Snca

Summary

Gene Symbol: Snca
Description: synuclein alpha
Alias: alpha-synuclein, synuclein, alpha (non A4 component of amyloid precursor)
Species: rat

Top Publications

  1. doi Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1
    Eun Jung Lee
    Department of Molecular Medicine and Brain and Cognitive Sciences, Ewha Womans University, Korea
    J Immunol 185:615-23. 2010
  2. pmc Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology
    J E Galvin
    Department of Neurology, Medical College of Pennsylvania Hahnemann University the Center for Neurodegenerative Disease Research, and the Department of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 157:361-8. 2000
  3. ncbi DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    Wenbo Zhou
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:43150-8. 2005
  4. ncbi Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
    M Ghee
    Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, Centre National de la Recherche Scientifique, UMR9923, Hopital de la Pitie Salpetriere, Paris, France
    J Neurochem 75:2221-4. 2000
  5. ncbi Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    M H Polymeropoulos
    Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1430, USA
    Science 276:2045-7. 1997
  6. ncbi Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    R Kruger
    Nat Genet 18:106-8. 1998
  7. ncbi Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    A Abeliovich
    Department of Neurology, University of California, San Francisco 94143, USA
    Neuron 25:239-52. 2000
  8. ncbi Age-dependent synuclein pathology following traumatic brain injury in mice
    K Uryu
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 184:214-24. 2003
  9. ncbi Expression of alpha-synuclein in different brain parts of adult and aged rats
    A Adamczyk
    Department of Cellular Signaling, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, PL 02 106 Warsaw, Poland
    J Physiol Pharmacol 56:29-37. 2005
  10. ncbi Neural activity controls the synaptic accumulation of alpha-synuclein
    Doris L Fortin
    Department of Neurology, Graduate Program in Biomedical Sciences, University of California, San Francisco, California 94143 2140, USA
    J Neurosci 25:10913-21. 2005

Research Grants

  1. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
  2. Robert A Rissman; Fiscal Year: 2015
  3. Rapid Screening Method: Gamma-hydroxybutyrate Detection
    Deborah Mash; Fiscal Year: 2002
  4. The Basis of Psychotic Symptoms in Parkinson's Disease
    Deborah Mash; Fiscal Year: 2008
  5. GENETIC MODEL OF NEURODEGENERATION
    Mel Feany; Fiscal Year: 2003
  6. Genetic Dissection of Neurodegenerative Dementias
    Mel Feany; Fiscal Year: 2005
  7. Drosophila Model of Parkinson's Disease
    Mel Feany; Fiscal Year: 2005
  8. Drosophila model of amyotrophic lateral sclerosis
    Mel Feany; Fiscal Year: 2007
  9. Aging in Drosophila models of human neurodegeneration
    Mel Feany; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications125 found, 100 shown here

  1. doi Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1
    Eun Jung Lee
    Department of Molecular Medicine and Brain and Cognitive Sciences, Ewha Womans University, Korea
    J Immunol 185:615-23. 2010
    ..Furthermore, our findings suggest that modulation of the activities of MMPs and/or PAR-1 may provide a new therapeutic strategy for Parkinson's disease...
  2. pmc Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology
    J E Galvin
    Department of Neurology, Medical College of Pennsylvania Hahnemann University the Center for Neurodegenerative Disease Research, and the Department of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 157:361-8. 2000
    ..These findings expand the concept of neurodegenerative synucleinopathies by implicating alphaS, betaS, and gammaS in the pathogenesis of NBIA 1...
  3. ncbi DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    Wenbo Zhou
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:43150-8. 2005
    ..We conclude that DJ-1 has multiple specific mechanisms for protecting dopamine neurons from cell death...
  4. ncbi Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
    M Ghee
    Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs, Centre National de la Recherche Scientifique, UMR9923, Hopital de la Pitie Salpetriere, Paris, France
    J Neurochem 75:2221-4. 2000
    ....
  5. ncbi Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    M H Polymeropoulos
    Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1430, USA
    Science 276:2045-7. 1997
    ..This finding of a specific molecular alteration associated with PD will facilitate the detailed understanding of the pathophysiology of the disorder...
  6. ncbi Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    R Kruger
    Nat Genet 18:106-8. 1998
  7. ncbi Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    A Abeliovich
    Department of Neurology, University of California, San Francisco 94143, USA
    Neuron 25:239-52. 2000
    ..These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission...
