Gene Symbol: Sox5
Description: SRY box 5
Alias: Sox5l1, transcription factor SOX-5, SRY (sex determining region Y)-box 5, SRY-box containing gene 5, SRY-box containing gene 5-like 1
Species: rat
Products:     Sox5

Top Publications

  1. Lefebvre V, Li P, de Crombrugghe B. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 1998;17:5718-33 pubmed
    Transcripts for a new form of Sox5, called L-Sox5, and Sox6 are coexpressed with Sox9 in all chondrogenic sites of mouse embryos...
  2. Smits P, Lefebvre V. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development. 2003;130:1135-48 pubmed
    ..b>Sox5 and Sox6 encode Sry-related HMG box transcription factors that act redundantly to promote chondroblast ..
  3. Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, et al. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. J Cell Sci. 2010;123:3780-8 pubmed publisher
    ..Our results suggest that Znf219 plays an important role in the regulation of chondrocyte differentiation as a transcriptional partner of Sox9. ..
  4. Kim H, Im G. Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev. 2011;20:2103-14 pubmed publisher
  5. Feng G, Yi P, Yang Y, Chai Y, Tian D, Zhu Z, et al. Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression. Development. 2013;140:3838-47 pubmed publisher
    ..We have thus identified TFs that function at distinct developmental stages to ensure appropriate neuroblast lineage progression and suggest that their vertebrate homologs might similarly regulate neural development. ..
  6. Baroti T, Zimmermann Y, Schillinger A, Liu L, Lommes P, Wegner M, et al. Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain. Glia. 2016;64:122-38 pubmed publisher
    ..Using mice with specific deletion of the SoxD proteins Sox5 and Sox6 in the central nervous system, we now show that SoxD proteins additionally influence migration of ..
  7. Brent A, Braun T, Tabin C. Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development. 2005;132:515-28 pubmed
    ..Our analysis of Sox5/Sox6 double mutants, in which the chondroprogenitors are unable to differentiate into cartilage, reveals that the ..
  8. Lai T, Jabaudon D, Molyneaux B, Azim E, Arlotta P, Menezes J, et al. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008;57:232-47 pubmed publisher
    ..We report that the transcription factor SOX5 controls the sequential generation of distinct corticofugal neuron subtypes by preventing premature emergence of ..
  9. Kim S, Im G. The expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide)/IHH (Indian hedgehog protein) in surgically induced osteoarthritis of the rat. Cell Biol Int. 2011;35:529-35 pubmed publisher

More Information


  1. Needham C, Shah S, Dahlin R, Kinard L, Lam J, Watson B, et al. Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2. Acta Biomater. 2014;10:4103-12 pubmed publisher
    ..Finally, the results of this study suggest that subchondral bone formation is necessary for correct cartilage healing. ..
  2. Kiselak E, Shen X, Song J, Gude D, Wang J, Brody S, et al. Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5. J Biol Chem. 2010;285:30496-505 pubmed publisher
    b>SOX5 is a transcription factor with homology to the high mobility group box region of the testis-determining factor, SRY...
  3. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..In contrast, Sox17 and Sox4 cooperate more strongly on the compressed than on the canonical element. Sox5 and Sox18 show some cooperation on both elements, whereas Sox8 and Sox9 compete on both elements...