Srd5a1

Summary

Gene Symbol: Srd5a1
Description: steroid 5 alpha-reductase 1
Alias: S5AR 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 1, SR type 1, steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Species: rat

Top Publications

  1. ncbi Distribution of rat hepatic steroid 5 alpha-reductase 1 as shown by immunohistochemistry
    W Eicheler
    Philipps University Marburg, Department of Anatomy and Cell Biology, Germany
    Exp Clin Endocrinol Diabetes 103:105-12. 1995
  2. doi Environmental enrichment attenuates the age-related decline in the mRNA expression of steroidogenic enzymes and reduces the methylation state of the steroid 5α-reductase type 1 gene in the rat hippocampus
    María F Rossetti
    Departamento de Bioquímica Clínica y Cuantitativa, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina Instituto de Salud y Ambiente del Litoral ISAL, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral CONICET, Santa Fe, Argentina
    Mol Cell Endocrinol 412:330-8. 2015
  3. ncbi Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord
    Christine Patte-Mensah
    Laboratoire de Neurophysiologie Cellulaire et Intégrée, Unité Mixte de Recherche 7519 Centre National de la Recherche Scientifique, Universite Louis Pasteur, 67084 Strasbourg, France
    J Comp Neurol 477:286-99. 2004
  4. doi 5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents
    Dawn E W Livingstone
    University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, U K
    Diabetes 64:447-58. 2015
  5. pmc Bisphenol A exposure during adulthood alters expression of aromatase and 5α-reductase isozymes in rat prostate
    Beatriz Castro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Granada, Granada, Spain
    PLoS ONE 8:e55905. 2013
  6. doi Expression of steroid 5α-reductase isozymes in prostate of adult rats after environmental stress
    Pilar Sanchez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
    FEBS J 280:93-101. 2013
  7. doi Steroid 5α-reductase in adult rat brain after neonatal testosterone administration
    Pilar Sanchez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
    IUBMB Life 64:81-6. 2012
  8. ncbi Influence of 17beta-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): possible relevance to mental disorders in women
    Rachel Maayan
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    Brain Res 1020:167-72. 2004
  9. ncbi Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Brain Res Mol Brain Res 139:193-200. 2005
  10. ncbi Steroid 5alpha-reductase isozymes in the adult female rat brain: central role of dihydrotestosterone
    J M Torres
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Avda de Madrid s n, 18012 Granada, Spain
    J Mol Endocrinol 36:239-45. 2006

Research Grants

  1. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006

Scientific Experts

  • Rachel Maayan
  • Dawn E W Livingstone
  • M Mar Romero
  • K Wako
  • Shuya Noguchi
  • Y Tsuruo
  • Kyoji Morita
  • A K Bhattacharyya
  • Dóra Ondré
  • Fabio Celotti
  • Roland H Stimson
  • WALTER MILLER
  • A Poletti
  • Michael J Lewis
  • M Klotsman
  • Pilar Sanchez
  • Esperanza Ortega
  • Raimundo G del Moral
  • Jesus M Torres
  • Beatriz Castro
  • Song Her
  • J M Torres
  • María F Rossetti
  • Alexandra Fischer
  • Pradeep P Kayampilly
  • Jaganathan Anbalagan
  • Tae Sung Kim
  • Katsuji Aizawa
  • M Szécsi
  • Marco Bortolato
  • P Sanchez
  • Pablo Vílchez
  • T C Shao
  • E Ortega
  • Yi Xu
  • A Colciago
  • Mostafa K El-Awady
  • B C J van der Eerden
  • Christine Patte-Mensah
  • K Pratis
  • Jessica Killian
  • Enrique H Luque
  • Guillermo S Moreno-Piovano
  • Jorgelina Varayoud
  • Jorge G Ramos
  • Thomas Thum
  • M F Taylor
  • Ovidiu Preda
  • Asunción Olmo
  • Juan De Dios Luna
  • J D Stuart
  • J Wolfling
  • Sonja Gaedicke
  • Arokya Mary Sashi
  • K M J Menon
  • Byung Mu Lee
  • Takashi Ushida
  • Frank Döring
  • Seiji Maeda
  • J Julesz
  • Ki Kyung Jung
  • Soon Sun Kim
  • Ganapathy Vengatesh
  • Jin Tae Hong
  • Jan Frank
  • I Toth
  • Hyung Sik Kim
  • Soon Young Han
  • Motoyuki Iemitsu
  • Michael Mariajoseph Aruldhas
  • Koji Sato
  • S Magony
  • Jone Arulrajadurai Stanley
  • Il Hyun Kang
  • Takayuki Akimoto
  • Soon Keun Hong
  • Noboru Mesaki
  • Takeshi Otsuki
  • James A Stewart
  • Gy Schneider
  • Ki Wan Oh
  • Hye Seon Nam
  • Ramalingam Neelamohan
  • Jung Hee Baek
  • Brett L Wanamaker
  • Tae Seok Kang
  • Gerald Rimbach
  • Mi Sook Lee
  • Carrie L Wagner
  • H Tian