  8. ncbi Age-dependent synuclein pathology following traumatic brain injury in mice
    K Uryu
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 184:214-24. 2003
    ..This model of age-dependent TBI-induced transient alterations in alpha-Syn provides an opportunity to examine possible links between TBI and mechanisms of disease in synucleinopathies...
  9. ncbi Expression of alpha-synuclein in different brain parts of adult and aged rats
    A Adamczyk
    Department of Cellular Signaling, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, PL 02 106 Warsaw, Poland
    J Physiol Pharmacol 56:29-37. 2005
    ..Beta-synuclein (BSN) was not changed in aged brain comparing to adult. Age-related alteration of ASN may affect the nerve terminals structure and function...
  10. ncbi Neural activity controls the synaptic accumulation of alpha-synuclein
    Doris L Fortin
    Department of Neurology, Graduate Program in Biomedical Sciences, University of California, San Francisco, California 94143 2140, USA
    J Neurosci 25:10913-21. 2005
    ..Furthermore, the dispersion of alpha-synuclein is graded with respect to stimulus intensity. Neural activity thus controls the normal function of alpha-synuclein at the nerve terminal and may influence its role in PD...
  11. pmc Autoantibodies to alpha-synuclein in inherited Parkinson's disease
    Katerina K Papachroni
    Laboratory of Biological Chemistry, University of Athens Medical School, Athens, Greece
    J Neurochem 101:749-56. 2007
    ..We hypothesise that these AAb could be involved in pathogenesis of the inherited form of PD...
  12. doi Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease
    Ji Young Park
    Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    Glia 56:1215-23. 2008
    ..This study indicates that alpha-syn can modulate the function of microglia and influence inflammatory changes such as those seen in neurodegenerative disorders...
  13. doi alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells
    Anna Kazmierczak
    Medical Research Center, Polish Academy of Sciences, Department of Cellular Signaling, Pawinskiego 5 Str, 02 106 Warsaw, Poland
    Neurochem Int 53:263-9. 2008
    ..Our results indicate that alpha-synuclein enhances the release and toxicity of amyloid beta leading to nitric oxide mediated irreversible mitochondria dysfunction and caspase-dependent programmed cell death...
  14. pmc Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
    He Jin Lee
    Department of Anatomy, School of Medicine, Konkuk University, Seoul 143 701, Korea
    J Biol Chem 285:9262-72. 2010
    ..This transmission step is thus an important mediator of pathogenic glial responses and could qualify as a new therapeutic target...
  15. pmc In vivo demonstration that alpha-synuclein oligomers are toxic
    Beate Winner
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:4194-9. 2011
    ..e., E57K and E35K), whereas the α-syn variants that form fibrils very quickly are less toxic. We show that α-syn oligomers are toxic in vivo and that α-syn oligomers might interact with and potentially disrupt membranes...
  16. doi Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro
    Grzegorz A Czapski
    Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
    FEBS Lett 587:3135-41. 2013
    ..Cdk5 and calpain inhibitors prevented ASN-evoked cell death. Our findings, indicating the participation of Cdk5 in ASN toxicity, provide new insight into how extracellular ASN may trigger dopaminergic cell dysfunction in PD. ..
  17. ncbi Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death
    James T Lee
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 17:906-17. 2008
    ..Our findings suggest that Siah-1-mediated alpha-synuclein ubiquitination may play a critical role in Lewy body formation and PD pathogenesis...
  18. ncbi Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
    S Engelender
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 22:110-4. 1999
    ..A few families have PD caused by mutations (A53T or A30P) in the gene SNCA (encoding alpha-synuclein)...
  19. ncbi Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein
    Cátia S Ribeiro
    Department of Anatomy, Federal University of Rio de Janeiro, Rio de Janeiro 21491 590, Brazil
    J Biol Chem 277:23927-33. 2002
    ..Our data indicated that synphilin-1 is a synaptic partner of alpha-synuclein, and it may mediate synaptic roles attributed to alpha-synuclein...
  20. ncbi Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease
    Makoto Hashimoto
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093 0624, USA
    J Neurochem 85:1468-79. 2003
    ..Thus, the caveolin-1/ERK pathway could be a therapeutic target for the alpha-synuclein-related neurodegenerative disorders...
  21. ncbi Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation
    Gwang Lee
    Genetic Pharmacology Unit, NINDS, National Institutes of Health, Bethesda, Maryland 20824, USA
    J Biol Chem 279:6834-9. 2004
    ..These observations collectively indicate that a ubiquitous post-translational modification such as phosphorylation can regulate inclusion body formation in the context of alpha-synuclein and synphilin-1 interaction...
