Sox2

Summary

Gene Symbol: Sox2
Description: SRY box 2
Alias: RGD1565646, transcription factor SOX-2, SRY (sex determining region Y)-box 2, SRY-box containing gene 2
Species: rat
Products:     Sox2

Top Publications

  1. Mansukhani A, Ambrosetti D, Holmes G, Cornivelli L, Basilico C. Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol. 2005;168:1065-76 pubmed
    ..down-regulation of the expression of many Wnt target genes and a concomitant induction of the transcription factor Sox2. Most of these changes could be reproduced by treatment of osteoblasts with exogenous FGF...
  2. Avilion A, Nicolis S, Pevny L, Perez L, Vivian N, Lovell Badge R. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003;17:126-40 pubmed
    ..The transcription factor SOX2 has also been implicated in the regulation of Fgf4 expression...
  3. Ferri A, Cavallaro M, Braida D, Di Cristofano A, Canta A, Vezzani A, et al. Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development. 2004;131:3805-19 pubmed
    In many species, the Sox2 transcription factor is a marker of the nervous system from the beginning of its development, and we have previously shown that Sox2 is expressed in embryonic neural stem cells...
  4. Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y. SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer. 2008;98:824-31 pubmed publisher
    ..We previously reported that the SOX2 protein is expressed in normal gastric mucosae but downregulated in some human gastric carcinomas...
  5. Yoshida S, Kato T, Susa T, Cai L, Nakayama M, Kato Y. PROP1 coexists with SOX2 and induces PIT1-commitment cells. Biochem Biophys Res Commun. 2009;385:11-5 pubmed publisher
    ..Our immunohistochemical studies demonstrated that PROP1 is consistently expressed in SOX2-expressing stem/progenitor cells in the rat pituitary from embryonic (E) to postnatal periods. At E13...
  6. Yuan H, Corbi N, Basilico C, Dailey L. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 1995;9:2635-45 pubmed
    ..Through the cloning and characterization of an F9 cell cDNA we now show that the latter activity is Sox2, a member of the Sry-related Sox factors family...
  7. Fong H, Hohenstein K, Donovan P. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells. 2008;26:1931-8 pubmed publisher
    ..Studies in mice have implicated three factors in regulating pluripotency in embryonic stem cells, Oct4, Nanog, and Sox2. However, significant differences in growth regulation between mouse embryonic stem and hES cells have been ..
  8. Fauquier T, Rizzoti K, Dattani M, Lovell Badge R, Robinson I. SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A. 2008;105:2907-12 pubmed publisher
    ..05%) population of progenitor cells in the adult pituitary gland. We show that these cells express SOX2, a marker of several early embryonic progenitor and stem cell types, and form "pituispheres" in culture, ..
  9. Palasingam P, Jauch R, Ng C, Kolatkar P. The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. J Mol Biol. 2009;388:619-30 pubmed publisher
    ..regulates endodermal lineage commitment and is thought to function antagonistically to the pluripotency determinant Sox2. To investigate the biochemical basis for the distinct functions of Sox2 and Sox17, we solved the crystal structure ..

More Information

Publications80

  1. Chew J, Loh Y, Zhang W, Chen X, Tam W, Yeap L, et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol. 2005;25:6031-46 pubmed
    ..Oct4 and Sox2 are transcription factors essential to the pluripotent and self-renewing phenotypes of ESCs...
  2. Du L, Yang Y, Xiao X, Wang C, Zhang X, Wang L, et al. Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma. Oral Oncol. 2011;47:709-13 pubmed publisher
    b>Sox2 is a marker of embryonic stem cell pluripotency and plays an important role in tumor progression...
  3. Boyer L, Lee T, Cole M, Johnstone S, Levine S, Zucker J, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122:947-56 pubmed
    The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture...
  4. Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Puceat M. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol. 2009;186:665-73 pubmed publisher
    ..When embryonic stem cell pluripotency is achieved, Oct4 switches from the Sox2 to the Sox17 promoter...
  5. Leis O, Eguiara A, López Arribillaga E, Alberdi M, Hernández García S, Elorriaga K, et al. Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene. 2012;31:1354-65 pubmed publisher
    ..Expression of pluripotency genes (Oct4, Nanog and Sox2) was tested in breast tumours by immunohistochemistry and it was found that Sox2 is expressed in early stage breast ..