Detail Information

Publications54

  1. ncbi Distribution of rat hepatic steroid 5 alpha-reductase 1 as shown by immunohistochemistry
    W Eicheler
    Philipps University Marburg, Department of Anatomy and Cell Biology, Germany
    Exp Clin Endocrinol Diabetes 103:105-12. 1995
    ..After androgen-deprivation a considerable increase in immunoreactivity was seen in male rat liver cells, indicating androgen-dependent suppression of the enzyme in male liver...
  2. doi Environmental enrichment attenuates the age-related decline in the mRNA expression of steroidogenic enzymes and reduces the methylation state of the steroid 5α-reductase type 1 gene in the rat hippocampus
    María F Rossetti
    Departamento de Bioquímica Clínica y Cuantitativa, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Santa Fe, Argentina Instituto de Salud y Ambiente del Litoral ISAL, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral CONICET, Santa Fe, Argentina
    Mol Cell Endocrinol 412:330-8. 2015
    ..Thus, sensory and social stimulation attenuate the age-related decline in the mRNA expression of hippocampal steroidogenic enzymes. Epigenetic mechanisms associated with differential promoter methylation could be involved. ..
  3. ncbi Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord
    Christine Patte-Mensah
    Laboratoire de Neurophysiologie Cellulaire et Intégrée, Unité Mixte de Recherche 7519 Centre National de la Recherche Scientifique, Universite Louis Pasteur, 67084 Strasbourg, France
    J Comp Neurol 477:286-99. 2004
    ..These results are the first demonstrating that oligodendrocytes and neurons of the SC possess the key enzymatic complex for synthesizing potent neuroactive steroids that may control spinal sensorimotor processes...
  4. doi 5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents
    Dawn E W Livingstone
    University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, U K
    Diabetes 64:447-58. 2015
    ..Variations in 5αR1 activity in obesity and with nonselective 5α-reductase inhibition in men with prostate disease may have important consequences for the onset and progression of metabolic liver disease. ..
  5. pmc Bisphenol A exposure during adulthood alters expression of aromatase and 5α-reductase isozymes in rat prostate
    Beatriz Castro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Granada, Granada, Spain
    PLoS ONE 8:e55905. 2013
    ..Our results may offer new insights into the role of BPA in the development of prostate disease and may be of great value for studying the prostate disease risk associated with exposure to BPA in adulthood...
  6. doi Expression of steroid 5α-reductase isozymes in prostate of adult rats after environmental stress
    Pilar Sanchez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
    FEBS J 280:93-101. 2013
    ..Further research is warranted to explore these effects of environmental stress on human health and their implications for environmental and occupational health policies...
  7. doi Steroid 5α-reductase in adult rat brain after neonatal testosterone administration
    Pilar Sanchez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
    IUBMB Life 64:81-6. 2012
    ....
  8. ncbi Influence of 17beta-estradiol on the synthesis of reduced neurosteroids in the brain (in vivo) and in glioma cells (in vitro): possible relevance to mental disorders in women
    Rachel Maayan
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    Brain Res 1020:167-72. 2004
    ..This process may be relevant to psychopathological disorders that are ascribed to drastic alterations in estrogen levels, such as premenstrual syndrome, pregnancy-related mental disorders, and postpartum "blues"...
  9. ncbi Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1
    Kyoji Morita
    Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Brain Res Mol Brain Res 139:193-200. 2005
    ....
  10. ncbi Steroid 5alpha-reductase isozymes in the adult female rat brain: central role of dihydrotestosterone
    J M Torres
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Avda de Madrid s n, 18012 Granada, Spain
