Snx3

Summary

Gene Symbol: Snx3
Description: sorting nexin 3
Alias: sorting nexin-3
Species: rat
Products:     Snx3

Top Publications

  1. Haft C, de la Luz Sierra M, Barr V, Haft D, Taylor S. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol. 1998;18:7278-87 pubmed
    ..deduced the amino acid sequences of three novel homologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4). In addition, we identified a presumed splice variant isoform of SNX1 (SNX1A)...
  2. Xu Y, Hortsman H, Seet L, Wong S, Hong W. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol. 2001;3:658-66 pubmed
    ..We show that SNX3 is associated with the early endosome through a novel motif (PX domain) capable of interaction with ..
  3. Pons V, Luyet P, Morel E, Abrami L, van der Goot F, Parton R, et al. Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 2008;6:e214 pubmed publisher
    ..By contrast, we find that the PtdIns3P-binding protein SNX3 is required for multivesicular body formation, but not for EGF receptor degradation...
  4. Braun V, Wong A, Landekic M, Hong W, Grinstein S, Brumell J. Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole. Cell Microbiol. 2010;12:1352-67 pubmed publisher
    ..We therefore studied whether sorting nexins, particularly sorting nexin 3 (SNX3), play a role in Salmonella infection...
  5. Zhong Q, Watson M, Lazar C, Hounslow A, Waltho J, Gill G. Determinants of the endosomal localization of sorting nexin 1. Mol Biol Cell. 2005;16:2049-57 pubmed
    ..Thus, the obligate dimerization of SNX1 that is driven by the C-terminal domain creates a high-affinity PI binding species that properly targets the holo protein to endosomes. ..
  6. Pons V, Ustunel C, Rolland C, Torti E, Parton R, Gruenberg J. SNX12 role in endosome membrane transport. PLoS ONE. 2012;7:e38949 pubmed publisher
    ..SNX12 is a member of the PX domain-containing sorting nexin family and shares high homology with SNX3, which plays a central role in the formation of intralumenal vesicles within multivesicular endosomes...
  7. Chua R, Wong S. SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells. Immunology. 2013;139:30-47 pubmed publisher
    ..We hypothesized that SNX3, a small sorting nexin that contains a single PI3P lipid-binding PX domain as its only protein domain, localizes to ..
  8. Chen C, Garcia Santos D, Ishikawa Y, Seguin A, Li L, Fegan K, et al. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab. 2013;17:343-52 pubmed publisher
    ..Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery ..
  9. Harrison M, Hung C, Liu T, Christiano R, Walther T, Burd C. A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A. 2014;111:267-72 pubmed publisher
    ..We show that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, SNX3, and the RAB7A GTPase, by the VPS35 retromer subunit...

More Information

Publications14

  1. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases. ..
  2. Harterink M, Port F, Lorenowicz M, McGough I, Silhankova M, Betist M, et al. A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011;13:914-923 pubmed publisher
    ..We have found that the unrelated sorting nexin, SNX3, has an evolutionarily conserved function in Wls recycling and Wnt secretion and show that SNX3 interacts directly ..
  3. Dong H, Yuan H, Jin W, Shen Y, Xu X, Wang H. Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2. Acta Biochim Biophys Sin (Shanghai). 2007;39:540-6 pubmed
    ..assay with the juxtamembrane and membrane-proximal catalytic domain of PCP-2 as "bait" Both AP-3 and SNX3 are molecules involved in intracellular trafficking of membrane receptors...
  4. Mizutani R, Yamauchi J, Kusakawa S, Nakamura K, Sanbe A, Torii T, et al. Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells. Cell Signal. 2009;21:1586-94 pubmed publisher
    ..Here, we show that lithium upregulates the expression of sorting nexin 3 (SNX3), one of the Phox (PX) domain-containing proteins involved in endosomal sorting, and regulates neurite ..
  5. Gallon M, Cullen P. Retromer and sorting nexins in endosomal sorting. Biochem Soc Trans. 2015;43:33-47 pubmed publisher
    ..Retromer function is reliant on a number of proteins from the SNX family. In the present article, we discuss this inter-relationship and how defects in retromer function are increasingly being linked with human disease. ..