Sst

Summary

Gene Symbol: Sst
Description: somatostatin
Alias: SS-14, SS-28, Smst, somatostatin
Species: rat
Products:     Sst

Top Publications

  1. El Kouhen K, Morisset J. Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line. Pancreas. 2010;39:127-34 pubmed publisher
    This study evaluated the role played by cholecystokinin (CCK) receptors' occupation in the control of somatostatin (SS) secretion in RIN-14B cells...
  2. Vainio L, Perjés A, Ryti N, Magga J, Alakoski T, Serpi R, et al. Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival. J Biol Chem. 2012;287:4572-80 pubmed publisher
    Neuronostatin, a recently discovered peptide encoded by somatostatin gene, is involved in regulation of neuronal function, blood pressure, food intake, and drinking behavior...
  3. Shimada M, Date Y, Mondal M, Toshinai K, Shimbara T, Fukunaga K, et al. Somatostatin suppresses ghrelin secretion from the rat stomach. Biochem Biophys Res Commun. 2003;302:520-5 pubmed
    ..b>Somatostatin, a peptide produced in the gastric oxyntic mucosa, is known to suppress secretion of several gastrointestinal ..
  4. Koyama M, Yin C, Ishii H, Sakuma Y, Kato M. Somatostatin inhibition of GnRH neuronal activity and the morphological relationship between GnRH and somatostatin neurons in rats. Endocrinology. 2012;153:806-14 pubmed publisher
    ..activity of GnRH neurons is regulated by a variety of bioactive substances, including the inhibitory peptide somatostatin. In the present study, we focused on somatostatin because intracerebroventricular injection of somatostatin ..
  5. Dournaud P, Boudin H, Schonbrunn A, Tannenbaum G, Beaudet A. Interrelationships between somatostatin sst2A receptors and somatostatin-containing axons in rat brain: evidence for regulation of cell surface receptors by endogenous somatostatin. J Neurosci. 1998;18:1056-71 pubmed
    Using an antipeptide antibody, we reported previously on the distribution of the somatostatin sst2A receptor subtype in rat brain...
  6. Samsam M, Covenas R, Yajeya J, Ahangari R, Narvaez J, Montes Gonzalo M, et al. [Implication of the neuropeptides methionine enkephalin, neurotensin and somatostatin of the caudal trigeminal nucleus in the experimental migraine]. Rev Neurol. 2002;34:724-9 pubmed
    ..To study whether there is or not a decrease of the immunoreactivity for methionine enkephalin, somatostatin and neurotensin in the caudal trigeminal nucleus after electrical stimulation of the trigeminal ganglion...
  7. Biemans B, Gerkema M, Van der Zee E. Increase in somatostatin immunoreactivity in the suprachiasmatic nucleus of aged Wistar rats. Brain Res. 2002;958:463-7 pubmed
    ..We compared somatostatin (SS) and substance P (SP) immunoreactivity (ir) in aged (20-26 months) and young (6 months) Wistar rats...
  8. Zaki M, Coudron P, McCuen R, Harrington L, Chu S, Schubert M. H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion. Am J Physiol Gastrointest Liver Physiol. 2013;304:G715-22 pubmed publisher
    ..cfu/ml) or spent broth alone (1:10(5) to 1:10(0) final dilution) caused a concentration-dependent increase in somatostatin (SST; maximal: 200 ± 20 and 194 ± 9% above basal; P < 0...
  9. Drexel M, Kirchmair E, Wieselthaler Hölzl A, Preidt A, Sperk G. Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy. J Neuropathol Exp Neurol. 2012;71:312-29 pubmed publisher
    ..Using immunohistochemistry and in situ hybridization for somatostatin and neuropeptide Y, we investigated plastic morphologic and neurochemical changes in parahippocampal neurons in ..

More Information

Publications62

  1. Roosterman D, Brune N, Kreuzer O, Feld M, Pauser S, Zarse K, et al. Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells. FEBS J. 2008;275:4728-39 pubmed publisher
    b>Somatostatin receptor (SSTR) endocytosis influences cellular responsiveness to agonist stimulation and somatostatin receptor scintigraphy, a common diagnostic imaging technique...
  2. Rudholm T, Wallin B, Theodorsson E, Naslund E, Hellstrom P. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 2009;152:8-12 pubmed publisher
    ..of the intestinal mucosa to acid and hyperosmolal solutions on the release of the inhibitory gut peptides somatostatin (SOM), neurotensin (NT) and vasoactive intestinal peptide (VIP) was studied in conscious rats during ..
