Src

Summary

Gene Symbol: Src
Description: v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Alias: Rous sarcoma oncogene, c-Src, p60-Src, pp60c-src, proto-oncogene c-Src, proto-oncogene tyrosine-protein kinase Src, tyrosine protein kinase c-src, tyrosine protein kinase pp60-c-src, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Species: rat

Top Publications

  1. pmc Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression
    Karen Block
    Department of Medicine, University of Texas Health Science Center, 7723 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 283:24061-76. 2008
  2. ncbi Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation
    S Katz
    Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000ICN Bahia Blanca, Argentina
    Int J Biochem Cell Biol 38:2082-91. 2006
  3. pmc Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences
    Amal Arachiche
    INSERM U688 Physiopathologie Mitochondriale, University Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    J Biol Chem 283:24406-11. 2008
  4. doi AT₂receptors recruit c-Src, SHP-1 and FAK upon activation by Ang II in PND15 rat hindbrain
    Leonardo R Seguin
    Instituto Multidisciplinario de Investigaciones Biológicas IMIBIO SL CONICET, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    Neurochem Int 60:199-207. 2012
  5. ncbi c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats
    Glaucia E Callera
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Hypertension 46:1032-8. 2005
  6. pmc HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes
    José Carlos Valle-Casuso
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
    PLoS ONE 7:e32448. 2012
  7. doi Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues
    Sergio E Alvarez
    Facultad de Quimica, Instituto Multidisciplinario de Investigaciones Biológicas IMIBIO CONICET, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    J Cell Biochem 105:703-11. 2008
  8. ncbi Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria
    Mauro Salvi
    Dipartimento di Chimica Biologica, Universita di Padova, Centro delle Biomembrane del CNR, Viale G Colombo 3, 35121 Padua, Italy
    Biochim Biophys Acta 1589:181-95. 2002
  9. ncbi Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src
    Glaucia E Callera
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Canada
    Hypertension 45:773-9. 2005
  10. doi Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment
    Hsiu Chuan Chou
    Tissue Regeneration Bio Device Tech Lab, Medical Electronics and Device Technology Center, Industrial Technology Research Institute, Hsinchu 31040, Taiwan
    Free Radic Biol Med 49:96-108. 2010

Research Grants

  1. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
  2. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007
  3. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2007
  4. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2009
  5. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
  6. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
  7. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications103 found, 100 shown here

  1. pmc Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression
    Karen Block
    Department of Medicine, University of Texas Health Science Center, 7723 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 283:24061-76. 2008
    ..total and on residues 9 and 373/376) are inhibited in cells transfected with small interfering RNA for Src, indicating that Src is upstream of PDK-1...
  2. ncbi Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation
    S Katz
    Departamento de Biologia, Bioquimica y Farmacia, Universidad Nacional del Sur, San Juan 670, B8000ICN Bahia Blanca, Argentina
    Int J Biochem Cell Biol 38:2082-91. 2006
    ..318220 (1 microM), a protein kinase C (PKC) inhibitor, and PP1 (50 microM), a potent and selective inhibitor of the Src-family tyrosine kinases. Ca(2+)-free extracellular medium (containing 0...
  3. pmc Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences
    Amal Arachiche
    INSERM U688 Physiopathologie Mitochondriale, University Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    J Biol Chem 283:24406-11. 2008
    An immunodetection study of protein tyrosine phosphatase 1B (PTP-1B), SHP-2, and Src in isolated mitochondria from different rat tissues (brain, muscle, heart, liver, and kidney) revealed their exclusive localization in the brain...
  4. doi AT₂receptors recruit c-Src, SHP-1 and FAK upon activation by Ang II in PND15 rat hindbrain
    Leonardo R Seguin
    Instituto Multidisciplinario de Investigaciones Biológicas IMIBIO SL CONICET, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    Neurochem Int 60:199-207. 2012
    ..The possible participation of c-Src in Ang II-mediated SHP-1 activation, we demonstrated by recruitment of c-Src in immunocomplexes obtained with anti ..
  5. ncbi c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats
    Glaucia E Callera
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Hypertension 46:1032-8. 2005
    ..previously demonstrated that nongenomic signaling by aldosterone in vascular smooth muscle cells occurs through c-Src-dependent pathways...
  6. pmc HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes
    José Carlos Valle-Casuso
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon INCYL, Universidad de Salamanca, Salamanca, Spain
    PLoS ONE 7:e32448. 2012
    ..The activity of oncogenes such as c-Src can up-regulate HIF-1α...
