Gene Symbol: Srm
Description: spermidine synthase
Alias: spermidine synthase
Dejima H, Kobayashi M, Takasaki H, Takeda N, Shirahata A, Samejima K. Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for aminopropyl transferases. Biol Pharm Bull. 2003;26:1005-8 pubmed
..configuration of S and R at the sulfonium center, was evaluated as a substrate for the measurement of spermidine synthase activity...
Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..
Krauss M, Langnaese K, Richter K, Brunk I, Wieske M, Ahnert Hilger G, et al
. Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment. J Neurochem. 2006;97:174-89 pubmed
..They are synthesized by a set of specific enzymes in which spermidine synthase is the rate-limiting step catalysing the formation of the spermine precursor spermidine from putrescine...
Lu S, Mato J. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012;92:1515-42 pubmed publisher
..In experimental models, it is effective as a chemopreventive agent in HCC and perhaps other forms of cancer as well. ..
Shirahata A, Takahashi N, Beppu T, Hosoda H, Samejima K. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Biochem Pharmacol. 1993;45:1897-903 pubmed
..4MCHA) and N-(3-aminopropyl)cyclohexylamine (APCHA), selectively and potently inhibited the activities of spermidine synthase and spermine synthase, respectively. They were subjected to in vivo studies using rats...
Sano M, Nishino I. Assay for spermidine synthase activity by micellar electrokinetic chromatography with laser-induced fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;845:80-3 pubmed
An assay for spermidine synthase (SPDS) activity in rat liver has been developed using micellar electrokinetic chromatography (MEKC) with laser-induced fluorescence (LIF) detection to enable the discovery of SPDS inhibitors...
Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, et al
. Structure and mechanism of spermidine synthases. Biochemistry. 2007;46:8331-9 pubmed
..Structural and biochemical studies have been carried out with the human spermidine synthase, which is highly specific for putrescine as the amine acceptor, and the Thermotoga maritima spermidine ..
Eloranta T, Khomutov A, Khomutov R, Hyvonen T. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. J Biochem. 1990;108:593-8 pubmed
..Neither drug had any significant effect at 1 mM concentration on the activities of spermidine synthase, methionine adenosyltransferase, S-adenosylhomocysteine hydrolase, and methylthioadenosine phosphorylase...