Gene Symbol: Sod2
Description: superoxide dismutase 2
Alias: MnSOD, superoxide dismutase [Mn], mitochondrial, Superoxide dimutase 2, mitochondrial, manganese superoxide dismutase, mitochondrial superoxide dismutase 2, superoxide dismutase 2, mitochondrial
Species: rat
Products:     Sod2

Top Publications

  1. Li Y, Huang T, Carlson E, Melov S, Ursell P, Olson J, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet. 1995;11:376-81 pubmed
    The Sod2 gene for Mn-superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation, was inactivated by ..
  2. Melov S, Schneider J, Day B, Hinerfeld D, Coskun P, Mirra S, et al. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet. 1998;18:159-63 pubmed
    ..Consequently, MnTBAP-treated Sod2tm1Cje(-/-) mice may provide an excellent model for examining the relationship between free radicals and neurodegenerative diseases and for screening new drugs to treat these disorders. ..
  3. Melov S, Coskun P, Patel M, Tuinstra R, Cottrell B, Jun A, et al. Mitochondrial disease in superoxide dismutase 2 mutant mice. Proc Natl Acad Sci U S A. 1999;96:846-51 pubmed
    ..biochemical and metabolic effects of inactivation of the mouse gene for the mitochondrial superoxide dismutase (CD1-Sod2(tm1Cje))...
  4. Lombard D, Alt F, Cheng H, Bunkenborg J, Streeper R, Mostoslavsky R, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007;27:8807-14 pubmed
    ..Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle. ..
  5. Korenaga D, Yasuda M, Honda M, Nozoe T, Inutsuka S. MnSOD expression within tumor cells is closely related to mode of invasion in human gastric cancer. Oncol Rep. 2003;10:27-30 pubmed
    b>Manganese superoxide dismutase (MnSOD) plays an important role in protecting cells from injury due to oxidative stress...
  6. Lebovitz R, Zhang H, Vogel H, Cartwright J, Dionne L, Lu N, et al. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A. 1996;93:9782-7 pubmed
    b>Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense against mitochondrial superoxide...
  7. Zenkel M, Kruse F, Naumann G, Schlötzer Schrehardt U. Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Invest Ophthalmol Vis Sci. 2007;48:5558-66 pubmed
    ..The expression of MAPKp38, heat shock proteins (HSP40, HSP60), and superoxide dismutase (SOD2) was increased up to threefold in PEX specimens...
  8. Strassburger M, Bloch W, Sulyok S, Schüller J, Keist A, Schmidt A, et al. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med. 2005;38:1458-70 pubmed
    To circumvent the early lethality of manganese superoxide dismutase (SOD2)-deficient mice, we have used a skin-specific strategy with introduction of loxP sites flanking exon 3 of the SOD2 gene...
  9. Munusamy S, Macmillan Crow L. Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells. Free Radic Biol Med. 2009;46:1149-57 pubmed publisher
    ..superoxide we have tested whether overexpression of the primary mitochondrial antioxidant, manganese superoxide dismutase (MnSOD), protects against hyperglycemia-induced renal injury using normal rat renal proximal tubular ..

More Information


  1. Lawler J, Kwak H, Kim J, Suk M. Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1496-502 pubmed publisher
    ..aging, recent data indicate that acute or short-term exercise upregulates the Mn isoform of superoxide dismutase (MnSOD), which may provide protection against ischemia-reperfusion injury and cell death by reducing oxidative stress...
  2. Ohashi M, Runge M, Faraci F, Heistad D. MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2006;26:2331-6 pubmed
    In mice that are heterozygous for mitochondrial superoxide dismutase (SOD2(+/-)) with apoE deficiency (apoE(-/-)), mitochondrial DNA damage increases formation of atherosclerotic lesions...
  3. Colombrita C, Calabrese V, Stella A, Mattei F, Alkon D, Scapagnini G. Regional rat brain distribution of heme oxygenase-1 and manganese superoxide dismutase mRNA: relevance of redox homeostasis in the aging processes. Exp Biol Med (Maywood). 2003;228:517-24 pubmed
    ..involved in the cellular defense against endogenous or exogenous oxidants: heme oxygenase-1 (HO-1) and manganese superoxide dismutase-2 (SOD-2)...
  4. Van Remmen H, Salvador C, Yang H, Huang T, Epstein C, Richardson A. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Arch Biochem Biophys. 1999;363:91-7 pubmed
    ..of several tissues (liver, kidney, lung, brain, heart, muscle, stomach, and spleen) from heterozygous manganese superoxide dismutase (MnSOD) mutant mice (Sod2-/+) was characterized...
