Gene Symbol: Snrnp70
Description: small nuclear ribonucleoprotein U1 subunit 70
Alias: Snrp70, U1 small nuclear ribonucleoprotein 70 kDa, U1 small nuclear ribonucleoprotein polypeptide A, small nuclear ribonucleoprotein 70 (U1)
Species: rat
Products:     Snrnp70

Top Publications

  1. Query C, Bentley R, Keene J. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell. 1989;57:89-101 pubmed
  2. Blencowe B, Issner R, Nickerson J, Sharp P. A coactivator of pre-mRNA splicing. Genes Dev. 1998;12:996-1009 pubmed
    ..The results suggest that a complex of the nuclear matrix proteins SRm160 and SRm300 functions as a coactivator of pre-mRNA splicing. ..
  3. Manji S, Pearson R, Pardee M, Paspaliaris V, d Apice A, Martin T, et al. Dual posttranscriptional targets of retinoic acid-induced gene expression. J Cell Biochem. 1999;72:411-22 pubmed
  4. Monneaux F, Briand J, Muller S. B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein. Eur J Immunol. 2000;30:2191-200 pubmed
    ..Segment 131 - 151 is localized within the RNP80 motif and contains residues that are highly conserved in many nuclear, nucleolar and cytoplasmic RNA binding proteins. ..
  5. Novakova Z, Man P, Novak P, Hozak P, Hodny Z. Separation of nuclear protein complexes by blue native polyacrylamide gel electrophoresis. Electrophoresis. 2006;27:1277-87 pubmed
    ..Moreover, practical advice for sample preparation is provided. ..
  6. Weber G, Trowitzsch S, Kastner B, Luhrmann R, Wahl M. Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO J. 2010;29:4172-84 pubmed publisher
    ..The intricate, multi-layered interplay of proteins and RNA rationalizes the hierarchical assembly of U snRNPs in vitro and in vivo. ..
  7. Katsumata Y, Kawaguchi Y, Baba S, Hattori S, Tahara K, Ito K, et al. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study. Mod Rheumatol. 2013;23:71-80 pubmed publisher
    ..The anti-U1-70k antibodies might be involved in the pathological mechanisms of psychiatric syndromes in SLE. ..
  8. Zhang L, Li X, Zhao R. Structural analyses of the pre-mRNA splicing machinery. Protein Sci. 2013;22:677-92 pubmed publisher
    ..This review discusses key recent findings in the structural analyses of the spliceosome and its components and how these findings advance our understanding of the function of the splicing machinery. ..
  9. Pabis M, Neufeld N, Steiner M, Bojic T, Shav Tal Y, Neugebauer K. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. RNA. 2013;19:1054-63 pubmed publisher
    ..Taken together, the data support a model whereby CBC promotes pre-mRNA splicing through a network of interactions with and among spliceosomal snRNPs during cotranscriptional spliceosome assembly. ..

More Information


  1. Bai B, Hales C, Chen P, GOZAL Y, Dammer E, Fritz J, et al. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci U S A. 2013;110:16562-7 pubmed publisher
    ..Thus, our results demonstrate unique U1 snRNP pathology and implicate abnormal RNA splicing in AD pathogenesis. ..