  7. doi Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues
    Sergio E Alvarez
    Facultad de Quimica, Instituto Multidisciplinario de Investigaciones Biológicas IMIBIO CONICET, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    J Cell Biochem 105:703-11. 2008
    ..Interestingly, following receptor stimulation (1 min) c-Src was associated to AT(2) or SHP-1 immunocomplexes...
  8. ncbi Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria
    Mauro Salvi
    Dipartimento di Chimica Biologica, Universita di Padova, Centro delle Biomembrane del CNR, Viale G Colombo 3, 35121 Padua, Italy
    Biochim Biophys Acta 1589:181-95. 2002
    ..Tyrosine phosphorylation disappears when mitochondria are treated with PP2, an inhibitor of the Src kinase family, suggesting the presence of members of this family in rat brain mitochondria...
  9. ncbi Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src
    Glaucia E Callera
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Canada
    Hypertension 45:773-9. 2005
    ..that aldosterone induces activation of vascular mitogen-activated protein (MAP) kinases and NADPH oxidase via c-Src-dependent mechanisms in vascular smooth muscle cells (VSMCs)...
  10. doi Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment
    Hsiu Chuan Chou
    Tissue Regeneration Bio Device Tech Lab, Medical Electronics and Device Technology Center, Industrial Technology Research Institute, Hsinchu 31040, Taiwan
    Free Radic Biol Med 49:96-108. 2010
    ..Importantly, Src kinase was shown to be a major upstream regulator of these events...
  11. pmc Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration
    Harihara S K Potula
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:31142-55. 2009
    ..In addition, 15(S)-HETE-induced VSMC migration was dependent on Src-mediated activation of signal transducer and activator of transcription-3 (STAT-3)...
  12. pmc Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury
    Mikiko Takikita-Suzuki
    Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Japan
    Am J Pathol 163:277-86. 2003
    ..In the present study, we examined the activation of Src tyrosine kinase, a crucially important signaling molecule for PDGFR, and assessed the role of Src in PDGF-B-..
  13. ncbi NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion
    Y Liu
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, 221002, Jiangsu, China
    Brain Res 909:51-8. 2001
    ..I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src and Pyk2, with NR2A was investigated...
  14. ncbi Role of c-SRC and ERK in acid-induced activation of NHE3
    Hirohiko Tsuganezawa
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9003, USA
    Kidney Int 62:41-50. 2002
    ..Incubation of cultured renal epithelial cells in acid media activates c-Src.
  15. doi Functional impact of PTP1B-mediated Src regulation on oxidative phosphorylation in rat brain mitochondria
    Etienne Hébert Chatelain
    Physiopathologie Mitochondriale, INSERM U688, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076, Bordeaux Cedex, France
    Cell Mol Life Sci 68:2603-13. 2011
    Given the presence of Src and PTP1B within rat brain mitochondria, we have investigated whether PTP1B regulates Src activity in mitochondria as in the cytosol...
  16. ncbi An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta
    Sara Arena
    Section of Pharmacology, Department of Oncology, Biology and Genetics, Univertsity of Genova 16132 Genova, Italy
    Mol Endocrinol 21:229-46. 2007
    ..and that involves, in a multimeric complex and sequential activation, the tyrosine kinases Janus kinase (JAK) 2 and Src, and the cytosolic phosphotyrosine phosphatase SHP-2...
  17. doi EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes
    Wei Hsuan Tung
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 224:376-86. 2010
    ..that EV71-induced COX-2 expression and PGE(2) production were attenuated by pretreatment with the inhibitors of c-Src (PP1), PDGFR (AG1296), PI3K (Wortmannin), MEK1/2 (PD98059), NF-kappaB (helenalin), and AP-1 (Tanshinone) and ..
  18. ncbi Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin
    Jaime Melendez
    The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, OH 45229, USA
    J Biol Chem 279:53516-23. 2004
    ..expression of RAFTK in neonatal rat cardiomyocytes involves concurrent increases in phosphorylation of Src, c-Jun N-terminal kinase, and p38 leading to characteristic apoptotic changes including cleavage of poly(ADP-ribose)..
  19. ncbi Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo
    Daniel G Sedding
    Department of Internal Medicine I Cardiology, Giessen University, Giessen, Germany
    Circ Res 96:635-42. 2005
    ..When VSMC were subjected to cyclic stretch (0.5 Hz at 125% resting length), PI3-K, Akt, and Src kinases were found activated...
  20. pmc 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeli
    Nikhlesh K Singh
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 286:22478-88. 2011
    ..Interference with EGFR activation blocked 15(S)-HETE-induced Src and STAT3 tyrosine phosphorylation, monocyte chemoattractant protein-1 (MCP-1) expression and VSMC migration...