  22. ncbi Parkin disrupts the alpha-synuclein/dopamine transporter interaction: consequences toward dopamine-induced toxicity
    Anna Moszczynska
    Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, 250 College Street, Toronto, ON M5T 1R8, Canada
    J Mol Neurosci 32:217-27. 2007
    ..Moreover, we have found that parkin protects against DA-induced cell toxicity in dopaminergic SK-N-SH cells. These findings will help identify the role of these proteins in the etiology and/or maintenance of Parkinson's disease...
  23. doi alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity
    Guangwei Liu
    Department of Neurobiology and Sino Japan Joint Laboratory for Neurodegenerative Diseases, Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Xuanwu Hospital of China Capital Medical University, Beijing, China
    Neurosci Lett 454:187-92. 2009
    ....
  24. ncbi Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway
    Agata Adamczyk
    Department of Cellular Signalling, Medical Research Centre, Polish Academy of Sciences, 02 106 Warsaw, Poland
    Folia Neuropathol 47:247-51. 2009
    ..The NO pool liberated by ASN could be involved in the decrease of PARP-1 activity. The direct interaction between ASN and PARP-1 protein should be taken into consideration...
  25. pmc A microRNA embedded AAV α-synuclein gene silencing vector for dopaminergic neurons
    Ye Han
    Neurobiology Program, Department of Pediatrics, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Brain Res 1386:15-24. 2011
    Alpha-synuclein (SNCA), an abundantly expressed presynaptic protein, is implicated in Parkinson's disease (PD)...
  26. pmc α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1
    Paula Desplats
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:31691-702. 2012
    ..This study provides a molecular basis for α-synuclein-mediated disruption of adult neurogenesis in Parkinson disease...
  27. pmc Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics
    Hemi Dimant
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 9:e92098. 2014
    ..disorder characterized by Lewy bodies, a pathological hallmark comprised mostly of aggregated alpha synuclein. Accumulating evidence demonstrates the association of smaller oligomeric aggregates to disease etiology and ..
  28. pmc α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy
    Verena E L May
    Department of Molecular Neurology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Neurobiol Aging 35:2357-68. 2014
    ..Taken together, efficacious induction of OPC maturation may open the window to restore glial and neuronal function in MSA...
  29. doi PAR2-mediated epigenetic upregulation of α-synuclein contributes to the pathogenesis of Parkinson׳s disease
    Ping Liu
    Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
    Brain Res 1565:82-9. 2014
    ..Blockade of NF-κB signaling significantly decreased histone H3 acetylation in Snca promoter region and α-synuclein expression in substantia nigra...
  30. pmc Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
    João P L Daher
    Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35294
    Proc Natl Acad Sci U S A 111:9289-94. 2014
    ..These results may provide value in the translation of LRRK2-targeting therapeutics to conditions where neuroinflammation may underlie aspects of neuronal dysfunction and degeneration. ..
  31. pmc Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells
    Benjamin Ettle
    Department of Molecular Neurology, Friedrich Alexander University Erlangen Nurnberg, 91054 Erlangen, Germany
    Mol Cell Neurosci 62:68-78. 2014
    ..Taken together, these findings suggest a tight link between the intracellular level of h-aSyn and maturation capacity of primary OPCs...
  32. pmc Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus
    Liang Liu
    Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing, China
    PLoS ONE 9:e103948. 2014
    ..serine protein kinase (CASK), nuclear factor erythroid 2-related factor 2 (NRF2) and alpha-synuclein (SNCA), were concurrently down- regulated, suggesting that miR-144, miR-153 and miR-340-5p may play important roles ..
  33. doi S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells
    Xiao Fang Wu
    Department of Forensic Medicine, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province 510515, PR China Electronic address
    Toxicol Lett 230:19-27. 2014
    ..Therefore, PDI plays a significant role in neurological disorders related to α-syn aggregation, and it suggests that PDI could be as a potential target to prevent METH-induced neurodegeneration. ..
  34. pmc Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration
    Kevin R Nash
    Molecular Pharmacology and Physiology Department, Byrd Alzheimer Institute, University of South Florida, Tampa, Florida, USA
    Mol Ther 23:17-23. 2015
    ..Interestingly, we did not observe a reduction in MHCII expression suggesting that soluble fractalkine is likely altering the microglial state to a more neuroprotective one rather than reducing antigen presentation. ..