  6. Shimozaki K, Zhang C, Suh H, Denli A, Evans R, Gage F. SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. J Biol Chem. 2012;287:5969-78 pubmed publisher
    ..Here we show that SRY-box-containing gene 2 (Sox2) and nuclear receptor tailless (TLX) form a molecular network in adult NSCs...
  7. Gao X, Tate P, Hu P, Tjian R, Skarnes W, Wang Z. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A. 2008;105:6656-61 pubmed publisher
    ..remodeling contributes to the proper expression of numerous genes involved in ES cell self-renewal, including Sox2, Utf1, and Oct4...
  8. Kelberman D, de Castro S, Huang S, Crolla J, Palmer R, Gregory J, et al. SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development. J Clin Endocrinol Metab. 2008;93:1865-73 pubmed publisher
    Heterozygous, de novo mutations in the transcription factor SOX2 are associated with bilateral anophthalmia or severe microphthalmia and hypopituitarism...
  9. Ha S, Pereira J, Jeong J, Huh J, Kim S. Purification of human transcription factors Nanog and Sox2, each in complex with Skp, an Escherichia coli periplasmic chaperone. Protein Expr Purif. 2009;67:164-8 pubmed publisher
    Nanog and Sox2 are key transcriptional factors involved in self-renewal and pluripotency of stem cells in human and other mammals...
  10. Ahmed M, Xu J, Xu P. EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development. 2012;139:1965-77 pubmed publisher
    ..BRG1 and BAF170 to drive neurogenesis cooperatively in 3T3 cells and cochlear nonsensory epithelial cells, and that SOX2 cooperates with these factors to mediate neuronal differentiation...
  11. Koike T, Wakabayashi T, Mori T, Hirahara Y, Yamada H. Sox2 promotes survival of satellite glial cells in vitro. Biochem Biophys Res Commun. 2015;464:269-74 pubmed publisher
    b>Sox2 is a transcriptional factor expressed in neural stem cells. It is known that Sox2 regulates cell differentiation, proliferation and survival of the neural stem cells...
  12. Nishimura N, Ueharu H, Nishihara H, Shibuya S, Yoshida S, Higuchi M, et al. Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene. J Reprod Dev. 2016;62:93-102 pubmed publisher
    ..5 (E11.5) in SOX2-expressing stem/progenitor cells and always coexists with SOX2 throughout life...
  13. Nishiguchi S, Wood H, Kondoh H, Lovell Badge R, Episkopou V. Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998;12:776-81 pubmed
    ..It appears that the direct interaction of the SOX1 protein with a promoter element conserved in all gamma-crystallin genes is responsible for their expression. ..
  14. Donner A, Episkopou V, Maas R. Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol. 2007;303:784-99 pubmed
    b>Sox2, which encodes an SRY-like HMG box transcription factor, is critical for vertebrate development. Sox2 mediates its transcriptional effects through the formation of complexes with specific co-factors, many of which are unknown...
  15. Li W, Wu J, Yang J, Sun S, Chai R, Chen Z, et al. Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A. 2015;112:166-71 pubmed publisher
  16. Zhang K, Haversat J, Mager J. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol. 2013;383:15-27 pubmed publisher
    ..of some lineage specific factors is markedly reduced in Ctr9 knockdown embryos, including Eomes, Elf5 and Sox2, while others are inappropriately expressed (Oct4, Nanog, Gata6, Fgf4 and Sox17)...
  17. Shen C, Zhang H, Wang P, Feng J, Li J, Xu Y, et al. Deoxycholic acid (DCA) confers an intestinal phenotype on esophageal squamous epithelium via induction of the stemness-associated reprogramming factors OCT4 and SOX2. Cell Cycle. 2016;15:1439-49 pubmed publisher
    ..This study focuses on the involvement of OCT4 and SOX2, 2 key cell-reprogramming factors, in the deoxycholic acid (DCA)-induced expression of the intestinal hallmarks ..
  18. McGowan S, Edelhauser H, Pfister R, Whikehart D. Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol Vis. 2007;13:1984-2000 pubmed
    ..It is suggested that stem cells reside in the posterior limbus and respond to corneal wounding to initiate an endothelial repair process. The stem cells may also contribute to a normal, slow replacement of corneal endothelial cells. ..
