Sox9

Summary

Gene Symbol: Sox9
Description: SRY box 9
Alias: SRY, transcription factor SOX-9, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal), SRY-box containing gene 9
Species: rat
Products:     Sox9

Top Publications

  1. Rockel J, Kudirka J, Guzi A, Bernier S. Regulation of Sox9 activity by crosstalk with nuclear factor-kappaB and retinoic acid receptors. Arthritis Res Ther. 2008;10:R3 pubmed publisher
    b>Sox9 and p300 cooperate to induce expression of cartilage-specific matrix proteins, including type II collagen, aggrecan and link protein...
  2. Barrionuevo F, Bagheri Fam S, Klattig J, Kist R, Taketo M, Englert C, et al. Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. Biol Reprod. 2006;74:195-201 pubmed
    ..The autosomal gene Sox9, a likely and possibly direct Sry target, can induce testis development in the absence of Sry...
  3. Akiyama H, Kamitani T, Yang X, Kandyil R, Bridgewater L, Fellous M, et al. The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site. Matrix Biol. 2005;23:499-505 pubmed
    b>Sox9 is a transcription factor that is critical for chondrogenesis, testis determination, and development of several other organs in vertebrates. Thus the levels of Sox9 protein and its activity may be tightly regulated...
  4. Kashimada K, Svingen T, Feng C, Pelosi E, Bagheri Fam S, Harley V, et al. Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J. 2011;25:3561-9 pubmed publisher
    ..to demonstrate that Cyp26b1 and transcription factor genes steroidogenic factor-1 (Sf1) and Sry-related HMG box 9 (Sox9) are coexpressed in Sertoli cells, whereas Cyp26b1 and Sf1 are coexpressed in Leydig cells in mouse fetal testes...
  5. Kent J, Wheatley S, Andrews J, Sinclair A, Koopman P. A male-specific role for SOX9 in vertebrate sex determination. Development. 1996;122:2813-22 pubmed
    ..with campomelic dysplasia, a bone dysmorphology and XY sex reversal syndrome, indicate that the SRY-related gene SOX9 is involved in both skeletal development and sex determination...
  6. Akiyama H, Chaboissier M, Behringer R, Rowitch D, Schedl A, Epstein J, et al. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A. 2004;101:6502-7 pubmed
    ..Several gene mutations are known to affect cardiac valve formation. Sox9 is activated when endocardial endothelial cells undergo mesenchymal transformation and migrate into an ..
  7. Chaboissier M, Kobayashi A, Vidal V, Lützkendorf S, van de Kant H, Wegner M, et al. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development. 2004;131:1891-901 pubmed
    ..gene Sry, which leads to the activation of male-specific genes including the HMG-box containing gene Sox9. From transgenic studies in mice it is clear that Sox9 is sufficient to induce testis formation...
  8. Afonja O, Raaka B, Huang A, Das S, Zhao X, Helmer E, et al. RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. Oncogene. 2002;21:7850-60 pubmed
    ..One candidate gene identified was SOX9, a member of the high mobility group (HMG) box gene family of transcription factors...
  9. Schmahl J, Kim Y, Colvin J, Ornitz D, Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004;131:3627-36 pubmed
    ..The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate.

More Information

Publications83

  1. Bi W, Deng J, Zhang Z, Behringer R, de Crombrugghe B. Sox9 is required for cartilage formation. Nat Genet. 1999;22:85-9 pubmed
    ..b>SOX9 is a high-mobility-group (HMG) domain transcription factor that is expressed in chondrocytes and other tissues...
  2. Foster J, Dominguez Steglich M, Guioli S, Kwok C, Weller P, Stevanovic M, et al. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature. 1994;372:525-30 pubmed
    ..breakpoint from a sex-reversed patient with campomelic dysplasia, followed by mutation analysis of an adjacent gene, indicates that SOX9, an SRY-related gene, is involved in both bone formation and control of testis development.
  3. Stolt C, Lommes P, Sock E, Chaboissier M, Schedl A, Wegner M. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003;17:1677-89 pubmed
    ..Here we analyzed spinal cord development of mice in which the transcription factor Sox9 was specifically ablated from neural stem cells by the CRE/loxP recombination system...
