Gene Symbol: Sorbs1
Description: sorbin and SH3 domain containing 1
Alias: CAP, SH3P12, sorbin and SH3 domain-containing protein 1, Cbl associated protein, ponsin
Species: rat
Products:     Sorbs1

Top Publications

  1. Ribon V, Printen J, Hoffman N, Kay B, Saltiel A. A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol. 1998;18:872-9 pubmed
    ..Here we describe the isolation and the characterization of a novel protein that we termed CAP for c-Cbl-associated protein...
  2. Ribon V, Herrera R, Kay B, Saltiel A. A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. J Biol Chem. 1998;273:4073-80 pubmed
    c-Cbl-associated protein, CAP, was originally cloned from a 3T3-L1 adipocyte cDNA expression library using full-length c-Cbl as a bait...
  3. Thirone A, Carvalheira J, Hirata A, Velloso L, Saad M. Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance. Endocrinology. 2004;145:281-93 pubmed
    ..exposure to insulin stimulates the tyrosine phosphorylation of Cbl and its association with Cbl-associated protein (CAP) in muscle and adipose tissue of rats in vivo...
  4. Nunes S, Ferralli J, Choi K, Brown Luedi M, Minet A, Chiquet Ehrismann R. The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. Exp Cell Res. 2005;305:122-32 pubmed
    ..One of the proteins identified is the c-Cbl-associated protein CAP/ponsin, an adaptor protein containing SH3 domains...
  5. Saito M, Lessard S, Rivas D, Reeder D, Hawley J, Yaspelkis B. Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism. 2008;57:1173-80 pubmed publisher
    We determined whether sustained aerobic exercise reverses high-fat diet-induced impairments in the c-Cbl associated protein (CAP)/Casitas b-lineage lymphoma (c-Cbl) signaling cascade in rodent skeletal muscle...
  6. Mandai K, Nakanishi H, Satoh A, Takahashi K, Satoh K, Nishioka H, et al. Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J Cell Biol. 1999;144:1001-17 pubmed nonepithelial cells, we attempted here to identify an l-afadin-binding protein(s) and isolated a protein, named ponsin. Ponsin had many splicing variants and the primary structures of two of them were determined...
  7. Baumann C, Ribon V, Kanzaki M, Thurmond D, Mora S, Shigematsu S, et al. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature. 2000;407:202-7 pubmed
    ..Cbl is recruited to the insulin receptor by interaction with the adapter protein CAP, through one of three adjacent SH3 domains in the carboxy terminus of CAP...
  8. Bernard J, Saito M, Liao Y, Yaspelkis B, Ivy J. Exercise training increases components of the c-Cbl-associated protein/c-Cbl signaling cascade in muscle of obese Zucker rats. Metabolism. 2008;57:858-66 pubmed publisher
    ..These results suggest that skeletal muscle insulin resistance is associated with reduced expression of TC10 and that this deficiency can be corrected with exercise training. ..
  9. Lin W, Huang C, Liu M, Chang H, Chen Y, Tai T, et al. Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. Genomics. 2001;74:12-20 pubmed
    SH3P12/CAP/ponsin, a gene product with a sorbin homology domain and three consecutive SH3 domains in the carboxy-terminus, has been isolated from murine adipocytes and identified as an important adaptor during insulin signaling...

More Information


  1. Xie J, Cai T, Zhang H, Lan M, Notkins A. The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. Genomics. 2002;80:54-61 pubmed
    ..that interacted with INSM1 by the yeast two-hybrid system and the binding of one of them, Cbl-associated protein (CAP), to INSM1 was confirmed by in vitro pull-down experiments, nuclear colocalization, and co-immunoprecipitation ..
  2. Lesniewski L, Hosch S, Neels J, De Luca C, Pashmforoush M, Lumeng C, et al. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007;13:455-62 pubmed
    ..positive role of Cap in glucose uptake, here we show that deletion of the gene encoding Cap (official gene name: Sorbs1) protects against high-fat diet (HFD)-induced insulin resistance in mice while also having an opposite, insulin-..
  3. Lin W, Chiu K, Chang H, Lee K, Tai T, Chuang L. Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes. Hum Mol Genet. 2001;10:1753-60 pubmed
    In the mouse, the SH3P12 or the c-Cbl-associated protein (CAP) has been shown as an important signaling molecule in insulin-stimulated glucose uptake...
  4. Satoh T. Rho GTPases in insulin-stimulated glucose uptake. Small Gtpases. 2014;5:e28102 pubmed publisher
    ..In addition, the role for another Rho family member TC10 and its regulatory mechanism in adipocyte insulin signaling are described. ..
  5. Lebre A, Jamot L, Takahashi J, Spassky N, Leprince C, Ravise N, et al. Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions. Hum Mol Genet. 2001;10:1201-13 pubmed
    ..R85 and CAP are generated by alternative splicing of the gene SH3P12 which we localized on chromosome 10q23-q24...
  6. Tosoni D, Cestra G. CAP (Cbl associated protein) regulates receptor-mediated endocytosis. FEBS Lett. 2009;583:293-300 pubmed publisher
    CAP (c-Cbl associated protein)/ponsin belongs to a family of adaptor proteins implicated in cell adhesion and signaling. Here we show that CAP binds to and co-localizes with the essential endocytic factor dynamin...