sodium coupled citrate transporter
Gene Symbol: sodium coupled citrate transporter
Description: solute carrier family 13 member 5
Alias: Nact, solute carrier family 13 member 5, Na(+)/citrate cotransporter, sodium-coupled citrate transporter, sodium-dependent citrate transporter, solute carrier family 13 (sodium-dependent citrate transporter), member 5
Gopal E, Miyauchi S, Martin P, Ananth S, Srinivas S, Smith S, et al
. Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. Am J Physiol Gastrointest Liver Physiol. 2007;292:G402-8 pubmed
In this article, we report on the expression and function of a Na(+)-coupled transporter for citrate, NaCT, in human and rat liver cell lines and in primary hepatocytes from the rat liver...
Yodoya E, Wada M, Shimada A, Katsukawa H, Okada N, Yamamoto A, et al
. Functional and molecular identification of sodium-coupled dicarboxylate transporters in rat primary cultured cerebrocortical astrocytes and neurons. J Neurochem. 2006;97:162-73 pubmed
..Na+-coupled dicarboxylate transporter 3, NaDC3/SDCT2) and NaC2 (formerly known as Na+-coupled citrate transporter, NaCT) have been shown to be expressed in brain...
Hardies K, de Kovel C, Weckhuysen S, Asselbergh B, Geuens T, Deconinck T, et al
. Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia. Brain. 2015;138:3238-50 pubmed publisher
..All three patients who tried the ketogenic diet responded well to this treatment, and future studies will allow us to ascertain whether this is a recurrent feature in this severe disorder. ..
Pesta D, Perry R, Guebre Egziabher F, Zhang D, Jurczak M, Fischer Rosinsky A, et al
. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Aging (Albany NY). 2015;7:1086-93 pubmed
..Together, these data suggest that inducible liver-selective reduction of mIndy in rats is able to ameliorate hepatic steatosis and insulin resistance, conditions occurring with high calorie diets and during aging. ..
Inoue K, Zhuang L, Maddox D, Smith S, Ganapathy V. Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain. J Biol Chem. 2002;277:39469-76 pubmed
..Here we report on the cloning and functional characterization of a plasma membrane transporter (NaCT for Na+ -coupled citrate transporter) from rat brain that mediates uphill cellular uptake of citrate coupled to an ..
Inoue K, Fei Y, Zhuang L, Gopal E, Miyauchi S, Ganapathy V. Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for tricarboxylic acid cycle intermediates. Biochem J. 2004;378:949-57 pubmed
In the present study, we report on the molecular cloning and functional characterization of mouse NaCT (Na+-coupled citrate transporter), the mouse orthologue of Drosophila Indy...
Neuschäfer Rube F, Lieske S, Kuna M, Henkel J, Perry R, Erion D, et al
. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes. 2014;63:1048-57 pubmed publisher
..Together, these data suggest that mIndy is a CREB-dependent glucagon target gene that is induced in fasting and in type 2 diabetes. Increased mIndy expression might contribute to the metabolic consequences of diabetes in the liver. ..
NeuschÃ¤fer Rube F, Schraplau A, Schewe B, Lieske S, KrÃ¼tzfeldt J, Ringel S, et al
. Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes. Toxicology. 2015;337:1-9 pubmed publisher
..be derived from the mitochondrium or be taken up from the blood via the plasma membrane sodium citrate transporter NaCT, the product of the mammalian INDY gene (SLC13A5)...