Src

Summary

Gene Symbol: Src
Description: SRC proto-oncogene, non-receptor tyrosine kinase
Alias: proto-oncogene tyrosine-protein kinase Src, Rous sarcoma oncogene, c-Src, p60-Src, pp60c-src, proto-oncogene c-Src, tyrosine protein kinase c-src, tyrosine protein kinase pp60-c-src, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Species: rat
Products:     Src

Top Publications

  1. Shajahan A, Timblin B, Sandoval R, Tiruppathi C, Malik A, Minshall R. Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. J Biol Chem. 2004;279:20392-400 pubmed
    ..We addressed the role of Src phosphorylation of the GTPase dynamin-2 in the mechanism of caveolae release and albumin transport...
  2. Liu Y, Zhang G, Gao C, Hou X. NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. Brain Res. 2001;909:51-8 pubmed
    ..I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src and Pyk2, with NR2A was investigated...
  3. Salvi M, Brunati A, Bordin L, La Rocca N, Clari G, Toninello A. Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria. Biochim Biophys Acta. 2002;1589:181-95 pubmed
    ..Tyrosine phosphorylation disappears when mitochondria are treated with PP2, an inhibitor of the Src kinase family, suggesting the presence of members of this family in rat brain mitochondria...
  4. Müller M, Klaile E, Vorontsova O, Singer B, Obrink B. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. J Cell Biol. 2009;187:569-81 pubmed publisher
    ..Although there is evidence that CEACAM1 binds and activates SHP-1, SHP-2, and c-Src, knowledge about the mechanism of transmembrane signaling is lacking...
  5. Melendez J, Turner C, Avraham H, Steinberg S, Schaefer E, Sussman M. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem. 2004;279:53516-23 pubmed
    ..expression of RAFTK in neonatal rat cardiomyocytes involves concurrent increases in phosphorylation of Src, c-Jun N-terminal kinase, and p38 leading to characteristic apoptotic changes including cleavage of poly(ADP-ribose)..
  6. Callera G, Touyz R, Tostes R, Yogi A, He Y, Malkinson S, et al. Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension. 2005;45:773-9 pubmed
    ..that aldosterone induces activation of vascular mitogen-activated protein (MAP) kinases and NADPH oxidase via c-Src-dependent mechanisms in vascular smooth muscle cells (VSMCs)...
  7. Knock G, Snetkov V, Shaifta Y, Drndarski S, Ward J, Aaronson P. Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery. Cardiovasc Res. 2008;80:453-62 pubmed publisher
    We investigated the role of src-family kinases (srcFKs) in hypoxic pulmonary vasoconstriction (HPV) and how this relates to Rho-kinase-mediated Ca(2+) sensitization and changes in intracellular Ca(2+) concentration ([Ca(2+)](i))...
  8. Singh N, Wang D, Kundumani Sridharan V, Van Quyen D, Niu J, Rao G. 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall rem. J Biol Chem. 2011;286:22478-88 pubmed publisher
    ..Interference with EGFR activation blocked 15(S)-HETE-induced Src and STAT3 tyrosine phosphorylation, monocyte chemoattractant protein-1 (MCP-1) expression and VSMC migration...
  9. Chou H, Chen Y, Lee T, Wu F, Chan H, Lyu P, et al. Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. Free Radic Biol Med. 2010;49:96-108 pubmed publisher
    ..Importantly, Src kinase was shown to be a major upstream regulator of these events...

More Information

Publications96

  1. Miyazaki T, Neff L, Tanaka S, Horne W, Baron R. Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol. 2003;160:709-18 pubmed
    The function of the nonreceptor tyrosine kinase c-Src as a plasma membrane-associated molecular effector of a variety of extracellular stimuli is well known...
  2. Arachiche A, Augereau O, Decossas M, Pertuiset C, Gontier E, Letellier T, et al. Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences. J Biol Chem. 2008;283:24406-11 pubmed publisher
    An immunodetection study of protein tyrosine phosphatase 1B (PTP-1B), SHP-2, and Src in isolated mitochondria from different rat tissues (brain, muscle, heart, liver, and kidney) revealed their exclusive localization in the brain...
