Genomes and Genes
Gene Symbol: Snrpe
Description: small nuclear ribonucleoprotein polypeptide E
Alias: small nuclear ribonucleoprotein E
- Valles I, Pajares M, Segura V, Guruceaga E, Gomez Roman J, Blanco D, et al. Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer. PLoS ONE. 2012;7:e42086 pubmed publisher..These genes play diverse roles in mRNA metabolism: three are associated with the spliceosome (ASCL3L1, SNRPB and SNRPE), whereas others participate in RNA-related processes such as translation (MARS and MRPL3), mRNA stability (PCBPC1)..
- Pasternack S, Refke M, Paknia E, Hennies H, Franz T, Schäfer N, et al. Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex. Am J Hum Genet. 2013;92:81-7 pubmed publisher..3-1q41 in a Spanish family. By direct sequencing, we identified the heterozygous mutation c.1A>G (p.Met1?) in SNRPE that results in loss of the start codon of the transcript...
- Akbari Moqadam F, Lange Turenhout E, Ariës I, Pieters R, den Boer M. MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. Leuk Res. 2013;37:1315-21 pubmed publisher..05). Co-expression of these miRNAs resulted in downregulation of DNTT, NUCKS1, MALAT1, SNRPE, PNO1, SET, KIF5B, PRPS2, RPS11, RPL38 and RPL23A (fold-change 1.3-1.9, p<0.05)...
- Lin S, Chang K, Hsu C, Chi L, Chien K, Liang Y, et al. Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. J Proteomics. 2013;94:186-201 pubmed publisher..We believe that the modified GeLC-MS/MS approach used here can be further applied to explore extremely low-abundance, extracellular LMr proteins with important biological functions in other cell lines and biospecimens. ..