Gene Symbol: Sptbn2
Description: spectrin, beta, non-erythrocytic 2
Alias: Spnb3, spectrin beta chain, non-erythrocytic 2, beta SpIII sigma 1, beta-III spectrin, beta-spectrin 3, glutamate transporter EAAT4-associated protein 41, spectrin beta chain, brain 2, spectrin, non-erythroid beta chain 2, spectrin-like protein GTRAP41
Species: rat
Products:     Sptbn2

Top Publications

  1. Stankewich M, Tse W, Peters L, Ch ng Y, John K, Stabach P, et al. A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles. Proc Natl Acad Sci U S A. 1998;95:14158-63 pubmed
    ..All of the tested tissues contain major 9.0-kb and minor 11.3-kb transcripts. The human betaIII spectrin gene (SPTBN2) maps to chromosome 11q13 and the mouse gene (Spnb3) maps to a syntenic region close to the centromere on ..
  2. Ohara O, Ohara R, Yamakawa H, Nakajima D, Nakayama M. Characterization of a new beta-spectrin gene which is predominantly expressed in brain. Brain Res Mol Brain Res. 1998;57:181-92 pubmed
  3. Sakaguchi G, Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, et al. A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13. Biochem Biophys Res Commun. 1998;248:846-51 pubmed
    ..by use of the yeast two-hybrid system, identified it to be a novel type of beta spectrin, and named it beta SpIII sigma 1. beta SpIII sigma 1 was specifically expressed in brain, where it was enriched in the synaptic vesicle and ..
  4. Zhang Y, Resneck W, Lee P, Randall W, Bloch R, Ursitti J. Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat. J Mol Cell Cardiol. 2010;48:1050-9 pubmed publisher
    ..Our results suggest that the embryonic mammalian heart expresses a significant amount of alpha II-spectrin with a reduced avidity for beta-spectrin and the ability to promote myocyte growth. ..
  5. Stankewich M, Gwynn B, Ardito T, Ji L, Kim J, Robledo R, et al. Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Proc Natl Acad Sci U S A. 2010;107:6022-7 pubmed publisher
    ..We have explored the mechanistic basis of this phenotype by targeted gene disruption of Spnb3. Mice lacking intact betaIII spectrin develop normally. By 6 months they display a mild nonprogressive ataxia...
  6. Page L, Sowerby P, Lui W, Robinson M. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. J Cell Biol. 1999;146:993-1004 pubmed
    ..The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins. ..
  7. Jackson M, Song W, Liu M, Jin L, Dykes Hoberg M, Lin C, et al. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 2001;410:89-93 pubmed
  8. Holleran E, Ligon L, Tokito M, Stankewich M, Morrow J, Holzbaur E. beta III spectrin binds to the Arp1 subunit of dynactin. J Biol Chem. 2001;276:36598-605 pubmed
    ..We hypothesize that the interaction between betaIII spectrin and Arp1 recruits dynein and dynactin to intracellular membranes and provides a direct link between the microtubule motor complex and its membrane-bounded cargo. ..
  9. Siddhanta A, Radulescu A, Stankewich M, Morrow J, Shields D. Fragmentation of the Golgi apparatus. A role for beta III spectrin and synthesis of phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2003;278:1957-65 pubmed
    ..response to diminished PtdIns(4,5)P(2) synthesis correlated with both the phosphorylation of a Golgi form of beta III spectrin, a PtdIns(4,5)P(2)-interacting protein, and changes in its intracellular redistribution...

More Information


  1. Legendre K, Safieddine S, Küssel Andermann P, Petit C, El Amraoui A. alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008;121:3347-56 pubmed publisher
    ..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin. ..
  2. Salcedo Sicilia L, Granell S, Jovic M, Sicart A, Mato E, Johannes L, et al. ?III spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex. J Biol Chem. 2013;288:2157-66 pubmed publisher
  3. Kobeissy F, Liu M, Yang Z, Zhang Z, Zheng W, Glushakova O, et al. Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions. Mol Neurobiol. 2015;52:696-709 pubmed publisher
    ..This work extends on previous published work that discusses the interplay spectrin family (αII-spectrin and βII-spectrin) and their susceptibility to protease proteolysis and their implication to neuronal cell death mechanisms. ..
  4. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..