    J Mol Endocrinol 36:239-45. 2006
    ..These results open up a new research line that may lead to a better understanding of the physiology of the CNS...
  11. ncbi Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    Yi Xu
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:4072-9. 2006
    ..e., SRD5A1 and SRD5A2)...
  12. ncbi Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer
    T C Shao
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Urol 178:1521-7. 2007
    ..We evaluated the effects of dutasteride for preventing or delaying prostate growth and neoplastic changes in a transgenic model of prostate cancer...
  13. ncbi Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer
    K Wako
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Pathol 61:448-54. 2008
    ..The association between the expression of androgen receptor (AR) or androgen-converting enzymes and malignant potential in prostate cancer (PCa) was examined...
  14. ncbi Effects of swim stress on mRNA and protein levels of steroid 5alpha-reductase isozymes in prefrontal cortex of adult male rats
    P Sanchez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Granada, Spain
    Neurochem Int 52:426-31. 2008
    ..These data may open up a new research line that could improve our understanding of the role of 5alpha-R isozymes in processes that accompany stress situations...
  15. ncbi Adrenocortical insufficiency in Otsuka Long-Evans Tokushima Fatty rats, a type 2 diabetes mellitus model
    Shuya Noguchi
    Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osakasayama, Osaka 589 8511, Japan
    Metabolism 56:1326-33. 2007
    ..We showed that adrenocortical insufficiency and adrenal atrophy were acquired in OLETF rats, and the possibility of elevated serum leptin relates to this phenomenon...
  16. ncbi Effects of sulpiride on prolactin and mRNA levels of steroid 5alpha-reductase isozymes in adult rat brain
    Pilar Sanchez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, School of Medicine, University of Granada, Avda de Madrid s n, 18012 Granada, Spain
    Neurochem Res 33:820-5. 2008
    ..Since 3alpha,5alpha-reduced neurosteroids and PRL exert anxiolytic effects in response to stress, these molecules and 5alpha-R may possibly participate in a common pathway of significant adaptation to stress situations...
  17. doi Antipsychotic-like properties of 5-alpha-reductase inhibitors
    Marco Bortolato
    Department of Neuroscience Bernard B Brodie, University of Cagliari, Monserrato, Cagliari, Italy
    Neuropsychopharmacology 33:3146-56. 2008
    ..p.) induced no catalepsy in either the bar test or the paw test. Our results suggest that 5AR inhibitors elicit antipsychotic-like effects in animals and may be proposed as a putative novel target in the management of psychotic disorders...
  18. doi Effects of sulpiride on mRNA levels of steroid 5alpha-reductase isozymes in prostate of adult rats
    Pilar Sanchez
    Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
    IUBMB Life 60:68-72. 2008
    ..Although a direct effect of sulpiride on prostate gland cannot be ruled out, hyperprolactinemia may be a factor to be considered in aging males, in whom prostatic diseases such as BPH and PCa are more frequent...
  19. doi Androgen synthesis in adrenarche
    Walter L Miller
    Department of Pediatrics, University of California, Room 672 S, San Francisco, CA 94143 0978, USA
    Rev Endocr Metab Disord 10:3-17. 2009
    ....
  20. doi Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors
    Song Her
    Division of Bio Imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, 200 701, South Korea
    J Mol Neurosci 41:252-62. 2010
    ..Thus, both Sp1 and Sp3 are considered to play a physiological role in the regulation of 5alpha-R gene expression, and hence the production of 5alpha-reduced neurosteroids in glial cells...
  21. doi Oleoyl-estrone increases adrenal corticosteroid synthesis gene expression in overweight male rats
    Maria Del Mar Romero