  3. Kowiański P, Moryś J, Dziewiatkowski J, Wójcik S, Sidor Kaczmarek J, Morys J. NPY-, SOM- and VIP-containing interneurons in postnatal development of the rat claustrum. Brain Res Bull. 2008;76:565-71 pubmed publisher
    ..The postnatal development of neuropeptide Y-, somatostatin- and vasoactive intestinal polypeptide-containing interneurons was studied during the 4 postnatal months (P0-..
  4. Argos P, Taylor W, Minth C, Dixon J. Nucleotide and amino acid sequence comparisons of preprosomatostatins. J Biol Chem. 1983;258:8788-93 pubmed
    ..Although there is a considerable number of amino acid substitutions within the aligned somatostatin-14 precursors, there is a high degree of structural relatedness among them...
  5. Kiagiadaki F, Koulakis E, Thermos K. Dopamine (D1) receptor activation and nitrinergic agents influence somatostatin levels in rat retina. Exp Eye Res. 2008;86:18-24 pubmed
    b>Somatostatin (SRIF) influences the release of two important neuromodulators of retinal circuitry, dopamine (DA) and nitric oxide (NO)...
  6. Li Y. Mechanisms for regulation of gastrin and somatostatin release from isolated rat stomach during gastric distention. World J Gastroenterol. 2003;9:129-33 pubmed
    ..the distention, the axonal blocker tetrodotoxin (TTX), the cholinergic antagonist atropine, or the putative somatostatin-antagonist cyclo (7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) were applied by vascular perfusion...
  7. Takahashi M, Takeda M, Matsumoto S. Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons. Brain Res Bull. 2014;100:76-83 pubmed publisher
    ..analysis combined with anatomical approach suggests that a potential disinhibitory mechanism involving somatostatin (SST), which is released by interneurons in the superficial dorsal horn, contributes to nociceptive ..
  8. Spangelo B, Horrell S, Goodwin A, Shroff S, Jarvis W. Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells. Neuroimmunomodulation. 2004;11:332-40 pubmed
    ..second messenger lysophosphatidylcholine (LPC) in the absence or presence of the inhibitory neurotransmitters somatostatin (SRIF) or gamma-aminobutyric acid (GABA)...
  9. Xidakis C, Mastrodimou N, Notas G, Renieri E, Kolios G, Kouroumalis E, et al. RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells. Regul Pept. 2007;143:76-82 pubmed
    The present study investigated the presence of somatostatin receptor subtypes (ssts) and the endogenous peptides somatostatin and cortistatin in rat Kupffer cells, since modulation of these cells by somatostatin may be important for the ..
  10. Kumar U. Somatostatin in medium-sized aspiny interneurons of striatum is responsible for their preservation in quinolinic acid and N-methyl-D-asparate-induced neurotoxicity. J Mol Neurosci. 2008;35:345-54 pubmed publisher
    b>Somatostatin (SST) is a multifunctional peptide and involves in several neurodegenerative diseases...
  11. Goodman R, Montminy M, Low M, Habener J. Biosynthesis of rat preprosomatostatin. Adv Exp Med Biol. 1985;188:31-47 pubmed
    The biologically active forms of somatostatin, somatostatin-14 (SS-14) and somatostatin-28 (SS-28) arise by post-translational cleavage of prosomatostatin. Prosomatostatin in turn is derived from a larger precursor, preprosomatostatin...
  12. Zhang Z, Si Y, Bai L. [Effect of Bnxia Xexin Decoction and its disassembled recipes on somatostatin in rats with stress gastric ulcer]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27:916-8 pubmed
    ..with BXD and its disassembled recipes respectively to observe the therapeutic efficacy and the changes of somatostatin (SS) expression in brain and gastric tissues. In the model group, the SS expression was 0.0237 +/- 0...
  13. Kasacka I, Majewski M. An immunohistochemical study of endocrine cells in the stomach of hypertensive rats. J Physiol Pharmacol. 2007;58:469-78 pubmed
    ..The effect of spontaneous hypertension on the distribution and occurrence of somatostatin-, gastrin- and serotonin-immunoreactive cells in the fundus and pylorus of the rat stomach was examined by ..
  14. Bell D, Zhao Y, McMaster B, McHenry E, Wang X, Kelso E, et al. SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes. Cell Physiol Biochem. 2008;22:653-64 pubmed publisher
    b>Somatostatin-14 (SRIF-14), a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts both positive and negative influences directly on contraction of ventricular cardiomyocytes, indicative of ..
