Snapin

Summary

Gene Symbol: Snapin
Description: SNAP-associated protein
Alias: Snapap, SNARE-associated protein Snapin, BLOC-1 subunit 7, SNARE associated protein snapin, biogenesis of lysosome-related organelles complex 1 subunit 7, synaptosomal-associated protein 25-binding protein
Species: rat
Products:     Snapin

Top Publications

  1. Kang S, Shin Y, Shim Y, Jeong S, Park I, Min B. Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. Exp Cell Res. 2005;309:305-15 pubmed
    ..Taken together, these results suggest that the clusterin interacts with SCLIP and the interaction may act as an important modulator during neuronal differentiation. ..
  2. Chheda M, Ashery U, Thakur P, Rettig J, Sheng Z. Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex. Nat Cell Biol. 2001;3:331-8 pubmed
    ..Here we identify Snapin, a protein of relative molecular mass 15,000 that is implicated in neurotransmission by binding to SNAP-25, as a ..
  3. Mistry A, Mallick R, Fröhlich O, Klein J, Rehm A, Chen G, et al. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein. J Biol Chem. 2007;282:30097-106 pubmed
    ..screen of a human kidney cDNA library with the UT-A1 intracellular loop (residues 409-594) as bait, we identified snapin, a ubiquitously expressed SNARE-associated protein, as a novel UT-A1 binding partner...
  4. Ilardi J, Mochida S, Sheng Z. Snapin: a SNARE-associated protein implicated in synaptic transmission. Nat Neurosci. 1999;2:119-24 pubmed
    ..We have now identified another SNAP-25-binding protein, called Snapin. Snapin was enriched in neurons and exclusively located on synaptic vesicle membranes...
  5. Wei S, Xu Y, Shi H, Wong S, Han W, Talbot K, et al. EHD1 is a synaptic protein that modulates exocytosis through binding to snapin. Mol Cell Neurosci. 2010;45:418-29 pubmed publisher
    ..Our yeast two hybrid screening experiments showed that EHD1 interacts with a synaptic protein, snapin, and the present study was carried out to further elucidate the functional significance of this interaction...
  6. Pan P, Tian J, Sheng Z. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron. 2009;61:412-24 pubmed publisher
    ..Using cortical neurons from snapin-deficient mice, we reveal a role for Snapin in facilitating synchronous release...
  7. Rüder C, Reimer T, Delgado Martinez I, Hermosilla R, Engelsberg A, Nehring R, et al. EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin. Mol Biol Cell. 2005;16:1245-57 pubmed
    ..Here, we demonstrate that EBAG9 interacts with Snapin, which is likely to be a modulator of Synaptotagmin-associated regulated exocytosis...
  8. Wu C, Lin J, Chien C, Chang W, Lai H, Chang C, et al. Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25. Mol Cell Biol. 2011;31:4874-86 pubmed publisher
    ..enzyme which catalyzes cAMP synthesis, regulates neurite outgrowth by direct interaction with a binding protein (Snapin) of Snap25 at the N terminus of AC6 (AC6-N)...
  9. Chen M, Lucas K, Akum B, Balasingam G, Stawicki T, Provost J, et al. A novel role for snapin in dendrite patterning: interaction with cypin. Mol Biol Cell. 2005;16:5103-14 pubmed
    ..of a rat brain cDNA library with cypin lacking the carboxyl terminal eight amino acids as bait, we identified snapin as a cypin binding partner...