    Department of Nutrition and Food Science, Faculty of Biology, University of Barcelona, Av Diagonal, 645, 08028 Barcelona, Spain
    Steroids 75:20-6. 2010
    ..e. serum turnover), a process not driven by limited energy availability but directly related to the administration of OE...
  22. doi Acute exercise activates local bioactive androgen metabolism in skeletal muscle
    Katsuji Aizawa
    Laboratory of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Steroids 75:219-23. 2010
    ..Finally, the expression of AR was significantly higher in female rats, but not in males after the exercise. These data suggest that acute exercise enhances the local bioactive androgen metabolism in the skeletal muscle of both sexes...
  23. pmc Effects of proportions of dietary macronutrients on glucocorticoid metabolism in diet-induced obesity in rats
    Roland H Stimson
    Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e8779. 2010
    ....
  24. doi Mechanism underlying transient gestational-onset hypothyroidism-induced impairment of posttesticular sperm maturation in adult rats
    Jaganathan Anbalagan
    Department of Endocrinology, Dr A L Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India
    Fertil Steril 93:2491-7. 2010
    ..To understand the mechanism underlying gestational-onset hypothyroidism-induced male infertility...
  25. doi Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver
    Alexandra Fischer
    Molecular Prevention Group, Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Heinrich Hecht Platz 10, 24118 Kiel, Germany
    Br J Nutr 104:935-40. 2010
    ..Two enzymes, 5-α-steroid reductase type 1 (SRD5A1) and the regulatory subunit of γ-glutamylcysteinyl synthetase (GCLM), which are differentially expressed on the ..
  26. doi Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
    M Szécsi
    1st Department of Medicine, University of Szeged, 8 10 H 6720 Szeged, Hungary
    Acta Biol Hung 61:274-81. 2010
    ..Tests revealed moderate inhibitory actions compared to finasteride, nevertheless, results provide interesting structure-activity relationship data...
  27. pmc Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells
    Pradeep P Kayampilly
    Department of Obstetrics and Gynecology, 6428 Medical Science I, 1150 West Medical Center Drive, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Endocrinology 151:5030-7. 2010
    ..The elevated levels of these metabolites, in turn, might adversely affect growth and proliferation of granulosa cells, thereby impairing follicle growth and ovulation...
  28. doi Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats
    Tae Sung Kim
    Health Effects Analysis Team, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, South Korea
    J Toxicol Environ Health A 73:1544-59. 2010
    ....
  29. ncbi Site-directed mutagenesis studies of rat steroid 5alpha-reductase (isozyme-1): mutation of residues in the cofactor binding and C-terminal regions
    A K Bhattacharyya
    C 410 Research Service, Veterans Affairs Medical Center, 1101 VA Drive, Lexington, KY 40506, USA
    J Steroid Biochem Mol Biol 77:177-82. 2001
    ....
  30. pmc Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases
    S Andersson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 87:3640-4. 1990
    ..However, synthetic 4-azasteroids demonstrated marked differences in their abilities to inhibit the human and rat steroid 5 alpha-reductases...
  31. pmc Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation
    S Andersson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 264:16249-55. 1989
    ..The data suggest that the steroid 5 alpha-reductase gene is differentially regulated by testosterone in androgen-responsive versus non-responsive tissues...
  32. ncbi Inhibition of rat steroid 5 alpha-reductase (isozyme 1) by suramin
    M F Taylor
    Department of Biochemistry, College of Medicine, University of Kentucky, Lexington, USA
    Steroids 60:452-6. 1995
    ..These results suggest that suramin inhibits rat steroid 5 alpha-reductase (isozyme 1) at the level of NADPH binding to the enzyme...