  5. Xiong Y, Shie F, Zhang J, Lee C, Ho Y. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. J Neurochem. 2005;95:732-44 pubmed TBI-induced formation of cortical lesion is determined by the expression levels of copper-zinc and manganese superoxide dismutase (CuZnSOD and MnSOD, respectively). However, the underlying biochemical mechanisms are not understood...
  6. Reddy V, Kasahara E, Hiraoka M, Lin L, Ho Y. Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium. Exp Eye Res. 2004;79:859-68 pubmed
    ..antioxidant enzymes that protect the cells against oxidative stress are superoxide dismutases: CuZnSOD (Sod1) and MnSOD (Sod2). The latter is also implicated in apoptosis...
  7. Fortunato G, Marciano E, Zarrilli F, Mazzaccara C, Intrieri M, Calcagno G, et al. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Clin Chem. 2004;50:2012-8 pubmed
    ..Therefore, genes involved in regulating the reactive oxygen species manganese-superoxide dismutase (SOD2) and the antioxidant paraoxonase (PON) could influence cochlea vulnerability to noise...
  8. Xu L, Emery J, Ouyang Y, Voloboueva L, Giffard R. Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia. 2010;58:1042-9 pubmed publisher
    ..Two well-studied protective proteins, heat shock protein 72 (Hsp72) or superoxide dismutase 2 (SOD2), were genetically targeted for expression in astrocytes using the astrocyte-specific human glial fibrillary acidic ..
  9. Van Remmen H, Qi W, Sabia M, Freeman G, Estlack L, Yang H, et al. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med. 2004;36:1625-34 pubmed
    ..antioxidant defense, we have generated mice (Sod2(+/-)/Gpx1(-/-)) that are deficient in Mn superoxide dismutase (MnSOD) and glutathione peroxidase 1 (Gpx1) by breeding Sod2(+/-) and Gpx1(-/-) mice together...
  10. Ventriglia M, Bocchio Chiavetto L, Scassellati C, Squitti R, Binetti G, Ghidoni R, et al. Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease. Aging Clin Exp Res. 2005;17:445-8 pubmed
    ..b>Manganese superoxide dismutase (MnSOD) plays a major role in protecting the mitochondrion from oxidative damage due to superoxide ..
  11. Ying Y, Balaban C. Regional distribution of manganese superoxide dismutase 2 (Mn SOD2) expression in rodent and primate spiral ganglion cells. Hear Res. 2009;253:116-24 pubmed publisher
    b>Manganese superoxide dismutase 2 (SOD2) is a key metabolic anti-oxidant enzyme for detoxifying free radicals inside mitochondria...
  12. Freiberger J, Coulombe K, Suliman H, Carraway M, Piantadosi C. Superoxide dismutase responds to hyperoxia in rat hippocampus. Undersea Hyperb Med. 2004;31:227-32 pubmed
    ..NBO) was associated with statistically significant increases in transcript levels of the antioxidant enzymes SOD2 (MnSOD) and SOD3 (EC-SOD) at 6 and 18 hours but not SOD1 (Cu, Zn SOD) respectively...
  13. Khan J, Black S. Developmental changes in murine brain antioxidant enzymes. Pediatr Res. 2003;54:77-82 pubmed
    ..These data will be important in our future understanding of the mechanisms by which hypoxia mediates injury in the immature and the mature brain. ..
  14. Cullen J, Mitros F, Oberley L. Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Pancreas. 2003;26:23-7 pubmed
    ..There appears to be a gradual decrease in antioxidant enzyme expression in pancreatic cells from normal pancreas to chronic pancreatitis to pancreatic cancer. ..
  15. Yan C, Huang A, Wu Z, Kaminski P, Wolin M, Hintze T, et al. Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Am J Physiol Heart Circ Physiol. 2005;288:H2225-31 pubmed
    ..These results suggest that Mn-SOD contributes significantly to the regulation of vascular function. ..
  16. Sreekumar R, Unnikrishnan J, Fu A, Nygren J, Short K, Schimke J, et al. Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am J Physiol Endocrinol Metab. 2002;283:E38-43 pubmed
    ..confirmed the changes in transcript levels of cytochrome-c oxidase III, superoxide dismutase (SOD)1, and SOD2 that were noted by the microarray approach...