  35. pmc Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida
    J Cell Physiol 230:1024-32. 2015
    ....
  36. pmc Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
    João P L Daher
    From the Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama 35294
    J Biol Chem 290:19433-44. 2015
    ..These results demonstrate that pharmacological inhibition of LRRK2 is well tolerated for a 4-week period of time in rats and can counteract dopaminergic neurodegeneration caused by acute α-synuclein overexpression. ..
  37. pmc Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons
    J C Koch
    Department of Neurology, University Medicine Gottingen, Gottingen, Germany
    Cell Death Dis 6:e1811. 2015
    ..We conclude that αSyn overexpression impairs neurite outgrowth and augments axonal degeneration, whereas axonal vesicle transport and autophagy are severely altered. ..
  38. ncbi Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein
    P H Tu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    Ann Neurol 44:415-22. 1998
    ....
  39. pmc Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    P J Kahle
    Laboratory for Alzheimer s and Parkinson s Disease Research, The Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    Am J Pathol 159:2215-25. 2001
    ..In conclusion, the specific accumulation of detergent-insoluble alpha-SYN in transgenic mice recapitulates a pivotal feature of human LB diseases...
  40. ncbi Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Acta Neuropathol 103:145-51. 2002
    ..No beta- or gamma-synuclein immunoreactivity was found in those cells. These results indicate that in the PNS, alpha-synuclein is a useful marker of Schwann cells and that it is not involved in tumorigenesis...
  41. ncbi Synucleins in glaucoma: implication of gamma-synuclein in glaucomatous alterations in the optic nerve
    Irina Surgucheva
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri, USA
    J Neurosci Res 68:97-106. 2002
    ..These data suggest that significant changes in the pattern of expression and/or localization occur in the glaucomatous optic nerve for gamma-synuclein but not for alpha- and beta-members of the synuclein family...
  42. ncbi Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Acta Neuropathol 104:455-61. 2002
    ....
  43. ncbi Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons
    Deborah C Mash
    Department of Neurology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci 23:2564-71. 2003
    ..However, the accumulation of alpha-synuclein protein with long-term cocaine abuse may put addicts at increased risk for developing the motor abnormalities of Parkinson's disease...
  44. doi Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression
    ALEXIS M JEANNOTTE
    Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, Georgetown University, Washington, DC, USA
    Neuropsychopharmacology 34:987-98. 2009
    ..These results are the first to implicate alpha-Syn or gamma-Syn in the pathophysiology of depression and suggest that targeting synucleins may provide a new therapeutic option for depression...
  45. pmc Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease
    Kenya Nishioka
    Department of Neuroscience, Mayo Clinic Florida, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Arch Neurol 67:970-5. 2010
    To determine the association of the genes that encode alpha-, beta-, and gamma-synuclein (SNCA, SNCB, and SNCG, respectively) with diffuse Lewy body disease (DLBD).
  46. doi Alpha- and beta-synucleins are new diagnostic tools for acute erythroid leukemia and acute megakaryoblastic leukemia
    Robert W Maitta
    Montefiore Medical Center Albert Einstein College of Medicine Bronx, Bronx, New York 10467, USA
    Am J Hematol 86:230-4. 2011
    ....
  47. doi Regulation of α-synuclein expression in cultured cortical neurons
    Richard Lee Clough
    Division of Basic Neuroscience, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    J Neurochem 117:275-85. 2011
    Alpha-synuclein (SNCA) is a predominantly neuronal protein involved in the control of neurotransmitter release...
  48. pmc Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein
    Judit Olah
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, H 1113 Budapest, Hungary
    J Biol Chem 286:34088-100. 2011
    ....
  49. pmc α-Synuclein fate is determined by USP9X-regulated monoubiquitination
    Ruth Rott
    Department of Pharmacology, The B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Proc Natl Acad Sci U S A 108:18666-71. 2011
    ..Our data indicate that monoubiquitination is a key determinant of α-synuclein fate...
  50. pmc Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies
    Haya Kisos
    Biochemistry and Molecular Biology, IMRIC, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 7:e46817. 2012
    ..Hence, pathogenic mechanisms leading to elevated levels of α-Syn in neurons underlie neuronal secretion and subsequent uptake of α-Syn by oligodendrocytes in MSA...
  51. doi Activity-dependent secretion of alpha-synuclein by enteric neurons
    Sébastien Paillusson
    INSERM, U913, Nantes, France
    J Neurochem 125:512-7. 2013
    ..Our study is the first to evidence that enteric neurons are capable of secreting alpha-synuclein, thereby providing new insights into the role of the ENS in the pathophysiology of PD...