  3. Pawlak G, Helfman D. MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. J Biol Chem. 2002;277:26927-33 pubmed
    Cellular transformation by v-Src is believed to be caused by aberrant activation of signaling pathways that are normally regulated by cellular Src...
  4. Hébert Chatelain E, Dupuy J, Letellier T, Dachary Prigent J. Functional impact of PTP1B-mediated Src regulation on oxidative phosphorylation in rat brain mitochondria. Cell Mol Life Sci. 2011;68:2603-13 pubmed publisher
    Given the presence of Src and PTP1B within rat brain mitochondria, we have investigated whether PTP1B regulates Src activity in mitochondria as in the cytosol...
  5. Tsuganezawa H, Sato S, Yamaji Y, Preisig P, Moe O, Alpern R. Role of c-SRC and ERK in acid-induced activation of NHE3. Kidney Int. 2002;62:41-50 pubmed
    ..Incubation of cultured renal epithelial cells in acid media activates c-Src. OKP cells were incubated in control (pH 7.4) or acid (7...
  6. Knock G, Shaifta Y, Snetkov V, Vowles B, Drndarski S, Ward J, et al. Interaction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery. Cardiovasc Res. 2008;77:570-9 pubmed
    We investigated the role of src family kinases (srcFK) in agonist-mediated Ca2+-sensitization in pulmonary artery and whether this involves interaction with the rho/rho-kinase pathway...
  7. Callera G, Montezano A, Yogi A, Tostes R, He Y, Schiffrin E, et al. c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension. 2005;46:1032-8 pubmed
    ..previously demonstrated that nongenomic signaling by aldosterone in vascular smooth muscle cells occurs through c-Src-dependent pathways...
  8. Takikita Suzuki M, Haneda M, Sasahara M, Owada M, Nakagawa T, Isono M, et al. Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury. Am J Pathol. 2003;163:277-86 pubmed
    ..In the present study, we examined the activation of Src tyrosine kinase, a crucially important signaling molecule for PDGFR, and assessed the role of Src in PDGF-B-..
  9. Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, et al. GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor. J Biol Chem. 2003;278:49936-44 pubmed
    ..c-Src has been proposed as a common mediator for these signals activated by both G protein-coupled receptors (GPCRs) and ..
  10. Zhang F, Zhang Q, Tengholm A, Sjoholm A. Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion. Am J Physiol Cell Physiol. 2006;291:C466-75 pubmed
    ..hGH caused tyrosine phosphorylation of Janus kinase (JAK)2 and c-Src, events inhibited by the JAK2 inhibitor AG490 or the Src kinase inhibitor PP2...
  11. Jang E, Jeong H, Park D, Kim D, Choi Y, Chung K, et al. Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells. PLoS ONE. 2015;10:e0129244 pubmed publisher
    ..In the present study, we investigated the interaction between 4-HNE and Src (a non-receptor tyrosine kinase) for its involvement in the molecular modulation of the inflammatory signaling ..
  12. Jung E, Kim C. Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in v-src-transformed Rat-1 fibroblasts. Exp Mol Med. 2002;34:476-80 pubmed
    ..Using anti-CPTP1 antibody, we identified CPTP1-like rat PTP1 of 51 kDa in Rat-1 and v-src-transformed Rat-1 fibroblasts...
  13. Du X, Huang J, Xu L, Tang D, Wu L, Zhang L, et al. The proto-oncogene c-src is involved in primordial follicle activation through the PI3K, PKC and MAPK signaling pathways. Reprod Biol Endocrinol. 2012;10:58 pubmed publisher
    C-src is an evolutionarily conserved proto-oncogene that regulates cell proliferation, differentiation and apoptosis...
