Gene Symbol: Sod1
Description: superoxide dismutase 1
Alias: CuZnSOD, superoxide dismutase [Cu-Zn], superoxide dismutase 1, soluble
Species: rat
Products:     Sod1

Top Publications

  1. Banci L, Bertini I, Durazo A, Girotto S, Gralla E, Martinelli M, et al. Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS. Proc Natl Acad Sci U S A. 2007;104:11263-7 pubmed
    ..2% are associated with mutations in the gene coding for the antioxidant enzyme copper-zinc superoxide dismutase (SOD1)...
  2. Webber D, Lopez I, Korsak R, Hirota S, Acuna D, Edmond J. Limiting iron availability confers neuroprotection from chronic mild carbon monoxide exposure in the developing auditory system of the rat. J Neurosci Res. 2005;80:620-33 pubmed
    ..The CO-exposed rat pups had decreased neurofilament proteins and increased copper, zinc-superoxide dismutase (SOD1) in the spiral ganglion neurons...
  3. Suge R, Shimazu T, Hasegawa H, Inoue I, Hayashibe H, Nagasaka H, et al. Cerebral antioxidant enzyme increase associated with learning deficit in type 2 diabetes rats. Brain Res. 2012;1481:97-106 pubmed publisher
    ..These results suggest that diabetes-induced brain impairment, which results in learning deficits, may have occurred before the appearance of the symptoms of overt diabetes. ..
  4. Khaper N, Kaur K, Li T, Farahmand F, Singal P. Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. Mol Cell Biochem. 2003;251:9-15 pubmed
    ..The protein levels for MnSOD, CuZnSOD, GSHPx at 1 and 16 weeks remained unchanged in treated and untreated PMI groups...
  5. Crapo J, Oury T, Rabouille C, Slot J, Chang L. Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc Natl Acad Sci U S A. 1992;89:10405-9 pubmed
    ..Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm. ..
  6. Yi S, Hwang I, Kim D, Shin J, Nam S, Choi J, et al. The chronological characteristics of SOD1 activity and inflammatory response in the hippocampi of STZ-induced type 1 diabetic rats. Neurochem Res. 2011;36:117-28 pubmed publisher
    ..animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, many studies have been conducted without considering temporal changes after STZ injection...
  7. Sau D, De Biasi S, Vitellaro Zuccarello L, Riso P, Guarnieri S, Porrini M, et al. Mutation of SOD1 in ALS: a gain of a loss of function. Hum Mol Genet. 2007;16:1604-18 pubmed
    ..Some familial cases (fALS) are linked to mutations of superoxide dismutase type-1 (SOD1), an antioxidant enzyme whose activity is preserved in most mutant forms...
  8. Craven P, Melhem M, Phillips S, DeRubertis F. Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Diabetes. 2001;50:2114-25 pubmed
    ..Thus, increases in cellular SOD-1 activity attenuate diabetic renal injury in vivo and also prevent stimulation of MC matrix protein synthesis induced in vitro by high glucose. ..
  9. Rosen D, Siddique T, Patterson D, Figlewicz D, Sapp P, Hentati A, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993;362:59-62 pubmed tight genetic linkage between FALS and a gene that encodes a cytosolic, Cu/Zn-binding superoxide dismutase (SOD1), a homodimeric metalloenzyme that catalyzes the dismutation of the toxic superoxide anion O2.- to O2 and H2O2 (ref...

More Information


  1. Agharazii M, St Louis R, Gautier Bastien A, Ung R, Mokas S, Larivière R, et al. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Am J Hypertens. 2015;28:746-55 pubmed publisher
    ..NADPH) oxidase subunits p22(phox) and p47(phox) were increased, whereas the expression of antioxidant enzymes (SOD1, SOD2, Gpx1, and Prdx1) was reduced in CKD + Ca/P/VitD rats...
