Gene Symbol: Sptbn1
Description: spectrin, beta, non-erythrocytic 1
Alias: Spnb1, Spnb2, spectrin beta chain, non-erythrocytic 1, bSPII-, beta II spectrin-like (short form), cytoskeleton protein, non-erythroid spectrin beta, short form of beta II spectrin, spectrin beta 2, spectrin beta chain, brain 1
Species: rat
Products:     Sptbn1

Top Publications

  1. Kontrogianni Konstantopoulos A, Frye C, Benz E, Huang S. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. J Biol Chem. 2001;276:20679-87 pubmed
    ..1G are distributed underneath the plasma membrane in PC12 cells. Collectively, these observations suggest that brain 4.1R and 4.1G may modulate the membrane mechanical properties of neuronal cells by promoting fodrin/actin association. ..
  2. Kizhatil K, Davis J, Davis L, Hoffman J, Hogan B, Bennett V. Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. J Biol Chem. 2007;282:26552-61 pubmed
    ..Biol. Chem. 282, 2029-2037 ). Together with the current findings, these data suggest a ankyrin/spectrin-based mechanism for coordinating membrane assembly with extracellular interactions of E-cadherin at sites of cell-cell contact. ..
  3. Legendre K, Safieddine S, K├╝ssel Andermann P, Petit C, El Amraoui A. alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008;121:3347-56 pubmed publisher
    ..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin. ..
  4. Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, et al. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J Immunol. 2014;192:771-81 pubmed publisher
    ..We conclude that GBP-1 is a downstream processor of IFN-? via which T cells regulate cytoskeleton-dependent cell functions. ..
  5. Scoles D, Huynh D, Morcos P, Coulsell E, Robinson N, Tamanoi F, et al. Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Nat Genet. 1998;18:354-9 pubmed
    ..Thus, schwannomin is a tumour suppressor directly involved in actin-cytoskeleton organization, which suggests that alterations in the cytoskeleton are an early event in the pathogenesis of some tumour types. ..
  6. Hayes N, Scott C, Heerkens E, Ohanian V, Maggs A, Pinder J, et al. Identification of a novel C-terminal variant of beta II spectrin: two isoforms of beta II spectrin have distinct intracellular locations and activities. J Cell Sci. 2000;113 ( Pt 11):2023-34 pubmed
    ..We conclude that variation in the structure of the C-terminal regions of betaII spectrin isoforms correlates with their differential intracellular targeting. ..
  7. Tang Y, Katuri V, Dillner A, Mishra B, Deng C, Mishra L. Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003;299:574-7 pubmed
    ..This study reveals an unexpected molecular link between a major dynamic scaffolding protein and a key signaling pathway. ..
  8. Mohler P, Yoon W, Bennett V. Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. J Biol Chem. 2004;279:40185-93 pubmed
    ..This work also establishes a functional hierarchy in which ankyrin-B determines the localization of beta(2)-spectrin and operates independently of beta(2)-spectrin in its role in organizing membrane-spanning proteins. ..
  9. Kim S, Shetty K, Katuri V, Kitisin K, Baek H, Tang Y, et al. TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. Biochem Biophys Res Commun. 2006;344:1216-23 pubmed
    ..Thus, in response to ELF deficiency, the abnormalities of G1/S checkpoint and senescence contribute their increment of susceptibility to malignant transformation. ..

More Information


  1. Page L, Sowerby P, Lui W, Robinson M. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. J Cell Biol. 1999;146:993-1004 pubmed
    ..The presence of an EH domain suggests that gamma-synergin links the AP-1 complex to another protein or proteins. ..
  2. Lencesova L, O Neill A, Resneck W, Bloch R, Blaustein M. Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes. J Biol Chem. 2004;279:2885-93 pubmed
    ..These PM and ER components appear to be linked through the cytoskeletal spectrin network, to which they are probably tethered by Ank 2. ..
  3. Lehtonen S, Lehtonen E, Kudlicka K, Holthofer H, Farquhar M. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am J Pathol. 2004;165:923-36 pubmed
  4. Cifuentes Diaz C, Chareyre F, Garcia M, Devaux J, Carnaud M, Levasseur G, et al. Protein 4.1B contributes to the organization of peripheral myelinated axons. PLoS ONE. 2011;6:e25043 pubmed publisher
    ..Thus, our results show that in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber. ..
  5. Xu K, Zhong G, Zhuang X. Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons. Science. 2013;339:452-6 pubmed publisher
    ..Sodium channels in axons were distributed in a periodic pattern coordinated with the underlying actin-spectrin-based cytoskeleton. ..