  14. Saavedra F, Redondo P, Hernández Cruz J, Salido G, Pariente J, Rosado J. Store-operated Ca(2+) entry and tyrosine kinase pp60(src) hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus. Arch Biochem Biophys. 2004;432:261-8 pubmed
    ..Consistent with this, the activity of the tyrosine kinase pp60(src) is enhanced in platelets from diabetic patients...
  15. Weilinger N, Lohman A, Rakai B, Ma E, Bialecki J, Maslieieva V, et al. Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nat Neurosci. 2016;19:432-42 pubmed publisher
    ..NMDARs, Src kinase and Panx1 form a signaling complex, and activation of Panx1 required phosphorylation at Y308...
  16. Weilinger N, Tang P, Thompson R. Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases. J Neurosci. 2012;32:12579-88 pubmed publisher
    ..Anoxia or exogenous NMDA activated Src family kinases (SFKs), as measured by increased phosphorylation of SFKs at Y416...
  17. Hossain M, Roulston C, Kamaruddin M, Chu P, Ng D, Dusting G, et al. A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. J Biol Chem. 2013;288:9696-709 pubmed publisher
    ..report that in cultured cortical neurons and in vivo in a rat model of focal ischemic stroke, the tyrosine kinase Src is cleaved by calpains at a site in the N-terminal unique domain...
  18. Xu J, Liu Y, Zhang G. Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase. J Biol Chem. 2008;283:29355-66 pubmed publisher
    ..propanoic acid (ATPA), a selective GluR5 agonist, could suppress Src tyrosine phosphorylation and interactions among N-methyl-D-aspartate (NMDA) receptor subunit 2A (NR2A), ..
  19. Holmes T, Fadool D, Ren R, Levitan I. Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science. 1996;274:2089-91 pubmed
    The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains. Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1...
  20. Li T, Yu X, Zhang G. Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region. FEBS Lett. 2008;582:1894-900 pubmed publisher
    ..Immunoprecipitation and immunoblot results showed that PP2 and MK801 significantly decreased the activation of Src, HPK1, MLK3, JNK3 and c-Jun, respectively, during ischemia/reperfusion...
  21. Bai Y, Xu G, Xu M, Li Q, Qin X. Inhibition of Src phosphorylation reduces damage to the blood-brain barrier following transient focal cerebral ischemia in rats. Int J Mol Med. 2014;34:1473-82 pubmed publisher
    ..Inhibitors of Src can markedly minimize the infarct size and preserve neurological function...
  22. Slomiany B, Slomiany A. Modulation of gastric mucosal inflammatory responses to Helicobacter pylori via ghrelin-induced protein kinase C? tyrosine phosphorylation. Inflammopharmacology. 2014;22:251-62 pubmed publisher
    ..responses to Helicobacter pylori by controlling the activation of constitutive nitric oxide synthase via Src/Akt-dependent phosphorylation that requires phosphatidylinositol 3-kinase (PI3K) participation...
  23. Beauséjour M, Noël D, Thibodeau S, Bouchard V, Harnois C, Beaulieu J, et al. Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis. 2012;17:566-78 pubmed publisher
    ..of PI3-K isoforms in HIEC cells and determined their roles in cell survival, as well as in the ?1 integrin/Fak/Src-mediated suppression of anoikis...
  24. Ziehr J, Sheibani N, Sorenson C. Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice. Am J Physiol Renal Physiol. 2004;287:F1154-63 pubmed
    ..of bcl-2 -/- proximal tubule cells in a scratch wound assay was completely inhibited by incubation with PP1 (Src inhibitor) and moderately affected by incubation with SB-203580 (p38 inhibitor)...
  25. Marignani P, Carpenter C. Vav2 is required for cell spreading. J Cell Biol. 2001;154:177-86 pubmed
    ..Vav2 nucleotide exchange is Src-dependent in vivo, since the coexpression of Vav2 and dominant negative Src, or treatment with the Src inhibitor ..
  26. Riggins R, DeBerry R, Toosarvandani M, Bouton A. Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Mol Cancer Res. 2003;1:428-37 pubmed
    ..The interaction between Cas and p85 PI3K appears to be driven primarily by Src-dependent tyrosine phosphorylation of Cas, and mapping studies indicate that the carboxyl terminus of Cas is ..
