Gene Symbol: Snrpc
Description: small nuclear ribonucleoprotein polypeptide C
Alias: Snrp1c, U1-C, U1C, U1 small nuclear ribonucleoprotein C, U1 snRNP C
Hoet R, Raats J, de Wildt R, Dumortier H, Muller S, Van Den Hoogen F, et al
. Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein; epitope mapping, immunolocalization and V-gene usage. Mol Immunol. 1998;35:1045-55 pubmed
To study the localization and function of the U1snRNP associated U1C protein, so far only human sera from systemic lupus erythematosus (SLE) overlap syndrome patients have been used...
Hochleitner E, Kastner B, Frohlich T, Schmidt A, Luhrmann R, Arnold G, et al
. Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry. J Biol Chem. 2005;280:2536-42 pubmed
..These data demonstrate that quantitative mass spectrometry has great potential for the determination of the stoichiometry of multiprotein complexes. ..
Zhang L, Li X, Zhao R. Structural analyses of the pre-mRNA splicing machinery. Protein Sci. 2013;22:677-92 pubmed publisher
..This review discusses key recent findings in the structural analyses of the spliceosome and its components and how these findings advance our understanding of the function of the splicing machinery. ..
Nelissen R, Heinrichs V, Habets W, Simons F, Luhrmann R, van Venrooij W. Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. Nucleic Acids Res. 1991;19:449-54 pubmed
..These data indicate that the binding of protein C to U1 snRNP is dependent on the presence of both the U1 snRNA and one or more of the U1 snRNP proteins. ..
Craft J, Mimori T, Olsen T, Hardin J. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. J Clin Invest. 1988;81:1716-24 pubmed
..These linked autoantibody sets provide further evidence that intact macromolecular structures are targeted by the immune response in SLE and related diseases. ..
Gunnewiek J, van Aarssen Y, Wassenaar R, Legrain P, van Venrooij W, Nelissen R. Homodimerization of the human U1 snRNP-specific protein C. Nucleic Acids Res. 1995;23:4864-71 pubmed
..snRNP-specific protein C contains an N-terminal zinc finger-like CH motif which is required for the binding of the U1C protein to the U1 snRNP particle...
Satoh M, Langdon J, Hamilton K, Richards H, Panka D, Eisenberg R, et al
. Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein. J Clin Invest. 1996;97:2619-26 pubmed
Rossi F, Forne T, Antoine E, Tazi J, Brunel C, Cathala G. Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction. J Biol Chem. 1996;271:23985-91 pubmed
..A consequence of this organization is that the U1-C protein makes direct contacts with the site, as it becomes cross-linked to the RNA oligo upon exposition of the reactions to shortwave UV light. ..
Will C, Rumpler S, Klein Gunnewiek J, van Venrooij W, Luhrmann R. In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes. Nucleic Acids Res. 1996;24:4614-23 pubmed
..Studies with recombinant U1-C protein mutants indicated that the N-terminal domain of U1-C is necessary and sufficient for the stimulation of E complex formation. ..