  52. doi Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats
    Lingling Lu
    Beijing Center of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China
    Acta Biochim Biophys Sin (Shanghai) 45:170-8. 2013
    ..Over-expression of α-syn may cause the degeneration of dopaminergic neurons through an interaction with mitochondrial VDAC1, which leads to mPTP activation, mitochondrial uncoupling, and cell death...
  53. pmc Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
    Bong Kyu Choi
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790 784, Korea
    Proc Natl Acad Sci U S A 110:4087-92. 2013
    ..Thus, the results suggest that large α-Syn oligomers function as inhibitors of dopamine release, which thus provides a clue, at the molecular level, to their neurotoxicity...
  54. pmc Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion
    Patrick Ejlerskov
    Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark
    J Biol Chem 288:17313-35. 2013
    ..g. lysosomal disturbance) or alter the polarity of vesicular transport of autophagosomes on microtubules, can result in an increased release of α-synuclein monomer and aggregates to the surroundings...
  55. ncbi alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
    N Ostrerova
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:5782-91. 1999
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases...
  56. ncbi Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
    ..These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions...
  57. ncbi Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
    D D Murphy
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 20:3214-20. 2000
    ..These data suggest that one function of alpha-synuclein may be to regulate the size of distinct pools of synaptic vesicles in mature neurons...
  58. pmc beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    E Masliah
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 98:12245-50. 2001
    ..Therefore, treatments that block the production or accumulation of beta-amyloid peptides could benefit a broader spectrum of disorders than previously anticipated...
  59. ncbi Tubulin seeds alpha-synuclein fibril formation
    Muhammad Abdul Alim
    Department of Neural Plasticity, Tokyo Institute of Psychiatry, Setagaya Ku, Tokyo 156 8585, Japan
    J Biol Chem 277:2112-7. 2002
    ..These findings suggest that an interaction between tubulin and alpha-synuclein might accelerate alpha-synuclein aggregation in diseased brains, leading to the formation of Lewy bodies...
  60. ncbi alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells
    Bong Hyun Ahn
    Department of Physiology, Research Institute of Molecular Genetics, and Anatomy, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    J Biol Chem 277:12334-42. 2002
    ..These results suggest that the association of alpha-synuclein with PLD, and modulation of PLD activity, is biologically important, but PLD does not appear to play an essential role in the pathophysiology of alpha-synuclein...
  61. ncbi Age-dependent differential regulation of genes encoding APP and alpha-synuclein in hippocampal synaptic plasticity
    A Stephan
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, CNRS UMR 8620, Universite Paris Sud, Orsay, France
    Hippocampus 12:55-62. 2002
    ..Whereas the level of alpha-synuclein mRNA is not apparently modified in normal LTP, it may reflect a mechanism of apoptotic cell death in aging that is in part responsible for decremental synaptic plasticity...
  62. ncbi A role for alpha-synuclein in the regulation of dopamine biosynthesis
    Ruth G Perez
    Department of Neurology and Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 22:3090-9. 2002
    ..If so, a loss of soluble alpha-synuclein, by reduced expression or aggregation, could increase dopamine synthesis with an accompanying increase in reactive dopamine metabolites...
  63. ncbi Expression of alpha-synuclein in non-apoptotic, slowly degenerating facial motoneurones
    L B Moran
    Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK
    J Neurocytol 30:515-21. 2001
    ..In addition, the extent of alpha-synuclein expression is related to the severity of neuronal injury...
  64. pmc alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    C Lo Bianco
    Institute of Neurosciences, Swiss Federal Institute of Technology Lausanne, EPFL, 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 99:10813-8. 2002
    ..Viral-mediated genetic models may contribute to elucidate the mechanism of alpha-syn-induced cell death and allow the screening of candidate therapeutic molecules...
  65. ncbi Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS
    J Y Li
    Department of Anatomy and Cell Biology, Neurobiology Unit, University of Goteborg, Box 420, SE 405 30, Goteborg, Sweden
    Neuroscience 113:463-78. 2002
    ..Gamma-synuclein appears to be present in both cholinergic and catecholaminergic regions, but very weak in the forebrain...
  66. ncbi The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility
    Yichin Liu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Department of Neurology, Harvard Medical School, Cambridge, MA 02139, USA
    Cell 111:209-18. 2002
    ..Thus, the ligase activity as well as the hydrolase activity of UCH-L1 may play a role in proteasomal protein degradation, a critical process for neuronal health...