  21. doi Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells
    Thaís F G Lucas
    Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, INFAR, Vila Clementino, Sao Paulo, Brazil
    Biol Reprod 83:307-17. 2010
    ..MAPK3/1 phosphorylation induced by ICI or G-1 was blocked by pertussis toxin, selective inhibitor of the SRC family of protein tyrosine kinases, metalloprotease inhibitor, MAP2K1/2 inhibitor, and epidermal growth factor ..
  22. ncbi Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases
    M Tsuda
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650, Japan
    J Biol Chem 273:13223-9. 1998
    SHPS-1 is a receptor-like glycoprotein that undergoes tyrosine phosphorylation and binds SHP-2, an Src homology 2 domain containing protein tyrosine phosphatase, in response to various mitogens...
  23. ncbi Interaction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery
    Greg A Knock
    Department of Asthma, Allergy and Respiratory Science, School of Medicine, King s College London, Room 3 20, Franklin Wilkins Building, Stamford Street, London SE1 9NH, UK
    Cardiovasc Res 77:570-9. 2008
    We investigated the role of src family kinases (srcFK) in agonist-mediated Ca2+-sensitization in pulmonary artery and whether this involves interaction with the rho/rho-kinase pathway.
  24. doi Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1
    Keiko Abe
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 31:987-98. 2008
    ..DN-Src and DN-Fyn suppressed Ang II-induced OPN promoter activity...
  25. pmc Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src
    Mario M Müller
    Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Cell Biol 187:569-81. 2009
    ..Although there is evidence that CEACAM1 binds and activates SHP-1, SHP-2, and c-Src, knowledge about the mechanism of transmembrane signaling is lacking...
  26. ncbi MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway
    Geraldine Pawlak
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    J Biol Chem 277:26927-33. 2002
    Cellular transformation by v-Src is believed to be caused by aberrant activation of signaling pathways that are normally regulated by cellular Src...
  27. doi Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex
    Yong Bae Kim
    Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 110 799, Korea
    J Biol Chem 283:10089-96. 2008
    ..with suspended cells, fibronectin-adherent cells showed enhanced pS(3)cofilin, depending on ILK expression and c-Src activity...
  28. ncbi The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J
    Bysani Chandrasekar
    Department of Medicine, Medicine Cardiology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:26263-77. 2005
    ..b>Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt ..
  29. ncbi 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells
    Thaís F G Lucas
    Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Biol Reprod 78:101-14. 2008
    ..Both effects reached a maximum after 10 min and were blocked by PP2, an inhibitor of the SRC family of protein tyrosine kinases, and by the antiestrogen ICI 182,780 (ICI)...
  30. ncbi Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway
    Bong Gun Ju
    Howard Hughes Medical Institute, University of California, San Diego, Department and School of Medicine, La Jolla, CA 92093, USA
    Cell 119:815-29. 2004
    ..The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms...
  31. ncbi Integrin activates receptor-like protein tyrosine phosphatase alpha, Src, and Rho to increase prolactin gene expression through a final phosphatidylinositol 3-kinase/cytoskeletal pathway that is additive with insulin
    Anthony I Vulin
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    Endocrinology 146:3535-46. 2005
    ..Others suggested that RPTPalpha was a key intermediary between integrins and activation of Src. We present evidence that inhibition of insulin-increased prolactin gene transcription was secondary to RPTPalpha ..
  32. doi Localization of caveolin-1 and c-src in mature and differentiating photoreceptors: raft proteins co-distribute with rhodopsin during development
    Agnes I Berta
    Department of Human Morphology and Developmental Biology, Semmelweis University Budapest, Tuzolto u 58, Budapest, Hungary
    J Mol Histol 42:523-33. 2011
    ..Therefore the purpose of our studies was to follow the localization pattern of caveolin-1, phospho-caveolin-1 and c-src in the developing retina and compare it to that observed in adults...
  33. ncbi Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in v-src-transformed Rat-1 fibroblasts
    Eun Joo Jung
    Department of Biochemistry, College of Medicine, Gyeongsang National University, Chinju 660 751, Korea
    Exp Mol Med 34:476-80. 2002
    ..Using anti-CPTP1 antibody, we identified CPTP1-like rat PTP1 of 51 kDa in Rat-1 and v-src-transformed Rat-1 fibroblasts...
  34. pmc Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion
    Renato Socodato
    Program of Neurosciences and Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niteroi, 24020 971, Brazil
    J Biol Chem 287:38680-94. 2012
    ..The Src-tyrosine kinase has been implicated in modulating neurotransmission in CNS...