  27. Irby R, Mao W, Coppola D, Kang J, Loubeau J, Trudeau W, et al. Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet. 1999;21:187-90 pubmed
    The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been implicated in the development of numerous human cancers...
  28. Mukhopadhyay U, Eves R, Jia L, Mooney P, Mak A. p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon. Mol Cell Biol. 2009;29:3088-98 pubmed publisher
    ..study, using vascular smooth muscle cells and NIH 3T3 fibroblast cells, we have shown that p53 potently suppresses Src-induced podosome/rosette formation, extracellular matrix digestion, cell migration, and invasion...
  29. Liang S, Pong K, Gonzales C, Chen Y, Ling H, Mark R, et al. Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia. J Pharmacol Exp Ther. 2009;331:827-35 pubmed publisher
    b>Src kinase signaling has been implicated in multiple mechanisms of ischemic injury, including vascular endothelial growth factor (VEGF)-mediated vascular permeability that leads to vasogenic edema, a major clinical complication in stroke ..
  30. Cheng Z, Zhu Q, Dee R, Opheim Z, Mack C, Cyr D, et al. Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J Biol Chem. 2017;292:2065-2079 pubmed publisher
    ..This novel mechanism to limit Beclin1 activity has important implications for treating a variety of pathologies associated with altered autophagic flux. ..
  31. Nasertorabi F, Tars K, Becherer K, Kodandapani R, Liljas L, Vuori K, et al. Molecular basis for regulation of Src by the docking protein p130Cas. J Mol Recognit. 2006;19:30-8 pubmed
    ..b>Src-family kinases (SFKs) bind a specific site in the carboxyl-terminal region of Cas and subsequently SFKs ..
  32. Obata Y, Fukumoto Y, Nakayama Y, Kuga T, Dohmae N, Yamaguchi N. The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. J Cell Sci. 2010;123:2649-62 pubmed publisher
    The Src-family tyrosine kinase Lyn has a role in signal transduction at the cytoplasmic face of the plasma membrane upon extracellular ligand stimulation...
  33. Berta A, Boesze Battaglia K, Magyar A, Szel A, Kiss A. Localization of caveolin-1 and c-src in mature and differentiating photoreceptors: raft proteins co-distribute with rhodopsin during development. J Mol Histol. 2011;42:523-33 pubmed publisher
    ..Therefore the purpose of our studies was to follow the localization pattern of caveolin-1, phospho-caveolin-1 and c-src in the developing retina and compare it to that observed in adults...
  34. Araki T, Nawa H, Neel B. Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J Biol Chem. 2003;278:41677-84 pubmed
  35. Pan Y, Tseng W, Chang P, Chen H. Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. J Cell Sci. 2013;126:5670-80 pubmed publisher
    ..Podosomes can self-organize into large rosette-like structures in Src-transformed fibroblasts, osteoclasts and some highly invasive cancer cells...
  36. Xu H, Zhao H, Tian W, Yoshida K, Roullet J, Cohen D. Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem. 2003;278:11520-7 pubmed
    ..This tyrosine phosphorylation was sensitive to the inhibitor of Src family tyrosine kinases, PP1, in a dose-dependent fashion...
  37. Hum J, Day R, Bidwell J, Wang Y, Pavalko F. Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression. PLoS ONE. 2014;9:e97942 pubmed publisher
    ..The high bone mass phenotype of mice with global deletion of either Pyk2 or Src suggests a role for these tyrosine kinases in repression of bone formation...
  38. Schliess F, Reissmann R, Reinehr R, vom Dahl S, Haussinger D. Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J Biol Chem. 2004;279:21294-301 pubmed
    ..Recently integrins were shown to sense hypoosmotic hepatocyte swelling. Here the role of integrins, Src, and focal adhesion kinase (FAK) in insulin signaling was investigated using the intact organ model of perfused rat ..