  67. ncbi The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
    Aaron Ciechanover
    Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Neuron 40:427-46. 2003
    ..This raises hopes for a better understanding of the pathogenetic mechanisms involved in these diseases and for the development of novel, mechanism-based therapeutic modalities...
  68. ncbi alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons
    Hardy J Rideout
    Departments of Neurology and Pathology, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:46915-20. 2004
    ..The lack of effect on survival in alpha-synuclein knock-out cultures further suggests that the fibrillar nature of the inclusions does not contribute to neuronal degeneration in this model...
  69. ncbi alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines
    Begoña Martìn-Clemente
    Departamento de Bioquìmica e Instituto de Investigaciones Biomédicas Alberto Sols, Universidad Autónoma de Madrid Consejo Superior de Investigaciones Cientìfica, Facultad de Medicina UAM, 28029 Madrid, Spain
    J Biol Chem 279:52984-90. 2004
    ..These results strengthen the suggestion that other mechanisms resulting in synuclein aggregation (not simply expression levels) may be the key to understand the possible effect of aggregated synuclein on proteasome function...
  70. ncbi p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies
    Evo Lindersson
    Institute of Medical Biochemistry and Stereological Research and Electron Microscopy Laboratory, University of Aarhus, Aarhus, DK 8000, Denmark
    J Biol Chem 280:5703-15. 2005
    ..We suggest that p25alpha plays a pro-aggregatory role in the common neurodegenerative disorders hall-marked by alpha-synuclein aggregates...
  71. ncbi Subcellular localisation of recombinant alpha- and gamma-synuclein
    Christian G Specht
    Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London, UCL, London WC1E 6BT, UK
    Mol Cell Neurosci 28:326-34. 2005
    ..However, gamma-synuclein lacks a C-terminal domain that causes nuclear localisation of the fusion protein, suggesting that the two synucleins might have different roles relating to the cell nucleus...
  72. ncbi Alpha-synuclein-positive structures induced in leupeptin-infused rats
    T Nakajima
    Department of Neuropsychiatry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain Res 1040:73-80. 2005
    ..The present finding suggests that the local accumulation of alpha-synuclein might be induced by the impaired metabolism of alpha-synuclein, which are likely related to lysosomal or ubiquitin-independent proteasomal systems...
  73. ncbi Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases
    Jee Young Sung
    Department of Biology, College of Science, Yonsei University, Seoul 120 749, Korea
    J Biol Chem 280:25216-24. 2005
    ..The present study suggests that the extracellularly secreted alpha-synuclein could be processed via the activation of MMP-3 in a selective manner...
  74. ncbi Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
    Xiangmin Peng
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cell Sci 118:3523-30. 2005
    ..Together the data reveal a functional interaction between alpha-synuclein and PP2A that leads to PP2A activation and underscores a key role for alpha-synuclein in protein phosphorylation...
  75. ncbi Non A beta component of Alzheimer's disease amyloid and amyloid beta peptides evoked poly(ADP-ribose) polymerase-dependent release of apoptosis-inducing factor from rat brain mitochondria
    A Adamczyk
    Department of Cellular Signalling, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 56:5-13. 2005
    ..Our data indicated that A beta and NAC peptides stimulate AIF-dependent apoptotic pathway that seems to be caspase independent process. The inhibition of PARP-1 may protect the brain against A beta and NAC toxicity...
  76. ncbi Molecular motors implicated in the axonal transport of tau and alpha-synuclein
    Michelle A Utton
    Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 118:4645-54. 2005
    ....
  77. ncbi Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model
    Hiromi Hayashita-Kinoh
    Research Institute for Diseases of Old Age, Juntendo University, Tokyo, Japan
    Biochem Biophys Res Commun 341:1088-95. 2006
    ..Down-regulation of alpha-synuclein expression could be potentially a suitable target for gene therapy of Parkinson's disease...
  78. ncbi Upregulation of alpha-synuclein in neurons and glia in inflammatory demyelinating disease
    Dimitrios Papadopoulos
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience, Imperial College Faculty of Medicine, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK
    Mol Cell Neurosci 31:597-612. 2006
    ....
  79. ncbi Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats
    Ewa Malatynska
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, PA 19477, USA
    J Mol Neurosci 29:269-77. 2006
    ..The revealed pattern and dynamics of changes in the levels of mRNA coding for synucleins would support the conclusion for an important role of these molecules during development and the aging process...