  15. Butler R, White L, Frederick Duus D, Kaigler K, Fadel J, Wilson M. Comparison of the activation of somatostatin- and neuropeptide Y-containing neuronal populations of the rat amygdala following two different anxiogenic stressors. Exp Neurol. 2012;238:52-63 pubmed publisher
    ..of the brains were prepared for dual-labeled immunohistochemistry and counts of c-Fos co-localized with somatostatin (SOM) or neuropeptide Y (NPY) were made in the basolateral (BLA), central (CEA), medial (MEA) nuclei of the ..
  16. Dello Russo C, Lisi L, Navarra P, Tringali G. Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes. J Neuroimmunol. 2009;213:78-83 pubmed publisher
    Here we compared the effects of cortistatin and somatostatin on the production of prostanoids from primary cultures of rat cortical microglia and astrocytes...
  17. Richardson R, Grkovic I, Anderson C. Cocaine- and amphetamine-related transcript peptide and somatostatin in rat intracardiac ganglia. Cell Tissue Res. 2006;324:17-24 pubmed
    The distribution of somatostatin and cocaine and amphetamine-regulated transcript (CART) was investigated in rat intracardiac ganglia...
  18. Kido T, Sumii K, Kawano M, Sumii M, Yoshihara M, Chayama K. Food deprivation enhances somatostatin and somatostatin receptor subtype expression in rat colon. Regul Pept. 2003;114:167-73 pubmed
    b>Somatostatin, a peptide distributed widely throughout the gut, inhibits a variety of gastrointestinal functions. We previously reported that fasting for 48 h increased gastric somatostatin peptide and mRNA content...
  19. Yosten G, Samson W. The melanocortins, not oxytocin, mediate the anorexigenic and antidipsogenic effects of neuronostatin. Peptides. 2010;31:1711-4 pubmed publisher
    Neuronostatin, a recently discovered peptide derived from the somatostatin preprohormone, significantly inhibited both food and water intake when administered centrally in adult male rats...
  20. Morishita M, Iwasaki Y, Onishi A, Asai M, Mutsuga N, Yoshida M, et al. The effects of GH-releasing hormone/somatostatin on the 5'-promoter activity of the GH gene in vitro. J Mol Endocrinol. 2003;31:441-8 pubmed
    The two hypothalamic hormones, GH-releasing hormone (GHRH) and somatostatin (SRIF), are known to regulate GH secretion...
  21. Zhao P, Canals M, Murphy J, Klingler D, Eriksson E, Pelayo J, et al. Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons. J Biol Chem. 2013;288:25689-700 pubmed publisher
    b>Somatostatin (SST) 14 and SST 28 activate somatostatin 2A receptors (SSTR2A) on enteric neurons to control gut functions...
  22. Yacubova E, Komuro H. Stage-specific control of neuronal migration by somatostatin. Nature. 2002;415:77-81 pubmed
    Developing neurons transiently express somatostatin and its receptors, but little is known about their function at these early stages...
  23. Baude A, Bleasdale C, Dalezios Y, Somogyi P, Klausberger T. Immunoreactivity for the GABAA receptor alpha1 subunit, somatostatin and Connexin36 distinguishes axoaxonic, basket, and bistratified interneurons of the rat hippocampus. Cereb Cortex. 2007;17:2094-107 pubmed
    ..experiments were consistent with the finding that only bistratified cells express the neuropeptide somatostatin. From the molecular profiles, we estimate that basket, bistratified, and axoaxonic cells represent about 60%, ..
  24. Naslund E, Skogar S, Efendic S, Hellstrom P. Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Regul Pept. 2002;106:89-95 pubmed
    ..The aim of the study is to assess the effect of LY315902 on fasting gastrointestinal motility, somatostatin and insulin release...
  25. Zou S, Kumar U. Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus. Brain Res. 2015;1622:114-26 pubmed publisher
    b>Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in different parts of the brain and functions as a neurotransmitter and neuromodulator...
  26. Seoane L, Al Massadi O, Barreiro F, Dieguez C, Casanueva F. Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system. J Endocrinol Invest. 2007;30:RC22-5 pubmed
    ..These results would confirm the capacity of GH and SS to act directly upon gastric level, inhibiting ghrelin secretion in vitro. ..
  27. Gower W, McCuen R, Arimura A, Coy D, Dietz J, Landon C, et al. Reciprocal paracrine pathways link atrial natriuretic peptide and somatostatin secretion in the antrum of the stomach. Regul Pept. 2003;110:101-6 pubmed
    ..superfused antral mucosal segments obtained from rat stomach to examine the paracrine pathways linking ANP and somatostatin secretion in this region.ANP (0.1 pM to 0...