  4. Panda D, Miao D, Lefebvre V, Hendy G, Goltzman D. The transcription factor SOX9 regulates cell cycle and differentiation genes in chondrocytic CFK2 cells. J Biol Chem. 2001;276:41229-36 pubmed
    b>SOX9 is a transcription factor that is essential for chondrocyte differentiation and cartilage formation. We stably overexpressed SOX9 cDNA in the rat chondrocytic cell line CFK2...
  5. Sudbeck P, Schmitz M, Baeuerle P, Scherer G. Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat Genet. 1996;13:230-2 pubmed
    Haploinsufficiency for SOX9 has recently been identified as the cause for both campomelic dysplasia (CD), a human skeletal malformation syndrome, and the associated autosomal XY sex reversal...
  6. Mori Akiyama Y, van den Born M, van Es J, Hamilton S, Adams H, Zhang J, et al. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology. 2007;133:539-46 pubmed
    The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell lineages...
  7. Bi W, Huang W, Whitworth D, Deng J, Zhang Z, Behringer R, et al. Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A. 2001;98:6698-703 pubmed
    In humans, SOX9 heterozygous mutations cause the severe skeletal dysmorphology syndrome campomelic dysplasia. Except for clinical descriptions, little is known about the pathogenesis of this disease...
  8. Lefebvre V, Li P, de Crombrugghe B. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 1998;17:5718-33 pubmed
    Transcripts for a new form of Sox5, called L-Sox5, and Sox6 are coexpressed with Sox9 in all chondrogenic sites of mouse embryos...
  9. Vidal V, Chaboissier M, de Rooij D, Schedl A. Sox9 induces testis development in XX transgenic mice. Nat Genet. 2001;28:216-7 pubmed
    Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads...
  10. Ng L, Wheatley S, Muscat G, Conway Campbell J, Bowles J, Wright E, et al. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol. 1997;183:108-21 pubmed
    Two lines of evidence suggest that the Sry-related gene Sox9 is important for chondrogenesis in mammalian embryos...
  11. Schepers G, Wilson M, Wilhelm D, Koopman P. SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J Biol Chem. 2003;278:28101-8 pubmed
    Sox8 is a member of the Sox family of developmental transcription factor genes and is closely related to Sox9, a key gene in the testis determination pathway in mammals...
  12. Huang W, Zhou X, Lefebvre V, de Crombrugghe B. Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol. 2000;20:4149-58 pubmed
    b>Sox9 is a high-mobility-group domain-containing transcription factor required for chondrocyte differentiation and cartilage formation...
  13. Furumatsu T, Tsuda M, Yoshida K, Taniguchi N, Ito T, Hashimoto M, et al. Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem. 2005;280:35203-8 pubmed
    ..We have previously reported that the multifunctional coactivator p300 is a member of the Sox9 (Sry-type high mobility group box 9)-related transcriptional apparatus and activates Sox9-dependent transcription ..
  14. Vidal V, Chaboissier M, Lützkendorf S, Cotsarelis G, Mill P, Hui C, et al. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol. 2005;15:1340-51 pubmed
    ..Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development...
  15. Seymour P, Freude K, Tran M, Mayes E, Jensen J, Kist R, et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007;104:1865-70 pubmed
    ..Here, we identify the transcription factor SOX9 as the first specific marker and maintenance factor of multipotential progenitors during pancreas organogenesis...
  16. Bell D, Leung K, Wheatley S, Ng L, Zhou S, Ling K, et al. SOX9 directly regulates the type-II collagen gene. Nat Genet. 1997;16:174-8 pubmed
    Mutations in human SOX9 are associated with campomelic dysplasia (CD), characterised by skeletal malformation and XY sex reversal...
  17. Kanazawa T, Gotoh M, Ohta K, Shiba N, Nakamura K. Three-dimensional ultrastructural analysis of development at the supraspinatus insertion by using focused ion beam/scanning electron microscope tomography in rats. J Orthop Res. 2016;34:969-76 pubmed publisher
    ..In this study, we analyzed postnatal development at the tendon-bone insertion in terms of temporal changes in SOX9/SCX expression and three-dimensional (3D) ultrastructure with FIB/SEM tomography, a new scanning electron ..