  35. doi Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells
    Jia Xiang Chen
    Department of Physiology, Medical College of Nanchang University, Donghu District, Nanchang 330006, People s Republic of China
    Mol Cell Biochem 358:67-73. 2011
    ..proliferation in a dose-dependent manner and significantly increased the protein levels of phosphated c-Src (p-c-Src) and phosphated signal transducer and activator of transcription 3 (p-STAT3)...
  36. doi The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene
    Jonathan M Levenson
    Galenea, Corp, Cambridge, MA 02139, USA
    Biochim Biophys Acta 1779:422-31. 2008
    ....
  37. pmc Myosin light chain kinase and Src control membrane dynamics in volume recovery from cell swelling
    Elisabeth T Barfod
    Department of Pharmacology, University of Vermont, Burlington, VT 05405 Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Mol Biol Cell 22:634-50. 2011
    ..Hypotonic exposure evoked increased biochemical association of the cell volume regulator Src with MLCK and with the endocytosis regulators cortactin and dynamin, which colocalized within these structures...
  38. doi SRC family kinase activity is up-regulated in hormone-refractory prostate cancer
    Oleg Tatarov
    Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Clin Cancer Res 15:3540-9. 2009
    Although Src family kinase (SFK) inhibitors are now in clinical trials for the treatment of androgen-independent prostate cancer (AIPC), there are no studies relating SFK activation to patient survival...
  39. pmc Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver
    Rakhee S Gupte
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Free Radic Biol Med 47:219-28. 2009
    ..Inhibition of PI3 kinase and Src kinases decreased (p < 0...
  40. ncbi Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases
    Kaiming Xu
    Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Biol Chem 282:32699-709. 2007
    ..Activation of PDGF receptor (PDGFR) in rat aortic vascular smooth muscle cells leads to c-Src-dependent stabilization of COX-2 mRNA requiring an AU-rich region within the 3'-untranslated region of this ..
  41. ncbi Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation
    Min Jin Lim
    Department of Biochemistry and Molecular Biology BK21 project, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Arch Biochem Biophys 465:197-208. 2007
    Role of c-Src in muscle differentiation has been controversial. Here, we investigated if c-Src positively or negatively regulates muscle differentiation, using H9c2 and C2C12 cell lines...
  42. ncbi Regulation of c-Src activity in glutamate-induced neurodegeneration
    Savita Khanna
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 282:23482-90. 2007
    c-Src is heavily expressed in the brain and in human neural tissues...
  43. pmc Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:23631-8. 2007
    ..Further studies implicate Src in this mechanism, showing that 1) PKCepsilon overexpression increases PKCdelta-Thr(505) phosphorylation in ..
  44. pmc Src-mediated cortactin phosphorylation regulates actin localization and injurious blebbing in acinar cells
    Vijay P Singh
    Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 19:2339-47. 2008
    ..We observed that suprastimulation results in a rapid activation of Src and relocalization of the actin-binding protein cortactin from the apical to the basolateral domain at the necks of ..
  45. doi Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region
    Ting Li
    Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China
    FEBS Lett 582:1894-900. 2008
    ..Immunoprecipitation and immunoblot results showed that PP2 and MK801 significantly decreased the activation of Src, HPK1, MLK3, JNK3 and c-Jun, respectively, during ischemia/reperfusion...
  46. pmc Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome
    Ryan Reed
    Department of Biochemistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Physiol Heart Circ Physiol 296:H1811-21. 2009
    ..Here, we determined whether the activation of Src, a possible upstream regulator, was altered in JCR rats and whether redox-dependent Src and Akt activation were ..
  47. doi FGF-1-induced reactions for biogenesis of apoE-HDL are mediated by src in rat astrocytes
    Tomo Nishida
    Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biochem 146:881-6. 2009
    ..FGF-1-induced phosphorylation of Src, and phosphorylation of MEK, ERK and Ark was inhibited by Src inhibitors in rat astrocytes...
  48. doi Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia
    Wei Wei Wang
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu, China
    Brain Res 1328:162-70. 2010
    ..We recently reported that the triplicate complex NR2A-PSD-95-Src is a signaling module to facilitate NMDA receptor over-activation...
  49. pmc Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase
    Jie Xu
    Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bio information, Xuzhou Medical College, Xuzhou 221002, China
    J Biol Chem 283:29355-66. 2008
    ..propanoic acid (ATPA), a selective GluR5 agonist, could suppress Src tyrosine phosphorylation and interactions among N-methyl-D-aspartate (NMDA) receptor subunit 2A (NR2A), ..
  50. ncbi Elevated Src kinase activity attenuates Tamoxifen response in vitro and is associated with poor prognosis clinically
    Liam Morgan
    Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, UK
    Cancer Biol Ther 8:1550-8. 2009
    Activated Src kinase may contribute to the progression and spread of breast cancers and recent in vitro evidence suggests a role for Src in acquired endocrine resistance...