  17. Chen W, Qiu J, Zhang Z, Luo H, Rosello Catafau J, Wu Z. Gene expression changes after hypoxic preconditioning in rat hepatocytes. Hepatobiliary Pancreat Dis Int. 2006;5:416-21 pubmed
    ..Among these genes, genes encoding superoxide dismutase 2 (SOD2) and interleukin 10 (IL-10) in the hypoxic preconditioning group were confirmed to be up-regulated with real-time ..
  18. Biaggio V, Pérez Chaca M, Valdez S, Gomez N, Gimenez M. Alteration in the expression of inflammatory parameters as a result of oxidative stress produced by moderate zinc deficiency in rat lung. Exp Lung Res. 2010;36:31-44 pubmed publisher
    ..Perhaps, zinc deficiency implications must be taken into account in health interventions because inflammation and prooxidant environment are associated with ZD in lung. ..
  19. Rana T, Bera A, Das S, Pan D, Bandyopadhyay S, Bhattacharya D, et al. Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents. Food Chem Toxicol. 2010;48:1072-7 pubmed publisher
    ..Interestingly, ascorbic acid markedly upregulated lymphocytes relative mRNA expression of lymphocytes SOD2 gene corresponding to GAPDH, house keeping candidate gene in arsenic-treated rat, which might provide anti-..
  20. Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe S, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics. 2003;16:29-37 pubmed
    ..the Sod2 gene (Sod2+/- mice) have been used to study the phenotype of life-long reduced Mn-superoxide dismutase (MnSOD) activity. The Sod2+/- mice have reduced MnSOD activity (50%) in all tissues throughout life...
  21. Castellano I, Cecere F, De Vendittis A, Cotugno R, Chambery A, Di Maro A, et al. Rat mitochondrial manganese superoxide dismutase: amino acid positions involved in covalent modifications, activity, and heat stability. Biopolymers. 2009;91:1215-26 pubmed publisher
    ..These data highlight the role played by some residues in ratSOD2 and suggest a fine regulation of the enzyme occurring in vivo. ..
  22. Cassano S, Agnese S, D Amato V, Papale M, Garbi C, Castagnola P, et al. Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells. J Biol Chem. 2010;285:24141-53 pubmed publisher
    ..This is accomplished by stimulation of mitochondrial manganese superoxide dismutase (MnSOD) both transcriptionally and post-transcriptionally via Ki-Ras and ERK1/2...
  23. Pias E, Ekshyyan O, Rhoads C, Fuseler J, Harrison L, Aw T. Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells. J Biol Chem. 2003;278:13294-301 pubmed
    ..Collectively, our results support a role for mitochondrial ROS in TBH-induced PC-12 apoptosis that is attenuated by Mn-SOD overexpression and is independent of cellular GSH levels per se. ..
  24. Sinha I, Pearce C, Cho B, Hannawa K, Roelofs K, Stanley J, et al. Differential regulation of the superoxide dismutase family in experimental aortic aneurysms and rat aortic explants. J Surg Res. 2007;138:156-62 pubmed
    ..of superoxide dismutases (SOD), a family of reactive oxygen catalyzing metalloenzymes, including manganese SOD (MnSOD), copper-zinc SOD (CuZnSOD), and extracellular SOD (EcSOD), in a rodent aortic aneurysm model...
  25. Fleissner F, Jazbutyte V, Fiedler J, Gupta S, Yin X, Xu Q, et al. Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism. Circ Res. 2010;107:138-43 pubmed publisher
    ..We identified a novel miR-21-dependent mechanism of ADMA-mediated APC dysfunction. MiR-21 antagonism therefore emerges as an interesting strategy to improve dysfunctional APCs in patients with coronary artery disease. ..
  26. Zhao Y, Oberley T, Chaiswing L, Lin S, Epstein C, Huang T, et al. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene. 2002;21:3836-46 pubmed
    Previous studies in our laboratories demonstrated that overexpression of manganese superoxide dismutase (MnSOD) suppressed both the incidence and multiplicity of papillomas in a DMBA/TPA multi-stage skin carcinogenesis model...
  27. Judge S, Jang Y, Smith A, Hagen T, Leeuwenburgh C. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J. 2005;19:419-21 pubmed
    ..In contrast, only protein carbonyls were elevated in SSM with age. Significant age-related increases in MnSOD, GPX, and CAT activities were detected in IFM, while in SSM, MnSOD, and GPX activities increased with age and CAT ..
  28. Dhar S, Tangpong J, Chaiswing L, Oberley T, St Clair D. Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Cancer Res. 2011;71:6684-95 pubmed publisher
    b>Manganese superoxide dismutase (MnSOD) plays a critical role in the survival of aerobic life, and its aberrant expression has been implicated in carcinogenesis and tumor resistance to therapy...