  18. Hargus G, Kist R, Kramer J, Gerstel D, Neitz A, Scherer G, et al. Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro. Int J Dev Biol. 2008;52:323-32 pubmed publisher
    The transcription factor Sox9 plays an important role during chondrogenesis...
  19. Hattori T, Eberspaecher H, Lu J, Zhang R, Nishida T, Kahyo T, et al. Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9. J Biol Chem. 2006;281:14417-28 pubmed
    We have identified PIAS1 (protein inhibitor of activated STAT-1), -3, -xalpha, and -xbeta as SOX9-associated polypeptides using the Gal4-based yeast two-hybrid system and a cDNA library derived from a chondrocytic cell line...
  20. Sinner D, Kordich J, Spence J, Opoka R, Rankin S, Lin S, et al. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007;27:7802-15 pubmed
    ..These findings indicate that Sox proteins can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts. ..
  21. Wilson M, Jeyasuria P, Parker K, Koopman P. The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. J Biol Chem. 2005;280:5917-23 pubmed
    ..Vanin-1 is co-expressed with the transcription factors steroidogenic factor-1 (SF-1) and SOX9 in Sertoli cells and, at a lower level, with SF-1 in Leydig cells in developing testes...
  22. Huang W, Lu N, Eberspaecher H, de Crombrugghe B. A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene. J Biol Chem. 2002;277:50668-75 pubmed
    A new long form of the c-Maf transcription factor (Lc-Maf) was identified and shown to interact specifically with SOX9 in a yeast two-hybrid cDNA library screening...
  23. Wang X, Fan J, Zhang M, Ni Y, Xu G. Upregulation of SOX9 in Glial (Müller) cells in retinal light damage of rats. Neurosci Lett. 2013;556:140-5 pubmed publisher
    Recent evidence suggests that SOX9 [sex-determining region Y (SRY) box 9], a transcription factor, plays a pivotal role in acquired diseases, revealing its importance in roles beyond development...
  24. Knower K, Kelly S, Ludbrook L, Bagheri Fam S, Sim H, Bernard P, et al. Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations. PLoS ONE. 2011;6:e17751 pubmed publisher
    In human embryogenesis, loss of SRY (sex determining region on Y), SOX9 (SRY-related HMG box 9) or SF1 (steroidogenic factor 1) function causes disorders of sex development (DSD)...
  25. Appleton C, Usmani S, Bernier S, Aigner T, Beier F. Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Arthritis Rheum. 2007;56:3693-705 pubmed
    ..We demonstrated the down-regulation of Sox9 messenger RNA and protein levels by TGFalpha...
  26. Coustry F, Oh C, Hattori T, Maity S, de Crombrugghe B, Yasuda H. The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res. 2010;38:6018-28 pubmed publisher
    Mutations in SOX9, a gene essential for chondrocyte differentiation cause the human disease campomelic dysplasia (CD)...
  27. Zalzali H, Naudin C, Bastide P, Quittau Prevostel C, Yaghi C, Poulat F, et al. CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium. Oncogene. 2008;27:7131-8 pubmed publisher
    A deletion of the transcription factor SOX9 gene in the mice intestine affects the morphology of the colon epithelium and leads to hyperplasia. Nevertheless, direct transcriptional targets of SOX9 in this tissue are still unknown...
  28. van der Flier L, van Gijn M, Hatzis P, Kujala P, Haegebarth A, Stange D, et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell. 2009;136:903-12 pubmed publisher
    ..The combined results from these gain- and loss-of-function experiments imply that Ascl2 controls intestinal stem cell fate. ..
  29. Schmidt K, Glaser G, Wernig A, Wegner M, Rosorius O. Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis. J Biol Chem. 2003;278:29769-75 pubmed
    ..was also detected in cell culture systems and occurred in parallel with down-regulation of the related Sox9. Overexpression of Sox8 or Sox9 on the other hand disrupted myoblasts in their ability to form myotubes...
  30. Pritchett J, Athwal V, Harvey E, Martin K, Llewellyn J, Ireland P, et al. Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells. PLoS ONE. 2014;9:e100091 pubmed publisher
    ..hepatic stellate cells (HSCs), in part, through down-regulation of pro-fibrotic Sex-determining region Y-box 9 (SOX9). Influence of EPIM on ECM was investigated in cultured primary rat HSCs...