  19. Teo A, Arnold S, Trotter M, Brown S, Ang L, Chng Z, et al. Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25:238-50 pubmed publisher
    ..Importantly, the pluripotency factors NANOG, OCT4, and SOX2 have an essential function in this network by actively directing differentiation...
  20. Huang Y, Luo M, Ni Y, Tsang J, Chan S, Lui P, et al. Increased SOX2 expression in less differentiated breast carcinomas and their lymph node metastases. Histopathology. 2014;64:494-503 pubmed publisher
    b>SOX2 is a key regulatory gene in embryonic stem cells. Although it has been implicated in cancer progression, its role in breast carcinoma is poorly understood...
  21. Hutchins A, Choo S, Mistri T, Rahmani M, Woon C, Ng C, et al. Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells. Stem Cells. 2013;31:269-81 pubmed publisher
    ..the well-known and most prevalent sox-oct motif, we also discovered a novel constrained spacer motif for Esrrb and Sox2 with a gap of between 2 and 8 bps that Essrb and Sox2 cobind in a selective fashion...
  22. Johnson L, Lamb K, Gao Q, Nowling T, Rizzino A. Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. Mol Reprod Dev. 1998;50:377-86 pubmed
    ..Taken together, these studies argue strongly that Sox-2 plays an important role in the expression of the FGF-4 gene in vivo. ..
  23. Shimozaki K, Clemenson G, Gage F. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci. 2013;33:4066-75 pubmed publisher
    ..Prx1 works with the transcription factor Sox2 as a coactivator, and depletion of Prx1 in cultured adult mouse NSCs reduces their self-renewal...
  24. Wiebe M, Nowling T, Rizzino A. Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. J Biol Chem. 2003;278:17901-11 pubmed
    ..Our findings suggest that the autoinhibitory domain can repress promiscuous binding of Sox-11 to DNA and plays an important role in regulating the recruitment of Sox-11 to specific genes. ..
  25. Lee H, Wu J, Chung J, Wrathall J. SOX2 expression is upregulated in adult spinal cord after contusion injury in both oligodendrocyte lineage and ependymal cells. J Neurosci Res. 2013;91:196-210 pubmed publisher
    ..These included Sox2 (sex determining region Y-box 2), a transcription factor that regulates self-renewal and potency of embryonic ..
  26. Niakan K, Ji H, Maehr R, Vokes S, Rodolfa K, Sherwood R, et al. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010;24:312-26 pubmed publisher
    ..cell types and maintain expression of pluripotency-associated transcription factors, including Oct4, Nanog, and Sox2. In contrast, forced expression of Sox17 down-regulates ES cell-associated gene expression and directly activates ..
  27. Laga A, Zhan Q, Weishaupt C, Ma J, Frank M, Murphy G. SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol. 2011;20:339-45 pubmed publisher
    b>SOX2 is an embryonic neural crest stem-cell transcription factor recently shown to be expressed in human melanoma and to correlate with experimental tumor growth...
  28. Tsuruzoe S, Ishihara K, Uchimura Y, Watanabe S, Sekita Y, Aoto T, et al. Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun. 2006;351:920-6 pubmed
    b>Sox2 is a member of the high mobility group (HMG) domain DNA-binding proteins for transcriptional control and chromatin architecture...
  29. Peltier J, Conway A, Keung A, Schaffer D. Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation. Stem Cells Dev. 2011;20:1153-61 pubmed publisher
    ..Here we demonstrate that Akt promotes expression of Sox2, a core transcription factor important for the self-renewal of NPCs...
  30. Bani Yaghoub M, Tremblay R, Lei J, Zhang D, Zurakowski B, Sandhu J, et al. Role of Sox2 in the development of the mouse neocortex. Dev Biol. 2006;295:52-66 pubmed
    ..Here, we examined the mechanism of Sox2 action during neocortical neurogenesis and gliogenesis...
  31. Guo Z, Packard A, Krolewski R, Harris M, Manglapus G, Schwob J. Expression of pax6 and sox2 in adult olfactory epithelium. J Comp Neurol. 2010;518:4395-418 pubmed publisher
    ..The transcription factors Pax6 and Sox2 are characteristic of stem cells in many tissues, including the brain...