  51. doi The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling
    Avraham I Jacob
    Mina and Everard Goodman Faculty of Life Sciences, Gonda Diagnostic Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Mol Endocrinol 44:155-69. 2010
    ..Basal binding of Src to PKCdelta was higher in both PKCdelta/alpha- and PKCalpha/delta-expressing cells compared to control...
  52. doi The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity
    Dag Schauwienold
    Abteilung Klinische Pharmakologie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Biol Chem 283:27748-56. 2008
    ..epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation...
  53. ncbi Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src
    Shuichi Saito
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44695-700. 2002
    ..at Tyr(1021), a phospholipase C-gamma binding site, involving the requirement of protein kinase C-delta and c-Src that is distinct from a ligand-dependent autophosphorylation...
  54. pmc Learning induces neurotrophin signaling at hippocampal synapses
    Lulu Y Chen
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 107:7030-5. 2010
    ..in this regard than other stimulation patterns, preferentially engaged NMDA receptors that, in turn, activated Src kinases...
  55. pmc Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury
    Ying Wang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Neuroinflammation 7:24. 2010
    ..The present study investigates the ability of DAF to protect primary cultured neuronal cells subjected to sodium cyanide (NaCN)-induced hypoxia from degeneration and apoptosis...
  56. ncbi Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling
    Anna Platek
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, CELL Unit, UCL 75 41, Avenue Hippocrate, 75, B 1200 Brussels, Belgium
    Exp Cell Res 313:1090-105. 2007
    Cancer cells depend on chemotaxis for invasion and frequently overexpress and/or activate Src. We previously reported that v-Src accelerates motility by promoting phosphoinositide 3-kinase (PI3-K) signalling but abrogates chemotaxis...
  57. ncbi The GTPase dynamin binds to and is activated by a subset of SH3 domains
    I Gout
    Ludwig Institute for Cancer Research, London, England
    Cell 75:25-36. 1993
    b>Src homology 3 (SH3) domains have been implicated in mediating protein-protein interactions in receptor signaling processes; however, the precise role of this domain remains unclear...
  58. ncbi Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability
    Michele L Criscuoli
    La Jolla Institute for Molecular Medicine, Division of Cancer Biology, San Diego, CA 92121, USA
    Blood 105:1508-14. 2005
    ..Previous studies have shown a requirement for Src kinase in VEGF-mediated VP and signaling in blood vessels...
  59. ncbi Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study
    Yong Mei Chen
    Population Council, New York, New York, 10021, USA
    Biol Reprod 69:656-72. 2003
    ..Studies by immunoprecipitation revealed that Fer kinase associated with N-cadherin, gamma-catenin, p120ctn, c-Src (a putative PTK and the product of the transforming, sarcoma-inducing gene of Rous sarcoma virus), Rab 8 (a GTPase),..
  60. ncbi Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src
    Nicolas Bilodeau
    Pediatric Research Unit, CRCHUL CHUQ, Faculty of Medicine, Laval University, Quebec, Canada
    FEBS J 273:992-1003. 2006
    ..DPP IV coimmunoprecipitated with the cellular tyrosine kinase Src (c-Src) with maximal association also observed after 2 min following insulin injection...
  61. ncbi Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha
    Dominique T Brandt
    Medizinische Hochschule Hannover, Department of Nephrology, 30625 Hannover, Germany
    J Biol Chem 278:34073-8. 2003
    ..reorganization of the actin cytoskeleton in smooth muscle cells is transmitted by the non-receptor tyrosine kinase, Src. Several authors have described how 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of cells results in an ..
  62. pmc Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin II
    Takayuki Endoh
    Department of Physiology, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 8502, Japan
    J Physiol 568:851-65. 2005
    ..Intracellular dialysis of the Galpha(i)-protein antibody attenuated the Ang II-induced facilitation of I(Ca). Both Src tyrosine kinase inhibitor and mitogen-activated protein kinase (MAPK) inhibitor attenuated the Ang II-induced ..
  63. ncbi Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src pathway in primary cultured rat osteoblasts
    Chih Hsin Tang
    Departments of Pharmacology and Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 280:22907-16. 2005
    ..acid tetrakis(acetoxymethyl ester)), phosphatidylinositol-phospholipase C inhibitor (U73122), or Src inhibitor (PP2) attenuated the PGE(2)-induced Fn expression...
