Gene Symbol: Srp68
Description: signal recognition particle 68
Alias: signal recognition particle 68 kDa protein
Species: rat
Products:     Srp68

Top Publications

  1. Menichelli E, Isel C, Oubridge C, Nagai K. Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. J Mol Biol. 2007;367:187-203 pubmed
    ..The S domain of SRP is composed of roughly half of the 7SL RNA and four proteins (SRP19, SRP54, and the SRP68/72 heterodimer)...
  2. Yoshida M, Kabe Y, Wada T, Asai A, Handa H. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008;73:987-94 pubmed
    ..This provides new insights into the mechanism underlying the effects of chemotherapies comprising TAS-103 and demonstrates the usefulness of the affinity beads. ..
  3. Becker M, Lapouge K, Segnitz B, Wild K, Sinning I. Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Nucleic Acids Res. 2017;45:470-481 pubmed publisher
    ..The two largest proteins SRP68 and SRP72 form a heterodimer and bind to a regulatory site of the SRP RNA...