  32. Mihelec M, Abraham P, Gibson K, Krowka R, Susman R, Storen R, et al. Novel SOX2 partner-factor domain mutation in a four-generation family. Eur J Hum Genet. 2009;17:1417-22 pubmed publisher
    ..In most cases the underlying genetic cause is unknown, but mutations in some genes, such as SOX2, cause ocular developmental defects, particularly anophthalmia, in a subset of patients...
  33. Dong S, Leung K, Pelling A, Lee P, Tang A, Heng H, et al. Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics. 2002;79:777-84 pubmed
    ..Ysb and Lcc show for the first time, to our knowledge, the presence of genes in the B-C region of chromosome 3 important for balance and hearing and the pigmentation and specification of coat hair. ..
  34. Yoshida S, Kato T, Yako H, Susa T, Cai L, Osuna M, et al. Significant quantitative and qualitative transition in pituitary stem?/? progenitor cells occurs during the postnatal development of the rat anterior pituitary. J Neuroendocrinol. 2011;23:933-43 pubmed publisher
    We reported recently that a pituitary-specific transcription factor PROP1 is present in SOX2-positive cells and disappears at the early stage of the transition from progenitor cell to committed cell during the embryonic development of the ..
  35. Higuchi M, Kato T, Chen M, Yako H, Yoshida S, Kanno N, et al. Temporospatial gene expression of Prx1 and Prx2 is involved in morphogenesis of cranial placode-derived tissues through epithelio-mesenchymal interaction during rat embryogenesis. Cell Tissue Res. 2013;353:27-40 pubmed publisher
    ..of PRX1 and PRX2 with novel antibodies specific for each factor, together with a stem/progenitor marker SOX2 (sex-determining region Y-box 2) in the primordia formed by epithelio-mesenchymal interaction...
  36. Hong N, Kim M, Min C, Kim H, Lee J. The co-expression of Neogenin with SOX2 in hippocampal neurons. Biochem Biophys Res Commun. 2017;490:453-459 pubmed publisher
    ..indicated that a significant population of fetal rat neuronal cells exhibiting Neogenin expression also displayed SOX2 expression, implying co-expression of Neogenin and SOX2 in the hippocampus...
  37. Card D, Hebbar P, Li L, Trotter K, Komatsu Y, Mishina Y, et al. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol. 2008;28:6426-38 pubmed publisher
    Oct4 and Sox2 are transcription factors required for pluripotency during early embryogenesis and for the maintenance of embryonic stem cell (ESC) identity...
  38. Qiao B, He B, Cai J, Yang W. The expression profile of Oct4 and Sox2 in the carcinogenesis of oral mucosa. Int J Clin Exp Pathol. 2014;7:28-37 pubmed
    This study is to detect the co-expression of embryonic stem cell-related markers (Oct4 and Sox2) in the carcinogenesis of oral mucosa...
  39. Taranova O, Magness S, Fagan B, Wu Y, Surzenko N, Hutton S, et al. SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 2006;20:1187-202 pubmed
    ..with anophthalmia (absent eye) or severe microphthalmia (small eye) show haploid insufficiency due to mutations in SOX2, a SOXB1-HMG box transcription factor...
  40. Kunarso G, Wong K, Stanton L, Lipovich L. Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics. 2008;9:155 pubmed publisher
    ..Transcriptional regulators including Oct4 (Oct3/4 index), Sox2 and Nanog are fundamental for maintaining the undifferentiated state...
  41. Rajab A, Kelberman D, de Castro S, Biebermann H, Shaikh H, Pearce K, et al. Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. Hum Mol Genet. 2008;17:2150-9 pubmed publisher
    ..expressed in defined regions of the sensory epithelium of the developing inner ear in a pattern overlapping that of SOX2, which precedes the onset of LHX3 expression and is known to be required for inner ear and pituitary development in ..
  42. Go M, Takenaka C, Ohgushi H. Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Exp Cell Res. 2008;314:1147-54 pubmed publisher
    ..With the aim of conferring higher capability on human bone marrow MSCs, we introduced the Sox2 or Nanog gene into the cells...