  31. Kim J, Ryoo Z, Chun J. Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J Biol Chem. 2007;282:29359-67 pubmed
    ..Cytl1 exerted its chondrogenic effect via stimulation of Sox9 transcriptional activity...
  32. Lincoln J, Kist R, Scherer G, Yutzey K. Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. Dev Biol. 2007;305:120-32 pubmed
    ..b>Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in ..
  33. Shintaku Y, Murakami T, Yanagita T, Kawanabe N, Fukunaga T, Matsuzaki K, et al. Sox9 expression during fracture repair. Cells Tissues Organs. 2011;194:38-48 pubmed publisher
    ..b>Sox9 is a key transcription factor for chondrogenesis and is also expressed in osteochondroprogenitors during embryonic ..
  34. Muto A, Iida A, Satoh S, Watanabe S. The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina. Exp Eye Res. 2009;89:549-58 pubmed publisher
    ..We found that two group E Sox genes, Sox8 and Sox9, are expressed in proliferating progenitors and then exclusively in Müller glial cells in mouse retina...
  35. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, et al. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol. 2009;9:47 pubmed publisher
    Chondrogenesis and subsequent endochondral ossification are processes tightly regulated by the transcription factor Sox9 (SRY-related high mobility group-Box gene 9), but molecular mechanisms underlying this activity remain unclear...
  36. Kang P, Lee H, Glasgow S, Finley M, Donti T, Gaber Z, et al. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012;74:79-94 pubmed publisher
    ..a crucial role in the onset of gliogenesis; we found that its induction is regulated by the transcription factor Sox9 and that this relationship mediates the initiation of gliogenesis...
  37. Meech R, Edelman D, Jones F, Makarenkova H. The homeobox transcription factor Barx2 regulates chondrogenesis during limb development. Development. 2005;132:2135-46 pubmed
    ..to elements within the cartilage-specific Col2a1 enhancer, and this binding was reduced by addition of Barx2 or Sox9 antibodies, or by mutation of a HMG box adjacent to the Barx2-binding element, suggesting cooperation between Barx2 ..
  38. Thomsen M, Butler C, Shen M, Swain A. Sox9 is required for prostate development. Dev Biol. 2008;316:302-11 pubmed publisher
    ..In this study we show that the transcription factor Sox9 is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development...
  39. Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger B, et al. Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009;136:2325-33 pubmed publisher
    ..In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts. Here, we investigated duct development in mouse liver and characterized the role of the SRY-related HMG box transcription factor 9 (SOX9).
  40. Kim Y, Kobayashi A, Sekido R, DiNapoli L, Brennan J, Chaboissier M, et al. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol. 2006;4:e187 pubmed
    ..In the mouse XY gonad, Sry normally initiates a feed-forward loop between Sox9 and Fgf9, which up-regulates Fgf9 and represses Wnt4 to establish the testis pathway...
  41. Bhandari R, Haque M, Skinner M. Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9. PLoS ONE. 2012;7:e43380 pubmed publisher
    ..in mammalian male sex determination is the induction of the testis determining factor Sry and its downstream gene Sox9. The current study provides one of the first genome wide analyses of the downstream gene binding targets for SRY ..
  42. Matsushita T, Matsui N, Fujioka H, Kubo S, Kuroda R, Kurosaka M, et al. Expression of transcription factor Sox9 in rat L6 myoblastic cells. Connect Tissue Res. 2004;45:164-73 pubmed
    ..In our present study, we investigated the pattern of expression of Sox9, a transcription factor known to play a key role in chondrogenesis, in a rat myoblastic cell line, L6...
  43. Yang X, Li J, Qin H, Yang H, Li J, Zhou P, et al. Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. J Biol Chem. 2005;280:18710-6 pubmed
    ..The present study shows that MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development. ..
  44. Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, et al. Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription. Mol Biol Cell. 2011;22:1300-11 pubmed publisher
    SRY-box-containing gene 9 (Sox9) is an essential transcription factor in chondrocyte lineage determination and differentiation...
