Gene Symbol: Sms
Description: spermine synthase
Alias: spermine synthase
Species: rat
Products:     Sms

Top Publications

  1. Eloranta T, Khomutov A, Khomutov R, Hyvonen T. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. J Biochem. 1990;108:593-8 pubmed
    ..Both compounds were good competitive inhibitors and poor substrates of spermine synthase, good substrates of cytosolic polyamine acetyltransferase, inactivators of S-adenosylmethionine ..
  2. Shirahata A, Takahashi N, Beppu T, Hosoda H, Samejima K. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Biochem Pharmacol. 1993;45:1897-903 pubmed
    ..APCHA), selectively and potently inhibited the activities of spermidine synthase and spermine synthase, respectively. They were subjected to in vivo studies using rats...
  3. Lorenz B, Francis F, Gempel K, Böddrich A, Josten M, Schmahl W, et al. Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene. Hum Mol Genet. 1998;7:541-7 pubmed
    ..The human SMS (spermine synthase) gene maps approximately 39 kb upstream of PHEX and is transcribed in the same direction...
  4. Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
    ..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..
  5. Lu S, Mato J. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012;92:1515-42 pubmed publisher
    ..In experimental models, it is effective as a chemopreventive agent in HCC and perhaps other forms of cancer as well. ..