  33. ncbi Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat
    D M Berman
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Mol Endocrinol 9:1561-70. 1995
    ..However, no evidence for feedforward regulation of either 5 alpha-reductase gene was detected in the fetus...
  34. ncbi Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone
    I Lopez-Solache
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Biochim Biophys Acta 1305:139-44. 1996
    ..The results demonstrated that rat type I 5 alpha-reductase mRNA is stimulated by pituitary hormones and castration but is decreased by DHT and hypophysectomy...
  35. ncbi Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones
    M E Lauber
    Institute of Pharmacology, University of Zurich, Switzerland
    Endocrinology 137:2718-30. 1996
    ..g. proliferation and differentiation. As several types of steroid hormones can serve as substrates for 5alpha-reductase, it remains to be elucidated which metabolite(s) mediates the possible actions of the_ enzyme in CNS development...
  36. ncbi Expression of rat steroid 5 alpha-reductase (isozyme-1) in Spodoptera frugiperda, SF21, insect cells: expression of rat steroid 5 alpha-reductase
    M F Taylor
    VA Medical Center, Lexington, Kentucky 40506, USA
    Steroids 62:373-8. 1997
    ..Photoaffinity labeling by [2'-32P]-2-azido-NAD P+ ([2'-32P]2N3-NAD P+) and [1,2(3)H] N-(benzylbenzoyl)-3-oxo-4-aza-4-methyl-5 alpha androstane-17 beta-carboxamide ([3H]-4MABP) also showed a labeled protein band at 26 kDa...
  37. ncbi Expression and regulation of steroid 5 alpha-reductase in the genital tubercle of the fetal rat
    H Tian
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, USA
    Dev Dyn 209:117-26. 1997
    ..Together with genetic data, the results implicate the mesenchyme as the crucial cell type in formation of the male external genitalia...
  38. ncbi Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brain
    A Poletti
    Istituto di Endocrinologia, Universita degli Studi di Milano, Italy
    Mol Cell Endocrinol 129:181-90. 1997
    ..The experiments were performed on the optic nerve, a myelinated structure very rich in 5alpha-R activity and the results clearly indicated the presence of a specific type 1 enzyme immunoreactivity in the myelin sheaths of axons...
  39. ncbi Steroid 5 alpha-reductase type 1 immunolocalized in the adrenal gland of normal, gonadectomized, and sex hormone-supplemented rats
    H Yokoi
    Department of Anatomy and Cell Biology, School of Medicine, The University of Tokushima, Japan
    Histochem Cell Biol 109:127-34. 1998
    ....
  40. ncbi Influence of serum-free culture conditions on subcellular localization of steroid 5alpha-reductase in rat C6 glioma cells
    Y Tsuruo
    Department of Anatomy and Cell Biology, Tokushima University School of Medicine, Kuramoto, Tokushima, 770 8503, Japan
    Brain Res 801:130-6. 1998
    ....
  41. ncbi Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile
    N A Pampori
    Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104 6048, USA
    Endocrinology 140:1245-54. 1999
    ....
  42. ncbi Dimorphic expression of testosterone metabolizing enzymes in the hypothalamic area of developing rats
    A Colciago
    Department of Endocrinology, University of Milan, via G Balzaretti, 9, 20133, Milano, Italy
    Brain Res Dev Brain Res 155:107-16. 2005
    ..It is concluded that rodent brain sexual differentiation probably involves the activation of both 5 alpha-R2 and aromatase enzymes in a sex- and time-specific pattern...
  43. ncbi Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat
    J D Stuart
    Division of Biochemistry, Glaxo Wellcome Inc, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 62:933-42. 2001
    ..Therefore, we hypothesize that because of its pharmacokinetic parameters and increased potency against r5AR1, GI198745 is more effective than finasteride in preventing the growth of the rat prostate...
  44. ncbi Testosterone, cytochrome P450, and cardiac hypertrophy
    Thomas Thum
