Gene Symbol: Snrpb
Description: small nuclear ribonucleoprotein polypeptides B and B1
Alias: small nuclear ribonucleoprotein-associated protein B, SM11, sm protein B, sm-B, smB, snRNP-B
Species: rat
Products:     Snrpb

Top Publications

  1. Weber G, Trowitzsch S, Kastner B, Luhrmann R, Wahl M. Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO J. 2010;29:4172-84 pubmed publisher
    ..The intricate, multi-layered interplay of proteins and RNA rationalizes the hierarchical assembly of U snRNPs in vitro and in vivo. ..
  2. Grimaldi K, Horn D, Hudson L, Terenghi G, Barton P, Polak J, et al. Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart. Dev Biol. 1993;156:319-23 pubmed
    The SmN protein is a tissue-specific splicing factor which is closely related to the ubiquitous SmB splicing protein but which is expressed only in the adult brain and heart...
  3. Li S, Klein E, Russo A, Simmons D, Rosenfeld M. Isolation of cDNA clones encoding small nuclear ribonucleoparticle-associated proteins with different tissue specificities. Proc Natl Acad Sci U S A. 1989;86:9778-82 pubmed
    ..A related cDNA, designated Sm11, predicts a protein highly homologous to but distinct from Sm51...
  4. Miranda T, Khusial P, Cook J, Lee J, Gunderson S, Pestka S, et al. Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. Biochem Biophys Res Commun. 2004;323:382-7 pubmed
    We report a novel modification of spliceosome proteins Sm D1, Sm D3, and Sm B/B'. L292 mouse fibroblasts were labeled in vivo with [3H]methionine...
  5. Valles I, Pajares M, Segura V, Guruceaga E, Gomez Roman J, Blanco D, et al. Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer. PLoS ONE. 2012;7:e42086 pubmed publisher
    ..These genes play diverse roles in mRNA metabolism: three are associated with the spliceosome (ASCL3L1, SNRPB and SNRPE), whereas others participate in RNA-related processes such as translation (MARS and MRPL3), mRNA ..
  6. Huntriss J, Latchman D, Williams D. The snRNP core protein SmB and tissue-specific SmN protein are differentially distributed between snRNP particles. Nucleic Acids Res. 1993;21:4047-53 pubmed
    ..component of the small nuclear ribonucleoprotein particle which is closely related to the ubiquitously expressed SmB protein but is expressed only in the brain and heart...
  7. Leung A, Nagai K, Li J. Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. Nature. 2011;473:536-9 pubmed publisher
    ..of the spliceosome, U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), contain seven Sm proteins (SmB/B', SmD1, SmD2, SmD3, SmE, SmF and SmG) in common...
  8. Craft J, Mimori T, Olsen T, Hardin J. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. J Clin Invest. 1988;81:1716-24 pubmed
    ..These linked autoantibody sets provide further evidence that intact macromolecular structures are targeted by the immune response in SLE and related diseases. ..
  9. Pillai R, Will C, Luhrmann R, Schumperli D, Muller B. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. EMBO J. 2001;20:5470-9 pubmed
    ..This novel type of Sm complex, composed of both conventional Sm proteins and the Sm-like Lsm10, is most likely to be important for U7 snRNP function and subcellular localization. ..

More Information


  1. Yang X, Torres M, Marzluff W, Dominski Z. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Mol Cell Biol. 2009;29:4045-56 pubmed publisher
    ..protein (SLBP), which interacts with the stem-loop structure upstream of the cleavage site, and both Lsm11 and SmB, which are components of the U7-specific Sm ring...