  28. Dror N, Tveria L, Meniv I, Ben Shmuel S, Filipovich T, Fleisher Berkovich S. Inhibitory effect of somatostatin on prostaglandin E2 synthesis by primary neonatal rat glial cells. Regul Pept. 2008;150:21-5 pubmed publisher
    Glial inflammation plays an integral role in the development of neurodegenerative disease. Although somatostatin is known to be a local anti-inflammatory factor in the periphery, evidence of a similar function in the brain is scarce...
  29. Jovanović A, Babović S, Damjanovic A, Puskas L, Lazić D, Cvetić T, et al. The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia. Coll Antropol. 2013;37:847-52 pubmed
    ..this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia...
  30. Wang J, Guo Y, Cao D, Luo R, Ma S, Wang H, et al. Tonic inhibition of somatostatin on C and Adelta afferent fibers in rat dorsal skin in vivo. Brain Res. 2009;1288:50-9 pubmed publisher
    The purpose of this study was to investigate the effect of somatostatin (SST) in peripheral nerve terminals using local application of the SST receptor (SSTR) antagonist cyclo-somatostatin (c-SOM) injected into the receptive fields of ..
  31. Li Y, Li X, Hua Guo -, Xu J, Zhang X, Li L, et al. Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats. Eur J Pharmacol. 2011;656:94-100 pubmed publisher
    ..receptor 3 in the submucosal plexus suppresses 5-HT-induced colonic ion secretion by increasing submucosal somatostatin release...
  32. Billova S, Galanopoulou A, Seidah N, Qiu X, Kumar U. Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain. Neuroscience. 2007;147:403-18 pubmed
    ..CPE), prohormone convertase 1 (PC1) and prohormone convertase 2 (PC2) may function as sorting elements for somatostatin (SST) for its maturation and processing to appropriate targets...
  33. Muroyama A, Uehara S, Yatsushiro S, Echigo N, Morimoto R, Morita M, et al. A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans. Diabetes. 2004;53:1743-53 pubmed
    ..b>Somatostatin from delta-cells, considered a local inhibitor of islet function, reduces insulin and glucagon secretion by ..
  34. Li D, Cai W, Li X, Niu D, Duan J. [Changes of encephalic contents of neuropeptides in rats with vascular dementia]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37:468-71 pubmed
    To investigate the changes of encephalic contents of somatostatin (SS) and arginine vasopressin (AVP) in rats with vascular dementia...
  35. Goodman R, Aron D, Roos B. Rat pre-prosomatostatin. Structure and processing by microsomal membranes. J Biol Chem. 1983;258:5570-3 pubmed
    The tetradecapeptide hormone somatostatin arises from proteolytic processing of a large precursor, pre-prosomatostatin...
  36. Montminy M, Goodman R, Horovitch S, Habener J. Primary structure of the gene encoding rat preprosomatostatin. Proc Natl Acad Sci U S A. 1984;81:3337-40 pubmed
    ..derived from a rat medullary thyroid carcinoma that encoded preprosomatostatin , a 116-amino-acid precursor of somatostatin. We now report the structural characterization of the rat somatostatin gene isolated from recombinant ..
  37. Kramer D, Caruso A, Nicoletti F, Genazzani A. Somatostatin and the somatostatin receptor 2 are reciprocally controlled by calcineurin during cerebellar granule cell maturation. J Neurochem. 2005;94:1374-83 pubmed
    ..In this study, we investigated whether an important mediator of neuronal migration, somatostatin (Srif), alongside its receptors, is controlled in this manner in cerebellar granule cells...
  38. Elrick M, Samson W, Corbett J, Salvatori A, Stein L, Kolar G, et al. Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells. Am J Physiol Regul Integr Comp Physiol. 2016;310:R143-55 pubmed publisher
    Neuronostatin (NST) is a recently described peptide that is produced from the somatostatin preprohormone in pancreatic δ-cells...
  39. Van Vugt H, Van de Heijning B, van der Beek E. Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids. Exp Brain Res. 2008;188:483-91 pubmed publisher
    ..in growth hormone release is driven by sex steroids, and is suggested to result mainly from differences in somatostatin (SOM) release patterns from the median eminence...
  40. Benoit R, Ling N, Esch F. A new prosomatostatin-derived peptide reveals a pattern for prohormone cleavage at monobasic sites. Science. 1987;238:1126-9 pubmed
    Cleavage of the peptide bonds of preprosomatostatin at basic residues near the carboxyl terminus yields somatostatin-14, somatostatin-28, and somatostatin-28 (1-12)...