  2. Fujita H, Fujishima H, Chida S, Takahashi K, Qi Z, Kanetsuna Y, et al. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. J Am Soc Nephrol. 2009;20:1303-13 pubmed publisher
    ..We observed down-regulation of cytosolic CuZn-SOD (SOD1) and extracellular CuZn-SOD (SOD3), but not mitochondrial Mn-SOD (SOD2), in the kidney of KK/Ta-Akita mice which ..
  3. Xu Y, Liachenko S, Tang P, Chan P. Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation. Stroke. 2009;40:2512-8 pubmed publisher
    ..Using transgenic (Tg) rats overexpressing copper zinc superoxide dismutase (SOD1), we investigated the role of this intrinsic antioxidant in the restoration of cerebral blood flow (CBF) after CAR...
  4. Chattopadhyay M, Durazo A, Sohn S, Strong C, Gralla E, Whitelegge J, et al. Initiation and elongation in fibrillation of ALS-linked superoxide dismutase. Proc Natl Acad Sci U S A. 2008;105:18663-8 pubmed publisher
    Familial amyotrophic lateral sclerosis (fALS) caused by mutations in copper-zinc superoxide dismutase (SOD1) is characterized by the presence of SOD1-rich inclusions in spinal cords...
  5. Al Majed A, Al Yahya A, Asiri Y, Al Gonaiah M, Mostafa A. Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. Res Commun Mol Pathol Pharmacol. 2004;115-116:49-62 pubmed
    ..This suggests that the induction of COX-2 might be involved in transient forebrain ischemia-induced oxidative damage and hence the selective COX-2 inhibitors might be a valuable therapeutic strategy against ischemic brain injury. ..
  6. Babich P, Tsymbalenko N, Masalova O, Platonova N, Shavlovskii M, Puchkova L, et al. Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. Bull Exp Biol Med. 2009;148:217-22 pubmed
    ..The expression of intracellular cuproenzyme genes and the content of SOD1 protein did not change, SOD1 activity in the cytosol decreased, and active SOD1 was detected in the mitochondrial ..
  7. McFadden S, Ding D, Reaume A, Flood D, Salvi R. Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol Aging. 1999;20:1-8 pubmed
    ..wild type (WT) mice with normal levels of Cu/Zn SOD and mutant knockout (KO) mice with a targeted deletion of Sod1, the gene that codes for Cu/Zn SOD. WT and KO mice exhibited similar patterns of hair cell loss with age, i.e...
  8. Barkats M, Horellou P, Colin P, Millecamps S, Faucon Biguet N, Mallet J. 1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase. J Neurosci Res. 2006;83:233-42 pubmed
    ..We investigated the neuroprotective potential of Cu/Zn superoxide dismutase (SOD1) overexpression in the rat substantia nigra (SN) following adenovirus-mediated gene transfer...
  9. Sharma N, Sethy N, Meena R, Ilavazhagan G, Das M, Bhargava K. Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain. Peptides. 2011;32:1217-24 pubmed publisher
    ..of Nrf2, the master regulator of antioxidant defense system and its downstream targets such as HO-1, GST and SOD1 by NAP supplementation, suggesting activation of Nrf2-mediated antioxidant defense response...
  10. Jin H, Wang Y, Wang X, Sun Y, Tang C, Du J. Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I/R) injury. Nitric Oxide. 2013;32:56-61 pubmed publisher
    ..Myocardial protein expressions of SOD1, SOD2, cystathionine ?-lyase (CSE) and iNOS were tested using Western blot...
  11. Kim J, Chae J, Nam S, Kim Y, Yoo D, Choi J, et al. Treadmill exercise prevents diabetes-induced increases in lipid peroxidation and decreases in Cu,Zn-superoxide dismutase levels in the hippocampus of Zucker diabetic fatty rats. J Vet Sci. 2015;16:11-6 pubmed, we investigated the effects of treadmill exercise on lipid peroxidation and Cu,Zn-superoxide dismutase (SOD1) levels in the hippocampus of Zucker diabetic fatty (ZDF) rats and lean control rats (ZLC) during the onset of ..
