Gene Symbol: Srpk1
Description: SRSF protein kinase 1
Alias: SRSF protein kinase 1, SFRS protein kinase 1, serine/arginine-rich protein specific kinase 1, serine/threonine-protein kinase SRPK1
Gui J, Lane W, Fu X. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369:678-82 pubmed
..We have now identified and cloned a kinase, SRPK1, which is regulated by the cell cycle and is specific for SR proteins; this kinase is related to a Caenorhabditis ..
Nikolakaki E, Kohen R, Hartmann A, Stamm S, Georgatsou E, Giannakouros T. Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B. J Biol Chem. 2001;276:40175-82 pubmed
..Human SRPK1, which was first identified as a kinase specific for the SR family of splicing factors, is located on chromosome ..
Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M. Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem Biophys Res Commun. 1998;242:357-64 pubmed
SR-protein-specific kinase 1 (SRPK1) is first identified as a specific kinase for SR splicing factors. By RT-PCR of a conserved kinase domain, novel SR-protein-specific kinase clones were isolated from mouse brain...
Tronchere H, Wang J, Fu X. A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. Nature. 1997;388:397-400 pubmed
..Therefore, Urp and U2AF35 may independently position RS-domain-containing factors within spliceosomes. ..
Kamachi M, Le T, Kim S, Geiger M, Anderson P, Utz P. Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. J Exp Med. 2002;196:1213-25 pubmed
..phosphorylation of serine residues by at least eight different SR protein kinase kinases (SRPKs), including SRPK1, SRPK2, and the scleroderma autoantigen topoisomerase I...
Lee C, Hague L, Li H, Donnelly R. Identification of toposome, a novel multisubunit complex containing topoisomerase IIalpha. Cell Cycle. 2004;3:638-47 pubmed
..containing two ATPase/helicase proteins (RNA helicase A and RHII/Gu), one serine/threonine protein kinase (SRPK1), one HMG protein (SSRP1), and two pre-mRNA splicing factors (PRP8 and hnRNP C)...
Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka Fujita M, Nishimura Sakurai Y, et al
. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 2010;54:3179-86 pubmed publisher
..Overexpression of SRPK1 or SRPK2 resulted in augmentation of HCV replication, while small interfering RNA (siRNA) knockdown of the SRPKs ..