  41. Pallis E, Vasilaki A, Fehlmann D, Kastellakis A, Hoyer D, Spyraki C, et al. Antidepressants influence somatostatin levels and receptor pharmacology in brain. Neuropsychopharmacology. 2009;34:952-63 pubmed publisher
    ..administration (acute and chronic) of the antidepressants citalopram and desmethylimipramine (DMI) influences somatostatin (somatotropin release inhibitory factor, SRIF) levels and SRIF receptor density (sst(1-5)) in rat brain...
  42. Guo X, Tan M, Xiong A, Guo L. [Effect of rheum on gastrointestinal hormones in rats with severe scald injury]. Zhonghua Shao Shang Za Zhi. 2008;24:111-3 pubmed
    To observe the changes in motilin (MTL), substance P (SP), vasoactive intestinal peptide (VIP) and somatostatin (SS) in plasma of rats with severe scald injury at early stage and the effect of rheum on their changes...
  43. Egido E, Hernandez R, Marco J, Silvestre R. Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas. Regul Pept. 2009;152:61-6 pubmed publisher
    ..Obestatin failed to significantly modify the glucagon and somatostatin responses to arginine, indicating that its stimulation of insulin output is not mediated by an alpha- or delta-..
  44. Salehi A, Qader S, Grapengiesser E, Hellman B. Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon. Regul Pept. 2007;144:43-9 pubmed
    It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon...
  45. Wei X, Zhao Y, Wong Riley M, Ju G, Liu Y. Synaptic relationship between somatostatin- and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats. J Neurochem. 2012;122:923-33 pubmed publisher
    ..b>Somatostatin (SST) and neurokinin 1 receptor (NK1R) immunoreactivity have been used as markers of the pre-BötC...
  46. Seredycz L, Lautt W. Hemorrhage results in hepatic insulin-sensitizing substance-dependent insulin resistance mediated by somatostatin in rats. Neuroendocrinology. 2006;84:94-102 pubmed
    ..Neither intervention was effective (32 +/- 6 and 36 +/- 3%, respectively). Exogenous somatostatin was shown to produce HDIR that could be blocked by the somatostatin receptor antagonist, cyclosomatostatin...
  47. Sun F, Dan H, Song Y, Cheng W. Effect of high temperature on gastrin, somatostatin and motilin production in ulcerous gastric antral mucosa of rats. Di Yi Jun Yi Da Xue Xue Bao. 2002;22:605-7 pubmed
    To investigate the changes of gastrin, somatostatin and motilin production in the gastric antral mucosa of rats with experimental gastric ulcer...
  48. Nakatsuka T, Fujita T, Inoue K, Kumamoto E. Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin. J Physiol. 2008;586:2511-22 pubmed publisher
    ..b>Somatostatin produced an outward current in a subpopulation of SG neurones and the slow IPSC was occluded during the ..
  49. Kumar U. Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus. J Comp Neurol. 2007;504:185-205 pubmed
    The hypothalamus is a major site of somatostatin (SST) production and action. SST is synthesized in several hypothalamic nuclei and involved in a variety of functions...
  50. Orikasa C, Kondo Y, Sakuma Y. Transient transcription of the somatostatin gene at the time of estrogen-dependent organization of the sexually dimorphic nucleus of the rat preoptic area. Endocrinology. 2007;148:1144-9 pubmed
    In situ hybridization detected a transient, sex-specific transcription of somatostatin gene in the central part of the rat medial preoptic nucleus, which coincides with the sexually dimorphic nucleus of the preoptic area (SDN-POA), during,..
  51. Lorber M. Somatostatin-like immunoreactivity (SLIR) in rat harderian and meibomian glands and glands of Zeis. Adv Exp Med Biol. 2002;506:81-9 pubmed
  52. Tavianini M, Hayes T, Magazin M, Minth C, Dixon J. Isolation, characterization, and DNA sequence of the rat somatostatin gene. J Biol Chem. 1984;259:11798-803 pubmed
    The gene encoding rat somatostatin has been isolated from a lambda phage gene library. Phage harboring the gene were identified by plaque hybridization using a nick-translated fragment derived from the cDNA for rat somatostatin...
  53. Goodman R, Jacobs J, Dee P, Habener J. Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma. J Biol Chem. 1982;257:1156-9 pubmed
    ..a hybridization probe encoding an anglerfish islet pre-prosomatostatin, a precursor of the tetradecapeptide somatostatin, we have identified and isolated a clone containing a 400-base pair complementary DNA encoding most of the rat ..