More Information

Publications26

  1. Zissimopoulos S, West D, Williams A, Lai F. Ryanodine receptor interaction with the SNARE-associated protein snapin. J Cell Sci. 2006;119:2386-97 pubmed
    ..b>Snapin, a ubiquitously expressed SNARE-associated protein, has been implicated in neurotransmission...
  2. Cai Q, Lu L, Tian J, Zhu Y, Qiao H, Sheng Z. Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons. Neuron. 2010;68:73-86 pubmed publisher
    ..Here, we report a role for Snapin in attaching dynein to late endosomes through its intermediate chain (DIC)...
  3. Vites O, Rhee J, Schwarz M, Rosenmund C, Jahn R. Reinvestigation of the role of snapin in neurotransmitter release. J Biol Chem. 2004;279:26251-6 pubmed
    b>Snapin, a 15-kDa protein, has been identified recently as a binding partner of SNAP-25. Moreover, snapin is regulated by phosphorylation and enhances synaptotagmin binding to SNAREs...
  4. Wolff S, Stöter M, Giamas G, Piesche M, Henne Bruns D, Banting G, et al. Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett. 2006;580:6477-84 pubmed
    In this study we identified snapin as an interaction partner of the CK1 isoform delta (CK1delta) in the yeast two-hybrid system and localized the interacting domains of both proteins...
  5. Suzuki F, Morishima S, Tanaka T, Muramatsu I. Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6. J Biol Chem. 2007;282:29563-73 pubmed
    ..We identified Snapin as a protein interacting with the C terminus of the alpha(1A)-AR...
  6. Suzuki F. [Roles of Snapin in alpha(1A)-adrenoceptor-induced calcium influx through TRPC6 channels]. Nihon Yakurigaku Zasshi. 2008;131:357-60 pubmed
  7. Starcevic M, Dell Angelica E. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2004;279:28393-401 pubmed
    ..Here, we report the identification of another four subunits of the complex. One is Snapin, a coiled-coil-forming protein previously characterized as a binding partner of synaptosomal-associated proteins ..
  8. Lee H, Nemecek D, Schindler C, Smith W, Ghirlando R, Steven A, et al. Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2012;287:5882-90 pubmed publisher
    ..BLOC-1 is an elongated complex that contains one copy each of the eight subunits pallidin, Cappuccino, dysbindin, Snapin, Muted, BLOS1, BLOS2, and BLOS3...
  9. Kim H, Zhong Q, Sheng Z, Yoshimori T, Liang C, Jung J. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci. 2012;125:4740-50 pubmed publisher
    ..endocytic trafficking pathway wherein Atg14L binds to and colocalizes with the fusogenic SNARE effector protein Snapin to facilitate endosome maturation...
  10. Granata A, Koo S, Haucke V, Schiavo G, Warner T. CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. EMBO J. 2011;30:181-93 pubmed publisher
    ..TA binds CSN4 and the synaptic regulator snapin in neuroblastoma cells and in brain synaptosomes...
  11. Somanath S, Partridge C, Marshall C, Rowe T, Turner M. Snapin mediates insulin secretory granule docking, but not trans-SNARE complex formation. Biochem Biophys Res Commun. 2016;473:403-7 pubmed publisher
    ..Here we demonstrate that in pancreatic β-cells the SNAP-25 accessory protein, snapin, C-terminal H2 domain binds SNAP-25 through its N-terminal Sn-1 domain...
  12. Granata A, Watson R, Collinson L, Schiavo G, Warner T. The dystonia-associated protein torsinA modulates synaptic vesicle recycling. J Biol Chem. 2008;283:7568-79 pubmed publisher
    ..In this study, we found that snapin, which binds SNAP-25 (synaptosome-associated protein of 25,000 Da) and enhances the association of the SNARE ..
  13. Krapivinsky G, Mochida S, Krapivinsky L, Cibulsky S, Clapham D. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron. 2006;52:485-96 pubmed
    ..with the synaptic vesicle proteins synapsin I and synaptotagmin I, and directly interacts with synaptic vesicular snapin. In sympathetic neurons, changes in TRPM7 levels and channel activity alter acetylcholine release, as measured by ..
  14. Yun H, Park J, Ho D, Kim H, Kim C, Oh H, et al. LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp Mol Med. 2013;45:e36 pubmed publisher
    ..Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts with LRRK2...
  15. Ginter Matuszewska B, Spik A, Rembiszewska A, Koyias C, Kupryjanczyk J, Jaruzelska J. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. Mol Hum Reprod. 2009;15:173-9 pubmed publisher
    ..Here, we found that PUMILIO2 interacts also with SNAPIN, a modulator of SNARE complex assembly, which is involved in vesicle trafficking...
  16. Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino J. BORC, a multisubunit complex that regulates lysosome positioning. Dev Cell. 2015;33:176-88 pubmed publisher
    ..In turn, this causes reduced cell spreading and migration, highlighting the importance of BORC-dependent centrifugal transport for non-degradative functions of lysosomes. ..
  17. Buxton P, Zhang X, Walsh B, Sriratana A, Schenberg I, Manickam E, et al. Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. Biochem J. 2003;375:433-40 pubmed
    ..One such factor, Snapin, has been reported to be a brain-specific protein that interacts with SNAP25, and regulates association of the ..