    Center of Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany
    FASEB J 16:1537-49. 2002
    ..We show alpha-MHC to be significantly repressed in cardiac hypertrophy and restored to normal on testosterone supplementation. We conclude that heart-specific steroid metabolism is of critical importance in cardiac hypertrophy..
  45. ncbi Changes in the expression of steroid metabolism-related genes in rat adrenal glands during selective REM sleep deprivation
    Kyoji Morita
    Neuroscience Group in Department of Pharmacology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Japan
    Life Sci 72:1973-82. 2003
    ..These results indicate that REM sleep deprivation by itself may affect the expression of steroid metabolism-related genes in the adrenal gland, suggesting a possible relation between REM sleep and adrenocortical steroid metabolism...
  46. ncbi 5alpha-reductase isoenzymes 1 and 2 in the rat testis during postnatal development
    Jessica Killian
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Biol Reprod 68:1711-8. 2003
    ..We conclude that both 5alphaR1 and 5alphaR2 isoenzymes are involved in the peak of 5alpha-reduced androgen biosynthesis in the testis during the pubertal initiation of spermatogenesis...
  47. ncbi Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH
    K Pratis
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    J Endocrinol 176:393-403. 2003
    ....
  48. ncbi Adrenergic activation of steroid 5alpha-reductase gene expression in rat C6 glioma cells: involvement of cyclic amp/protein kinase A-mediated signaling pathway
    Kyoji Morita
    Department of Pharmacology, Tokushima University Schoolof Medicine, Kuramoto, Tokushima 770 8503, Japan
    J Mol Neurosci 22:205-12. 2004
    ....
  49. ncbi Steroid 5alpha reductase mRNA type 1 is differentially regulated by androgens and glucocorticoids in the rat liver
    Mostafa K El-Awady
    Department of Biomedical Technology, National Research Center, Cairo, Egypt
    Endocr J 51:37-46. 2004
    ..Moreover, our findings appear to indicate that regulation of 5alphaR1 gene is primarily at the post-transcriptional level...
  50. ncbi Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation
    B C J van der Eerden
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Endocrinol 180:457-67. 2004
    ..This process may contribute to the beneficial effects of estrogen on bone mass accrual, possibly by intracrinology...
  51. ncbi A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH
    M Klotsman
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA
    Pharmacogenomics J 4:251-9. 2004
    ..polytomous logistic regression analysis was conducted to evaluate associations between two silent polymorphisms in SRD5A1 (codon positions 30 and 116), two polymorphisms in SRD5A2 (Val89Leu substitution and C to T transition in intron 1)..
  52. pmc Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma
    Michael J Lewis
    Department of Biology University of Western Ontario, London, Canada
    BMC Cancer 4:27. 2004
    ..The aim of this study was to determine if the differences in enzyme activities between tumorous and nontumorous breast tissues are associated with differences in progesterone metabolizing enzyme gene expression...
  53. ncbi Nerve growth factor induces elevation of steroid 5alpha-reductase mRNA levels in rat C6 glioma cells through expression of transcription factor Egr-1
    Song Her
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5485, USA
    Brain Res Mol Brain Res 126:157-64. 2004
    ....
  54. ncbi Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor
    A E Thigpen
    Department of Molecular Genetics, University of Texas, Southwestern Medical Center, Dallas 75235
    J Biol Chem 267:8577-83. 1992
    ..Finasteride was a competitive inhibitor of the native and all chimeric enzymes tested, suggesting that the tetrapeptide segments form a portion of the substrate-binding domain of steroid 5 alpha-reductase...

Research Grants1

  1. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006
    ..abstract_text> ..