Gene Symbol: Smyd2
Description: SET and MYND domain containing 2
Alias: HSKM-B, N-lysine methyltransferase SMYD2, SET and MYND domain-containing protein 2, histone methyltransferase SMYD2
Species: rat
Products:     Smyd2

Top Publications

  1. Kruse J, Gu W. Modes of p53 regulation. Cell. 2009;137:609-22 pubmed publisher
    ..To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53. ..
  2. Brown M, Sims R, Gottlieb P, Tucker P. Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer. 2006;5:26 pubmed
    ..Here, we report the identification and characterization of the SET domain-containing protein, Smyd2. Smyd2 mRNA is most highly expressed in heart and brain tissue, as demonstrated by northern analysis and in situ ..
  3. Huang J, Perez Burgos L, Placek B, Sengupta R, Richter M, Dorsey J, et al. Repression of p53 activity by Smyd2-mediated methylation. Nature. 2006;444:629-32 pubmed
    ..Here we report a lysine methyltransferase, Smyd2, that methylates a previously unidentified site, Lys 370, in p53...
  4. He Y, Korboukh I, Jin J, Huang J. Targeting protein lysine methylation and demethylation in cancers. Acta Biochim Biophys Sin (Shanghai). 2012;44:70-9 pubmed publisher
    ..We also discuss the potential and the caveats of targeting protein lysine methylation for the treatment of cancer. ..
  5. Chen J, Jiang H, Xu L, Zhu L, Wang L, Wen H, et al. Dysregulation of CREB binding protein triggers thrombin-induced proliferation of vascular smooth muscle cells. Mol Cell Biochem. 2008;315:123-30 pubmed publisher
    ..These findings suggest that CBP plays a pivotal role in the S phase progression of VSMCs. ..
  6. Diehl F, Brown M, van Amerongen M, Novoyatleva T, Wietelmann A, Harriss J, et al. Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS ONE. 2010;5:e9748 pubmed publisher
    ..The highly related paralogue, Smyd2 is a histone 3 lysine 4- and lysine 36-specific methyltransferase expressed in heart and brain...
  7. Voelkel T, Andresen C, Unger A, Just S, Rottbauer W, Linke W. Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Biochim Biophys Acta. 2013;1833:812-22 pubmed publisher
    ..of the Smyd protein family of lysine methyltransferases are particularly abundant in the cytoplasm, with Smyd1 and Smyd2 being most highly expressed in the heart and in skeletal muscles...
  8. Hamamoto R, Toyokawa G, Nakakido M, Ueda K, Nakamura Y. SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation. Cancer Lett. 2014;351:126-33 pubmed publisher
    ..Here we demonstrate that HSP90AB1 is methylated by the histone methyltransferase SMYD2 and that it plays a critical role in human carcinogenesis...
  9. Oduru S, Campbell J, Karri S, Hendry W, Khan S, Williams S. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. BMC Genomics. 2003;4:22 pubmed publisher
    ..Each gene was expressed primarily in testis, suggesting that they may play roles in the development and/or function of testicular cells...

More Information


  1. Saddic L, West L, Aslanian A, Yates J, Rubin S, Gozani O, et al. Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem. 2010;285:37733-40 pubmed publisher
    ..Here we demonstrate that RB can be methylated by SMYD2 at lysine 860, a highly conserved and novel site of modification...
  2. Diao Y, Guo X, Li Y, Sun K, Lu L, Jiang L, et al. Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. Cell Stem Cell. 2012;11:231-41 pubmed publisher
    ..Collectively, our work establishes Pax3/7BP as an essential adaptor linking Pax3/7 with the H3K4 HMT to regulate the proliferation of MPCs. ..