  64. ncbi The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue
    Ilaria Le Pera
    Department of Experimental and Clinical Medicine, Medical School of Catanzaro, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
    Oncogene 24:3187-95. 2005
    ..Here, we report that the r-PTPeta protein binds to c-Src in living cells and dephosphorylates the c-Src inhibitory tyrosine phosphorylation site (Tyr 529), thereby ..
  65. ncbi Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains
    Eun Mi Hur
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang 790 784, Republic of Korea
    J Biol Chem 279:5852-60. 2004
    ..Bradykinin caused activation of p60Src and Src-dependent phosphorylation of the EGFR on Tyr-845 in lipid rafts, as well as recruitment of phospholipase C (PLC) ..
  66. ncbi Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells
    Ayesha N Shajahan
    Department of Pharmacology, University of Illinois, College of Medicine, M C 868, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 279:20392-400. 2004
    ..We addressed the role of Src phosphorylation of the GTPase dynamin-2 in the mechanism of caveolae release and albumin transport...
  67. ncbi PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells
    Yutaro Obara
    The Vollum Institute, L474, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 117:6085-94. 2004
    Recent studies suggest that the tyrosine kinase Src plays an important role in the hormonal regulation of extracellular signal-regulated kinases (ERKs) via cyclic AMP (cAMP)...
  68. ncbi Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways
    Peichun Gui
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    J Biol Chem 281:14015-25. 2006
    ..These sites are known to be phosphorylated by protein kinase A (PKA) and c-Src, respectively, and are conserved between rat neuronal (Cav1.2c) and smooth muscle (Cav1.2b) isoforms...
  69. ncbi Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia
    Min Chen
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, 221002 P R, Jiangsu, China
    Neurosci Lett 339:29-32. 2003
    ..receptor subunit 2A (NR2A) and the interactions among NR2A, postsynaptic density protein 95 (PSD-95), Fyn/Src after brain ischemia/reperfusion (I/R)...
  70. ncbi Increased expression of neuronal Src and tyrosine phosphorylation of NMDA receptors in rat brain after systemic treatment with MK-801
    A Linden
    A I Virtanen Institute, University of Kuopio, P O B 1627, 70211 Kuopio, Finland
    Neuropharmacology 40:469-81. 2001
    ..that systemic treatment with the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 increases Src expression and NMDA receptor phosphorylation in rat brain...
  71. ncbi Regulation of an ERG K+ current by Src tyrosine kinase
    Francisco S Cayabyab
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network and Department of Physiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 277:13673-81. 2002
    ..The whole cell ERG current was reduced by protein-tyrosine kinase inhibitors or the Src-selective inhibitory peptide, src40-58, but not by a scrambled peptide...
  72. ncbi Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1
    Lakshmi S Chaturvedi
    Surgical Service, John D Dingell Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 282:14-28. 2007
    ..However, the upstream mediators of these effects are unknown. We investigated whether Src and Rac1 mediate deformation-induced FAK and ERK phosphorylation and proliferation in human Caco-2 and rat IEC-6 ..
  73. pmc Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity
    G R Wilson
    Department of Academic Surgery, Research and Education Building 2nd Floor, South Manchester University Hospital, Wythenshawe, Manchester, UK
    Br J Cancer 95:1410-4. 2006
    Overexpression and/or activity of c-Src non-receptor tyrosine kinase is associated with progression of several human epithelial cancers including breast cancer...
  74. ncbi Activating SRC mutation in a subset of advanced human colon cancers
    R B Irby
    Department of Surgery, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa 33612, USA
    Nat Genet 21:187-90. 1999
    The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been implicated in the development of numerous human cancers...
  75. ncbi Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate
    J M Verdi
    Amgen Institute, Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto M5G 2C1, Canada
    Curr Biol 6:1134-45. 1996
    ..Part of the Drosophila NUMB protein exhibits homology to the SHC phosphotyrosine-binding (PTB) domain, suggesting a potential link to tyrosine-kinase signal transduction...
  76. ncbi Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy
    Akira Mima
    Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Lab Invest 86:927-39. 2006
    ..staining and Western blotting showed that the increased expression of Smad1, phospho-Smad1, and phospho-Src was inhibited by olmesartan...
  77. ncbi Cloning of the proto-oncogene c-src from rat testis
    O Al-Khalili
    Department of Physiology, Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, GA, USA
    DNA Seq 12:425-9. 2001
    The cellular homolog of the oncogene v-src, the proto-oncogene c-src, was cloned from rat testis using a high stringency polymerase chain reaction...
  78. ncbi Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation
    Maurizio Longo
    Department of Experimental Medicine, University of L Aquila, 67100 L Aquila, Italy
    Bone 34:100-11. 2004
    ..PKCzeta, was evidenced at over-confluence, along with transient increases in expression and kinase activity of c-Src, accompanied by membrane translocation of the kinase-activated enzyme...