  12. Elchuri S, Oberley T, Qi W, Eisenstein R, Jackson Roberts L, Van Remmen H, et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene. 2005;24:367-80 pubmed
    Mice deficient in CuZn superoxide dismutase (CuZnSOD) showed no overt abnormalities during development and early adulthood, but had a reduced lifespan and increased incidence of neoplastic changes in the liver...
  13. Lopes R, Neves K, Tostes R, Montezano A, Touyz R. Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension. Hypertension. 2015;66:1240-50 pubmed publisher
    ..6±3.1 versus SHRSP 74.6±3.2, P<0.05) in SHRSP, effects corrected by L-sulforaphane. Our findings suggest that Nrf2 downregulation contributes to redox-sensitive vascular dysfunction in hypertension. ..
  14. Constantino L, Gonçalves R, Giombelli V, Tomasi C, Vuolo F, Kist L, et al. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Intensive Care Med Exp. 2014;2:17 pubmed publisher
    ..After 3, 6, and 12 h, CLP protein content and expression of SOD1, SOD2, and SOD3 were evaluated, and SOD activity was assessed...
  15. Son D, Kojima I, Inagi R, Matsumoto M, Fujita T, Nangaku M. Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis. Am J Physiol Renal Physiol. 2008;294:F62-72 pubmed
    ..were alpha(2u)-globulin PGCL1, eukaryotic translation elongation factor 1alpha(2), and Cu/Zn superoxide dismutase (SOD1). Among these proteins, we focused on Cu/Zn-SOD, a crucial antioxidant...
  16. Keithley E, Canto C, Zheng Q, Wang X, Fischel Ghodsian N, Johnson K. Cu/Zn superoxide dismutase and age-related hearing loss. Hear Res. 2005;209:76-85 pubmed
    ..Antioxidant enzymes such as Cu/Zn superoxide dismutase (SOD1) protect cells from toxic, reactive oxygen species and may be involved in age-related degeneration...
  17. Teilum K, Smith M, Schulz E, Christensen L, Solomentsev G, Oliveberg M, et al. Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization. Proc Natl Acad Sci U S A. 2009;106:18273-8 pubmed publisher
    ..lateral sclerosis (ALS) is a neurodegenerative disease linked to the misfolding of Cu/Zn superoxide dismutase (SOD1). ALS-related defects in SOD1 result in a gain of toxic function that coincides with aberrant oligomerization...
  18. Gao J, Zhong M, Fan Z, Yuan N, Zhou Y, Zhang F, et al. SOD1 overexpression in paraventricular nucleus improves post-infarct myocardial remodeling and ventricular function. Pflugers Arch. 2012;463:297-307 pubmed publisher
    ..This study was designed to determine whether superoxide dismutase 1 (SOD1) overexpression in the PVN attenuated the sympathetic activation and cardiac dysfunction in rats after an episode ..
  19. Maremanda K, Khan S, Jena G. Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5. Biol Trace Elem Res. 2016;173:452-64 pubmed publisher
    ..Diabetic testes showed decreased Nrf2, HO-1, SOD1, PCNA, and Bcl-2 expressions whereas increased COX-2, NF-?B, MT, IL-6, and p-ERK levels...
  20. Casareno R, Waggoner D, Gitlin J. The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase. J Biol Chem. 1998;273:23625-8 pubmed
    Dominantly inherited mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) result in the fatal motor neuron disease familial amyotrophic lateral sclerosis (FALS)...
  21. Yu F, Narasimhan P, Saito A, Liu J, Chan P. Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury. J Cereb Blood Flow Metab. 2008;28:44-52 pubmed
    ..expression of pPRAS40 after SCI by immunohistochemistry and Western blot using copper/zinc-superoxide dismutase (SOD1) transgenic (Tg) rats and wild-type (Wt) littermates...