  39. Xu K, Kitchen C, Shu H, Murphy T. Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases. J Biol Chem. 2007;282:32699-709 pubmed
    ..Activation of PDGF receptor (PDGFR) in rat aortic vascular smooth muscle cells leads to c-Src-dependent stabilization of COX-2 mRNA requiring an AU-rich region within the 3'-untranslated region of this ..
  40. Wang H, Wang A, Aylor K, Barrett E. Caveolin-1 phosphorylation regulates vascular endothelial insulin uptake and is impaired by insulin resistance in rats. Diabetologia. 2015;58:1344-53 pubmed publisher
    ..tyrosine 14 (Tyr(14))-caveolin-1 phosphorylation in mediating EC insulin uptake and the role of cellular Src-kinase (cSrc), TNF-α/IL-6 and high fat diet (HFD) in regulating this process...
  41. Choudhury G, Mahimainathan L, Das F, Venkatesan B, Ghosh Choudhury N. c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells. Cell Signal. 2006;18:1854-64 pubmed
    ..We examined the role of c-Src tyrosine kinase in this process...
  42. Alvarez S, Seguin L, Villarreal R, Nahmias C, Ciuffo G. Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues. J Cell Biochem. 2008;105:703-11 pubmed publisher
    ..Interestingly, following receptor stimulation (1 min) c-Src was associated to AT(2) or SHP-1 immunocomplexes...
  43. Wang B, Liang R, Liu Z, Luo B, Ding Y, Chen Z, et al. Hippocampal Src kinase is required for novelty-induced enhancement of contextual fear extinction. Biochem Biophys Res Commun. 2016;472:656-61 pubmed publisher
    ..b>Src family kinases (SFKs) act as a molecular hub for regulation of NMDA receptors...
  44. Vindis C, Cerretti D, Daniel T, Huynh Do U. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol. 2003;162:661-71 pubmed
    ..Here we demonstrate that activated EphB1 recruits the adaptor proteins Grb2 and p52Shc and promotes p52Shc and c-Src tyrosine phosphorylation as well as MAPK/extracellular signal-regulated kinase (ERK) activation...
  45. Romero M, Jimenez R, Sanchez M, López Sepúlveda R, Zarzuelo A, Tamargo J, et al. Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation. Atherosclerosis. 2010;212:78-85 pubmed publisher
    ET-1 induces vascular O(2)(*-) production via activation of NADPH oxidase. We have investigated whether c-Src and MAPKs activation are involved in ET-1-induced vascular oxidative response...
  46. Li D, Shatos M, Hodges R, Dartt D. Role of PKC? activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013;54:5661-74 pubmed publisher
    ..To determine the order and components of the signaling pathway utilized by epidermal growth factor (EGF) to stimulate conjunctival goblet cell proliferation...
  47. Jacob A, Horovitz Fried M, Aga Mizrachi S, Brutman Barazani T, Okhrimenko H, Zick Y, et al. The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling. J Mol Endocrinol. 2010;44:155-69 pubmed publisher
    ..Basal binding of Src to PKCdelta was higher in both PKCdelta/alpha- and PKCalpha/delta-expressing cells compared to control...
  48. Li Y, Langlais P, Gamper N, Liu F, Shapiro M. Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. J Biol Chem. 2004;279:45399-407 pubmed
    b>Src tyrosine kinase suppresses KCNQ (M-type) K(+) channels in a subunit-specific manner representing a mode of modulation distinct from that involving G protein-coupled receptors...
  49. Longo M, Brama M, Marino M, Bernardini S, Korach K, Wetsel W, et al. Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. Bone. 2004;34:100-11 pubmed
    ..PKCzeta, was evidenced at over-confluence, along with transient increases in expression and kinase activity of c-Src, accompanied by membrane translocation of the kinase-activated enzyme...
  50. Duffy H, Ashton A, O Donnell P, Coombs W, Taffet S, Delmar M, et al. Regulation of connexin43 protein complexes by intracellular acidification. Circ Res. 2004;94:215-22 pubmed
    ..Coimmunoprecipitation studies revealed decreased binding of ZO-1 and increased binding of c-Src to Cx43 at low pHi...
