Gene Symbol: SSAT
Description: spermidine/spermine N1-acetyl transferase 1
Alias: Ab2-402, SSAT, Sat, diamine acetyltransferase 1, Spermidine / spermine N1-acyltransferase (diamine acetyltransferase), diamine N-acetyltransferase 1
Nagesh Babu G, Sailor K, Sun D, Dempsey R. Spermidine/spermine N1-acetyl transferase activity in rat brain following transient focal cerebral ischemia and reperfusion. Neurosci Lett. 2001;300:17-20 pubmed
..Spermidine/Spermine N(1)-acetyl transferase (SSAT) is the key enzyme responsible for interconversion of spermine and spermidine to spermidine and putrescine ..
Blot A, Billups D, Bjørkmo M, Quazi A, Uwechue N, Chaudhry F, et al
. Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons. Neuroscience. 2009;164:998-1008 pubmed publisher
Ferioli M, Berselli D, Caimi S. Effect of mitoguazone on polyamine oxidase activity in rat liver. Toxicol Appl Pharmacol. 2004;201:105-11 pubmed
..Therefore, we hypothesized that the enzyme involved in mitoguazone response of the liver is the polyamine oxidase, which acts on acetylated polyamines as substrate. ..
Bewley M, Graziano V, Jiang J, Matz E, Studier F, Pegg A, et al
. Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc Natl Acad Sci U S A. 2006;103:2063-8 pubmed
Spermidine/spermine N1-acetyltransferase (SSAT) is a key enzyme in the control of polyamine levels in human cells, as acetylation of spermidine and spermine triggers export or degradation...
Krick W, Schnedler N, Burckhardt G, Burckhardt B. Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions. Am J Physiol Renal Physiol. 2009;297:F145-54 pubmed publisher
..the sodium-dependent sulfate transporter, NaSi-1, located at the apical membrane, and the sulfate-anion exchanger, sat-1, located at the basolateral membrane...
Tucker J, Murphy J, Kisiel N, Diegelman P, Barbour K, Davis C, et al
. Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res. 2005;65:5390-8 pubmed
..showed that activation of polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase-1 (SSAT) suppresses tumor outgrowth in a mouse prostate cancer model...
Semenza G. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda). 2009;24:97-106 pubmed publisher
..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively. ..
Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..
Wang Z, Zahedi K, Barone S, Tehrani K, Rabb H, Matlin K, et al
. Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. J Am Soc Nephrol. 2004;15:1844-52 pubmed
To ascertain the role of spermidine/spermine N-1-acetyl-transferase (SSAT; the rate-limiting enzyme in polyamine catabolism) in cell injury, cultured kidney (HEK 293) cells conditionally overexpressing SSAT were generated...