  22. Noshita N, Sugawara T, Hayashi T, Lewén A, Omar G, Chan P. Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J Neurosci. 2002;22:7923-30 pubmed
    ..focal cerebral ischemia (FCI) using transgenic (Tg) mice that overexpress copper/zinc superoxide dismutase (SOD1)...
  23. Geller B, Winge D. Rat liver Cu,Zn-superoxide dismutase. Subcellular location in lysosomes. J Biol Chem. 1982;257:8945-52 pubmed
    ..However, the possibility that a small amount (less than 0.1% of total cellular) is located in the mitochondria cannot be excluded. ..
  24. Taysi S, Kocer I, Memisogullari R, Kiziltunc A. Serum oxidant/antioxidant status in patients with Behçet's disease. Ann Clin Lab Sci. 2002;32:377-82 pubmed
  25. Ding A, Kalaignanasundaram P, Ricardo S, Abdelkader A, Witting P, Broughton B, et al. Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Clin Exp Pharmacol Physiol. 2012;39:917-29 pubmed publisher
    ..Total renal superoxide dismutase (SOD) activity was sevenfold less and expression of SOD1 mRNA was 70% less in kidney tissue from LPK compared with Lewis rats...
  26. Wang J, Farr G, Zeiss C, Rodriguez Gil D, Wilson J, Furtak K, et al. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A. 2009;106:1392-7 pubmed publisher
    Recent studies suggest that superoxide dismutase 1 (SOD1)-linked amyotrophic lateral sclerosis results from destabilization and misfolding of mutant forms of this abundant cytosolic enzyme...
  27. Jena S, Anand C, Chainy G, Dandapat J. Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin. Neurol Sci. 2012;33:869-73 pubmed publisher
    ..The decreased translated products (SOD1 and SOD2) and the unchanged activity of SOD in cerebral cortex of PTU-treated rats were increased on ..
  28. Seshadri G, Che P, Boopathy A, Davis M. Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase. Stem Cells Dev. 2012;21:3136-46 pubmed publisher
    ..CPCs contained significantly higher levels of SOD1 and SOD2 as compared with adult cardiac cell types, both at the protein and activity levels...
  29. Li X, Zhang M, Zhou H. The morphological features and mitochondrial oxidative stress mechanism of the retinal neurons apoptosis in early diabetic rats. J Diabetes Res. 2014;2014:678123 pubmed publisher
    ..05). In summary, the apoptosis of the retinal neurons occurred at 8 weeks after the onset of diabetes. Retinal neuron apoptosis in early diabetic rats may be associated with the decreased activity and mRNA of MnSOD. ..
  30. Lin Z, Xu H, Wang J, Lin Q, Ruan Z, Liu F, et al. SIRT5 desuccinylates and activates SOD1 to eliminate ROS. Biochem Biophys Res Commun. 2013;441:191-5 pubmed publisher
    Cu/Zn superoxide dismutase (SOD1) is a key antioxidant enzyme. Deficiency of SOD1 is associated with various human diseases, including cancer. Here, we report that SOD1 is succinylated and that succinylation decreases its activity...
  31. Hajiani M, Razi F, Golestani A, Frouzandeh M, Owji A, Khaghani S, et al. Time- and dose-dependent differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase enzymatic activity and mRNA level by vitamin E in rat blood cells. Redox Rep. 2012;17:101-7 pubmed publisher
    ..Only the chronic administration of higher doses of alpha-tocopherol is associated with the increased activity and expression of Mn-SOD in rats. Cu/Zn-SOD activity and expression does not dramatically change in response to vitamin E. ..
  32. Ji H, Zhang X, Du Y, Liu H, Li S, Li L. Polydatin modulates inflammation by decreasing NF-?B activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Brain Res Bull. 2012;87:50-9 pubmed publisher
    ..the expression of glioma-associated oncogene homolog1 (Gli1), Patched-1 (Ptch1) and Superoxide dismutase 1 (SOD1) after pMCAO, six time points were included...