  43. Shen J, Jia W, Yu Y, Chen J, Cao X, Du Y, et al. Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells. 2015;33:661-73 pubmed publisher
    ..Together, our results suggest that Pwp1 plays important roles in the differentiation potential of mESCs. ..
  44. Kelberman D, Rizzoti K, Avilion A, Bitner Glindzicz M, Cianfarani S, Collins J, et al. Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. J Clin Invest. 2006;116:2442-55 pubmed
    The transcription factor SOX2 is expressed most notably in the developing CNS and placodes, where it plays critical roles in embryogenesis...
  45. Song N, Jia X, Jia L, Ma X, Li F, Wang E, et al. Expression and role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epithelium. Cell Prolif. 2010;43:49-55 pubmed publisher
    To explore the role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epithelium. An ex vivo model of rat tracheal epithelial regeneration using 5-fluorouracil (5-FU) was developed, to induce injury...
  46. Tomihara Newberger C, Haub O, Lee H, Soares V, Manova K, Lacy E. The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives. Dev Biol. 1998;204:34-54 pubmed
  47. Muotri A, Chu V, Marchetto M, Deng W, Moran J, Gage F. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature. 2005;435:903-10 pubmed
    ..The molecular mechanism of action is probably mediated through Sox2, because a decrease in Sox2 expression during the early stages of neuronal differentiation is correlated with ..
  48. Kamachi Y, Sockanathan S, Liu Q, Breitman M, Lovell Badge R, Kondoh H. Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J. 1995;14:3510-9 pubmed
    ..This work is the first to show delta- and gamma-crystallin genes as examples of direct regulatory targets of SOX proteins and provides evidence that diversified crystallin genes are regulated, at least partly, by a common mechanism. ..
  49. Collignon J, Sockanathan S, Hacker A, Cohen Tannoudji M, Norris D, Rastan S, et al. A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996;122:509-20 pubmed
    ..However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties. ..
  50. Johansson H, Simonsson S. Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY). 2010;2:815-22 pubmed
    ..We found that all three core transcription factors, namely Oct4, Sox2 and Nanog, individually formed complexes with nucleophosmin (Npm1)...
  51. Zhao M, Amiel S, Christie M, Muiesan P, Srinivasan P, Littlejohn W, et al. Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J Endocrinol. 2007;195:407-14 pubmed
    ..This study assessed the expression of classic stem cell markers: Oct4, Sox2 and CD34 in islet-enriched fractions versus exocrine cell-enriched fractions from 25 adult human pancreases ..
  52. Nonaka H, Niidome T, Shinozuka Y, Akaike A, Kihara T, Sugimoto H. A role for SOX2 in the generation of microtubule-associated protein 2-positive cells from microglia. Biochem Biophys Res Commun. 2009;380:60-4 pubmed publisher
    ..In this study, we investigated the role of SOX2, a high-mobility group DNA binding domain transcription factor, in the generation of microglia-derived MAP2-..
  53. Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, et al. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells. 2009;27:2969-78 pubmed publisher
    ..Oct4, Sox2, and Klf4, factors that share many target genes in embryonic stem (ES) cells, are critical components in various ..
  54. Sinner D, Kordich J, Spence J, Opoka R, Rankin S, Lin S, et al. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007;27:7802-15 pubmed
    ..These findings indicate that Sox proteins can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts. ..
  55. Schrock A, Göke F, Wagner P, Bode M, Franzen A, Braun M, et al. Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer. PLoS ONE. 2013;8:e59201 pubmed publisher
    The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells...
  56. Fantes J, Ragge N, Lynch S, McGill N, Collin J, Howard Peebles P, et al. Mutations in SOX2 cause anophthalmia. Nat Genet. 2003;33:461-3 pubmed
    A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia...
  57. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..b>Sox2, Sox14, Sox21 and Sox15 strongly cooperate on the canonical element but compete with Oct4 on a recently discovered ..
  58. Kiernan A, Pelling A, Leung K, Tang A, Bell D, Tease C, et al. Sox2 is required for sensory organ development in the mammalian inner ear. Nature. 2005;434:1031-5 pubmed
    ..are due to the absence (in Lcc mutants) or reduced expression (in Ysb mutants) of the transcription factor SOX2, specifically within the developing inner ear...