  45. Brisby H, Wei A, Molloy T, Chung S, Murrell G, Diwan A. The effect of running exercise on intervertebral disc extracellular matrix production in a rat model. Spine (Phila Pa 1976). 2010;35:1429-36 pubmed publisher
  46. Ling S, Chang X, Schultz L, Lee T, Chaux A, Marchionni L, et al. An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res. 2011;71:3812-21 pubmed publisher
    ..the expression, regulation, and function of the transcriptional regulator SRY-related high-mobility group box 9 (Sox9) in urothelial development, injury repair, and cancer...
  47. Oh C, Maity S, Lu J, Zhang J, Liang S, Coustry F, et al. Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS ONE. 2010;5:e10113 pubmed publisher
    Our previous work has provided strong evidence that the transcription factor SOX9 is completely needed for chondrogenic differentiation and cartilage formation acting as a "master switch" in this differentiation...
  48. Pappas G, Kriho V, Pesold C. Reelin in the extracellular matrix and dendritic spines of the cortex and hippocampus: a comparison between wild type and heterozygous reeler mice by immunoelectron microscopy. J Neurocytol. 2001;30:413-25 pubmed
    ..We speculate that the haploinsufficient reeler mouse may provide a model for future studies of the role of reelin, as it may be related to psychosis vulnerability. ..
  49. Imamura T, Imamura C, Iwamoto Y, Sandell L. Transcriptional Co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. J Biol Chem. 2005;280:16625-34 pubmed
    ..eliminating DNA binding and subsequent repression; second, binding of CBP/p300 to the transcriptional activator Sox9 increases Sox9 DNA binding to the Cd-rap promoter leading to further stimulation of gene transcription...
  50. Bastide P, Darido C, Pannequin J, Kist R, Robine S, Marty Double C, et al. Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J Cell Biol. 2007;178:635-48 pubmed
    The HMG-box transcription factor Sox9 is expressed in the intestinal epithelium, specifically, in stem/progenitor cells and in Paneth cells...
  51. Chen Z, Huang J, Liu Y, Dattilo L, Huh S, Ornitz D, et al. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development. 2014;141:2691-701 pubmed publisher
    ..b>Sox9 expression localizes to the presumptive conjunctival epithelium as early as E11...
  52. Wang C, Zhang T, Liu W, Meng H, Song Y, Wang W. Sox9-induced chondrogenesis in mesenchymal stem cells was mediated by ERK5 signal pathway. Cell Mol Biol (Noisy-le-grand). 2016;62:1-7 pubmed
    b>Sox9 is a member of the high-mobility-group (HMG) box protein superfamily, which is expressed predominantly among cells in mesenchymal condensations during the early development of embryonic skeletons...
  53. Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, et al. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011;138:1507-19 pubmed publisher
    During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior to the hypertrophic chondrocyte stage...
  54. Stöckl S, Bauer R, Bosserhoff A, Göttl C, Grifka J, Grassel S. Sox9 modulates cell survival and adipogenic differentiation of multipotent adult rat mesenchymal stem cells. J Cell Sci. 2013;126:2890-902 pubmed publisher
    b>Sox9 is a key transcription factor in early chondrogenesis with distinct roles in differentiation processes and during embryonic development...
  55. Gruber H, Ingram J, Norton H, Wei L, Frausto A, Mills B, et al. Alterations in growth plate and articular cartilage morphology are associated with reduced SOX9 localization in the magnesium-deficient rat. Biotech Histochem. 2004;79:45-52 pubmed
    ..Immunolocalization of Sox9 was decreased in both articular and growth plate cartilage in experimental animals compared to controls, suggesting ..
  56. Kim S, Im G. The expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide)/IHH (Indian hedgehog protein) in surgically induced osteoarthritis of the rat. Cell Biol Int. 2011;35:529-35 pubmed publisher
  57. Yu Z, Xu N, Wang W, Pan S, Li K, Liu J. Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin Med J (Engl). 2009;122:2483-8 pubmed
    ..change in intervertebral disc degeneration is the decrease of chondrocyte specific gene and protein expression of Sox9 and collagen type II...
