Gene Symbol: Snx6
Description: sorting nexin 6
Alias: sorting nexin-6
Cavet M, Pang J, Yin G, Berk B. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J. 2008;22:3607-16 pubmed publisher
..We demonstrate that GIT1 interacts with sorting nexin 6 (SNX6), a member of the SNX family that increases EGFR trafficking between endosomes and lysosomes, thereby ..
Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al
. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
..We now describe a novel member of this family, SNX6, which interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases...
Sander L, Frank S, Bolat S, Blank U, Galli T, Bigalke H, et al
. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol. 2008;38:855-63 pubmed publisher
..In summary, our data show that mature human MC express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation...
Hao X, Wang Y, Ren F, Zhu S, Ren Y, Jia B, et al
. SNX25 regulates TGF-? signaling by enhancing the receptor degradation. Cell Signal. 2011;23:935-46 pubmed publisher
..We have characterized that PXA domain of SNX25 is required for the degradation of T?RI. Our findings demonstrate that SNX25 negatively regulates TGF-? signaling by enhancing the receptor degradation through lysosome pathway. ..
Gallon M, Cullen P. Retromer and sorting nexins in endosomal sorting. Biochem Soc Trans. 2015;43:33-47 pubmed publisher
..Retromer function is reliant on a number of proteins from the SNX family. In the present article, we discuss this inter-relationship and how defects in retromer function are increasingly being linked with human disease. ..
Wassmer T, Attar N, Harterink M, van Weering J, Traer C, Oakley J, et al
. The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell. 2009;17:110-22 pubmed publisher
..whose membrane-bound subcomplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6. We establish that retromer requires a dynamic spatial organization of the endosomal network, which is regulated ..
Hong Z, Yang Y, Zhang C, Niu Y, Li K, Zhao X, et al
. The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. Cell Res. 2009;19:1334-49 pubmed publisher
..In this study, we found that one of SNX1/2's dimerization partners, SNX6, interacts with the p150(Glued) subunit of the dynein/dynactin motor complex...
Rivera J, Megias D, Bravo J. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. J Cell Biochem. 2010;111:1464-72 pubmed publisher
b>Sorting nexin 6 (SNX6), a predominantly cytoplasmic protein involved in intracellular trafficking of membrane receptors, was identified as a TGF-? family interactor...