Gene Symbol: Sptb
Description: spectrin, beta, erythrocytic
Alias: Spnb1, spectrin beta chain, erythrocytic, erythroid spectrin beta, spectrin beta 1, spectrin beta chain, erythrocyte
Species: rat
Products:     Sptb

Top Publications

  1. Sassa S, Bernstein S. Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp Hematol. 1978;6:479-87 pubmed
  2. An X, Debnath G, Guo X, Liu S, Lux S, Baines A, et al. Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate. Biochemistry. 2005;44:10681-8 pubmed
    ..1R ternary complex in vitro. Furthermore, the binding of 4.1R to 1-301 is greatly enhanced by PIP(2), implying the existence of a regulatory switch in the cell. ..
  3. Nestor M, Cai X, Stone M, Bloch R, Thompson S. The actin binding domain of ?I-spectrin regulates the morphological and functional dynamics of dendritic spines. PLoS ONE. 2011;6:e16197 pubmed publisher
    ..We suggest that ?I-spectrin is a synaptic protein that can modulate both the morphological and functional dynamics of dendritic spines, perhaps via interaction with actin and Rac3. ..
  4. Bennett V, Stenbuck P. The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes. Nature. 1979;280:468-73 pubmed
    ..It is concluded that a fraction of band 3 is attached to the erythrocyte cytoskeleton through association with ankyrin, which in turn is bound to spectrin. ..
  5. Garbarz M, Tse W, Gallagher P, Picat C, Lecomte M, Galibert F, et al. Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation. J Clin Invest. 1991;88:76-81 pubmed
  6. Bodine D, Birkenmeier C, Barker J. Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes. Cell. 1984;37:721-9 pubmed
    ..Analysis of spectrin synthesis in mice homozygous and heterozygous for several alleles of sph indicates that the sph locus is the structural gene locus for alpha spectrin. We have mapped the sph locus to mouse Chromosome 1. ..
  7. Bugge T, Kombrinck K, Xiao Q, Holmbäck K, Daugherty C, Witte D, et al. Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. Blood. 1997;90:4522-31 pubmed
  8. Kaysser T, Wandersee N, Bronson R, Barker J. Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis. Blood. 1997;90:4610-9 pubmed
    ..The severity of the renal disease and its presence in all moribund mice suggests kidney failure rather than the fibrotic heart lesions as the major cause of death in these mice. ..
  9. Wakayama Y, Inoue M, Kojima H, Murahashi M, Shibuya S, Yamashita S, et al. Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles. Acta Neuropathol. 2000;99:654-62 pubmed
    ..These results suggest that aciculin is associated with dystrophin and may interact with both the N- and C-terminal domains of dystrophin. ..

More Information


  1. Devarajan P, Scaramuzzino D, Morrow J. Ankyrin binds to two distinct cytoplasmic domains of Na,K-ATPase alpha subunit. Proc Natl Acad Sci U S A. 1994;91:2965-9 pubmed
  2. Koh T, Escobedo J. Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Am J Physiol Cell Physiol. 2004;286:C713-22 pubmed
  3. Maciag M, Płochocka D, Adamowicz Salach A, Burzynska B. Novel beta-spectrin mutations in hereditary spherocytosis associated with decreased levels of mRNA. Br J Haematol. 2009;146:326-32 pubmed publisher
    ..qPCR experiments indicated that the spectrin beta gene (SPTB) could be involved in anaemia pathogenesis...
  4. Korsgren C, Lux S. The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding. Blood. 2010;116:2600-7 pubmed publisher
    ..1R complex. A model, based on the structure of ?-actinin, suggests that the EF domain modulates the function of the ABD and that the C-terminal EF hands (EF(34)) may bind to the linker that connects the ABD to the first spectrin repeat. ..