  80. ncbi Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody
    S Yu
    Key Laboratory on Neurodegenerative Diseases of Ministry of Education, Beijing Institute of Geriatrics and Xuanwu Hospital of the Capital University of Medical Sciences, Beijing 100053, China
    Neuroscience 145:539-55. 2007
    ..This finding indicates an important physiological function of this molecule in the nuclei of brain neurons, which deserves further investigations...
  81. ncbi Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein
    Anya M Y Lin
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Pineal Res 43:163-71. 2007
    ..Accordingly, melatonin may be therapeutically useful for the treatment of arsenite-induced apoptosis in central nervous system...
  82. ncbi Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies
    Aasami Ishii
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    FEBS Lett 581:4711-7. 2007
    ..Taken together, these findings suggest that CK2 may be involved in the hyperphosphorylation of alpha-synuclein in alpha-synucleinopathies...
  83. pmc The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease
    Oleg S Gorbatyuk
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 105:763-8. 2008
    ..This suggests possible new therapeutic targets for Parkinson Disease...
  84. doi alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease
    Kohichi Kawahara
    Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92039 0624, USA
    J Biol Chem 283:6979-87. 2008
    ..These studies provide a new perspective on the potential nature of pathogenic alpha-synuclein and parkin interactions in Parkinson disease...
  85. doi Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety
    S Chiavegatto
    Department of Pharmacology, Biomedical Sciences Institute, University of Sao Paulo, Cidade Universitaria, 05508 900, Sao Paulo, SP, Brazil
    Mol Psychiatry 14:894-905. 2009
    ....
  86. pmc Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008
    ..These results indicate that CMA and macroautophagy are important pathways for WT ASYN degradation in neurons and underline the importance of CMA as degradation machinery in the nervous system...
  87. pmc Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
    Christophe Lo Bianco
    Wallenberg Neuroscience Center, Division of Neurobiology, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Clin Invest 118:3087-97. 2008
    ..Hsp104 likely protects dopaminergic neurons by antagonizing toxic alpha-synuclein assemblies and might have therapeutic potential for PD and other neurodegenerative amyloidoses...
  88. pmc Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data
    Shireen Vali
    Cell Works Group, Inc, 3rd Floor, West Wing, Neil Rao Tower, 118, Road 3, EPIP, White field, Bangalore 560066, India
    Free Radic Biol Med 45:1290-301. 2008
    ....
  89. doi Lrrk2 and alpha-synuclein are co-regulated in rodent striatum
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, Retzius väg 8 B2 4, S 17177 Stockholm, Sweden
    Mol Cell Neurosci 39:586-91. 2008
    ..Because striatal Lrrk2 and alpha-synuclein levels were not changed by dopamine depletion, we conclude that Lrrk2 and alpha-synuclein mRNA levels are possibly co-regulated, but they are not influenced by striatal dopamine levels...
  90. doi Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody
    Ling Zhang
    Beijing Institute for Neuroscience, Capital Medical University, Beijing Center of Neural Regeneration and Repairing, Beijing 100069, China
    Brain Res 1244:40-52. 2008
    ..The relative high level of mitochondrial alpha-Syn in hippocampus, striatum and substantia nigral neurons may have special pathophysiological significance, which deserves further investigation...
  91. doi Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies
    G Vivacqua
    Department of Neurobiology, Beijing Institute of Geriatrics, Beijing 100053, China
    Neuroscience 158:1478-87. 2009
    ....
  92. pmc Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation
    Raymonde Szargel
    Department of Pharmacology, The B Rappaport Faculty of Medicine and Institute of Medical Research, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 284:11706-16. 2009
    ..Our results suggest a novel function for synphilin-1A as a regulator of SIAH activity and formation of Lewy body-like inclusions...
  93. doi Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis
    Kai Yin Chau
    University Department of Clinical Neurosciences, Institute of Neurology, University College London, London, UK
    J Neurochem 110:1005-13. 2009
    b>Alpha synuclein can be phosphorylated at serine129 (P-S129), and the presence of highly phosphorylated alpha-synuclein in Lewy bodies suggests changes to its phosphorylation status has an important pathological role...
  94. pmc Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Exp Neurol 220:109-19. 2009
    ..Finally, this study establishes the utility of the aging Fischer 344 rat for the study of synucleopathies and tauopathies in the GI tract...