  51. Tucker B, Rahimtula M, Mearow K. Src and FAK are key early signalling intermediates required for neurite growth in NGF-responsive adult DRG neurons. Cell Signal. 2008;20:241-57 pubmed
    ..While activation of the various signalling intermediates (Src, FAK, Akt, MAPK) could be detected as early as 10 min-1 h after stimulation, significant neurite growth was ..
  52. Saito S, Frank G, Mifune M, Ohba M, Utsunomiya H, Motley E, et al. Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem. 2002;277:44695-700 pubmed
    ..at Tyr(1021), a phospholipase C-gamma binding site, involving the requirement of protein kinase C-delta and c-Src that is distinct from a ligand-dependent autophosphorylation...
  53. Lee H, Park D, Wang X, Scherer P, Schwartz P, Lisanti M. Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J Biol Chem. 2002;277:34556-67 pubmed
    ..Here, we present the first evidence that caveolin-2 is a phosphoprotein. We show that caveolin-2 undergoes Src-induced phosphorylation on tyrosine 19...
  54. Tsuda M, Matozaki T, Fukunaga K, Fujioka Y, Imamoto A, Noguchi T, et al. Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases. J Biol Chem. 1998;273:13223-9 pubmed
    SHPS-1 is a receptor-like glycoprotein that undergoes tyrosine phosphorylation and binds SHP-2, an Src homology 2 domain containing protein tyrosine phosphatase, in response to various mitogens...
  55. Madan N, Xu Y, Duan Q, Banerjee M, Larre I, Pierre S, et al. Src-independent ERK signaling through the rat α3 isoform of Na/K-ATPase. Am J Physiol Cell Physiol. 2017;312:C222-C232 pubmed publisher
    ..In contrast to Na/K-ATPase α1, α3 could not regulate Src. Upon exposure to ouabain, Src activation did not occur, yet ERK was activated through Src-independent pathways ..
  56. Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, et al. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006;25:1242-52 pubmed
    ..A signaling cascade triggered by this interaction involves activation of Src kinase and phosphorylation of ephrinB...
  57. Courter D, Lomas L, Scatena M, Giachelli C. Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB. J Biol Chem. 2005;280:12145-51 pubmed
    ..The Src family of tyrosine kinases represents important transducers during integrin signaling, and the C terminus of beta3 ..
  58. Wilson G, Cramer A, Welman A, Knox F, Swindell R, Kawakatsu H, et al. Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity. Br J Cancer. 2006;95:1410-4 pubmed
    Overexpression and/or activity of c-Src non-receptor tyrosine kinase is associated with progression of several human epithelial cancers including breast cancer...
  59. Hsieh H, Wang H, Wu C, Tung W, Yang C. Lipoteichoic acid induces matrix metalloproteinase-9 expression via transactivation of PDGF receptors and NF-kappaB activation in rat brain astrocytes. Neurotox Res. 2010;17:344-59 pubmed publisher
    ..immunofluorescent staining analyses showed that LTA induced MMP-9 expression and activation via a TLR2-activated c-Src-dependent transactivation of PDGFR pathway...
  60. Holgado Madruga M, Wong A. Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol. 2003;23:4471-84 pubmed
    ..Gab1 phosphorylation is sensitive to the Src family kinase inhibitor PP2...
  61. Brunton V, Avizienyte E, Fincham V, Serrels B, Metcalf C, Sawyer T, et al. Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res. 2005;65:1335-42 pubmed
    b>Src tyrosine kinase expression and activity are elevated during colon cancer progression. How this contributes to the malignant phenotype is not fully understood...
  62. Bharti S, Inoue H, Bharti K, Hirsch D, Nie Z, Yoon H, et al. Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol. 2007;27:8271-83 pubmed
    Invadopodia are Src-induced cellular structures that are thought to mediate tumor invasion...