  79. ncbi pp60c-Src Kinase mediates growth effects of the full-length precursor progastrin1-80 peptide on rat intestinal epithelial cells, in vitro
    D Brown
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Endocrinology 144:201-11. 2003
    ..In previous studies, we reported an increase in Tyr phosphorylation of pp60(c-Src) in intestinal epithelial cells (IEC) in response to the fully processed form of gastrin [gastrin(1-17) (G17)]...
  80. pmc Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    E S Oh
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 19:3205-15. 1999
    ..Both in vitro and in vivo studies indicate that SHPS-1 tyrosyl phosphorylation is catalyzed by Src family protein tyrosine kinases (PTKs)...
  81. ncbi GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor
    Judith Haendeler
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:49936-44. 2003
    ..c-Src has been proposed as a common mediator for these signals activated by both G protein-coupled receptors (GPCRs) and ..
  82. ncbi Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and Src
    Shu Q Liu
    Biomedical Engineering Department, E334, Technology Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
    Am J Physiol Heart Circ Physiol 285:H1081-90. 2003
    ..Here, we investigated the role of platelet-derived growth factor (PDGF)-beta receptor and Src in the regulation of such processes...
  83. ncbi Load-induced focal adhesion mechanotransduction is altered with aging in the Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta
    K M Rice
    Department of Pharmacology, Physiology, and Toxicology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755 1090, USA
    Biogerontology 8:257-67. 2007
    ..Immunoblot analysis showed increases in the aortic content of FAK (15%), FAK related non-kinase (p41-FRNK) (28%), Src (92%), RhoA (41%), and paxillin (23%) in the very aged aortae...
  84. ncbi Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells
    Rebecca B Riggins
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    Mol Cancer Res 1:428-37. 2003
    ..The interaction between Cas and p85 PI3K appears to be driven primarily by Src-dependent tyrosine phosphorylation of Cas, and mapping studies indicate that the carboxyl terminus of Cas is ..
  85. ncbi Src tyrosine kinase regulates insulin-induced activation of protein kinase C (PKC) delta in skeletal muscle
    Tovit Rosenzweig
    Gonda Goldschmeid Center, Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Cell Signal 16:1299-308. 2004
    ..In this study, we investigated the possibility that the Src family of nonreceptor tyrosine kinases may be involved upstream insulin signaling...
  86. ncbi Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes
    Ching Hang Wong
    Population Council, Center for Biomedical Research, New York, New York 10021, USA
    Endocrinology 146:1192-204. 2005
    ..For instance, the protein levels of beta1-integrin, Tyr-phosphorylated focal adhesion kinase (p-FAK), and c-Src were induced during the T suppression-induced germ cell loss and recovery, implicating that these proteins are ..
  87. ncbi Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury
    Rita Carini
    Department of Medical Sciences, University A Avogadro, Novara, Italy
    J Hepatol 46:692-9. 2007
    ..Glycine hepatoprotection is well known. However, the mechanisms involved are still poorly characterized...
  88. ncbi Effect of radicicol infusion on the Src tyrosine kinase activity of rat hippocampus before and after training in an inhibitory avoidance task
    Patricia Pereira
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600, Anexo, Porto Alegre, 90035 003, RS, Brazil
    Neurochem Res 32:1150-5. 2007
    ..Previous work showed that intra-hippocampal infusion of the Src-PTK inhibitor radicicol inhibits memory acquisition, consolidation, and retrieval of one-trial step-down inhibitory ..
  89. ncbi Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
    P Sheth
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 293:G308-18. 2007
    ..Reduced expression of c-Src, TLR4, or LBP by specific small interfering RNA attenuated lipopolysaccharide-induced permeability and ..
  90. ncbi Chronic nicotine-induced switch in Src-family kinase signaling for long-term potentiation induction in hippocampal CA1 pyramidal cells
    Yoshihiko Yamazaki
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    Eur J Neurosci 24:3271-84. 2006
    Here, we show that chronic nicotine exposure induces changes in Src signaling for the modulation of N-methyl-D-aspartate receptor (NMDAR) function and LTP induction in CA1 pyramidal cells...
  91. pmc The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src
    Norikazu Yamana
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Mol Cell Biol 26:6844-58. 2006
    ..active Cdc42, which work together for cell polarization, localized in the front of migrating cells, while active c-Src, which regulates adhesion turnover, localized in focal adhesions...
