Gene Symbol: SSAT
Description: spermidine/spermine N1-acetyl transferase 1
Alias: Ab2-402, SSAT, Sat, diamine acetyltransferase 1, Spermidine / spermine N1-acyltransferase (diamine acetyltransferase), diamine N-acetyltransferase 1
Species: rat
Products:     SSAT

Top Publications

  1. Nagesh Babu G, Sailor K, Sun D, Dempsey R. Spermidine/spermine N1-acetyl transferase activity in rat brain following transient focal cerebral ischemia and reperfusion. Neurosci Lett. 2001;300:17-20 pubmed
    ..Spermidine/Spermine N(1)-acetyl transferase (SSAT) is the key enzyme responsible for interconversion of spermine and spermidine to spermidine and putrescine ..
  2. Blot A, Billups D, Bjørkmo M, Quazi A, Uwechue N, Chaudhry F, et al. Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons. Neuroscience. 2009;164:998-1008 pubmed publisher
  3. Ferioli M, Berselli D, Caimi S. Effect of mitoguazone on polyamine oxidase activity in rat liver. Toxicol Appl Pharmacol. 2004;201:105-11 pubmed
    ..Therefore, we hypothesized that the enzyme involved in mitoguazone response of the liver is the polyamine oxidase, which acts on acetylated polyamines as substrate. ..
  4. Bewley M, Graziano V, Jiang J, Matz E, Studier F, Pegg A, et al. Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc Natl Acad Sci U S A. 2006;103:2063-8 pubmed
    Spermidine/spermine N1-acetyltransferase (SSAT) is a key enzyme in the control of polyamine levels in human cells, as acetylation of spermidine and spermine triggers export or degradation...
  5. Krick W, Schnedler N, Burckhardt G, Burckhardt B. Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions. Am J Physiol Renal Physiol. 2009;297:F145-54 pubmed publisher
    ..the sodium-dependent sulfate transporter, NaSi-1, located at the apical membrane, and the sulfate-anion exchanger, sat-1, located at the basolateral membrane...
  6. Tucker J, Murphy J, Kisiel N, Diegelman P, Barbour K, Davis C, et al. Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res. 2005;65:5390-8 pubmed
    ..showed that activation of polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase-1 (SSAT) suppresses tumor outgrowth in a mouse prostate cancer model...
  7. Semenza G. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda). 2009;24:97-106 pubmed publisher
    ..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively. ..
  8. Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
    ..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..
  9. Wang Z, Zahedi K, Barone S, Tehrani K, Rabb H, Matlin K, et al. Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. J Am Soc Nephrol. 2004;15:1844-52 pubmed
    To ascertain the role of spermidine/spermine N-1-acetyl-transferase (SSAT; the rate-limiting enzyme in polyamine catabolism) in cell injury, cultured kidney (HEK 293) cells conditionally overexpressing SSAT were generated...

More Information


  1. Berger F, Kramer D, Porter C. Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem Soc Trans. 2007;35:336-9 pubmed
    ..In particular, the polyamine catabolic enzyme SSAT (spermidine/spermine N(1)-acetyltransferase) seems to have different roles in tumorigenesis, depending upon the ..
  2. Ryu J, Cho Y, Chun Y, Park J. Myocardial SSAT induction via AMPK signaling and its implication for ischemic injury. Biochem Biophys Res Commun. 2008;366:438-44 pubmed
    Spermidine/spermine N-1-acetyl-transferase (SSAT) is a catabolic enzyme that participates in polyamine metabolism...
  3. Eloranta T, Khomutov A, Khomutov R, Hyvonen T. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. J Biochem. 1990;108:593-8 pubmed
    ..The results suggest that compounds of this type are valuable tools in unraveling the physiology of polyamines. ..
  4. Aitkenhead M, Wang S, Nakatsu M, Mestas J, Heard C, Hughes C. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc Res. 2002;63:159-71 pubmed
    ..These data expand the suite of genes implicated in vascular remodeling and angiogenesis. ..