  63. Abe K, Nakashima H, Ishida M, Miho N, Sawano M, Soe N, et al. Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1. Hypertens Res. 2008;31:987-98 pubmed publisher
    ..DN-Src and DN-Fyn suppressed Ang II-induced OPN promoter activity...
  64. Chen J, Xu L, Wang X, Qin H, Wang J. Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells. Mol Cell Biochem. 2011;358:67-73 pubmed publisher
    ..proliferation in a dose-dependent manner and significantly increased the protein levels of phosphated c-Src (p-c-Src) and phosphated signal transducer and activator of transcription 3 (p-STAT3)...
  65. Huo J, Dykstra C, Gurd J. Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. Neurosci Lett. 2006;401:266-70 pubmed
    ..The onset of SE was accompanied by activation of Src-family tyrosine kinases and Pyk2 in the post-synaptic density, consistent with a role for these enzymes in SE-..
  66. Barfod E, Moore A, Van de Graaf B, Lidofsky S. Myosin light chain kinase and Src control membrane dynamics in volume recovery from cell swelling. Mol Biol Cell. 2011;22:634-50 pubmed publisher
    ..Hypotonic exposure evoked increased biochemical association of the cell volume regulator Src with MLCK and with the endocytosis regulators cortactin and dynamin, which colocalized within these structures...
  67. Phillippe M, Sweet L, Bradley D, Engle D. Role of nonreceptor protein tyrosine kinases during phospholipase C-gamma 1-related uterine contractions in the rat. Reprod Sci. 2009;16:265-73 pubmed publisher
    ..Western blots were performed utilizing antibodies to phosphotyrosine-phospholipase C1, total phospholipase C1, c-Src kinase and Lck kinase...
  68. Khurana S, Tomar A, George S, Wang Y, Siddiqui M, Guo H, et al. Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp Cell Res. 2008;314:530-42 pubmed
    ..The LPA-induced increase in cell migration required activation of c-src kinase and downstream tyrosine phosphorylation of villin by c-src kinase...
  69. Lei H, Kazlauskas A. A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor ?. Mol Cell Biol. 2014;34:110-22 pubmed publisher
    ..When PDGFRs are activated by PDGF, reactive oxygen species (ROS) and Src family kinases (SFKs) act downstream of PDGFRs to enhance PDGF-mediated tyrosine phosphorylation of various ..
  70. Maa M, Chang M, Chen Y, Lin C, Yu C, Yang Y, et al. Requirement of inducible nitric-oxide synthase in lipopolysaccharide-mediated Src induction and macrophage migration. J Biol Chem. 2008;283:31408-16 pubmed publisher
    Previously, we have demonstrated the induction of Src in lipopolysaccharide (LPS)-stimulated macrophages...
  71. Kim E, Lee S, Mian M, Yun S, Song M, Yi K, et al. Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. FEBS J. 2006;273:793-804 pubmed
    ..To identify and characterize proteins that interact with the Src homology 2 (SH2) domain of Src and potentially regulate Src activity, we used a pull-down assay using GST-Src-SH2 ..
  72. Eiam Ong S, Sinphitukkul K, Manotham K, Eiam Ong S. Rapid nongenomic action of aldosterone on protein expressions of Hsp90( ? and ? ) and pc-Src in rat kidney. Biomed Res Int. 2013;2013:346480 pubmed publisher
    ..receptor (EGFR) through activation of upstream signals, heat shock protein 90 ? (Hsp90 ? ), and cytosolic (c)-Src kinase. We demonstrated that aldosterone rapidly elevates EGFR phosphorylation in rat kidney...
  73. Sreenivasappa H, Chaki S, Lim S, Trzeciakowski J, Davidson M, Rivera G, et al. Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src. Integr Biol (Camb). 2014;6:743-54 pubmed publisher
    ..e. fibronectin) in the context of RhoA-Src crosstalk...
  74. Kim H, Laing M, Muller W. c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling. Oncogene. 2005;24:5629-36 pubmed
    The c-Src tyrosine kinase has been implicated to play an integral role in modulating growth factor receptor, integrin and steroid receptor function...
