and suppressed the testicular level of steroidogenic acute regulatory (StAR) protein and serum level of testosterone significantly...
  55. Tsai S, Lu C, Lin C, Wang P. Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. J Cell Biochem. 2003;90:1276-86 pubmed
    ..the protein expressions of cytochrome P450 side chain cleavage enzyme (P450scc) and steroidogenic acute regulatory (StAR) protein were also investigated...
  56. Jo Y, Stocco D. Regulation of steroidogenesis and steroidogenic acute regulatory protein in R2C cells by DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene-1). Endocrinology. 2004;145:5629-37 pubmed
    ..One, the MA-10 mouse tumor cell line, produces steroids and the steroidogenic acute regulatory (StAR) protein only when stimulated by trophic hormones and cAMP analogs...
  57. Zhang W, Jia H. Effect and mechanism of cadmium on the progesterone synthesis of ovaries. Toxicology. 2007;239:204-12 pubmed
    ..study, we investigated whether Cd also disrupts progesterone synthesis via steroidogenic acute regulatory protein (StAR) and P450 cholesterol side-chain cleavage (P450scc), which play important roles in progesterone synthesis...
  58. Sandhoff T, McLean M. Prostaglandin F2? reduces steroidogenic acute regulatory (StAR) protein messenger ribonucleic acid expression in the rat ovary. Endocrine. 1996;5:183-90 pubmed publisher
    ..Steroidogenic acute regulatory (StAR) protein is thought to mediate the rapid increase in steroid hormone biosynthesis in response to tropic hormones by ..
  59. Liu Q, Merkler K, Zhang X, McLean M. Prostaglandin F2alpha suppresses rat steroidogenic acute regulatory protein expression via induction of Yin Yang 1 protein and recruitment of histone deacetylase 1 protein. Endocrinology. 2007;148:5209-19 pubmed
    ..plays a pivotal role in ovarian luteolysis by inhibiting the expression of steroidogenic acute regulatory (StAR) protein, leading to a decrease in intracellular cholesterol transport and luteal steroid production...
  60. Ren S, Hylemon P, Marques D, Gurley E, Bodhan P, Hall E, et al. Overexpression of cholesterol transporter StAR increases in vivo rates of bile acid synthesis in the rat and mouse. Hepatology. 2004;40:910-7 pubmed
    ..Previously, we have shown that overexpression of the steroidogenic acute regulatory protein (StAR), a mitochondrial cholesterol transport protein, increases bile acid biosynthesis more than 5-fold via the acidic ..
  61. Ariyoshi N, Kim Y, Artemenko I, Bhattacharyya K, Jefcoate C. Characterization of the rat Star gene that encodes the predominant 3.5-kilobase pair mRNA. ACTH stimulation of adrenal steroids in vivo precedes elevation of Star mRNA and protein. J Biol Chem. 1998;273:7610-9 pubmed
    The steroidogenic acute regulatory protein (STAR) participates in steroidogenesis through the mitochondrial transfer of cholesterol to cytochrome P450scc. The rat adrenal Star gene is transcribed as a 3. 5-kilobase pair (kb) and 1...
  62. Caron K, Soo S, Wetsel W, Stocco D, Clark B, Parker K. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc Natl Acad Sci U S A. 1997;94:11540-5 pubmed
    ..studies showed that a 30-kDa mitochondrial phosphoprotein, designated steroidogenic acute regulatory protein (StAR), is essential for this translocation...