  33. Delabar J, Nicole A, d Auriol L, Jacob Y, Meunier Rotival M, Galibert F, et al. Cloning and sequencing of a rat CuZn superoxide dismutase cDNA. Correlation between CuZn superoxide dismutase mRNA level and enzyme activity in rat and mouse tissues. Eur J Biochem. 1987;166:181-7 pubmed
    The molecular cloning and nucleotide sequence of a cDNA clone (pR SOD) for rat CuZn superoxide dismutase (CuZnSOD) is reported...
  34. Ohlemiller K, McFadden S, Ding D, Flood D, Reaume A, Hoffman E, et al. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol Neurootol. 1999;4:237-46 pubmed
    ..Knockout' mice with targeted deletion of Sod1, the gene that codes for Cu/Zn-SOD, develop normally but show enhanced susceptibility to central nervous system ..
  35. Pajovic S, Pejic S, Stojiljković V, Gavrilovic L, Dronjak S, Kanazir D. Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models. Physiol Res. 2006;55:453-60 pubmed
    The study deals with activity of three antioxidant enzymes, copper, zinc-superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), catalase (CAT) in hippocampus of rats, following the exposure to single chronic (individual ..
  36. Didion S, Ryan M, Didion L, Fegan P, Sigmund C, Faraci F. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002;91:938-44 pubmed
    ..We tested the hypothesis that selective loss of CuZnSOD results in increased superoxide and altered vascular responsiveness in CuZnSOD-deficient (CuZnSOD(-/-)) mice ..
  37. Shimazu T, Inoue I, Araki N, Asano Y, Sawada M, Furuya D, et al. A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke. 2005;36:353-9 pubmed
    ..Our data point to CuZn-SOD as the mediator of this neuroprotection. ..
  38. Sharma N, Sharma S, Gupta A, Prabhakar S, Singh R, Anand A. Predictive model for earlier diagnosis of suspected age-related macular degeneration patients. DNA Cell Biol. 2013;32:549-55 pubmed publisher
    ..namely, serum complement factor H (CFH), serum chemokine (C-C motif) ligand 2 (CCL2), serum superoxide dismutase 1 (SOD1), polymorphism in CCL2 (rs4586), stress, and comorbidity were found to be significant (p<0.05)...
  39. Maremanda K, Jena G. Methotrexate-induced germ cell toxicity and the important role of zinc and SOD1: Investigation of molecular mechanisms. Biochem Biophys Res Commun. 2017;483:596-601 pubmed publisher
    ..To further investigate the role of Zn and Zn-dependent SOD1, rats were injected intratesticularly with diethyldithiocarbamate (DEDTC) for three days after MTX 20 mg/kg i.p...
  40. Nguyen M, Larivière R, Julien J. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron. 2001;30:135-47 pubmed
    ..the hyperphosphorylation of tau and neurofilament (NF) proteins in mice expressing a mutant superoxide dismutase (SOD1(G37R)) linked to amyotrophic lateral sclerosis (ALS)...
  41. Girotto S, Cendron L, Bisaglia M, Tessari I, Mammi S, Zanotti G, et al. DJ-1 is a copper chaperone acting on SOD1 activation. J Biol Chem. 2014;289:10887-99 pubmed publisher
    ..Both DJ-1 and SOD1, proteins involved in familial Parkinson disease and amyotrophic lateral sclerosis, respectively, play a protective ..
  42. Noriega G, Tomaro M, del Batlle A. Bilirubin is highly effective in preventing in vivo delta-aminolevulinic acid-induced oxidative cell damage. Biochim Biophys Acta. 2003;1638:173-8 pubmed
    ..These results add further support to the proposal assigning bilirubin a key protective role against oxidative damage here induced by ALA. ..