  58. Sharma P, Knowell A, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, et al. Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol Cancer. 2013;12:67 pubmed publisher
    ..Expression of Id1, Sox9, Myc, androgen receptor, Akt, p-Akt, Pten and Nkx3.1 was investigated by immunohistochemistry...
  59. Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, et al. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. J Cell Sci. 2010;123:3780-8 pubmed publisher
    b>Sox9 is an essential transcription factor for chondrogenesis by regulating the expression of chondrogenic genes. However, its regulatory mechanism is not fully understood...
  60. Shen J, Ingraham H. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol Endocrinol. 2002;16:529-40 pubmed
    ..Among the approximately 20 known members of the Sox gene family, we focused on Sox3, Sox8, and Sox9, based on their coexpression with SF-1 in the embryonic testis...
  61. Hines E, Jones M, Verheyden J, Harvey J, Sun X. Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A. 2013;110:19444-9 pubmed publisher
    ..these tissues by genetically disrupting SM formation (through Srf inactivation) or cartilage formation (through Sox9 inactivation) and assessing the impact on the remaining lineage...
  62. Furumatsu T, Shukunami C, Amemiya Kudo M, Shimano H, Ozaki T. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription. Int J Biochem Cell Biol. 2010;42:148-56 pubmed publisher
    During musculoskeletal development, Sry-type HMG box 9 (Sox9) has a crucial role in mesenchymal condensation and chondrogenesis...
  63. Hoff S, Zeller F, Von Weyhern C, Wegner M, Schemann M, Michel K, et al. Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J Comp Neurol. 2008;509:356-71 pubmed publisher
    ..This is a comprehensive set of quantitative EGC measures in man and guinea pig that provides a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut...
  64. Davies S, Sakano S, Zhu Y, Sandell L. Distribution of the transcription factors Sox9, AP-2, and [delta]EF1 in adult murine articular and meniscal cartilage and growth plate. J Histochem Cytochem. 2002;50:1059-65 pubmed
    ..We have shown that transcription factors Sox9, AP-2, and [delta]EF1 are able to alter the rate of CD-RAP transcription in vitro: Sox9 upregulates, AP-2 exhibits ..
  65. Nakamuta N, Kobayashi S. Expression of p63 in the mouse primordial germ cells. J Vet Med Sci. 2004;66:1365-70 pubmed
    ..These results imply that p63 may be involved in the regulation of PGC development by controlling the gene expression required for their migration and colonization to the gonads. ..
  66. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..Sox5 and Sox18 show some cooperation on both elements, whereas Sox8 and Sox9 compete on both elements...
  67. Peacock J, Levay A, Gillaspie D, Tao G, Lincoln J. Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circ Res. 2010;106:712-9 pubmed publisher
    ..The SRY-related transcription factor Sox9 is expressed in developing and mature heart valves, and its function is required for expression of cartilage-..
  68. Seymour P, Freude K, Dubois C, Shih H, Patel N, Sander M. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008;323:19-30 pubmed publisher
    We have previously shown the transcription factor SOX9 to be required for the maintenance of multipotential pancreatic progenitor cells in the early embryonic pancreas...
  69. Fauquier T, Rizzoti K, Dattani M, Lovell Badge R, Robinson I. SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A. 2008;105:2907-12 pubmed publisher
    ..Differentiation of cells in the pituispheres was associated with the expression of nestin, SOX9, and S100...
  70. Ottolenghi C, Omari S, Garcia Ortiz J, Uda M, Crisponi L, Forabosco A, et al. Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet. 2005;14:2053-62 pubmed
    ..This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life. ..
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    ..Here we show that SOX9, a gene involved in campomelic dysplasia (CD) in humans, together with its close homologue SOX8, plays an essential ..
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    ..Gene expression study revealed that mRNA of Notch family members (notch1-3) and sox9 in NSCs was significantly upregulated by Mi cells, and this up-regulation was inhibited by AG490...
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    ..In a mouse model of cartilage injury and in end-stage human OA cartilage, the miR-29 family was also regulated. SOX9 repressed expression of miR-29a-3p and miR-29b-3p via the 29a/b1 promoter...
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    ..Its expression has been shown to be dependent on SOX9, a master transcription factor required for chondrogenesis that binds to an enhancer region in intron 1...