  92. ncbi Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus
    Jeanne Zhen Huo
    Centre for the Neurobiology of Stress, Department of Life Sciences, University of Toronto at Scarborough, Toronto, Ontario, Canada M1C 1A4
    Neurosci Lett 401:266-70. 2006
    ..The onset of SE was accompanied by activation of Src-family tyrosine kinases and Pyk2 in the post-synaptic density, consistent with a role for these enzymes in SE-..
  93. ncbi Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion
    Fan Zhang
    Research Center, Karolinska Institute, Stockholm South Hospital, SE 11883 Stockholm, Sweden
    Am J Physiol Cell Physiol 291:C466-75. 2006
    ..hGH caused tyrosine phosphorylation of Janus kinase (JAK)2 and c-Src, events inhibited by the JAK2 inhibitor AG490 or the Src kinase inhibitor PP2...
  94. doi Roles of c-Src in alpha1B-adrenoceptor phosphorylation and desensitization
    R Alcántara-Hernández
    Departamento de Biologia Celular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Ap Postal 70 248, Mexico DF 04510
    Auton Autacoid Pharmacol 28:29-39. 2008
    1 The role of the protein tyrosine kinase, c-Src, on the function and phosphorylation of alpha1B-adrenoceptors (alpha1B-AR) and their association with G-protein-coupled receptor kinase (GRK) isozymes was studied...
  95. ncbi L-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases
    Maddalena Napolitano
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
    Neurosci Lett 398:211-4. 2006
    ..denervation resulted in a progressive increase of contraversive circling behavior and modulated the expression of Src, Lyn and PKC kinases...
  96. pmc Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation
    Geng Xian Shi
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone Street, Lexington, KY 40536 0509, USA
    Mol Cell Biol 28:4940-51. 2008
    ..Instead, Rin is activated in a Src kinase-dependent manner...
  97. ncbi P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1
    Kristof Van Kolen
    Laboratory of Cellular Biochemistry, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk Antwerpen, Belgium
    Cell Signal 18:1169-81. 2006
    ..Treatment of cells with the Ca2+ chelator BAPTA-AM and inhibition of Src and PLD2 with PP2 or 1-butanol, respectively, abrogated P2Y12 receptor-mediated activation of Rap1 and PKB...
  98. pmc c-Src tyrosine kinase, a critical component for 5-HT2A receptor-mediated contraction in rat aorta
    Rong Lu
    Department of Anaesthesiology, Division of Molecular Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7115, USA
    J Physiol 586:3855-69. 2008
    ..We previously proposed that one signalling mechanism of 5-HT-induced vasoconstriction could be c-Src, a member of the Src tyrosine kinase family...
  99. ncbi Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia
    Jeong Sun Choi
    Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, Korea
    Neurosci Lett 380:1-5. 2005
    To better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60kDa, in the ischemic brain, we investigated the time course and regional distribution of active Src expression by using a ..
  100. doi Requirement of inducible nitric-oxide synthase in lipopolysaccharide-mediated Src induction and macrophage migration
    Ming Chei Maa
    Institute of Medical Science, China Medical University, Taichung 40402
    J Biol Chem 283:31408-16. 2008
    Previously, we have demonstrated the induction of Src in lipopolysaccharide (LPS)-stimulated macrophages...
  101. pmc Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation
    Matthew J Hayes
    Division of Cell Biology, University College London Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, United Kingdom
    J Biol Chem 284:10202-10. 2009
    Cell transformation by v-Src involves rearrangement of the actin cytoskeleton, disassembly of focal adhesions, and the development of anchorage-independent growth...

Research Grants27

  1. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  2. Thrombin-Stimulated Intrauterine Signaling Pathway
    Mark Phillippe; Fiscal Year: 2007
    ..These studies are anticipated to significantly improve our understanding of the mechanisms underlying preterm labor in the presence of intrauterine infection. ..
  3. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2007
    ..In the first specific aim, we plan to investigate the Src tyrosine kinase as a candidate signaling molecule that regulates PI 3-K and Akt activity as well as mesangial cell ..
  4. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2009
    ..The primary goal of this proposal is to better understand the role of inflammatory cytokines, interleukin-18 in particular, in myocardial hypertrophy and its transition to failure. ..
  5. PHOSPHORYLATION IN RENAL CELL INJURY
    Goutam Ghosh Choudhury; Fiscal Year: 2004
    ..These studies will identify important signaling mechanisms involved in glomerular pathology and help to establish effective therapeutic modalities for treatment of proliferative forms of GN. ..
  6. PI/PLC FUNCTION IN PREGNANT RAT MYOMETRIUM
    Mark Phillippe; Fiscal Year: 2002
    ..s. ..
  7. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2010
    ..The results obtained from these experiments will help designing drugs targeting fibrosis, which constitutes the pathology of diabetic nephropathy. ..