  75. Cejudo Martin P, Yuen A, Vlahovich N, Lock P, Courtneidge S, Díaz B. Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5. PLoS ONE. 2014;9:e107674 pubmed publisher
    Tks5 is a scaffold protein and Src substrate involved in cell migration and matrix degradation through its essential role in invadosome formation and function...
  76. Alai M, Mui A, Cutler R, Bustelo X, Barbacid M, Krystal G. Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J Biol Chem. 1992;267:18021-5 pubmed
    ..Nonetheless, our data suggest that c-kit may utilize p95vav to mediate downstream signaling in hemopoietic cells. ..
  77. Murillo M, del Castillo G, Sánchez A, Fernandez M, Fabregat I. Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes. Oncogene. 2005;24:4580-7 pubmed
    ..We show that TGF-beta1 activates the epidermal growth factor receptor (EGFR) and phosphorylates c-Src. EGFR is required for Akt activation. Blocking EGFR signalling amplifies the apoptotic response to TGF-beta1...
  78. Kim T, Kim H, Kim J. PKCdelta-dependent functional switch of rpS3 between translation and DNA repair. Biochim Biophys Acta. 2009;1793:395-405 pubmed publisher
    ..In conclusion, we propose that the destiny of rpS3 molecules between translation and DNA repair is regulated by PKCdelta-dependent phosphorylation. ..
  79. Lee N, Cheng C. Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. J Cell Physiol. 2005;202:344-60 pubmed
    ..system utilizing Sertoli and germ cells was used to study the regulation of several protein kinases, including c-Src (the cellular form of the v-src transforming gene of Rous Sarcoma virus, RSV), carboxyl-terminal Src kinase (Csk), ..
  80. Chen L, Rex C, Sanaiha Y, Lynch G, Gall C. Learning induces neurotrophin signaling at hippocampal synapses. Proc Natl Acad Sci U S A. 2010;107:7030-5 pubmed publisher
    ..in this regard than other stimulation patterns, preferentially engaged NMDA receptors that, in turn, activated Src kinases...
  81. Han C, Bowen W, Michalopoulos G, Wu T. Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. J Cell Physiol. 2008;216:486-97 pubmed publisher
    ..The observations that PE induced the formation of c-Src-Stat3 binding complex and phosphorylation of epidermal growth factor receptor (EGFR) and that inhibiting Src and ..
  82. Chandrasekar B, Mummidi S, Valente A, Patel D, Bailey S, Freeman G, et al. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt. J Biol Chem. 2005;280:26263-77 pubmed
    ..b>Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt ..
  83. Sedding D, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, et al. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circ Res. 2005;96:635-42 pubmed
    ..When VSMC were subjected to cyclic stretch (0.5 Hz at 125% resting length), PI3-K, Akt, and Src kinases were found activated...
  84. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude G. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 2003;4:915-25 pubmed
  85. Yamazaki Y, Jia Y, Wong J, Sumikawa K. Chronic nicotine-induced switch in Src-family kinase signaling for long-term potentiation induction in hippocampal CA1 pyramidal cells. Eur J Neurosci. 2006;24:3271-84 pubmed
    Here, we show that chronic nicotine exposure induces changes in Src signaling for the modulation of N-methyl-D-aspartate receptor (NMDAR) function and LTP induction in CA1 pyramidal cells...
  86. Hu J, Liu G, Li Y, Gao W, Huang Y. Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons. Mol Brain. 2010;3:20 pubmed publisher
    ..This effect was completely blocked by small interfering RNA knockdown of Fyn, but not Src. Under control conditions, neither Fyn nor Src knockdown exhibited significant effect on basal NR2B expression...
  87. Socodato R, Santiago F, Portugal C, Domingues A, Santiago A, Relvas J, et al. Calcium-permeable ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion. J Biol Chem. 2012;287:38680-94 pubmed publisher
    ..The Src-tyrosine kinase has been implicated in modulating neurotransmission in CNS...