Gene Symbol: Sptbn2
Description: spectrin, beta, non-erythrocytic 2
Alias: Spnb3, spectrin beta chain, non-erythrocytic 2, beta SpIII sigma 1, beta-III spectrin, beta-spectrin 3, glutamate transporter EAAT4-associated protein 41, spectrin beta chain, brain 2, spectrin, non-erythroid beta chain 2, spectrin-like protein GTRAP41
Stankewich M, Tse W, Peters L, Ch ng Y, John K, Stabach P, et al
. A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles. Proc Natl Acad Sci U S A. 1998;95:14158-63 pubmed
..All of the tested tissues contain major 9.0-kb and minor 11.3-kb transcripts. The human betaIII spectrin gene (SPTBN2) maps to chromosome 11q13 and the mouse gene (Spnb3) maps to a syntenic region close to the centromere on ..
Ohara O, Ohara R, Yamakawa H, Nakajima D, Nakayama M. Characterization of a new beta-spectrin gene which is predominantly expressed in brain. Brain Res Mol Brain Res. 1998;57:181-92 pubmed
Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, et al
. A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13. Biochem Biophys Res Commun. 1998;248:846-51 pubmed
..by use of the yeast two-hybrid system, identified it to be a novel type of beta spectrin, and named it beta SpIII sigma 1. beta SpIII sigma 1 was specifically expressed in brain, where it was enriched in the synaptic vesicle and ..
Zhang Y, Resneck W, Lee P, Randall W, Bloch R, Ursitti J. Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat. J Mol Cell Cardiol. 2010;48:1050-9 pubmed publisher
..Our results suggest that the embryonic mammalian heart expresses a significant amount of alpha II-spectrin with a reduced avidity for beta-spectrin and the ability to promote myocyte growth. ..
Stankewich M, Gwynn B, Ardito T, Ji L, Kim J, Robledo R, et al
. Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Proc Natl Acad Sci U S A. 2010;107:6022-7 pubmed publisher
..We have explored the mechanistic basis of this phenotype by targeted gene disruption of Spnb3. Mice lacking intact betaIII spectrin develop normally. By 6 months they display a mild nonprogressive ataxia...
Page L, Sowerby P, Lui W, Robinson M. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. J Cell Biol. 1999;146:993-1004 pubmed
..The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins. ..
Jackson M, Song W, Liu M, Jin L, Dykes Hoberg M, Lin C, et al
. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 2001;410:89-93 pubmed
Holleran E, Ligon L, Tokito M, Stankewich M, Morrow J, Holzbaur E. beta III spectrin binds to the Arp1 subunit of dynactin. J Biol Chem. 2001;276:36598-605 pubmed
..We hypothesize that the interaction between betaIII spectrin and Arp1 recruits dynein and dynactin to intracellular membranes and provides a direct link between the microtubule motor complex and its membrane-bounded cargo. ..
Siddhanta A, Radulescu A, Stankewich M, Morrow J, Shields D. Fragmentation of the Golgi apparatus. A role for beta III spectrin and synthesis of phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2003;278:1957-65 pubmed
..response to diminished PtdIns(4,5)P(2) synthesis correlated with both the phosphorylation of a Golgi form of beta III spectrin, a PtdIns(4,5)P(2)-interacting protein, and changes in its intracellular redistribution...