Gene Symbol: Spred1
Description: sprouty-related, EVH1 domain containing 1
Alias: sprouty-related, EVH1 domain-containing protein 1, sprouty protein with EVH-1 domain 1, related sequence
Species: rat
Products:     Spred1

Top Publications

  1. Johne C, Matenia D, Li X, Timm T, Balusamy K, Mandelkow E. Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. Mol Biol Cell. 2008;19:1391-403 pubmed publisher
    ..and identified two new interaction partners of MARKK, the regulatory Sprouty-related protein with EVH-1 domain1 (Spred1) and the testis-specific protein kinase (TESK1)...
  2. Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, et al. Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Biochem Biophys Res Commun. 2003;302:767-72 pubmed
    ..The finding of Spred-3 revealed the presence of a novel family of regulators for the Ras/MAP kinase pathway, each member of which may have different specificities for extracellular signals. ..
  3. Li D, Jackson R, Yusoff P, Guy G. Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J Biol Chem. 2010;285:35374-85 pubmed publisher
    The mammalian SPRED (Sprouty-related protein with an EVH1 domain) proteins include a family of three members, SPRED1-3. Currently, little is known about their biochemistry...
  4. Jakob P, Doerries C, Briand S, Mocharla P, Krankel N, Besler C, et al. Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity. Circulation. 2012;126:2962-75 pubmed publisher
    ..Reduced miR-126 expression was identified as a novel mechanism limiting their capacity to improve cardiac neovascularization and function that can be targeted by miR-126 mimic transfection. ..
  5. van Mil A, Vrijsen K, Goumans M, Metz C, Doevendans P, Sluijter J. MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells. J Mol Med (Berl). 2013;91:1001-12 pubmed publisher
    ..miR-1 was found to directly target and inhibit the expression of sprouty-related EVH1 domain-containing protein 1 (Spred1). Knocking down Spred1 phenocopies the functional effect seen for miR-1 upregulation...
  6. Friedmacher F, Gosemann J, Fujiwara N, Takahashi H, Hofmann A, Puri P. Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia. Pediatr Surg Int. 2013;29:1193-8 pubmed publisher
    ..5 in nitrofen-induced PH. Decreased expression of Sproutys and SPREDs during the terminal pseudoglandular stage may disrupt lung branching morphogenesis by interfering with epithelial-mesenchymal interactions contributing to PH. ..
  7. Pitzler L, Auler M, Probst K, Frie C, Bergmeier V, Holzer T, et al. miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction. Stem Cells. 2016;34:1297-309 pubmed publisher
    ..Subsequent miRNA target analysis showed that miR-126-3p inhibits SPRED1 and PLK2 expression, induces ERK1/2 phosphorylation and stimulates TLR3 expression to modulate cell-cell and cell-..
  8. Wang S, Aurora A, Johnson B, Qi X, McAnally J, Hill J, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008;15:261-71 pubmed publisher
    ..These findings have important therapeutic implications for a variety of disorders involving abnormal angiogenesis and vascular leakage. ..
  9. Fish J, Santoro M, Morton S, Yu S, Yeh R, Wythe J, et al. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008;15:272-84 pubmed publisher
    ..in part by directly repressing negative regulators of the VEGF pathway, including the Sprouty-related protein SPRED1 and phosphoinositol-3 kinase regulatory subunit 2 (PIK3R2/p85-beta)...

More Information


  1. Quintanar Audelo M, Yusoff P, Sinniah S, Chandramouli S, Guy G. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. J Biol Chem. 2011;286:23102-12 pubmed publisher
    ..Finally, we found two tyrosine residues on SPRED1 that are required, when phosphorylated, to inhibit Ras/ERK activation and identified Tyr-420 as a specific ..