  29. Aiyer H, Li Y, Harper N, Myers S, Martin R. Molecular changes in the esophageal epithelium after a subchronic exposure to cigarette smoke in the presence of bile-acid reflux. Inhal Toxicol. 2011;23:304-11 pubmed publisher
    ..01). Cigarette smoke aggravates reflux-induced BE and potentially accelerates the progression of BE to EAC through the loss of manganese superoxide dismutase (MnSOD), and overexpression of NF-?B- and COX-2-mediated factors.
  30. Hamilton K, Quindry J, French J, Staib J, Hughes J, Mehta J, et al. MnSOD antisense treatment and exercise-induced protection against arrhythmias. Free Radic Biol Med. 2004;37:1360-8 pubmed
    ..An exercise-induced increase in myocardial manganese superoxide dismutase (MnSOD) activity has been reported to be vital for protection against infarction...
  31. Martin R, Lan Q, Hughes K, Doll M, Martini B, Lissowska J, et al. No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1). J Surg Res. 2005;124:92-7 pubmed
    b>Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species, constituting a major cellular defense mechanism against agents that induce oxidative stress...
  32. Vnukov V, Gutsenko O, Milutina N, Ananyan A, Danilenko A, Panina S, et al. Influence of SkQ1 on Expression of Nrf2 Transcription Factor Gene, ARE-Controlled Genes of Antioxidant Enzymes and Their Activity in Rat Blood Leukocytes. Biochemistry (Mosc). 2015;80:586-91 pubmed publisher
    ..increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes...
  33. Bonder C, Knight D, Hernandez Saavedra D, McCord J, Kubes P. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2004;287:G676-84 pubmed
    ..subjected to I/R and tested the hypothesis that I/R-induced neutrophil recruitment was inhibited by treatment with SOD2/3...
  34. Kiningham K, St Clair D. Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. Cancer Res. 1997;57:5265-71 pubmed
    b>Manganese superoxide dismutase (MnSOD) is reduced in a variety of tumor cells and has been proposed to be a new type of tumor suppressor gene. The mechanism(s) by which MnSOD suppresses cancer development is currently unknown...
  35. Kienhöfer J, Häussler D, Ruckelshausen F, Muessig E, Weber K, Pimentel D, et al. Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents. FASEB J. 2009;23:2034-44 pubmed publisher
    ..b>Manganese superoxide dismutase (SOD2) was detected by Western blot in the nucleoid fractions...
  36. Ono M, Sekiya C, Ohhira M, Namiki M, Endo Y, Suzuki K, et al. Elevated level of serum Mn-superoxide dismutase in patients with primary biliary cirrhosis: possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis. J Lab Clin Med. 1991;118:476-83 pubmed
    ..These data suggested that free radicals including superoxide anion are possibly involved in the pathogenesis of the disease and Mn-SOD may play some role in a protection against the superoxide anion. ..
  37. Holla L, Kankova K, Vasku A. Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma. Clin Biochem. 2006;39:299-302 pubmed
    To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects...
  38. Friedman J, Rebel V, Derby R, Bell K, Huang T, Kuypers F, et al. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. J Exp Med. 2001;193:925-34 pubmed
    b>Manganese superoxide dismutase 2 (SOD2) is a critical component of the mitochondrial pathway for detoxification of O2(-), and targeted disruption of this locus leads to embryonic or neonatal lethality in mice...
  39. Liu Y, Tang L, Chen B. Effects of antioxidant gene therapy on retinal neurons and oxidative stress in a model of retinal ischemia/reperfusion. Free Radic Biol Med. 2012;52:909-15 pubmed publisher
    ..The aim of this study was to investigate the neuroprotective effect of manganese superoxide dismutase (SOD2) on retinal ganglion cells (RGCs) in an I/R-induced retinal injury model...
  40. Liu X, Wang A, Lo Muzio L, Kolokythas A, Sheng S, Rubini C, et al. Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. BMC Cancer. 2010;10:365 pubmed publisher
    ..Previous studies showed that deregulation of manganese superoxide dismutase (SOD2) expression is a frequent event in TSCC and may be associated with enhanced cell invasion...
  41. Rodriguez Iturbe B, Sepassi L, Quiroz Y, Ni Z, Wallace D, Vaziri N. Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence. J Appl Physiol (1985). 2007;102:255-60 pubmed
    ..O(2)(-) produced by the mitochondria is converted to hydrogen peroxide by mitochondrial superoxide dismutase (SOD2)...