  95. pmc Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry
    Zihao Wang
    Department of Biological Chemistry, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 9:153-60. 2010
    ..Using this strategy, eight O-GlcNAc sites were mapped from a tau-enriched sample from rat brain. Sites of GlcNAcylation were characterized on important neuronal proteins such as tau, synucleins, and methyl CpG-binding protein 2...
  96. ncbi Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on alpha-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain
    Agata Adamczyk
    Department of Cellular Signaling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, PL 02 106 Warszawa, Poland
    Pharmacol Rep 61:1078-85. 2009
    ..We suggest that nitric oxide liberated by the over-activated neuronal isoform of NOS could react with superoxide to form peroxynitrite, which modulates the function of a variety of biomolecules including proteins, lipids, and DNA...
  97. pmc Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
    Vanesa Sanchez-Guajardo
    Central Nervous System Disease Modeling Group, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e8784. 2010
    ..Furthermore, our data suggest that the microglial response is modulated by early events related to alpha-syn expression in substantia nigra and persists at the long term...
  98. pmc Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions
    Katerina E Paleologou
    Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, EPFL, Lausanne, Switzerland
    J Neurosci 30:3184-98. 2010
    ..Together, our findings provide novel mechanistic insight into the role of phosphorylation at S87 and S129 in the pathogenesis of synucleinopathies and potential roles of phosphorylation in alpha-syn normal biology...
  99. doi Overexpression of alpha-synuclein down-regulates BDNF expression
    Yuhe Yuan
    Key Laboratory of Bioactive Substances and Resources Utilization, Ministry of Education, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People s Republic of China
    Cell Mol Neurobiol 30:939-46. 2010
    ..Therefore, the impaired PKC signal pathway caused by alpha-synuclein overexpression might account at least partially for the down-regulation of BDNF...
  100. pmc In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration
    Oleg S Gorbatyuk
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gene Therapy Center Cancer Genetics Research Complex, Building 1376 1376 Mowry Road, Room CG 208 Gainesville, FL 32610, USA
    Mol Ther 18:1450-7. 2010
    ..Our data show that alpha-syn plays an important role in the rat SNc and suggest that both up- and downregulation of wild-type alpha-syn expression increase the risk of nigrostriatal pathology...
  101. pmc α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration
    Oleg S Gorbatyuk
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA
    Mol Ther 18:1758-68. 2010
    ..Our data also demonstrate that it is possible to use viral-mediated gene transfer to study gene interactions in vivo...

Research Grants9

  1. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    ..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
  2. Robert A Rissman; Fiscal Year: 2015
    ..abstract_text> ..
  3. Rapid Screening Method: Gamma-hydroxybutyrate Detection
    Deborah Mash; Fiscal Year: 2002
    ..Both of these methods will be tested on GHB-spiked controls and residual blood and urine specimens obtained from the Miami-Dade County Medical Examiner Department and the Emergency Department of Jackson Memorial Hospital. ..
  4. The Basis of Psychotic Symptoms in Parkinson's Disease
    Deborah Mash; Fiscal Year: 2008
    ..Recent publications from our group, our preliminary results, the brain tissue availability and the multidisciplinary team assembled provide strong support for the feasibility of this project. [unreadable] [unreadable] [unreadable]..
  5. GENETIC MODEL OF NEURODEGENERATION
    Mel Feany; Fiscal Year: 2003
    ..A co-sponsor expert in human molecular genetics and neurodegenerative diseases has been selected to complement the primary laboratory's expertise in Drosophila molecular genetics and development. ..
  6. Genetic Dissection of Neurodegenerative Dementias
    Mel Feany; Fiscal Year: 2005
    ..These novel modifiers will represent candidate members of the presenilin complex, as well as upstream regulatory factors. ..
  7. Drosophila Model of Parkinson's Disease
    Mel Feany; Fiscal Year: 2005
    ..We can abolish inclusion formation in a-synuclein transgenic flies, and will determine if inclusions are required for neurotoxicity. ..
  8. Drosophila model of amyotrophic lateral sclerosis
    Mel Feany; Fiscal Year: 2007
    ..The role of excitotoxicity will be explored with genetic manipulations, in particular by overexpression of glial glutamate transporters. [unreadable] [unreadable]..
  9. Aging in Drosophila models of human neurodegeneration
    Mel Feany; Fiscal Year: 2007
    ..Pathways critical for these vulnerabilities will provide important therapeutic targets. [unreadable] [unreadable] [unreadable]..