  59. Sun Y, Zhang R, Wang M, Zhang Y, Qi J, Li J. SOX2 autoantibodies as noninvasive serum biomarker for breast carcinoma. Cancer Epidemiol Biomarkers Prev. 2012;21:2043-7 pubmed publisher
    ..has been established between antibodies to the transcription factor sex-determining region Y (SRY)-box 2 (SOX2) and small cell lung cancer...
  60. Haslinger A, Schwarz T, Covic M, Lie D. Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci. 2009;29:2103-14 pubmed publisher
    ..neuronally committed precursors and immature neurons but that Sox11 is not expressed in non-committed Sox2-expressing precursor cells and mature neurons of the adult neurogenic lineage...
  61. Schneider A, Bardakjian T, Reis L, Tyler R, Semina E. Novel SOX2 mutations and genotype-phenotype correlation in anophthalmia and microphthalmia. Am J Med Genet A. 2009;149A:2706-15 pubmed publisher
    b>SOX2 represents a High Mobility Group domain containing transcription factor that is essential for normal development in vertebrates...
  62. Aktug H, Uysal A, Yavasoglu A, Oltulu F, Akarca S, Yılmaz Dilsiz O, et al. The detrimental effects of diabetes on pluripotency determined by KLF4, SOX2, C-MYC and OCT4 immunoreactivity in rat testes. Adv Clin Exp Med. 2013;22:327-35 pubmed
    ..in testicular tissue due to STZ induced diabetes regarding pluripotency via transcription factors like Klf4, Sox2, c-Myc and Oct4, and to determine weight changes in both the subjects and the testes during the experiment...
  63. Zhao C, Ma D, Zawadzka M, Fancy S, Elis Williams L, Bouvier G, et al. Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination. J Neurosci. 2015;35:11482-99 pubmed publisher
    ..However, comparatively little is known about the role of Sox2, especially during CNS remyelination...
  64. Zhang D, Wang H, Liu H, Tao T, Wang N, Shen A. nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription. Mol Neurobiol. 2016;53:6444-6458 pubmed publisher
    ..In the present study, we identified a specific interaction between nNOS and Sox2 (SRY (sex determining region Y)-box 2), a member of the Sox family of transcription factors, both in vivo and in ..
  65. Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S. Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem. 2005;280:24371-9 pubmed
    Sox family transcription factors play essential roles in cell differentiation, development, and sex determination. Sox2 was previously thought to be the sole Sox protein expressed in mouse embryonic stem (ES) cells...
  66. Zhang Y, Qi X, Yao Y, Liu Z, Xia C. Expression pattern of transcription factor SOX2 in reprogrammed oligodendrocyte precursor cells and microglias: Implications for glial neurogenesis. Acta Neurobiol Exp (Wars). 2014;74:33-43 pubmed
    ..In this study, we investigated the role of SRY (sex-determining region)-box 2 (SOX2), a high-mobility group DNA binding domain transcription factor, in the reprogramming of OPCs and MGs and molecular ..
  67. Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross M, Vriend G, et al. New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 1998;12:2073-90 pubmed
    ..Expression, DNA binding, and transactivation data are consistent with the hypothesis that OPN expression is regulated by Oct-4 and Sox-2 in preimplantation development. ..
  68. Konno D, Iwashita M, Satoh Y, Momiyama A, Abe T, Kiyonari H, et al. The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS ONE. 2012;7:e46577 pubmed publisher
  69. Xu N, Papagiannakopoulos T, Pan G, Thomson J, Kosik K. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell. 2009;137:647-58 pubmed publisher
    ..We identify the pluripotency factors OCT4, SOX2, and KLF4 as direct targets of miR-145 and show that endogenous miR-145 represses the 3' untranslated regions of ..
  70. Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedorova M, Parkinson D, et al. EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell. 2010;143:145-55 pubmed publisher
    ..Mechanistically, we find that cell-sorting downstream of EphB2 is mediated by the stemness factor Sox2 through N-cadherin relocalization to Schwann cell-cell contacts...
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    ..At least five SOX genes, Sox2, Sox6, Sox7, Sox13, and Sox17, were expressed in F9 cells, and of these, Sox7 and Sox17 were dramatically induced ..