  42. Kakko S, Paivansalo M, Koistinen P, Kesaniemi Y, Kinnula V, Savolainen M. The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis. Atherosclerosis. 2003;168:147-52 pubmed
    Redox-state of the cells of vascular walls is an important determinant of atherosclerosis. Manganese superoxide dismutase (MnSOD) is an essential anti-oxidant enzyme working in mitochondria of mammalian cells...
  43. Hodge D, Peng B, Pompeia C, Thomas S, Cho E, Clausen P, et al. Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation. Cancer Biol Ther. 2005;4:585-92 pubmed
    ..There are numerous reports that levels of manganese superoxide dismutase enzyme (MnSOD), an antioxidant enzyme responsible for the attenuation of ROS, are lowered in cancer ..
  44. Raho G, Cassano N, D Argento V, Vena G, Zanotti F. Over-expression of Mn-superoxide dismutase as a marker of oxidative stress in lesional skin of chronic idiopathic urticaria. Clin Exp Dermatol. 2003;28:318-20 pubmed
  45. Vasilaki A, Csete M, Pye D, Lee S, Palomero J, McArdle F, et al. Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. Free Radic Biol Med. 2006;41:1719-25 pubmed
    ..muscle myotubes derived from muscles of wild-type mice and mice that were heterozygous knockout for manganese superoxide dismutase (Sod2(+/-)), homozygous knockout for glutathione peroxidase 1 (GPx1(-/-)), or MnSOD transgenic ..
  46. Fujimura M, Morita Fujimura Y, Kawase M, Copin J, Calagui B, Epstein C, et al. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J Neurosci. 1999;19:3414-22 pubmed addressed using knock-out mutants that are deficient in the level of the mitochondrial antioxidant manganese superoxide dismutase (Mn-SOD)...
  47. Pimenta A, Lambertucci R, Gorjao R, Silveira L, Curi R. Effect of a single session of electrical stimulation on activity and expression of citrate synthase and antioxidant enzymes in rat soleus muscle. Eur J Appl Physiol. 2007;102:119-26 pubmed
    ..This increase in expression of CAT may play an important role in counteracting the potential deleterious effects of elevated oxidative stress induced by a high oxidative demand in skeletal muscles subjected to exercise training. ..
  48. Khaper N, Kaur K, Li T, Farahmand F, Singal P. Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. Mol Cell Biochem. 2003;251:9-15 pubmed
    ..The protein levels for MnSOD, CuZnSOD, GSHPx at 1 and 16 weeks remained unchanged in treated and untreated PMI groups...
  49. Namikawa C, Shu Ping Z, Vyselaar J, Nozaki Y, Nemoto Y, Ono M, et al. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. J Hepatol. 2004;40:781-6 pubmed
    ..transfer protein (MTP) and the 1183 T/C polymorphism in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD). NASH patients had a much higher incidence of the MTP gene G allele (P=0...
  50. Amara S, Douki T, Garel C, Favier A, Sakly M, Rhouma K, et al. Effects of static magnetic field exposure on antioxidative enzymes activity and DNA in rat brain. Gen Physiol Biophys. 2009;28:260-5 pubmed
    ..Our results indicated that sub-chronic exposure to SMF induced oxidative stress in rat hippocampus and frontal cortex. Metallothionein induction protected probably DNA against oxidative damage. ..
  51. Ikegami T, Suzuki Y, Shimizu T, Isono K, Koseki H, Shirasawa T. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun. 2002;296:729-36 pubmed
    b>Manganese superoxide dismutase (MnSOD) is the enzyme that converts toxic O(2)(-) to H(2)O(2) in mitochondria. Previous reports showed that a deficiency of MnSOD in mice was neonatal lethal...
  52. Marcus D, Strafaci J, Freedman M. Differential neuronal expression of manganese superoxide dismutase in Alzheimer's disease. Med Sci Monit. 2006;12:BR8-14 pubmed
    Manganese-dependent superoxide dismutase (MnSOD) is a major defense mechanism against potential cellular damage by reactive oxygen species (ROS)...
  53. Möllsten A, Marklund S, Wessman M, Svensson M, Forsblom C, Parkkonen M, et al. A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy. Diabetes. 2007;56:265-9 pubmed
    Oxidative stress has been suggested to contribute to the development of diabetic nephropathy. Manganese superoxide dismutase (MnSOD) protects the cells from oxidative damage by scavenging free radicals...