Gene Symbol: Snrpa
Description: small nuclear ribonucleoprotein polypeptide A
Alias: U1 small nuclear ribonucleoprotein A
Sinha K, Perumal K, Chen Y, Reddy R. Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase. J Biol Chem. 1999;274:30826-31 pubmed
Pabis M, Neufeld N, Steiner M, Bojic T, Shav Tal Y, Neugebauer K. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. RNA. 2013;19:1054-63 pubmed publisher
..Taken together, the data support a model whereby CBC promotes pre-mRNA splicing through a network of interactions with and among spliceosomal snRNPs during cotranscriptional spliceosome assembly. ..
Novakova Z, Man P, Novak P, Hozak P, Hodny Z. Separation of nuclear protein complexes by blue native polyacrylamide gel electrophoresis. Electrophoresis. 2006;27:1277-87 pubmed
..Moreover, practical advice for sample preparation is provided. ..
Ray D, Kazan H, Chan E, Pena Castillo L, Chaudhry S, Talukder S, et al
. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol. 2009;27:667-70 pubmed publisher
..We anticipate that RNAcompete will be a valuable tool for the study of RNA-protein interactions. ..
Weber G, Trowitzsch S, Kastner B, Luhrmann R, Wahl M. Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO J. 2010;29:4172-84 pubmed publisher
..The intricate, multi-layered interplay of proteins and RNA rationalizes the hierarchical assembly of U snRNPs in vitro and in vivo. ..
Zhang L, Li X, Zhao R. Structural analyses of the pre-mRNA splicing machinery. Protein Sci. 2013;22:677-92 pubmed publisher
..This review discusses key recent findings in the structural analyses of the spliceosome and its components and how these findings advance our understanding of the function of the splicing machinery. ..
Craft J, Mimori T, Olsen T, Hardin J. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. J Clin Invest. 1988;81:1716-24 pubmed
..These linked autoantibody sets provide further evidence that intact macromolecular structures are targeted by the immune response in SLE and related diseases. ..
Bai B, Hales C, Chen P, GOZAL Y, Dammer E, Fritz J, et al
. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci U S A. 2013;110:16562-7 pubmed publisher
..Thus, our results demonstrate unique U1 snRNP pathology and implicate abnormal RNA splicing in AD pathogenesis. ..