  43. Panov A, Kubalik N, Zinchenko N, Hemendinger R, Dikalov S, Bonkovsky H. Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene. Neurobiol Dis. 2011;44:53-62 pubmed publisher
    ..analysis showed that tgSCM had lower contents of complexes III (-60%) and IV (-35%), and the presence of mutated SOD1 protein in both tgBM and tgSCM...
  44. Pickles S, Destroismaisons L, Peyrard S, Cadot S, Rouleau G, Brown R, et al. Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1. Hum Mol Genet. 2013;22:3947-59 pubmed publisher
    Mutant superoxide dismutase 1 (SOD1) selectively associates with spinal cord mitochondria in rodent models of SOD1-mediated amyotrophic lateral sclerosis...
  45. Lalonde R, Dumont M, Paly E, London J, Strazielle C. Characterization of hemizygous SOD1/wild-type transgenic mice with the SHIRPA primary screen and tests of sensorimotor function and anxiety. Brain Res Bull. 2004;64:251-8 pubmed
    b>SOD1 is one of several overexpressed genes in Down's syndrome...
  46. Turner B, Atkin J, Farg M, Zang D, Rembach A, Lopes E, et al. Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis. J Neurosci. 2005;25:108-17 pubmed
    Mutations in the intracellular metalloenzyme superoxide dismutase 1 (SOD1) are linked to neurotoxicity in familial amyotrophic lateral sclerosis (ALS) by an unclear mechanism...
  47. Strassburger M, Bloch W, Sulyok S, Schüller J, Keist A, Schmidt A, et al. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med. 2005;38:1458-70 pubmed
    ..far unreported, we found a substantial decrease in the activity of the cytosolic copper, zinc superoxide dismutase (SOD1) in the heart tissue of SOD2(+/-) mice, suggesting that the breakdown of mitochondrial membranes in the heart of ..
  48. Wheeler M, Katuna M, Smutney O, Froh M, Dikalova A, Mason R, et al. Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury. Hum Gene Ther. 2001;12:2167-77 pubmed
    ..v. with 1 x 10(9) plaque-forming units (PFU) of adenovirus containing the transgene for cytosolic Cu/Zn-SOD (Ad.SOD1), mitochondrial Mn-SOD (Ad.SOD2), extracellular Cu/Zn-SOD (Ad...
  49. Staecker H, Zheng Q, Van De Water T. Oxidative stress in aging in the C57B16/J mouse cochlea. Acta Otolaryngol. 2001;121:666-72 pubmed
    ..There was an overall increase in SOD1 mRNA levels when comparing 1 and 9 month time points, and a transient increase in the expression level of catalase ..
  50. Lehmann T, Luedde T, Schwabe R, Bunzendahl H, Samulski R, Lemasters J, et al. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. 2006;12:550-9 pubmed
    ..Donor rats were infected with adenoviruses either expressing SOD1 (Ad.SOD1) or beta-galactosidase (Ad.lacZ)...
  51. Yang J, Marden J, Fan C, Sanlioglu S, Weiss R, Ritchie T, et al. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Mol Ther. 2003;7:341-53 pubmed
  52. Aquilano K, Vigilanza P, Rotilio G, Ciriolo M. Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1. FASEB J. 2006;20:1683-5 pubmed
    ..We investigated the role of the copper,zinc superoxide dismutase (SOD1) in the maintenance of intracellular redox homeostasis by analyzing the early effects of SOD1 down-regulation in SH-..
  53. Olofsson E, Marklund S, Behndig A. Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice. Invest Ophthalmol Vis Sci. 2009;50:2913-8 pubmed publisher
    ..have previously demonstrated that lenses from mice lacking the antioxidant enzyme copper-zinc superoxide dismutase (SOD1) show elevated levels of superoxide radicals and are more prone in vitro to develop glucose-induced cataract than ..